Article
Multidisciplinary Sciences
Krzysztof Cipora, Flavia H. Santos, Karin Kucian, Ann Dowker
Summary: In this paper, the authors discuss the widely accepted claims about mathematics anxiety (MA) and propose areas of focus for future research. These areas include theoretical clarifications, construct validity, the discrepancy between state and trait MA, prevalence of MA and establishing external criteria, effects of MA in different groups, applications in classrooms and policy, effects outside educational settings, and consequences for mental health and well-being.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Editorial Material
Chemistry, Multidisciplinary
Benjamin Mudrak, Sara Bosshart, Wolfram Koch, Allison Leung, Donna Minton, Mitsuo Sawamoto, Sarah Tegen
Summary: ChemRxiv was launched in 2017 as a platform for immediate sharing of research in chemistry and related fields. Over the past five years, it has become the premier preprint server for the chemical sciences, with a global audience and diverse scholarly content that accelerates scientific progress. As ChemRxiv celebrates its fifth anniversary, it looks forward to future advancements.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Editorial Material
Chemistry, Multidisciplinary
Benjamin Mudrak, Sara Bosshart, Wolfram Koch, Allison Leung, Donna Minton, Mitsuo Sawamoto, Sarah Tegen
Summary: ChemRxiv, launched in 2017, has become the leading preprint server for the chemical sciences, providing researchers with a platform to share their latest research and advancing scientific progress globally.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Biochemical Research Methods
Juan J. Galano-Frutos, Helena Garcia-Cebollada, Javier Sancho
Summary: This study discusses the inadequacy of the accuracy of bioinformatics tools in analyzing amino acid substitutions, proposes a more precise method of conducting full-atom molecular dynamics simulations, and describes the goal of interpreting human genetic variations on a large scale through MD simulations.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Hospitality, Leisure, Sport & Tourism
Vladimir Perdomo-Verdecia, Macarena Sacristan-Diaz, Pedro Garrido-Vega
Summary: This study offers an overview of Lean Management (LM) research in the hospitality industry and identifies the lack of research studies in this field. The study highlights the limited use of LM tools in hotels, with VSM and the 5S applications being the most prominent. More research is needed on specific applications and under-reported practices in hotel activities.
INTERNATIONAL JOURNAL OF HOSPITALITY MANAGEMENT
(2022)
Review
Chemistry, Multidisciplinary
Lan Yuan, Zhaoyi Geng, Jikun Xu, Fen Guo, Chuang Han
Summary: This review provides a comprehensive understanding of the structure-property-catalysis interplays of metal-semiconductor heterostructures (MSHs) for photoredox reactions, focusing on monitoring key photophysical/photochemical processes and design parameters. Applications of MSHs for solar energy conversion and the challenges/opportunities for further promoting this field are also discussed.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Medicine, General & Internal
Aqeel M. Alenazi, Ahmed S. Alhowimel, Mohammed M. Alshehri, Bader A. Alqahtani, Norah A. Alhwoaimel, Neil A. Segal, Patricia M. Kluding
Summary: Diabetes mellitus (DM) and osteoarthritis (OA) are prevalent worldwide and are associated with chronic pain and disability. They have been found to coexist within the same population, with DM potentially influencing the development and progression of OA. Common risk factors for both diseases include age, sex, race, and metabolic disorders. Research is needed to analyze the relationship between DM and OA and identify other possible contributing factors.
Review
Hematology
Sigrid S. Skanland, Jennifer R. Brown
Summary: Phosphatidylinositol 3-kinase (PI3K) inhibitors have shown efficacy in CLL, but their use is limited due to severe toxicity and availability of more tolerable agents. Optimizing the administration of current PI3K inhibitors and developing next-generation agents is important to improve tolerability. Strategies to overcome limitations include intermittent dosing and combination with other agents, as well as identifying biomarkers to personalize treatment decisions.
Review
Psychology, Clinical
Helga Ask, Rosa Cheesman, Eshim S. Jami, Daniel F. Levey, Kirstin L. Purves, Heike Weber
Summary: Anxiety disorders are common worldwide and often have early onset, with long-lasting consequences. While research on the genetics of anxiety has lagged behind other psychiatric disorders, progress is being made, offering opportunities for future research and potentially new therapeutic approaches. Investigations into gene-environment interactions and causal associations with related traits and disorders are expected to expand, with a focus on larger sample sizes and studies among young individuals.
PSYCHOLOGICAL MEDICINE
(2021)
Review
Oncology
Elisa Albi, Antonella Capasso, Luana Schiattone, Paolo Ghia, Lydia Scarfo
Summary: Chronic lymphocytic leukemia is a heterogeneous disease that requires personalized management and a deep understanding of the patient's biology. With the availability of targeted drugs, specific biomarkers can be used to tailor treatment strategies and improve disease control and patient outcomes.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Neurosciences
Song Li, Congcong Jia, Tianbai Li, Weidong Le
Summary: Parkinson's disease is the second most common neurodegenerative disease, but the exact mechanisms are still not clearly understood. Current diagnostic tools and therapies are mostly symptomatic, and researchers are now focusing on exploring the close association between PD and sleep disorders and gut symptoms.
NEUROSCIENCE BULLETIN
(2021)
Article
Surgery
Kinga Skowron Olortegui, Peter Angelos
Summary: Surgeons should be mindful of avoiding unprofessional behaviors and preventing the stressors that drive them. This is critically important for the future of our profession.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Review
Health Care Sciences & Services
Ruggero De Maria Marchiano, Gabriele Di Sante, Geny Piro, Carmine Carbone, Giampaolo Tortora, Luca Boldrini, Antonella Pietragalla, Gennaro Daniele, Maria Tredicine, Alfredo Cesario, Vincenzo Valentini, Daniela Gallo, Gabriele Babini, Marika D'Oria, Giovanni Scambia
Summary: The emergence of Precision Medicine has revolutionized translational research globally, emphasizing patient-centric therapeutic choices and digitizing individual health status. Real world data-based translational applications offer a promising alternative to traditional evidence-based medicine approaches.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Polymer Science
Zhao-Yu Ma, Yu-Ren Xue, Hao-Cheng Yang, Jian Wu, Zhi-Kang Xu
Summary: Surface and interface engineering plays a crucial role in tailoring the structures and properties of polymer membranes for sustainable development. This Perspective provides an overview of both conventional and emerging strategies in membrane surface engineering and discusses current trends in surface and interface engineering for porous and thin-film composite membranes, including the evolution from uniform functionalization to asymmetric performance construction and the regulation of interfacial polymerization.
Article
Chemistry, Multidisciplinary
Nitish Govindarajan, Georg Kastlunger, Hendrik H. Heenen, Karen Chan
Summary: With the looming climate crisis, there is an urgent need to transition to sustainable production of fuels and chemicals using renewable energy through electrochemical conversion. Adjusting components of the electrochemical environment like electrolyte, cations, and buffering anions can greatly enhance catalytic activity and bring us a step closer to optimizing electrochemical pathways for sustainable energy conversion.
Article
Hematology
Alexander C. Leeksma, Panagiotis Baliakas, Theodoros Moysiadis, Anna Puiggros, Karla Plevova, Anne-Marie van der Kevie-Kersemaekers, Hidde Posthuma, Ana E. Rodriguez-Vicente, Anh Nhi Tran, Gisela Barbany, Larry Mansouri, Rebeqa Gunnarsson, Helen Parker, Eva van den Berg, Mar Bellido, Zadie Davis, Meaghan Wall, Ilaria Scarpelli, Anders Osterborg, Lotta Hansson, Marie Jarosova, Paolo Ghia, Pino Poddighe, Blanca Espinet, Sarka Pospisilova, Constantine Tam, Loic Ysebaert, Florence Nguyen-Khac, David Oscier, Claudia Haferlach, Jacqueline Schoumans, Marian Stevens-Kroef, Eric Eldering, Kostas Stamatopoulos, Richard Rosenquist, Jonathan C. Strefford, Clemens Mellink, Arnon P. Kater
Summary: Genomic arrays have been shown to be an accurate tool for risk stratification in CLL, with high genomic complexity being an independent adverse prognosticator. Lowering the size cutoff for CNA did not significantly improve risk assessment. Arrays detected more chromosomal abnormalities and performed at least as well as simultaneous chromosome banding analysis for risk stratification.
Article
Oncology
Isabel Gonzalez-Gascon-y-Marin, Carolina Munoz-Novas, Inigo Figueroa, Maria Hernandez-Sanchez, Ana-Eugenia Rodriguez-Vicente, Miguel Quijada-Alamo, Claudia Perez-Carretero, Carol Moreno, Rosa Collado, Blanca Espinet, Anna Puiggros, Natalia de las Heras, Francesc Bosch, Jose-Angel Hernandez
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2020)
Article
Hematology
Andreas Agathangelidis, Anastasia Chatzidimitriou, Katerina Gemenetzi, Veronique Giudicelli, Maria Karypidou, Karla Plevova, Zadie Davis, Xiao-Jie Yan, Sabine Jeromin, Christof Schneider, Lone Bredo Pedersen, Renee C. Tschumper, Lesley-Ann Sutton, Panagiotis Baliakas, Lydia Scarfo, Ellen J. van Gastel, Marine Armand, Eugen Tausch, Bella Biderman, Constance Baer, Davide Bagnara, Alba Navarro, Anne Langlois de Septenville, Valentina Guido, Gerlinde Mitterbauer-Hohendanner, Aleksandar Dimovski, Christian Brieghel, Sarah Lawless, Manja Meggendorfer, Kamila Brazdilova, Matthias Ritgen, Monica Facco, Cristina Tresoldi, Andrea Visentin, Andrea Patriarca, Mark Catherwood, Lisa Bonello, Andrey Sudarikov, Katrina Vanura, Maria Roumelioti, Hana Skuhrova Francova, Theodoros Moysiadis, Silvio Veronese, Krzysztof Giannopoulos, Larry Mansouri, Teodora Karan-Djurasevic, Raphael Sandaltzopoulos, Csaba Bodor, Franco Fais, Arnon Kater, Irina Panovska, Davide Rossi, Salem Alshemmari, Panagiotis Panagiotidis, Paul Costeas, Blanca Espinet, Darko Antic, Letizia Foroni, Marco Montillo, Livio Trentin, Niki Stavroyianni, Gianluca Gaidano, Paola Francia di Celle, Carsten Niemann, Elias Campo, Achilles Anagnostopoulos, Christiane Pott, Kirsten Fischer, Michael Hallek, David Oscier, Stephan Stilgenbauer, Claudia Haferlach, Diane Jelinek, Nicholas Chiorazzi, Sarka Pospisilova, Marie-Paule Lefranc, Sofia Kossida, Anton W. Langerak, Chrysoula Belessi, Frederic Davi, Richard Rosenquist, Paolo Ghia, Kostas Stamatopoulos
Summary: The study found that a significant portion of CLL patients belong to stereotyped subsets, with 19 major subsets retaining their relative size and ranking while 10 new ones emerged. Higher-level relationships were evident between subsets, particularly for major stereotyped subsets with unmutated IGHV genes, which were identified to have close relations with other subsets called satellites. Satellite subsets accounted for 3% of the entire cohort, suggesting a novel aspect of repertoire restriction with implications for refined molecular classification of CLL.
Article
Hematology
Gonzalo Blanco, Anna Puiggros, Barbara Sherry, Lara Nonell, Xavier Calvo, Eulalia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, Gerardo Ferrer, Florencia Palacios, Magdalena Arnal, Maria Rodriguez-Rivera, Eva Gimeno, Eugenia Abella, Kanti R. Rai, Pau Abrisqueta, Francesc Bosch, Alexandre Calon, Ana Ferrer, Nicholas Chiorazzi, Blanca Espinet
Summary: Studies have revealed differences in the inflammatory environment between MBL and CLL, highlighting an active role for antigen stimulation in the very early stages of the disease, potentially related to malignant B-cell transformation.
EXPERIMENTAL HEMATOLOGY
(2021)
Article
Hematology
Silvia Ramos-Campoy, Anna Puiggros, Silvia Bea, Sandrine Bougeon, Maria Jose Larrayoz, Dolors Costa, Helen Parker, Gian Matteo Rigolin, Margarita Ortega, Maria Laura Blanco, Rosa Collado, Rocio Salgado, Tycho Baumann, Eva Gimeno, Carolina Moreno, Francesc Bosch, Xavier Calvo, Maria Jose Calasanz, Antonio Cuneo, Jonathan C. Strefford, Florence Nguyen-Khac, David Oscier, Claudia Haferlach, Jacqueline Schoumans, Blanca Espinet
Summary: This study compared the effectiveness of chromosome banding analysis (CBA) and genomic microarrays (GM) in risk stratification of CLL patients. The results showed moderate agreement between the two methods, but discordant classification in individual cases. Most discrepancies were technique-dependent and no significant correlation in the number of abnormalities was found when different filtering strategies were applied for GM. However, both CBA and GM showed similar predictive values for time to first treatment (TTFT) and overall survival. High complexity defined by both CBA and GM remained significant in the multivariate analysis for TTFT. Validation studies are needed to establish the prognostic value of genome complexity based on GM data in future prospective studies.
Article
Hematology
Anna Puiggros, Gonzalo Blanco, Aura Muntasell, Maria Rodriguez-Rivera, Lara Nonell, Mireia Altadill, Eulalia Puigdecanet, Magdalena Arnal, Xavier Calvo, Eva Gimeno, Eugenia Abella, Pau Abrisqueta, Francesc Bosch, Jose Yelamos, Ana Ferrer, Miguel Lopez-Botet, Blanca Espinet
Summary: Reduced percentages of CD94/NKG2C(+) NK cells were observed in CLL and MBL patients independently of HCMV serostatus and NKG2C zygosity, particularly in CLL patients with increased lymphocytosis, which could potentially be related to the exposure to tumor cells.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2021)
Article
Pathology
Ivonne Vazquez, Natalia Papaleo, Joan Lop, Anna Puiggros, Blanca Sanchez-Gonzalez, Ramon Diez-Feijoo, Eva Gimeno, Marcio Andrade-Campos, Antonio Salar, Blanca Espinet, Marta Salido, Gustavo Tapia, Joaquim Carreras, Ana Ferrer, Leonor Arenillas, Xavier Calvo, Luis Colomo
Summary: The study found that LMO2 clone SP51 has high specificity, accuracy, and predictive value in screening for MYC rearrangements in CD10-positive LBCL.
Article
Oncology
Dolors Costa, Isabel Granada, Blanca Espinet, Rosa Collado, Neus Ruiz-Xiville, Anna Puiggros, Marisol Uribe, Amparo Arias, Candida Gomez, Julio Delgado, Arturo Pereira, Laura Magnano, Dolors Colomer, Cristina Lopez, Silvia Bea
Summary: Chromosomal translocations in CLL are rare, with 7.5% of cases showing translocations in a study of 2843 patients. Various chromosomes, mostly 14, 18, and 13, were involved in the translocations, with breakpoints in genes related to CLL. Identifying novel translocations contributes to understanding the genetic complexity of CLL and may impact clinical outcomes.
GENES CHROMOSOMES & CANCER
(2022)
Article
Oncology
Thomas Chatzikonstantinou, Anargyros Kapetanakis, Lydia Scarfo, Georgios Karakatsoulis, David Allsup, Alejandro Alonso Cabrero, Martin Andres, Darko Antic, Monica Baile, Panagiotis Baliakas, Dominique Bron, Antonella Capasso, Sofia Chatzileontiadou, Raul Cordoba, Juan-Gonzalo Correa, Carolina Cuellar-Garcia, Lorenzo De Paoli, Maria Rosaria De Paolis, Giovanni Del Poeta, Christos Demosthenous, Maria Dimou, David Donaldson, Michael Doubek, Maria Efstathopoulou, Barbara Eichhorst, Shaimaa El-Ashwah, Alicia Enrico, Blanca Espinet, Lucia Farina, Angela Ferrari, Myriam Foglietta, Henrik Frederiksen, Moritz Furstenau, Jose A. Garcia-Marco, Rocio Garcia-Serra, Massimo Gentile, Eva Gimeno, Andreas Glenthoj, Maria Gomes da Silva, Odit Gutwein, Yervand K. Hakobyan, Yair Herishanu, Jose Angel Hernandez-Rivas, Tobias Herold, Idanna Innocenti, Gilad Itchaki, Ozren Jaksic, Ann Janssens, Olga B. Kalashnikova, Elzbieta Kalicinska, Linda Katharina Karlsson, Arnon P. Kater, Sabina Kersting, Jorge Labrador, Deepesh Lad, Luca Laurenti, Mark-David Levin, Enrico Lista, Alberto Lopez-Garcia, Lara Malerba, Roberto Marasca, Monia Marchetti, Juan Marquet, Mattias Mattsson, Francesca R. Mauro, Ivana Milosevic, Fatima Miras, Marta Morawska, Marina Motta, Talha Munir, Roberta Murru, Carsten U. Niemann, Raquel Nunes Rodrigues, Jacopo Olivieri, Lorella Orsucci, Maria Papaioannou, Miguel Arturo Pavlovsky, Inga Piskunova, Viola Maria Popov, Francesca Maria Quaglia, Giulia Quaresmini, Kristian Qvist, Gianluigi Reda, Gian Matteo Rigolin, Rosa Ruchlemer, Gevorg Saghumyan, Amit Shrestha, Martin Simkovic, Martin Spacek, Paolo Sportoletti, Oana Stanca, Niki Stavroyianni, Tamar Tadmor, Doreen Te Raa, Sanne H. Tonino, Livio Trentin, Ellen Van der Spek, Michel van Gelder, Roel van Kampen, Marzia Varettoni, Andrea Visentin, Candida Vitale, Ewa Wasik-Szczepanek, Tomasz Wrobel, Lucrecia Yanez San Segundo, Mohamed Yassin, Marta Coscia, Alessandro Rambaldi, Emili Montserrat, Robin Foa, Antonio Cuneo, Kostas Stamatopoulos, Paolo Ghia
Summary: Patients with CLL are more susceptible to the impact of COVID-19, with age, CLL-directed treatment, and cardiac failure being significant risk factors for outcomes. Untreated patients have a better chance of survival, and age, cardiac failure, and CLL-directed treatment are significant risk factors for OS.
Article
Oncology
Anna Puiggros, Silvia Ramos-Campoy, Joanna Kamaso, Mireia de la Rosa, Marta Salido, Carme Melero, Maria Rodriguez-Rivera, Sandrine Bougeon, Rosa Collado, Eva Gimeno, Rocio Garcia-Serra, Sara Alonso, Marco Antonio Moro-Garcia, Maria Dolores Garcia-Malo, Xavier Calvo, Leonor Arenillas, Ana Ferrer, Tuomo Mantere, Alexander Hoischen, Jacqueline Schoumans, Blanca Espinet
Summary: This study investigated the use of optical genome mapping (OGM) in assessing the cytogenetics of chronic lymphocytic leukemia (CLL). The results showed that OGM can identify most known abnormalities and provide new structural information. OGM had better accuracy than current methods in predicting the time to first treatment. A complex OGM group defined by the number of abnormalities was associated with TP53 abnormalities and shorter time to first treatment.
Article
Hematology
Salvador Carrillo-Tornel, Tzu Hua Chen-Liang, Maria Zurdo, Anna Puiggros, Andrea Gomez-Llonin, Maria Dolores Garcia-Malo, Ernesto Jose Cuenca-Zamora, Francisco Jose Ortuno, Ana Maria Hurtado Lopez, Blanca Espinet, Andres Jerez
Summary: Prior studies have shown that chronic lymphocytic leukemia (CLL) has an indolent course due to dysregulated cyclin genes keeping most cells in the G(0)-G(1) cell cycle phase. This dysregulation is also observed in T lymphoblastic leukemia with NOTCH1 mutation. This study aimed to comprehensively investigate the cell cycle in NOTCH1-mutated CLL and identify potential therapeutic targets. The results revealed a distinct transcriptome profile in NOTCH1-mutated CLL cells, with an overexpression of early-phase effectors and increased cell cycling. Inhibition of NOTCH1 gamma-secretase and CDK4/6 showed promise as new therapeutic approaches for targeting NOTCH1-mutated CLL.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Letter
Hematology
Marie Solange Flores-Moran, Juan Jose Rodriguez-Sevilla, Leonor Arenillas, Xavier Calvo, Ana Puiggros, Blanca Espinet, Beatriz Costan, Maria Rodriguez-Rivera, Marta Salido, Ana Ferrer del Alamo
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Antonio Jose Cabrera-Serrano, Jose Manuel Sanchez-Maldonado, Rob ter Horst, Angelica Macauda, Paloma Garcia-Martin, Yolanda Benavente, Stefano Landi, Alyssa Clay-Gilmour, Yasmeen Niazi, Blanca Espinet, Juan Jose Rodriguez-Sevilla, Eva Maria Perez, Rossana Maffei, Gonzalo Blanco, Matteo Giaccherini, James R. Cerhan, Roberto Marasca, Miguel Angel Lopez-Nevot, Tzu Chen-Liang, Hauke Thomsen, Irene Gamez, Daniele Campa, Victor Moreno, Silvia de Sanjose, Rafael Marcos-Gragera, Maria Garcia-Alvarez, Trinidad Dierssen-Sotos, Andres Jerez, Aleksandra Butrym, Aaron D. Norman, Mario Luppi, Susan L. Slager, Kari Hemminki, Yang Li, Sonja I. Berndt, Delphine Casabonne, Miguel Alcoceba, Anna Puiggros, Mihai G. Netea, Asta Foersti, Federico Canzian, Juan Sainz
Summary: Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults worldwide. However, a study found that the GWAS-identified risk variants for CLL do not significantly impact overall survival and disease progression in CLL patients. The polygenic risk scores (PRSs) built with these risk variants also have limited accuracy in predicting patient survival and disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)