The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity

Evolution of Secondary Metabolite Genes in Three Closely Related Marine Actinomycete Species

(2011) Kelle C. Freel et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

Widespread Occurrence of Secondary Lipid Biosynthesis Potential in Microbial Lineages

(2011) Christine N. Shulse et al.   PLoS One

Sequence-Based Analysis of Secondary-Metabolite Biosynthesis in Marine Actinobacteria

(2010) E. A. Gontang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Newick utilities: high-throughput phylogenetic tree processing in the UNIX shell

(2010) T. Junier et al.   BIOINFORMATICS

The Discovery of Salinosporamide K from the Marine Bacterium “Salinispora pacifica” by Genome Mining Gives Insight into Pathway Evolution

(2010) Alessandra S. Eustáquio et al.   CHEMBIOCHEM

Genomics-inspired discovery of natural products

(2010) Jaclyn M Winter et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

How to discover new antibiotics: harvesting the parvome

(2010) Julian Davies   CURRENT OPINION IN CHEMICAL BIOLOGY

Biosynthesis of polyketides by trans-AT polyketide synthases

(2010) Jörn Piel   NATURAL PRODUCT REPORTS

Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria

(2010) J. A. V. Blodgett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria

(2009) Kevin Penn et al.   ISME Journal

Function-Oriented Biosynthesis of β-Lactone Proteasome Inhibitors inSalinispora tropica

(2009) Markus Nett et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bioinformatic perspectives on NRPS/PKS megasynthases: Advances and challenges

(2009) Holger Jenke-Kodama et al.   NATURAL PRODUCT REPORTS

Next-generation gap

(2009) John D McPherson   NATURE METHODS

The Pfam protein families database

(2009) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Evolution of metabolic diversity: Insights from microbial polyketide synthases

(2009) Holger Jenke-Kodama et al.   PHYTOCHEMISTRY

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

(2009) A. S. Eustaquio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Towards Prediction of Metabolic Products of Polyketide Synthases: An In Silico Analysis

(2009) Gitanjali Yadav et al.   PLoS Computational Biology

Genome Mining for Novel Natural Product Discovery

(2008) Gregory L. Challis   JOURNAL OF MEDICINAL CHEMISTRY

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

(2008) TuAnh Nguyen et al.   NATURE BIOTECHNOLOGY

Phylogeny.fr: robust phylogenetic analysis for the non-specialist

(2008) A. Dereeper et al.   NUCLEIC ACIDS RESEARCH

ClustScan : an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures

(2008) Antonio Starcevic et al.   NUCLEIC ACIDS RESEARCH

A Computational Screen for Type I Polyketide Synthases in Metagenomics Shotgun Data

(2008) Konrad U. Foerstner et al.   PLoS One

Evolution of polyketide synthases in bacteria

(2008) C. P. Ridley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA