Discovery of microbial natural products by activation of silent biosynthetic gene clusters
出版年份 2015 全文链接
标题
Discovery of microbial natural products by activation of silent biosynthetic gene clusters
作者
关键词
-
出版物
NATURE REVIEWS MICROBIOLOGY
Volume 13, Issue 8, Pages 509-523
出版商
Springer Nature
发表日期
2015-06-29
DOI
10.1038/nrmicro3496
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection
- (2015) Fang Guo et al. METABOLIC ENGINEERING
- An irresistible newcomer
- (2015) Gerard Wright NATURE
- A new antibiotic kills pathogens without detectable resistance
- (2015) Losee L. Ling et al. NATURE
- Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes
- (2015) Tilmann Weber et al. TRENDS IN BIOTECHNOLOGY
- Automated Genome Mining of Ribosomal Peptide Natural Products
- (2014) Hosein Mohimani et al. ACS Chemical Biology
- Synthetic Biology Tools for Bioprospecting of Natural Products in Eukaryotes
- (2014) Shiela E. Unkles et al. CHEMISTRY & BIOLOGY
- Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2
- (2014) Ekaterina Gavrish et al. CHEMISTRY & BIOLOGY
- In silico tools for the analysis of antibiotic biosynthetic pathways
- (2014) Tilmann Weber INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
- NRPquest: Coupling Mass Spectrometry and Genome Mining for Nonribosomal Peptide Discovery
- (2014) Hosein Mohimani et al. JOURNAL OF NATURAL PRODUCTS
- Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products
- (2014) Daniel Krug et al. NATURAL PRODUCT REPORTS
- Reconstructing fungal natural product biosynthetic pathways
- (2014) C. M. Lazarus et al. NATURAL PRODUCT REPORTS
- A talented genus
- (2014) Marcel Jaspars et al. NATURE
- An environmental bacterial taxon with a large and distinct metabolic repertoire
- (2014) Micheal C. Wilson et al. NATURE
- Functional optimization of gene clusters by combinatorial design and assembly
- (2014) Michael J Smanski et al. NATURE BIOTECHNOLOGY
- Improved Lanthipeptide Detection and Prediction for antiSMASH
- (2014) Kai Blin et al. PLoS One
- High-throughput platform for the discovery of elicitors of silent bacterial gene clusters
- (2014) M. R. Seyedsayamdost PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A
- (2014) Kazuya Yamanaka et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Yeast Synthetic Biology Platform Generates Novel Chemical Structures as Scaffolds for Drug Discovery
- (2014) Jens Klein et al. ACS Synthetic Biology
- Pep2Path: Automated Mass Spectrometry-Guided Genome Mining of Peptidic Natural Products
- (2014) Marnix H. Medema et al. PLoS Computational Biology
- Activation and identification of five clusters for secondary metabolites inStreptomyces albus J1074
- (2014) Carlos Olano et al. Microbial Biotechnology
- Genetic Basis for the Biosynthesis of the Pharmaceutically Important Class of Epoxyketone Proteasome Inhibitors
- (2013) Michelle Schorn et al. ACS Chemical Biology
- Cloning and Heterologous Expression of the Thioviridamide Biosynthesis Gene Cluster from Streptomyces olivoviridis
- (2013) Masumi Izawa et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Bacterium Induces Cryptic Meroterpenoid Pathway in the Pathogenic FungusAspergillus fumigatus
- (2013) Claudia C. König et al. CHEMBIOCHEM
- Imaging Mass Spectrometry of a Coral Microbe Interaction with Fungi
- (2013) Wilna J. Moree et al. JOURNAL OF CHEMICAL ECOLOGY
- Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways
- (2013) Gregory L. Challis JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Discovery and Synthetic Refactoring of Tryptophan Dimer Gene Clusters from the Environment
- (2013) Fang-Yuan Chang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Natural product isolation – how to get from biological material to pure compounds
- (2013) Franz Bucar et al. NATURAL PRODUCT REPORTS
- From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes
- (2013) Kyung Bo Kim et al. NATURAL PRODUCT REPORTS
- Using NMR to identify and characterize natural products
- (2013) Rosemary C. Breton et al. NATURAL PRODUCT REPORTS
- antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers
- (2013) Kai Blin et al. NUCLEIC ACIDS RESEARCH
- BAGEL3: automated identification of genes encoding bacteriocins and (non-)bactericidal posttranslationally modified peptides
- (2013) Auke J. van Heel et al. NUCLEIC ACIDS RESEARCH
- Structurally Diverse Chaetophenol Productions Induced by Chemically Mediated Epigenetic Manipulation of Fungal Gene Expression
- (2013) Teigo Asai et al. ORGANIC LETTERS
- Classification of the Adenylation and Acyl-Transferase Activity of NRPS and PKS Systems Using Ensembles of Substrate Specific Hidden Markov Models
- (2013) Barzan I. Khayatt et al. PLoS One
- Phage P1-Derived Artificial Chromosomes Facilitate Heterologous Expression of the FK506 Gene Cluster
- (2013) Adam C. Jones et al. PLoS One
- Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products
- (2013) J. G. Owen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery of a family of γ-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster
- (2013) John D. Sidda et al. Chemical Science
- Antiterminator-Mediated Unveiling of Cryptic Polythioamides in an Anaerobic Bacterium
- (2012) Swantje Behnken et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters
- (2012) Kozo Ochi et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Chemical Perturbation of Secondary Metabolism Demonstrates Important Links to Primary Metabolism
- (2012) Arryn Craney et al. CHEMISTRY & BIOLOGY
- Natural Products As Sources for New Pesticides
- (2012) Charles L. Cantrell et al. JOURNAL OF NATURAL PRODUCTS
- Tetarimycin A, an MRSA-Active Antibiotic Identified through Induced Expression of Environmental DNA Gene Clusters
- (2012) Dimitris Kallifidas et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Terpenoid synthase structures: a so far incomplete view of complex catalysis
- (2012) Yang Gao et al. NATURAL PRODUCT REPORTS
- A genomic approach to the cryptic secondary metabolome of the anaerobic world
- (2012) Anne-Catrin Letzel et al. NATURAL PRODUCT REPORTS
- Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
- (2012) Paul G. Arnison et al. NATURAL PRODUCT REPORTS
- Regulation of fungal secondary metabolism
- (2012) Axel A. Brakhage NATURE REVIEWS MICROBIOLOGY
- Interkingdom metabolic transformations captured by microbial imaging mass spectrometry
- (2012) W. J. Moree et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Posttranslational β-methylation and macrolactamidination in the biosynthesis of the bottromycin complex of ribosomal peptide antibiotics
- (2012) Juan Pablo Gomez-Escribano et al. Chemical Science
- Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145
- (2012) Juan Pablo Gomez-Escribano et al. Chemical Science
- Transcriptional regulatory elements in fungal secondary metabolism
- (2011) Wenbing Yin et al. JOURNAL OF MICROBIOLOGY
- Metabolites from the Induced Expression of Cryptic Single Operons Found in the Genome of Burkholderia pseudomallei
- (2011) John B. Biggins et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler
- (2011) Zengyi Shao et al. Molecular BioSystems
- The regulation of the secondary metabolism of Streptomyces: new links and experimental advances
- (2011) Gilles P. van Wezel et al. NATURAL PRODUCT REPORTS
- Fidaxomicin versus Vancomycin forClostridium difficileInfection
- (2011) Thomas J. Louie et al. NEW ENGLAND JOURNAL OF MEDICINE
- NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity
- (2011) Marc Röttig et al. NUCLEIC ACIDS RESEARCH
- antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
- (2011) Marnix H. Medema et al. NUCLEIC ACIDS RESEARCH
- Acyldepsipeptide HDAC Inhibitor Production Induced inBurkholderia thailandensis
- (2011) John B. Biggins et al. ORGANIC LETTERS
- Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
- (2011) L. Laureti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Closthioamide: An Unprecedented Polythioamide Antibiotic from the Strictly Anaerobic Bacterium Clostridium cellulolyticum
- (2010) Thorger Lincke et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Mycolic Acid-Containing Bacteria Induce Natural-Product Biosynthesis inStreptomycesSpecies
- (2010) Hiroyasu Onaka et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Use of Ichip for High-Throughput In Situ Cultivation of "Uncultivable" Microbial Species
- (2010) D. Nichols et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Cloning large natural product gene clusters from the environment: Piecing environmental DNA gene clusters back together with TAR
- (2010) Jeffrey H. Kim et al. BIOPOLYMERS
- Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms
- (2010) Yi-Ming Chiang et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Nonribosomal peptide synthetases: structures and dynamics
- (2010) Matthias Strieker et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- SMURF: Genomic mapping of fungal secondary metabolite clusters
- (2010) Nora Khaldi et al. FUNGAL GENETICS AND BIOLOGY
- Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans
- (2010) Kirstin Scherlach et al. JOURNAL OF ANTIBIOTICS
- Rare earth elements activate the secondary metabolite–biosynthetic gene clusters in Streptomyces coelicolor A3(2)
- (2010) Yukinori Tanaka et al. JOURNAL OF ANTIBIOTICS
- Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1
- (2010) Nancy L McKenzie et al. JOURNAL OF ANTIBIOTICS
- Characterization and Manipulation of the Pathway-Specific Late Regulator AlpW Reveals Streptomyces ambofaciens as a New Producer of Kinamycins
- (2010) R. Bunet et al. JOURNAL OF BACTERIOLOGY
- E. coli NusG Inhibits Backtracking and Accelerates Pause-Free Transcription by Promoting Forward Translocation of RNA Polymerase
- (2010) Kristina M. Herbert et al. JOURNAL OF MOLECULAR BIOLOGY
- Chemical Epigenetics Alters the Secondary Metabolite Composition of Guttate Excreted by an Atlantic-Forest-Soil-DerivedPenicillium citreonigrum
- (2010) Xiaoru Wang et al. JOURNAL OF NATURAL PRODUCTS
- Genome Mining inStreptomyces avermitilis: Cloning and Characterization of SAV_76, the Synthase for a New Sesquiterpene, Avermitilol
- (2010) Wayne K. W. Chou et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Induced Biosynthesis of Cryptic Polyketide Metabolites in a Burkholderia thailandensis Quorum Sensing Mutant
- (2010) Keishi Ishida et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Origins and Evolution of Antibiotic Resistance
- (2010) J. Davies et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2)
- (2010) M. Gottelt et al. MICROBIOLOGY-SGM
- Biosynthesis of polyketides by trans-AT polyketide synthases
- (2010) Jörn Piel NATURAL PRODUCT REPORTS
- SBSPKS: structure based sequence analysis of polyketide synthases
- (2010) Swadha Anand et al. NUCLEIC ACIDS RESEARCH
- CDD: a Conserved Domain Database for the functional annotation of proteins
- (2010) A. Marchler-Bauer et al. NUCLEIC ACIDS RESEARCH
- The Biosynthetic Logic of Polyketide Diversity
- (2009) Christian Hertweck ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Strategies for the Discovery of New Natural Products by Genome Mining
- (2009) Malek Zerikly et al. CHEMBIOCHEM
- The long-overlooked enzymology of a nonribosomal peptide synthetase-independent pathway for virulence-conferring siderophore biosynthesis
- (2009) Daniel Oves-Costales et al. CHEMICAL COMMUNICATIONS
- Microbial drug discovery: 80 years of progress
- (2009) Arnold L Demain et al. JOURNAL OF ANTIBIOTICS
- A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, inAspergillus nidulans
- (2009) Yi-Ming Chiang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Genomic basis for natural product biosynthetic diversity in the actinomycetes
- (2009) Markus Nett et al. NATURAL PRODUCT REPORTS
- Epigenome manipulation as a pathway to new natural product scaffolds and their congeners
- (2009) Robert H. Cichewicz NATURAL PRODUCT REPORTS
- Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12
- (2009) Takeshi Hosaka et al. NATURE BIOTECHNOLOGY
- Chromatin-level regulation of biosynthetic gene clusters
- (2009) Jin Woo Bok et al. Nature Chemical Biology
- Sequencing technologies — the next generation
- (2009) Michael L. Metzker NATURE REVIEWS GENETICS
- Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans
- (2009) V. Schroeckh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prediction and Manipulation of the Stereochemistry of Enoylreduction in Modular Polyketide Synthases
- (2008) David H. Kwan et al. CHEMISTRY & BIOLOGY
- Control of bacterial transcription, translation and replication by (p)ppGpp
- (2008) Anjana Srivatsan et al. CURRENT OPINION IN MICROBIOLOGY
- Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection
- (2008) TuAnh Nguyen et al. NATURE BIOTECHNOLOGY
- DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways
- (2008) Zengyi Shao et al. NUCLEIC ACIDS RESEARCH
- Epigenetic remodeling of the fungal secondary metabolome
- (2008) Russell B. Williams et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- A chemical epigenetics approach for engineering the in situbiosynthesis of a cryptic natural product from Aspergillus niger
- (2008) Jon C. Henrikson et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining
- (2008) C. Corre et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- VelB/VeA/LaeA Complex Coordinates Light Signal with Fungal Development and Secondary Metabolism
- (2008) O. Bayram et al. SCIENCE
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