Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries

Mitochondrial autophagy: Life and breath of the cell

(2014) Gregg L. Semenza   Autophagy

Apoptosis meets autophagy-like cell death in the ischemic penumbra: Two sides of the same coin?

(2014) Abdelhaq Rami et al.   Autophagy

Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways

(2014) Ya-Dan Wen et al.   Autophagy

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

(2014) Rajarshi Ghosh et al.   CELL

Melatonin stimulates antioxidant enzymes and reduces oxidative stress in experimental traumatic brain injury: the Nrf2–ARE signaling pathway as a potential mechanism

(2014) Ke Ding et al.   FREE RADICAL BIOLOGY AND MEDICINE

Docosahexaenoic Acid Reduces ER Stress and Abnormal Protein Accumulation and Improves Neuronal Function Following Traumatic Brain Injury

(2014) G. Begum et al.   JOURNAL OF NEUROSCIENCE

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

(2014) Claudio Hetz et al.   NATURE REVIEWS NEUROSCIENCE

NADPH oxidase inhibition improves neurological outcome in experimental traumatic brain injury

(2014) Xin-Yu Lu et al.   NEUROCHEMISTRY INTERNATIONAL

Endoplasmic reticulum stress is associated with neuroprotection against apoptosis via autophagy activation in a rat model of subarachnoid hemorrhage

(2014) Feng Yan et al.   NEUROSCIENCE LETTERS

The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning

(2013) Bo Gao et al.   ACTA PHARMACOLOGICA SINICA

Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca2+handling in ageing rabbit hearts

(2013) Leroy L. Cooper et al.   JOURNAL OF PHYSIOLOGY-LONDON

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

The effect of NADPH-oxidase inhibitor apocynin on cognitive impairment induced by moderate lateral fluid percussion injury: Role of inflammatory and oxidative brain damage

(2013) Ana Paula Oliveira Ferreira et al.   NEUROCHEMISTRY INTERNATIONAL

Endoplasmic reticulum stress response in the rat contusive spinal cord injury model-susceptibility in specific cell types

(2013) D Matsuyama et al.   SPINAL CORD

The protective role of Bax Inhibitor-1 against chronic mild stress through the inhibition of monoamine oxidase A

(2013) Hwa-Young Lee et al.   Scientific Reports

Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies

(2012) Gang Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

NADPH oxidases as therapeutic targets in ischemic stroke

(2012) Timo Kahles et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inflammation, Endoplasmic Reticulum Stress, Autophagy, and the Monocyte Chemoattractant Protein-1/CCR2 Pathway

(2012) Pappachan E. Kolattukudy et al.   CIRCULATION RESEARCH

Autophagy in the Central Nervous System: Implications for Neurodegenerative Disorders

(2012) Maria Xilouri et al.   CNS & Neurological Disorders-Drug Targets

Targeting C/EBP homologous protein with siRNA attenuates cerebral vasospasm after experimental subarachnoid hemorrhage

(2012) Zhaohui He et al.   EXPERIMENTAL NEUROLOGY

An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases

(2012) Bidur Bhandary et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nitric Oxide: Considerations for the Treatment of Ischemic Stroke

(2012) Nicole A Terpolilli et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Endoplasmic reticulum dysfunction in neurological disease

(2012) Benoit D Roussel et al.   LANCET NEUROLOGY

Autophagy activation is associated with neuroprotection against apoptosis via a mitochondrial pathway in a rat model of subarachnoid hemorrhage

(2012) C.-h. Jing et al.   NEUROSCIENCE

Stress management at the ER: Regulators of ER stress-induced apoptosis

(2012) Adrienne M. Gorman et al.   PHARMACOLOGY & THERAPEUTICS

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

Sodium phenylbutyrate ameliorates focal cerebral ischemic/reperfusion injury associated with comorbid type 2 diabetes by reducing endoplasmic reticulum stress and DNA fragmentation

(2011) Krishnamoorthy Srinivasan et al.   BEHAVIOURAL BRAIN RESEARCH

Attenuating the endoplasmic reticulum stress response improves functional recovery after spinal cord injury

(2011) Sujata Saraswat Ohri et al.   GLIA

Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning

(2010) Rui Sheng et al.   Autophagy

Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury

(2010) Maryla Krajewska et al.   BRAIN RESEARCH

Calcium, ischemia and excitotoxicity

(2010) Kinga Szydlowska et al.   CELL CALCIUM

The Role of Endoplasmic Reticulum Stress in the Progression of Atherosclerosis

(2010) Ira Tabas   CIRCULATION RESEARCH

The Endoplasmic Reticulum Stress Sensor, ATF6α, Protects against Neurotoxin-induced Dopaminergic Neuronal Death

(2010) Naohiro Egawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

(2010) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Antioxidant therapies for traumatic brain injury

(2010) Edward D. Hall et al.   Neurotherapeutics

Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes

(2010) A Ruiz et al.   Cell Death & Disease

Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase

(2009) Célio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Endoplasmic reticulum Ca2+ release through ryanodine and IP3 receptors contributes to neuronal excitotoxicity

(2009) Asier Ruiz et al.   CELL CALCIUM

Molecular Mechanisms Leading to Neuroprotection/Ischemic Tolerance: Effect of Preconditioning on the Stress Reaction of Endoplasmic Reticulum

(2009) J. Lehotský et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular Bak

(2009) Martina Klee et al.   EMBO JOURNAL

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

(2009) C. Hetz et al.   GENES & DEVELOPMENT

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

(2009) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Inhibition of NADPH Oxidase is Neuroprotective after Ischemia—Reperfusion

(2009) Hai Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Endoplasmic Reticulum Stress Plays Critical Role in Brain Damage After Cerebral Ischemia/Reperfusion in Rats

(2009) Venkata Prasuja Nakka et al.   NEUROTOXICITY RESEARCH

The Novel Free Radical Scavenger, Edaravone, Increases Neural Stem Cell Number Around the Area of Damage Following Rat Traumatic Brain Injury

(2009) Tatsuki Itoh et al.   NEUROTOXICITY RESEARCH

Mitochondrial Targets for Stroke

(2009) Peter S. Vosler et al.   STROKE

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

(2008) Masato Koike et al.   AMERICAN JOURNAL OF PATHOLOGY

ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo

(2008) Philipp S. Lange et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Advances in Neuronal Cell Death 2007

(2008) Maged M. Harraz et al.   STROKE

Potential Role of PUMA in Delayed Death of Hippocampal CA1 Neurons After Transient Global Cerebral Ischemia

(2008) Kuniyasu Niizuma et al.   STROKE

Carnosic acid, acatechol-typeelectrophilic compound, protects neurons bothin vitroandin vivothrough activation of the Keap1/Nrf2 pathway viaS-alkylation of targeted cysteines on Keap1

(2007) Takumi Satoh et al.   JOURNAL OF NEUROCHEMISTRY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY