Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease

(2014) Yijiao Xu et al.   CELLULAR SIGNALLING

Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations

(2014) Yao-Tsung Yeh et al.   FREE RADICAL BIOLOGY AND MEDICINE

mTOR in aging, metabolism, and cancer

(2013) Marion Cornu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Rotenone induces neuronal death by microglial phagocytosis of neurons

(2013) Julius V. Emmrich et al.   FEBS Journal

Induction of apoptosis by antimycin A in differentiated PC12 cell line

(2013) Xu Lanju et al.   JOURNAL OF APPLIED TOXICOLOGY

Pesticides, Microglial NOX2, and Parkinson's Disease

(2013) Thomas Taetzsch et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

p38MAPK/p53-Mediated Bax induction contributes to neurons degeneration in rotenone-induced cellular and rat models of Parkinson’s disease

(2013) Feng Wu et al.   NEUROCHEMISTRY INTERNATIONAL

Caspofungin Kills Candida albicans by Causing both Cellular Apoptosis and Necrosis

(2012) Binghua Hao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanisms to prevent caspase activation in rotenone-induced dopaminergic neurodegeneration: role of ATP depletion and procaspase-9 degradation

(2012) HeeWon Kang et al.   APOPTOSIS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson’s disease models

(2012) Nian Xiong et al.   CRITICAL REVIEWS IN TOXICOLOGY

mTOR kinase, a key player in the regulation of glial functions: Relevance for the therapy of multiple sclerosis

(2012) Cinzia Dello Russo et al.   GLIA

Conditional Expression of Parkinson's Disease-Related Mutant  -Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1

(2012) X. Lin et al.   JOURNAL OF NEUROSCIENCE

Rotenone-Induced Death of RGC-5 Cells is Caspase Independent, Involves the JNK and p38 Pathways and is Attenuated by Specific Green Tea Flavonoids

(2012) T. A. Kamalden et al.   NEUROCHEMICAL RESEARCH

Distinct Effects of Rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on Cellular Bioenergetics and Cell Death

(2012) Samantha Giordano et al.   PLoS One

Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

(2012) Zhao Zhong Chong et al.   PROGRESS IN NEUROBIOLOGY

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

An effective novel delivery strategy of rasagiline for Parkinson's disease

(2011) Marcos Fernández et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Redox Regulation of the Intrinsic Pathway in Neuronal Apoptosis

(2010) James L. Franklin   ANTIOXIDANTS & REDOX SIGNALING

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death

(2010) Long Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Involvement of mTOR in globular adiponectin-induced generation of reactive oxygen species

(2010) Akie Fujimoto et al.   FREE RADICAL RESEARCH

Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

(2010) Long Chen et al.   LABORATORY INVESTIGATION

Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia

(2009) Kuniyasu Niizuma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

(2009) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

The Hypoxia-Inducible Factor 1/NOR-1 Axis Regulates the Survival Response of Endothelial Cells to Hypoxia

(2009) L. Martorell et al.   MOLECULAR AND CELLULAR BIOLOGY

A highly reproducible rotenone model of Parkinson's disease

(2009) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Rapamycin protects against rotenone-induced apoptosis through autophagy induction

(2009) T. Pan et al.   NEUROSCIENCE

Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises

(2008) Timothy A Yap et al.   CURRENT OPINION IN PHARMACOLOGY

Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson's disease

(2008) Derek A. Drechsel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5

(2008) Long Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis

(2008) Long Chen et al.   JOURNAL OF NEUROCHEMISTRY

Oxidative and Inflammatory Pathways in Parkinson’s Disease

(2008) Rebecca L. Miller et al.   NEUROCHEMICAL RESEARCH

Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins

(2008) L Liu et al.   ONCOGENE

Pesticide/Environmental Exposures and Parkinson's Disease in East Texas

(2008) Amanpreet S. Dhillon et al.   Journal of Agromedicine

Role of mTOR in physiology and pathology of the nervous system

(2007) Lukasz Swiech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS