标题
Methylglyoxal in Metabolic Disorders: Facts, Myths, and Promises
作者
关键词
-
出版物
MEDICINAL RESEARCH REVIEWS
Volume 37, Issue 2, Pages 368-403
出版商
Wiley
发表日期
2016-09-16
DOI
10.1002/med.21410
参考文献
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- Methylglyoxal induces hyperpermeability of the blood–retinal barrier via the loss of tight junction proteins and the activation of matrix metalloproteinases
- (2012) Junghyun Kim et al. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
- Phlorotannins from Brown Algae (Fucus vesiculosus) Inhibited the Formation of Advanced Glycation Endproducts by Scavenging Reactive Carbonyls
- (2012) Haiyan Liu et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Exploring Mechanisms of Diabetes-Related Macrovascular Complications: Role of Methylglyoxal, a Metabolite of Glucose on Regulation of Vascular Contractility
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- Investigation of Aqueous-Phase Photooxidation of Glyoxal and Methylglyoxal by Aerosol Chemical Ionization Mass Spectrometry: Observation of Hydroxyhydroperoxide Formation
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- Antiglycative effect of fruit and vegetable seed extracts: inhibition of AGE formation and carbonyl-trapping abilities
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- Methylglyoxal, Cognitive Function and Cerebral Atrophy in Older People
- (2012) Velandai Srikanth et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy
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- Postprandial impairment of flow-mediated dilation and elevated methylglyoxal after simple but not complex carbohydrate consumption in dogs
- (2012) Jennifer L. Adolphe et al. NUTRITION RESEARCH
- Methylglyoxal promotes oxidative stress and endothelial dysfunction
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- Hydroimidazolone Modification of the Conserved Arg12 in Small Heat Shock Proteins: Studies on the Structure and Chaperone Function Using Mutant Mimics
- (2012) Ram H. Nagaraj et al. PLoS One
- Long Term Running Biphasically Improves Methylglyoxal-Related Metabolism, Redox Homeostasis and Neurotrophic Support within Adult Mouse Brain Cortex
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- Expression of Transient Receptor Potential Ankyrin 1 (TRPA1) and Its Role in Insulin Release from Rat Pancreatic Beta Cells
- (2012) De-Shou Cao et al. PLoS One
- Late-Onset Running Biphasically Improves Redox Balance, Energy- and Methylglyoxal-Related Status, as well as SIRT1 Expression in Mouse Hippocampus
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- Angiogenesis Impairment in Diabetes: Role of Methylglyoxal-Induced Receptor for Advanced Glycation Endproducts, Autophagy and Vascular Endothelial Growth Factor Receptor 2
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- Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1
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- RAGE influences obesity in mice
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- Methylglyoxal causes structural and functional alterations in adipose tissue independently of obesity
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- Podocytopathy in Diabetes: A Metabolic and Endocrine Disorder
- (2011) Ana Diez-Sampedro et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- Advanced Glycation Urinary Protein-Bound Biomarkers and Severity of Diabetic Nephropathy in Man
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- Advanced glycation end products and diabetic retinopathy
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- Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications
- (2011) Ravichandran Ramasamy et al. Annals of the New York Academy of Sciences
- Ellagic acid, a new antiglycating agent: its inhibition ofNϵ-(carboxymethyl)lysine
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- Differential effects of insulin on peripheral diabetes-related changes in mitochondrial bioenergetics: Involvement of advanced glycosylated end products
- (2011) Aline Pertile Remor et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- AGE-BSA down-regulates endothelial connexin43 gap junctions
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- Metformin restores endothelial function in aorta of diabetic rats
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- Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome
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- Genistein Inhibits Advanced Glycation End Product Formation by Trapping Methylglyoxal
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- Human aldo–keto reductase AKR7A2 protects against the cytotoxicity and mutagenicity of reactive aldehydes and lowers intracellular reactive oxygen species in hamster V79-4 cells
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- Glycation of LDL by Methylglyoxal Increases Arterial Atherogenicity: A Possible Contributor to Increased Risk of Cardiovascular Disease in Diabetes
- (2011) N. Rabbani et al. DIABETES
- Chronic Methylglyoxal Infusion by Minipump Causes Pancreatic β-Cell Dysfunction and Induces Type 2 Diabetes in Sprague-Dawley Rats
- (2011) Arti Dhar et al. DIABETES
- Carbonylation Contributes to SERCA2a Activity Loss and Diastolic Dysfunction in a Rat Model of Type 1 Diabetes
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- Fibrin(ogen) may be an important target for methylglyoxal-derived AGE modification in elastic arteries of humans
- (2011) Terje Lund et al. Diabetes & Vascular Disease Research
- Restriction of Advanced Glycation End Products Improves Insulin Resistance in Human Type 2 Diabetes: Potential role of AGER1 and SIRT1
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- Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E
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- Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology
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- Resveratrol protects against methylglyoxal-induced apoptosis and disruption of embryonic development in mouse blastocysts
- (2011) Fu-Jen Huang et al. ENVIRONMENTAL TOXICOLOGY
- Increased glyoxalase I levels inhibit accumulation of oxidative stress and an advanced glycation end product in mouse mesangial cells cultured in high glucose
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- NF-B-Inducing Kinase Increases Renal Tubule Epithelial Inflammation Associated with Diabetes
- (2011) Yanhua Zhao et al. Experimental Diabetes Research
- Targeted Proteomics of Isolated Glomeruli from the Kidneys of Diabetic Rats: Sorbin and SH3 Domain Containing 2 Is a Novel Protein Associated with Diabetic Nephropathy
- (2011) Shinya Nakatani et al. Experimental Diabetes Research
- Protection from diabetes-induced peripheral sensory neuropathy — A role for elevated glyoxalase I?
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- Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans
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- Formation of Early and Advanced Maillard Reaction Products Correlates to the Ripening of Cheese
- (2011) Robert Spanneberg et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Endogenous formation of Nε-(carboxymethyl)lysine is increased in fatty livers and induces inflammatory markers in an in vitro model of hepatic steatosis
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- Accumulation of renin and imidazolone in peritubular capillary endothelial cells in insulin-resistant hypertensive rats
- (2011) Zoltán Wagner et al. JOURNAL OF NEPHROLOGY
- Targeted reduction of advanced glycation improves renal function in obesity
- (2011) Brooke E. Harcourt et al. KIDNEY INTERNATIONAL
- Relationship of methylglyoxal-adduct biogenesis to LDL and triglyceride levels in diabetics
- (2011) Zdenka Turk et al. LIFE SCIENCES
- Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals
- (2011) Michal Schnaider Beeri et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Long-term methylglyoxal treatment impairs smooth muscle contractility in organ-cultured rat mesenteric artery
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- Fisetin Lowers Methylglyoxal Dependent Protein Glycation and Limits the Complications of Diabetes
- (2011) Pamela Maher et al. PLoS One
- Cloning and Characterization of AKR4C14, a Rice Aldo–Keto Reductase, from Thai Jasmine Rice
- (2011) Rawint Narawongsanont et al. PROTEIN JOURNAL
- Glyoxalase in diabetes, obesity and related disorders
- (2011) Naila Rabbani et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Glyoxalase in tumourigenesis and multidrug resistance
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- Glyoxalase in ageing
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- Advanced Glycation End Product Recognition by the Receptor for AGEs
- (2011) Jing Xue et al. STRUCTURE
- Cranberry phytochemicals inhibit glycation of human hemoglobin and serum albumin by scavenging reactive carbonyls
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- A Global Perspective of the Genetic Basis for Carbonyl Stress Resistance
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- Advanced glycation endproducts: from precursors to RAGE: round and round we go
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- Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome
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- Receptor for advanced glycation end-products (RAGE) regulation of adiposity and adiponectin is associated with atherogenesis in apoE-deficient mouse
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- Oxidative stress and aging: Is methylglyoxal the hidden enemy?This review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.
- (2010) Kaushik M. Desai et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Cytotoxic role of methylglyoxal in rat retinal pericytes: Involvement of a nuclear factor-kappaB and inducible nitric oxide synthase pathway
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- Increased Glycation and Oxidative Damage to Apolipoprotein B100 of LDL Cholesterol in Patients With Type 2 Diabetes and Effect of Metformin
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- Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse
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- Delayed intervention with AGE inhibitors attenuates the progression of diabetes-accelerated atherosclerosis in diabetic apolipoprotein E knockout mice
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- Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction
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- Methylglyoxal Is a Predictor in Type 2 Diabetic Patients of Intima-Media Thickening and Elevation of Blood Pressure
- (2010) Susumu Ogawa et al. HYPERTENSION
- Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats
- (2010) Olaf Brouwers et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- KIOM-79 prevents methyglyoxal-induced retinal pericyte apoptosis in vitro and in vivo
- (2010) Ohn Soon Kim et al. JOURNAL OF ETHNOPHARMACOLOGY
- Methylglyoxal Content in Drinking Coffee as a Cytotoxic Factor
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- Methylglyoxal Enhances Sodium Nitroprusside–Induced Relaxation in Rat Aorta
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- Differential effects of advanced glycation end-products on renal tubular cell inflammation
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- Methylglyoxal Alters the Function and Stability of Critical Components of the Protein Quality Control
- (2010) Carla Figueira Bento et al. PLoS One
- The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal
- (2010) Carla Figueira Bento et al. PLoS One
- AGER1 regulates endothelial cell NADPH oxidase-dependent oxidant stress via PKC-δ: implications for vascular disease
- (2009) Weijing Cai et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Hyperglycemia and Glycation in Diabetic Complications
- (2009) Anne Negre-Salvayre et al. ANTIOXIDANTS & REDOX SIGNALING
- Methylglyoxal-induced mitochondrial dysfunction in vascular smooth muscle cells
- (2009) Hui Wang et al. BIOCHEMICAL PHARMACOLOGY
- Alagebrium attenuates acute methylglyoxal-induced glucose intolerance in Sprague-Dawley rats
- (2009) Arti Dhar et al. BRITISH JOURNAL OF PHARMACOLOGY
- Angiogenesis, adipokines and breast cancer
- (2009) Linda Vona-Davis et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Hyperglycemia-Induced Reactive Oxygen Species Increase Expression of the Receptor for Advanced Glycation End Products (RAGE) and RAGE Ligands
- (2009) D. Yao et al. DIABETES
- Reductive Metabolism of AGE Precursors: A Metabolic Route for Preventing AGE Accumulation in Cardiovascular Tissue
- (2009) S. P. Baba et al. DIABETES
- Hyperglycemia Impairs Proteasome Function by Methylglyoxal
- (2009) M. A. Queisser et al. DIABETES
- Anti-glycative effects of oleanolic acid and ursolic acid in kidney of diabetic mice
- (2009) Zhi-hong Wang et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Profiling of α-Dicarbonyl Content of Commercial Honeys from Different Botanical Origins: Identification of 3,4-Dideoxyglucoson-3-ene (3,4-DGE) and Related Compounds
- (2009) Eric Marceau et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats
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- Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague–Dawley rats
- (2009) Qi Guo et al. JOURNAL OF HYPERTENSION
- Receptor for AGE (RAGE) and its ligands—cast into leading roles in diabetes and the inflammatory response
- (2009) Shi Fang Yan et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Methylglyoxal Inhibits Smooth Muscle Contraction in Isolated Blood Vessels
- (2009) Masashi Mukohda et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Modification of Collagen IV by Glucose or Methylglyoxal Alters Distinct Mesangial Cell Functions
- (2009) A. Pozzi et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Effects of pyridoxamine (K-163) on glucose intolerance and obesity in high-fat diet C57BL/6J mice
- (2009) Shinji Hagiwara et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues
- (2009) H. Thangarajah et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone
- (2008) Dag S. Fosmark et al. ACTA OPHTHALMOLOGICA
- Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Is Associated With Increased Aortic Pulse Wave Velocity in Adults
- (2008) R. D. Semba et al. AMERICAN JOURNAL OF HYPERTENSION
- Plasma α-Oxoaldehyde Levels in Diabetic and Nondiabetic Chronic Kidney Disease Patients
- (2008) Keisuke Nakayama et al. AMERICAN JOURNAL OF NEPHROLOGY
- Suppression of Renal α-Dicarbonyl Compounds Generated following Ureteral Obstruction by Kidney-Specific α-Dicarbonyl/l-Xylulose Reductase
- (2008) Hiroko Odani et al. Annals of the New York Academy of Sciences
- The Dicarbonyl Proteome
- (2008) Naila Rabbani et al. Annals of the New York Academy of Sciences
- Methylglyoxal: Its Presence in Beverages and Potential Scavengers
- (2008) Di Tan et al. Annals of the New York Academy of Sciences
- Effect of methylglyoxal modification on stress-induced aggregation of client proteins and their chaperoning by human αA-crystallin
- (2008) Ashis Biswas et al. BIOCHEMICAL JOURNAL
- Aminoacetone, a Putative Endogenous Source of Methylglyoxal, Causes Oxidative Stress and Death to Insulin-Producing RINm5f Cells
- (2008) Adriano Sartori et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Fructose and carbonyl metabolites as endogenous toxins
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- Modulation of Insulin Action by Advanced Glycation Endproducts: A New Player in the Field
- (2008) C. Schalkwijk et al. HORMONE AND METABOLIC RESEARCH
- Leptin Decreases Postprandially in People with Type 2 Diabetes, an Effect Reduced by the Cooking Method
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- The “Metabolic Memory”: Is More Than Just Tight Glucose Control Necessary to Prevent Diabetic Complications?
- (2008) Antonio Ceriello et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Methylglyoxal production in vascular smooth muscle cells from different metabolic precursors
- (2008) Arti Dhar et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Dietary soy isoflavones increase insulin secretion and prevent the development of diabetic cataracts in streptozotocin-induced diabetic rats
- (2008) Mei-Ping Lu et al. NUTRITION RESEARCH
- AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation
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- Pyridoxamine Protects Proteins from Functional Damage by 3-Deoxyglucosone: Mechanism of Action of Pyridoxamine†
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- Effects of α-lipoic acid on endothelial function in aged diabetic and high-fat fed rats
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- The tandem of free radicals and methylglyoxal
- (2007) Miklós Péter Kalapos CHEMICO-BIOLOGICAL INTERACTIONS
- Methylglyoxal causes strong weakening of detoxifying capacity and apoptotic cell death in rat hippocampal neurons
- (2007) Silvia Di Loreto et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Endothelial dysfunction in the streptozotocin-induced diabetic apoE-deficient mouse
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