Methylglyoxal Induces Platelet Hyperaggregation and Reduces Thrombus Stability by Activating PKC and Inhibiting PI3K/Akt Pathway

ADP-Stimulated Activation of Akt During Integrin Outside-In Signaling Promotes Platelet Spreading by Inhibiting Glycogen Synthase Kinase-3β

(2012) Kelly A. O’Brien et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes

(2012) V. Randriamboavonjy et al.   BLOOD

Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal

(2012) Margaret G. Distler et al.   JOURNAL OF CLINICAL INVESTIGATION

Role and regulation of phosphatidylinositol 3-kinase   in platelet integrin  2 1 signaling

(2011) A. Consonni et al.   BLOOD

Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E

(2011) F. Fiory et al.   DIABETOLOGIA

Glyoxalase in diabetes, obesity and related disorders

(2011) Naila Rabbani et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Signaling During Platelet Adhesion and Activation

(2010) Zhenyu Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deletion of the p110  isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

(2010) V. Martin et al.   BLOOD

AMPK  2 subunit is involved in platelet signaling, clot retraction, and thrombus stability

(2010) V. Randriamboavonjy et al.   BLOOD

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

(2010) O. Brouwers et al.   DIABETOLOGIA

Genetic evidence for a predominant role of PI3K  catalytic activity in ITAM- and integrin-mediated signaling in platelets

(2009) I. Canobbio et al.   BLOOD

Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation

(2009) M. T. HARPER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS