标题
DNA Damage-Mediated Neurotoxicity in Parkinson’s Disease
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 24, Issue 7, Pages 6313
出版商
MDPI AG
发表日期
2023-03-28
DOI
10.3390/ijms24076313
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Kinases control of regulated cell death revealing druggable targets for Parkinson’s disease
- (2023) Heba M. Mansour et al. AGEING RESEARCH REVIEWS
- Inflammation and DNA damage: cause, effect or both
- (2023) Antonio Pezone et al. Nature Reviews Rheumatology
- DNA damage‐induced neuroinflammation in neurodegenerative disease
- (2022) Xuan Song et al. Alzheimers & Dementia
- The key players of parthanatos: opportunities for targeting multiple levels in the therapy of parthanatos-based pathogenesis
- (2022) Libo Liu et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Senescence and impaired DNA damage responses in alpha-synucleinopathy models
- (2022) Ye-Seul Yoon et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Poly(ADP-ribose) drives condensation of FUS via a transient interaction
- (2022) Kevin Rhine et al. MOLECULAR CELL
- PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson’s disease
- (2022) Hyejin Park et al. CELL
- The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease
- (2022) Brage Brakedal et al. Cell Metabolism
- Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease
- (2022) Gwyneth Welch et al. EMBO REPORTS
- Fueling genome maintenance: On the versatile roles of NAD+ in preserving DNA integrity
- (2022) Joanna A. Ruszkiewicz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes
- (2022) Anna Maria Sole Giordano et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction
- (2022) Julie Bourseguin et al. NUCLEIC ACIDS RESEARCH
- STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy
- (2022) Jared T. Hinkle et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DNA Damage, Defective DNA Repair, and Neurodegeneration in Amyotrophic Lateral Sclerosis
- (2022) Anna Konopka et al. Frontiers in Aging Neuroscience
- Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome
- (2022) Wouter Huiting et al. eLife
- Tracing brain genotoxic stress in Parkinson’s disease with a novel single-cell genetic sensor
- (2022) Madison Wynne El-Saadi et al. Science Advances
- Molecular Mechanisms of Parthanatos and Its Role in Diverse Diseases
- (2022) Ping Huang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau
- (2022) Pablo Gracia et al. Nature Communications
- Neuroinflammation represents a common theme amongst genetic and environmental risk factors for Alzheimer and Parkinson diseases
- (2022) Rachel J. Boyd et al. Journal of Neuroinflammation
- Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders
- (2022) Ashley N. Brandebura et al. NATURE REVIEWS NEUROSCIENCE
- α-synucleinopathy exerts sex-dimorphic effects on the multipurpose DNA repair/redox protein APE1 in mice and humans
- (2022) Kristin M. Miner et al. PROGRESS IN NEUROBIOLOGY
- Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins
- (2022) Junli Gao et al. Science Translational Medicine
- Inhibition of Chk2 promotes neuroprotection, axon regeneration, and functional recovery after CNS injury
- (2022) Matthew J. Taylor et al. Science Advances
- Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration
- (2022) Gwyneth M. Welch et al. Science Advances
- Nuclear localization of alpha-synuclein affects the cognitive and motor behavior of mice by inducing DNA damage and abnormal cell cycle of hippocampal neurons
- (2022) Yue Pan et al. Frontiers in Molecular Neuroscience
- Biomolecular condensates can both accelerate and suppress aggregation of α-synuclein
- (2022) Wojciech P. Lipiński et al. Science Advances
- p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)
- (2021) Maya Maor-Nof et al. CELL
- SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models
- (2021) Oh‐Chan Kwon et al. EMBO Molecular Medicine
- Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency
- (2021) Ji-Hoon Lee et al. MOLECULAR CELL
- LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination‐mediated DNA double strand break repair
- (2021) Lifeng Chen et al. Clinical and Translational Medicine
- Oxidative stress and regulated cell death in Parkinson’s disease
- (2021) P.A. Dionísio et al. AGEING RESEARCH REVIEWS
- The cell biology of Parkinson’s disease
- (2021) Nikhil Panicker et al. JOURNAL OF CELL BIOLOGY
- Parkinson's disease
- (2021) Bastiaan R Bloem et al. LANCET
- Challenges in the diagnosis of Parkinson's disease
- (2021) Eduardo Tolosa et al. LANCET NEUROLOGY
- Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?
- (2021) Anna Ainslie et al. Open Biology
- Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies
- (2021) Cheng-Fu Su et al. Frontiers in Pharmacology
- Sirtuins as pharmacological targets in neurodegenerative and neuropsychiatric disorders
- (2021) Jefferson A. Leite et al. BRITISH JOURNAL OF PHARMACOLOGY
- Molecular mechanisms of cell death in neurological diseases
- (2021) Diane Moujalled et al. CELL DEATH AND DIFFERENTIATION
- DNA damage and regulation of protein homeostasis
- (2021) Tanya T. Paull DNA REPAIR
- DNA Damage-Induced Neurodegeneration in Accelerated Ageing and Alzheimer’s Disease
- (2021) Heling Wang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Emerging role of PARP‐1 and PARthanatos in ischemic stroke
- (2021) Shuiqiao Liu et al. JOURNAL OF NEUROCHEMISTRY
- Progress towards therapies for disease modification in Parkinson's disease
- (2021) Nirosen Vijiaratnam et al. LANCET NEUROLOGY
- Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
- (2021) Henry Jay Forman et al. NATURE REVIEWS DRUG DISCOVERY
- Cellular functions of the protein kinase ATM and their relevance to human disease
- (2021) Ji-Hoon Lee et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- PARkinson's: From cellular mechanisms to potential therapeutics
- (2021) Zsofia Lengyel-Zhand et al. PHARMACOLOGY & THERAPEUTICS
- NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING
- (2021) Yujun Hou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson’s Disease Models
- (2021) Dinesh Kumar Verma et al. Cells
- Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair
- (2021) Aditi et al. NEURON
- DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication
- (2021) Haibo Wang et al. Frontiers in Molecular Neuroscience
- Contributions of DNA Damage to Alzheimer’s Disease
- (2020) Xiaozeng Lin et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Diagnosis and Treatment of Parkinson Disease
- (2020) Melissa J. Armstrong et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- DNA damage and repair in Parkinson's disease: Recent advances and new opportunities
- (2020) Claudia P. Gonzalez‐Hunt et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Parkinson’s disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging
- (2020) Xi Chen et al. Molecular Neurodegeneration
- LRRK2 in Parkinson disease: challenges of clinical trials
- (2020) Eduardo Tolosa et al. Nature Reviews Neurology
- Poly(ADP-ribose): A Dynamic Trigger for Biomolecular Condensate Formation
- (2020) Anthony K.L. Leung TRENDS IN CELL BIOLOGY
- Protecting the Aging Genome
- (2020) Michael A. Petr et al. TRENDS IN CELL BIOLOGY
- Cellular Senescence in Neurodegenerative Diseases
- (2020) Carmen Martínez-Cué et al. Frontiers in Cellular Neuroscience
- PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease
- (2020) Preston Ge et al. Molecular Neurodegeneration
- Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
- (2020) Helmut Sies et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The MRE11 complex: A versatile toolkit for the repair of broken DNA
- (2020) Giordano Reginato et al. DNA REPAIR
- Caffeine: An Overview of Its Beneficial Effects in Experimental Models and Clinical Trials of Parkinson’s Disease
- (2020) Giovanni Schepici et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- α-Synuclein aggregation nucleates through liquid–liquid phase separation
- (2020) Soumik Ray et al. Nature Chemistry
- Cellular senescence and Alzheimer disease: the egg and the chicken scenario
- (2020) Sara Saez-Atienzar et al. NATURE REVIEWS NEUROSCIENCE
- Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease
- (2020) Manish Sharma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
- (2020) Chien-Hsiung Yu et al. CELL
- The role of DNA damage response in amyotrophic lateral sclerosis
- (2020) Yu Sun et al. Essays in Biochemistry
- Astrocyte Crosstalk in CNS Inflammation
- (2020) Mathias Linnerbauer et al. NEURON
- Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases
- (2020) Tim Bartels et al. SCIENCE
- DNA Damage Triggers a New Phase in Neurodegeneration
- (2020) Fabio Pessina et al. TRENDS IN GENETICS
- DNA damage induced neuroinflammation in neurodegenerative disease
- (2020) Xuan Song et al. Alzheimers & Dementia
- Brain Selective Estrogen Treatment Protects Dopaminergic Neurons and Preserves Behavioral Function in MPTP-induced Mouse Model of Parkinson’s Disease
- (2020) Nidheesh Thadathil et al. Journal of Neuroimmune Pharmacology
- Cellular senescence in ageing: from mechanisms to therapeutic opportunities
- (2020) Raffaella Di Micco et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Impaired non-homologous end joining in human primary alveolar type II cells in emphysema
- (2019) Beata Kosmider et al. Scientific Reports
- Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases
- (2019) Alberto J. Espay et al. NEUROLOGY
- PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins
- (2019) Yongjia Duan et al. CELL RESEARCH
- New insights of poly(ADP-ribosylation) in neurodegenerative diseases: A focus on protein phase separation and pathologic aggregation
- (2019) Cong Liu et al. BIOCHEMICAL PHARMACOLOGY
- SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer
- (2019) Neelum Aziz Yousafzai et al. Cell Death & Disease
- Accumulation of cytoplasmic DNA due to ATM deficiency activates the microglial viral response system with neurotoxic consequences
- (2019) Xuan Song et al. JOURNAL OF NEUROSCIENCE
- DNA double-strand break repair-pathway choice in somatic mammalian cells
- (2019) Ralph Scully et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders
- (2019) Allison J. Schaser et al. Scientific Reports
- Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease
- (2019) Benjamin G. Trist et al. AGING CELL
- Current role of mammalian sirtuins in DNA repair
- (2019) Francisco Alejandro Lagunas-Rangel DNA REPAIR
- The genetic architecture of Parkinson's disease
- (2019) Cornelis Blauwendraat et al. LANCET NEUROLOGY
- Ageing as a risk factor for neurodegenerative disease
- (2019) Yujun Hou et al. Nature Reviews Neurology
- Poly(ADP-Ribosylation) in Age-Related Neurological Disease
- (2019) Leeanne McGurk et al. TRENDS IN GENETICS
- Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos
- (2019) Nirmal Robinson et al. Redox Biology
- Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons
- (2019) Markus Riessland et al. Cell Stem Cell
- Parkinson disease
- (2019) R. Balestrino et al. EUROPEAN JOURNAL OF NEUROLOGY
- Senescence and Inflammatory Markers for Predicting Clinical Progression in Parkinson’s Disease: The ICICLE-PD Study
- (2019) Carmen Martin-Ruiz et al. Journal of Parkinsons Disease
- Peroxiredoxin 5 Silencing Sensitizes Dopaminergic Neuronal Cells to Rotenone via DNA Damage-Triggered ATM/p53/PUMA Signaling-Mediated Apoptosis
- (2019) Mei-Jen Wang et al. Cells
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- (2018) Lorenzo Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives
- (2018) Darren J. Baker et al. JOURNAL OF CLINICAL INVESTIGATION
- Mechanisms and functions of cellular senescence
- (2018) Nicolás Herranz et al. JOURNAL OF CLINICAL INVESTIGATION
- The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
- (2018) Tuo Li et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Protective and therapeutic activity of honokiol in reversing motor deficits and neuronal degeneration in the mouse model of Parkinson’s disease
- (2018) Hwei-Hsien Chen et al. Pharmacological Reports
- NAD+supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
- (2018) Yujun Hou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ATM directs DNA damage responses and proteostasis via genetically separable pathways
- (2018) Ji-Hoon Lee et al. Science Signaling
- α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
- (2018) Marthe H. R. Ludtmann et al. Nature Communications
- Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease
- (2018) Shankar J. Chinta et al. Cell Reports
- The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease
- (2018) David C. Schöndorf et al. Cell Reports
- Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites
- (2018) Takeshi Yasuda et al. PLoS Genetics
- ATM directs DNA damage responses and proteostasis via genetically separable pathways
- (2018) Ji-Hoon Lee et al. Science Signaling
- Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease
- (2018) Géraldine Gelders et al. Journal of Immunology Research
- Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization
- (2018) Leeanne McGurk et al. MOLECULAR CELL
- Roles of DNA repair enzyme OGG1 in innate immunity and its significance for lung cancer
- (2018) Spiros Vlahopoulos et al. PHARMACOLOGY & THERAPEUTICS
- Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease
- (2018) Chiara Milanese et al. Cell Death & Disease
- Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease
- (2018) Tae-In Kam et al. SCIENCE
- LRRK2 interacts with ATM and regulates Mdm2–p53 cell proliferation axis in response to genotoxic stress
- (2017) Zhongcan Chen et al. HUMAN MOLECULAR GENETICS
- Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson’s Disease
- (2017) Velmarini Vasquez et al. JOURNAL OF ALZHEIMERS DISEASE
- The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?
- (2017) Edward Fielder et al. JOURNAL OF ALZHEIMERS DISEASE
- Enforced DNA repair enzymes rescue neurons from apoptosis induced by target deprivation and axotomy in mouse models of neurodegeneration
- (2017) Lee J. Martin et al. MECHANISMS OF AGEING AND DEVELOPMENT
- cGAS is essential for cellular senescence
- (2017) Hui Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies
- (2017) Mathieu Bourdenx et al. PROGRESS IN NEUROBIOLOGY
- SIRT1 Enhances the Survival of Human Embryonic Stem Cells by Promoting DNA Repair
- (2017) Jiho Jang et al. Stem Cell Reports
- Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options
- (2016) Wilbert P. Vermeij et al. Annual Review of Pharmacology and Toxicology
- DNA damage preceding dopamine neuron degeneration in A53T human α-synuclein transgenic mice
- (2016) Degui Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
- (2016) Evandro Fei Fang et al. Cell Metabolism
- DNA Double Strand Breaks: A Common Theme in Neurodegenerative Diseases
- (2016) Daniela Merlo et al. Current Alzheimer Research
- SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair
- (2016) Berta N Vazquez et al. EMBO JOURNAL
- Dopaminergic neuron-specific deletion of p53 gene is neuroprotective in an experimental Parkinson's disease model
- (2016) Xin Qi et al. JOURNAL OF NEUROCHEMISTRY
- The epidemiology of Parkinson's disease: risk factors and prevention
- (2016) Alberto Ascherio et al. LANCET NEUROLOGY
- Understanding Dopaminergic Cell Death Pathways in Parkinson Disease
- (2016) Patrick P. Michel et al. NEURON
- A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
- (2016) Y. Wang et al. SCIENCE
- How neuroinflammation contributes to neurodegeneration
- (2016) R. M. Ransohoff SCIENCE
- Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson’s disease
- (2016) S Lehmann et al. Cell Death & Disease
- SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability
- (2016) Lei Li et al. Nature Communications
- Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease
- (2016) Sara Sepe et al. Cell Reports
- ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA
- (2016) Hui Zhang et al. Cell Reports
- SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9–Rad1–Hus1 checkpoint clamp
- (2015) Bor-Jang Hwang et al. BMC MOLECULAR BIOLOGY
- A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
- (2015) Avinash Patel et al. CELL
- A review on protein-protein interaction network of APE1/Ref-1 and its associated biological functions
- (2015) S. Thakur et al. CELL BIOCHEMISTRY AND FUNCTION
- Blockade of metabotropic glutamate receptor 5 protects against DNA damage in a rotenone-induced Parkinson's disease model
- (2015) Ning Xia et al. FREE RADICAL BIOLOGY AND MEDICINE
- Damage to dopaminergic neurons is mediated by proliferating cell nuclear antigen through the p53 pathway under conditions of oxidative stress in a cell model of Parkinson's disease
- (2015) DA-WEI LI et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- DNA damage in neurodegenerative diseases
- (2015) Fabio Coppedè et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Genomic integrity and the ageing brain
- (2015) Hei-man Chow et al. NATURE REVIEWS NEUROSCIENCE
- NAD+ Treatment Can Prevent Rotenone-Induced Increases in DNA Damage, Bax Levels and Nuclear Translocation of Apoptosis-Inducing Factor in Differentiated PC12 Cells
- (2015) Yunyi Hong et al. NEUROCHEMICAL RESEARCH
- The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
- (2015) C. Kang et al. SCIENCE
- NAD+ in aging, metabolism, and neurodegeneration
- (2015) E. Verdin SCIENCE
- Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)
- (2015) Matthias Altmeyer et al. Nature Communications
- Engrailed Homeoprotein Protects Mesencephalic Dopaminergic Neurons from Oxidative Stress
- (2015) Hocine Rekaik et al. Cell Reports
- Neuroinflammation in Parkinson’s disease and its potential as therapeutic target
- (2015) Qinqin Wang et al. Translational Neurodegeneration
- Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction
- (2014) Evandro Fei Fang et al. CELL
- Pharmacological Treatment of Parkinson Disease
- (2014) Barbara S. Connolly et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Cellular senescence: from physiology to pathology
- (2014) Daniel Muñoz-Espín et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- DNA Damage and Its Links to Neurodegeneration
- (2014) Ram Madabhushi et al. NEURON
- Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis
- (2014) S. A. Andrabi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- p53 prevents neurodegeneration by regulating synaptic genes
- (2014) Paola Merlo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease
- (2014) X.-H. Lu et al. Science Translational Medicine
- Nicotinamide mononucleotide improves energy activity and survival rate in an in vitro model of Parkinson’s disease
- (2014) LEI LU et al. Experimental and Therapeutic Medicine
- Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species
- (2014) Priscila Britto Campos et al. Frontiers in Aging Neuroscience
- Environmental Toxins and Parkinson's Disease
- (2013) Samuel M. Goldman Annual Review of Pharmacology and Toxicology
- Oxidative damage to macromolecules in human Parkinson disease and the rotenone model
- (2013) Laurie H. Sanders et al. FREE RADICAL BIOLOGY AND MEDICINE
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- Maintaining genome stability in the nervous system
- (2013) Peter J McKinnon NATURE NEUROSCIENCE
- Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss
- (2013) Yunjong Lee et al. NATURE NEUROSCIENCE
- Advances in the genetics of Parkinson disease
- (2013) Joanne Trinh et al. Nature Reviews Neurology
- NAD+ treatment prevents rotenone-induced apoptosis and necrosis of differentiated PC12 cells
- (2013) Yunyi Hong et al. NEUROSCIENCE LETTERS
- Mitochondrial dysfunction and oxidative stress in Parkinson's disease
- (2013) Sudhakar Raja Subramaniam et al. PROGRESS IN NEUROBIOLOGY
- DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation
- (2013) J. Cadet et al. Cold Spring Harbor Perspectives in Biology
- NF-κB inhibition delays DNA damage–induced senescence and aging in mice
- (2012) Jeremy S. Tilstra et al. JOURNAL OF CLINICAL INVESTIGATION
- Pathogenesis of Parkinson's disease
- (2012) Etienne C. Hirsch et al. MOVEMENT DISORDERS
- Ogg1 null mice exhibit age-associated loss of the nigrostriatal pathway and increased sensitivity to MPTP
- (2012) Fernando Cardozo-Pelaez et al. NEUROCHEMISTRY INTERNATIONAL
- Various modes of cell death induced by DNA damage
- (2012) O Surova et al. ONCOGENE
- Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
- (2011) L Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Physiological consequences of defects in ERCC1–XPF DNA repair endonuclease
- (2011) Siobhán Q. Gregg et al. DNA REPAIR
- Malfunctioning DNA Damage Response (DDR) Leads to the Degeneration of Nigro-Striatal Pathway in Mouse Brain
- (2011) Michal Kirshner et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- 6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death
- (2011) Alison I Bernstein et al. Molecular Neurodegeneration
- DNA repair deficiency in neurodegeneration
- (2011) Dennis Kjølhede Jeppesen et al. PROGRESS IN NEUROBIOLOGY
- SIRT6 Promotes DNA Repair Under Stress by Activating PARP1
- (2011) Z. Mao et al. SCIENCE
- Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos)
- (2011) Y. Wang et al. Science Signaling
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Human AP endonuclease 1 (APE1): From mechanistic insights to druggable target in cancer
- (2010) Rachel Abbotts et al. CANCER TREATMENT REVIEWS
- Activation of ataxia telangiectasia muted under experimental models and human Parkinson’s disease
- (2010) Antoni Camins et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Protein homeostasis and aging in neurodegeneration
- (2010) Peter M. Douglas et al. JOURNAL OF CELL BIOLOGY
- SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA
- (2010) Wei Fan et al. MOLECULAR CELL
- The toxic influence of paraquat on hippocampus of mice: Involvement of oxidative stress
- (2010) Qing Chen et al. NEUROTOXICOLOGY
- Regulation of DNA repair by parkin
- (2009) Shyan-Yuan Kao BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease
- (2009) Tuan Hoang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
- (2009) Francis Rodier et al. NATURE CELL BIOLOGY
- SIRT1 deacetylates APE1 and regulates cellular base excision repair
- (2009) Tohru Yamamori et al. NUCLEIC ACIDS RESEARCH
- Mechanism of metal-mediated DNA damage and apoptosis induced by 6-hydroxydopamine in neuroblastoma SH-SY5Y cells
- (2008) Hatasu Kobayashi et al. FREE RADICAL RESEARCH
- Regulation of WRN Protein Cellular Localization and Enzymatic Activities by SIRT1-mediated Deacetylation
- (2008) Kai Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- DNA Damage and Repair
- (2008) Lee J. Martin JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in aDrosophilamodel of Parkinson's disease
- (2008) Haiqun Jia et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Paraquat-Induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells: Involvement of p53 and Mitochondria
- (2008) Wonsuk Yang et al. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
- SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70
- (2008) N. R. Sundaresan et al. MOLECULAR AND CELLULAR BIOLOGY
- Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis
- (2008) Claire Henchcliffe et al. Nature clinical practice. Neurology
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started