Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?
出版年份 2021 全文链接
标题
Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?
作者
关键词
-
出版物
Open Biology
Volume 11, Issue 4, Pages -
出版商
The Royal Society
发表日期
2021-04-21
DOI
10.1098/rsob.200296
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer
- (2020) Daniel J. McGrail et al. CANCER CELL
- Autophagy and disease: unanswered questions
- (2020) Ying Yang et al. CELL DEATH AND DIFFERENTIATION
- The evolutionary history of 2,658 cancers
- (2020) Moritz Gerstung et al. NATURE
- The repertoire of mutational signatures in human cancer
- (2020) Ludmil B. Alexandrov et al. NATURE
- Mechanisms Linking Mitochondrial Dysfunction and Proteostasis Failure
- (2020) Bingwei Lu et al. TRENDS IN CELL BIOLOGY
- Protecting the Aging Genome
- (2020) Michael A. Petr et al. TRENDS IN CELL BIOLOGY
- Common Functions of Disordered Proteins across Evolutionary Distant Organisms
- (2020) Arndt Wallmann et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation
- (2020) Patricia Richard et al. Autophagy
- P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease
- (2020) Kathleen M. Farmer et al. Acta Neuropathologica Communications
- Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
- (2019) Joy Mitra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death
- (2019) Fatima Gasset-Rosa et al. NEURON
- The proteostasis network and its decline in ageing
- (2019) Mark S. Hipp et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription
- (2019) Rui Gao et al. eLife
- Nuclear Phospho-SOD1 Protects DNA from Oxidative Stress Damage in Amyotrophic Lateral Sclerosis
- (2019) Matteo Bordoni et al. Journal of Clinical Medicine
- Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease
- (2019) Niraj M. Shanbhag et al. Acta Neuropathologica Communications
- Validation of the γH2AX biomarker for genotoxicity assessment: a review
- (2019) B. Kopp et al. ARCHIVES OF TOXICOLOGY
- Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells
- (2019) Christopher M. Brennan et al. GENES & DEVELOPMENT
- SOD1-positive aggregate accumulation in the CNS predicts slower disease progression and increased longevity in a mutant SOD1 mouse model of ALS
- (2019) Cindy Gill et al. Scientific Reports
- Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders
- (2019) Allison J. Schaser et al. Scientific Reports
- Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia
- (2019) Laurence Renaud et al. Acta Neuropathologica Communications
- The DNA damage response to transcription stress
- (2019) Hannes Lans et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The DNA-damage response and nuclear events as regulators of nonapoptotic forms of cell death
- (2019) Evgeniia A. Prokhorova et al. ONCOGENE
- Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling
- (2019) Yuanbo Wu et al. MITOCHONDRION
- Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome
- (2019) Ping Jun Zhu et al. SCIENCE
- Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions
- (2019) Fumiaki Mori et al. Acta Neuropathologica Communications
- Cytoplasmic Restriction of Mutated SOD1 Impairs the DNA Repair Process in Spinal Cord Neurons
- (2019) Li et al. Cells
- Changes to the TDP-43 and FUS Interactomes Induced by DNA Damage
- (2019) Tetsuya Kawaguchi et al. JOURNAL OF PROTEOME RESEARCH
- TDP-43 aggregation inside micronuclei reveals a potential mechanism for protein inclusion formation in ALS
- (2019) Cristian A. Droppelmann et al. Scientific Reports
- Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing
- (2019) Diego Perez-Rodriguez et al. Acta Neuropathologica Communications
- Nuclear Genomic Instability and Aging
- (2018) Laura J. Niedernhofer et al. Annual Review of Biochemistry
- The MRE11–RAD50–NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair
- (2018) Aleem Syed et al. Annual Review of Biochemistry
- PolyQ-expanded huntingtin and ataxin-3 sequester ubiquitin adaptors hHR23B and UBQLN2 into aggregates via conjugated ubiquitin
- (2018) Hui Yang et al. FASEB JOURNAL
- Prion-like low-complexity sequences: Key regulators of protein solubility and phase behavior
- (2018) Titus Franzmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ubiquilin 2: Shuttling Clients Out of Phase?
- (2018) Ipsita Subudhi et al. MOLECULAR CELL
- ATM directs DNA damage responses and proteostasis via genetically separable pathways
- (2018) Ji-Hoon Lee et al. Science Signaling
- NEK1 loss-of-function mutation induces DNA damage accumulation in ALS patient-derived motoneurons
- (2018) Julia Higelin et al. Stem Cell Research
- Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington’s disease patients
- (2018) Georgina Askeland et al. Scientific Reports
- ATM directs DNA damage responses and proteostasis via genetically separable pathways
- (2018) Ji-Hoon Lee et al. Science Signaling
- Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease
- (2018) Chiara Milanese et al. Cell Death & Disease
- Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
- (2018) Haibo Wang et al. Nature Communications
- A Chemical Chaperone Decouples TDP-43 Disordered Domain Phase Separation from Fibrillation
- (2018) Kyoung-Jae Choi et al. BIOCHEMISTRY
- p62/SQSTM1 – steering the cell through health and disease
- (2018) Pablo Sánchez-Martín et al. JOURNAL OF CELL SCIENCE
- Mechanisms of DNA damage, repair, and mutagenesis
- (2017) Nimrat Chatterjee et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
- Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson’s Disease
- (2017) Velmarini Vasquez et al. JOURNAL OF ALZHEIMERS DISEASE
- Ubiquitin Accumulation on Disease Associated Protein Aggregates Is Correlated with Nuclear Ubiquitin Depletion, Histone De-Ubiquitination and Impaired DNA Damage Response
- (2017) Adi Ben Yehuda et al. PLoS One
- The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair
- (2017) Ruth M. Densham et al. Nucleus
- The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair
- (2017) Ruth M. Densham et al. Nucleus
- Alzheimer's Disease and the Amyloid-β Peptide
- (2017) M. Paul Murphy et al. JOURNAL OF ALZHEIMERS DISEASE
- Are aberrant phase transitions a driver of cellular aging?
- (2016) Simon Alberti et al. BIOESSAYS
- Sequestration of cellular interacting partners by protein aggregates: implication in a loss-of-function pathology
- (2016) Hui Yang et al. FEBS Journal
- Heat shock proteins as potential targets for protective strategies in neurodegeneration
- (2016) Harm H Kampinga et al. LANCET NEUROLOGY
- Phasing in and out
- (2016) James Shorter Nature Chemistry
- NEK1 variants confer susceptibility to amyotrophic lateral sclerosis
- (2016) Kevin P Kenna et al. NATURE GENETICS
- E4 ligase–specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis
- (2016) Leena Ackermann et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Human Senataxin Modulates Structural Plasticity of the Neuromuscular Junction in Drosophila through a Neuronally Conserved TGFβ Signalling Pathway
- (2016) Zeeshan Mushtaq et al. Neurodegenerative Diseases
- E4 ligase–specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis
- (2016) Leena Ackermann et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- DNA damage in neurodegenerative diseases
- (2015) Fabio Coppedè et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice
- (2015) Elsa Suberbielle et al. Nature Communications
- Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism
- (2015) Valerie R. Osterberg et al. Cell Reports
- DNA Damage, DNA Repair, Aging, and Neurodegeneration
- (2015) Scott Maynard et al. Cold Spring Harbor Perspectives in Medicine
- Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3
- (2015) Rui Gao et al. PLoS Genetics
- The Role of Oxidative Stress in Neurodegenerative Diseases
- (2015) Geon Ha Kim et al. Experimental Neurobiology
- DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes
- (2015) Peter Sykora et al. NUCLEIC ACIDS RESEARCH
- Aneuploidy: implications for protein homeostasis and disease
- (2014) A. B. Oromendia et al. Disease Models & Mechanisms
- Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms
- (2014) Tatyana A. Shelkovnikova et al. HUMAN MOLECULAR GENETICS
- ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects
- (2014) Haiyan Qiu et al. JOURNAL OF CLINICAL INVESTIGATION
- FUS is sequestered in nuclear aggregates in ALS patient fibroblasts
- (2014) Jacob C. Schwartz et al. MOLECULAR BIOLOGY OF THE CELL
- The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis
- (2014) Eveliina Pollari et al. Frontiers in Cellular Neuroscience
- A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions
- (2014) Marie Violet et al. Frontiers in Cellular Neuroscience
- Alpha-synuclein biology in Lewy body diseases
- (2014) Woojin Scott Kim et al. Alzheimers Research & Therapy
- Amyloid-β and Tau
- (2014) George S. Bloom JAMA Neurology
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones
- (2013) Maria Udan-Johns et al. HUMAN MOLECULAR GENETICS
- The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage
- (2013) Adam S. Mastrocola et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Stress granules as crucibles of ALS pathogenesis
- (2013) Yun R. Li et al. JOURNAL OF CELL BIOLOGY
- Mutations of the Huntington’s Disease Protein Impact on the ATM-Dependent Signaling and Repair Pathways of the Radiation-Induced DNA Double-Strand Breaks: Corrective Effect of Statins and Bisphosphonates
- (2013) Mélanie L. Ferlazzo et al. MOLECULAR NEUROBIOLOGY
- Silencing Mutant ATXN3 Expression Resolves Molecular Phenotypes in SCA3 Transgenic Mice
- (2013) Edgardo Rodríguez-Lebrón et al. MOLECULAR THERAPY
- Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51–Rad52 interaction
- (2013) Steven Bergink et al. NATURE CELL BIOLOGY
- Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β
- (2013) Elsa Suberbielle et al. NATURE NEUROSCIENCE
- Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons
- (2013) Wen-Yuan Wang et al. NATURE NEUROSCIENCE
- SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons
- (2013) Matthew M Dobbin et al. NATURE NEUROSCIENCE
- PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage
- (2013) Stuart L. Rulten et al. NUCLEIC ACIDS RESEARCH
- DNA Damage Response: Three Levels of DNA Repair Regulation
- (2013) B. M. Sirbu et al. Cold Spring Harbor Perspectives in Biology
- Senataxin Plays an Essential Role with DNA Damage Response Proteins in Meiotic Recombination and Gene Silencing
- (2013) Olivier J. Becherel et al. PLoS Genetics
- Age-Related Somatic Structural Changes in the Nuclear Genome of Human Blood Cells
- (2012) Lars A. Forsberg et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells
- (2012) Silvia Stingele et al. Molecular Systems Biology
- Rate constants and mechanisms of intrinsically disordered proteins binding to structured targets
- (2012) Huan-Xiang Zhou et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Molecular chaperones in protein folding and proteostasis
- (2011) F. Ulrich Hartl et al. NATURE
- The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks
- (2011) Mayura Meerang et al. NATURE CELL BIOLOGY
- Toward understanding Machado–Joseph disease
- (2011) Maria do Carmo Costa et al. PROGRESS IN NEUROBIOLOGY
- Cellular Strategies of Protein Quality Control
- (2011) B. Chen et al. Cold Spring Harbor Perspectives in Biology
- Protein folding, protein homeostasis, and cancer
- (2011) John H. Van Drie Chinese Journal of Cancer
- TDP-43: A DNA and RNA binding protein with roles in neurodegenerative diseases
- (2010) Sadaf T. Warraich et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Nuclear Tau, a Key Player in Neuronal DNA Protection
- (2010) Audrey Sultan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mutant huntingtin impairs Ku70-mediated DNA repair
- (2010) Yasushi Enokido et al. JOURNAL OF CELL BIOLOGY
- Predicting intrinsic disorder in proteins: an overview
- (2009) Bo He et al. CELL RESEARCH
- Inhibiting the transcription factor HSF1 as an anticancer strategy
- (2009) Luke Whitesell et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- The DNA-damage response in human biology and disease
- (2009) Stephen P. Jackson et al. NATURE
- DNA repair deficiency and neurological disease
- (2009) Peter J. McKinnon NATURE REVIEWS NEUROSCIENCE
- Fe65 is required for Tip60-directed histone H4 acetylation at DNA strand breaks
- (2009) M. Stante et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The comet assay: topical issues
- (2008) A. R. Collins et al. MUTAGENESIS
- Adapting Proteostasis for Disease Intervention
- (2008) William E. Balch et al. SCIENCE
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