The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease

Parkinson's disease

(2021) Bastiaan R Bloem et al.   LANCET

Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain

(2021) Lilah Toker et al.   Molecular Neurodegeneration

DNA damage and repair in Parkinson's disease: Recent advances and new opportunities

(2020) Claudia P. Gonzalez‐Hunt et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals

(2020) Donald A. Lamb et al.   Aging-US

NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis

(2020) Nady Braidy et al.   EXPERIMENTAL GERONTOLOGY

Evaluation of the NAD+ biosynthetic pathway in ALS patients and effect of modulating NAD+ levels in hSOD1-linked ALS mouse models

(2020) Benjamin A. Harlan et al.   EXPERIMENTAL NEUROLOGY

Nicotinamide riboside protects noise-induced hearing loss by recovering the hair cell ribbon synapses

(2020) Shuguang Han et al.   NEUROSCIENCE LETTERS

Validation of Serum Neurofilament Light Chain as a Biomarker of Parkinson’s Disease Progression

(2020) Brit Mollenhauer et al.   MOVEMENT DISORDERS

RNA-Seq Signatures Normalized by mRNA Abundance Allow Absolute Deconvolution of Human Immune Cell Types

(2019) Gianni Monaco et al.   Cell Reports

Dysfunction of Cellular Proteostasis in Parkinson’s Disease

(2019) Šárka Lehtonen et al.   Frontiers in Neuroscience

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

(2019) Dietrich Conze et al.   Scientific Reports

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

(2019) Yasir S. Elhassan et al.   Cell Reports

Nicotinamide and NAFLD: Is There Nothing New Under the Sun?

(2019) Maria Guarino et al.   Metabolites

NAD+ in Brain Aging and Neurodegenerative Disorders

(2019) Sofie Lautrup et al.   Cell Metabolism

Systemic activation of Nrf2 pathway in Parkinson's disease

(2019) Sara Petrillo et al.   MOVEMENT DISORDERS

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

(2018) Ole L Dollerup et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Biomarkers for mitochondrial energy metabolism diseases

(2018) Sara Boenzi et al.   Essays in Biochemistry

Network imaging biomarkers: insights and clinical applications in Parkinson's disease

(2018) Katharina A Schindlbeck et al.   LANCET NEUROLOGY

Unveiling a hidden 31 P signal coresonating with extracellular inorganic phosphate by outer-volume-suppression and localized 31 P MRS in the human brain at 7T

(2018) Jimin Ren et al.   MAGNETIC RESONANCE IN MEDICINE

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease

(2018) David C. Schöndorf et al.   Cell Reports

Nicotinamide ribose ameliorates cognitive impairment of aged and Alzheimer’s disease model mice

(2018) Xian Xie et al.   METABOLIC BRAIN DISEASE

Gene therapy reduces Parkinson’s disease symptoms by reorganizing functional brain connectivity

(2018) Martin Niethammer et al.   Science Translational Medicine

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Precision medicine for disease modification in Parkinson disease

(2017) Alberto J. Espay et al.   Nature Reviews Neurology

OXSA: An open-source magnetic resonance spectroscopy analysis toolbox in MATLAB

(2017) Lucian A. B. Purvis et al.   PLoS One

Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration

(2016) Sarmistha Mukherjee et al.   HEPATOLOGY

Safety assessment of nicotinamide riboside, a form of vitamin B3

(2016) DB Conze et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders

(2016) Jenni M. Lehtonen et al.   NEUROLOGY

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

(2016) Samuel A. J. Trammell et al.   Nature Communications

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Regulation of Histone Acetylation by Autophagy in Parkinson Disease

(2015) Goonho Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

MDS clinical diagnostic criteria for Parkinson's disease

(2015) Ronald B. Postuma et al.   MOVEMENT DISORDERS

Quantification ofin vivo31P NMR brain spectra using LCModel

(2015) Dinesh Kumar Deelchand et al.   NMR IN BIOMEDICINE

OXPHOS-Mediated Induction of NAD+ Promotes Complete Oxidation of Fatty Acids and Interdicts Non-Alcoholic Fatty Liver Disease

(2015) Thomas E. Akie et al.   PLoS One

Insights into Neuroinflammation in Parkinson’s Disease: From Biomarkers to Anti-Inflammatory Based Therapies

(2015) Natália Pessoa Rocha et al.   Biomed Research International

Activation of SIRT3 by the NAD+ Precursor Nicotinamide Riboside Protects from Noise-Induced Hearing Loss

(2014) Kevin D. Brown et al.   Cell Metabolism

Network modulation following sham surgery in Parkinson’s disease

(2014) Ji Hyun Ko et al.   JOURNAL OF CLINICAL INVESTIGATION

Frequency and phase drift correction of magnetic resonance spectroscopy data by spectral registration in the time domain

(2014) Jamie Near et al.   MAGNETIC RESONANCE IN MEDICINE

The ongoing pursuit of neuroprotective therapies in Parkinson disease

(2014) Dilan Athauda et al.   Nature Reviews Neurology

Characterization of disease-related covariance topographies withSSMPCAtoolbox: Effects of spatial normalization and PET scanners

(2013) Shichun Peng et al.   HUMAN BRAIN MAPPING

Metabolic network as a progression biomarker of premanifest Huntington’s disease

(2013) Chris C. Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Gannet: A batch-processing tool for the quantitative analysis of gamma-aminobutyric acid-edited MR spectroscopy spectra

(2013) Richard A.E. Edden et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Intracellular redox state revealed by in vivo31P MRS measurement of NAD+and NADH contents in brains

(2013) Ming Lu et al.   MAGNETIC RESONANCE IN MEDICINE

Validation of parkinsonian disease-related metabolic brain patterns

(2013) Laura K. Teune et al.   MOVEMENT DISORDERS

Metabolic brain network in the Chinese patients with Parkinson's disease based on 18F-FDG PET imaging

(2013) Ping Wu et al.   PARKINSONISM & RELATED DISORDERS

Metabolic brain networks in translational neurology: Concepts and applications

(2012) Martin Niethammer et al.   ANNALS OF NEUROLOGY

Improved Sequence Learning with Subthalamic Nucleus Deep Brain Stimulation: Evidence for Treatment-Specific Network Modulation

(2012) H. Mure et al.   JOURNAL OF NEUROSCIENCE

Multivariate Data Analysis for Neuroimaging Data: Overview and Application to Alzheimer’s Disease

(2010) Christian Habeck et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Gene function analysis in complex data sets using ErmineJ

(2010) Jesse Gillis et al.   Nature Protocols

Parkinson's disease tremor-related metabolic network: Characterization, progression, and treatment effects

(2010) Hideo Mure et al.   NEUROIMAGE

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY