Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS

(2021) Xinxin Zuo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Breakdown of supersaturation barrier links protein folding to amyloid formation

(2021) Masahiro Noji et al.   Communications Biology

Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency

(2021) Ji-Hoon Lee et al.   MOLECULAR CELL

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

(2021) Simon Alberti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates

(2021) Hong-Wei Yue et al.   Scientific Reports

Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?

(2021) Anna Ainslie et al.   Open Biology

The Diverse Functions of Small Heat Shock Proteins in the Proteostasis Network

(2021) Kevin Reinle et al.   JOURNAL OF MOLECULAR BIOLOGY

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

(2020) Anne-Laure Mahul-Mellier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protecting the Aging Genome

(2020) Michael A. Petr et al.   TRENDS IN CELL BIOLOGY

Chaperone client proteins evolve slower than non-client proteins

(2020) Manish Prakash Victor et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation

(2020) Zhenying Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain

(2020) Devin Kepchia et al.   Alzheimers Research & Therapy

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells

(2020) Seung W. Ryu et al.   PLOS BIOLOGY

Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force

(2020) Aurélie Zbinden et al.   DEVELOPMENTAL CELL

Affinity proteomic dissection of the human nuclear cap-binding complex interactome

(2020) Yuhui Dou et al.   NUCLEIC ACIDS RESEARCH

Protein Solubility Predictions Using the CamSol Method in the Study of Protein Homeostasis

(2019) Pietro Sormanni et al.   Cold Spring Harbor Perspectives in Biology

Abundance of Synaptic Vesicle-Related Proteins in Alpha-Synuclein-Containing Protein Inclusions Suggests a Targeted Formation Mechanism

(2019) Amellia McCormack et al.   NEUROTOXICITY RESEARCH

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins

(2019) Yongjia Duan et al.   CELL RESEARCH

Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network

(2019) Anan Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liquid–Liquid Phase Separation in Disease

(2019) Simon Alberti et al.   Annual Review of Genetics

Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of 'quasi-ordered' states

(2019) Amanda F Clouser et al.   eLife

Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease

(2019) Jack M. Webster et al.   Frontiers in Pharmacology

Regulation of small heat shock proteins by hetero-oligomer formation

(2019) Evgeny V. Mymrikov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A metastable subproteome underlies inclusion formation in muscle proteinopathies

(2019) Prajwal Ciryam et al.   Acta Neuropathologica Communications

Doxorubicin-induced DNA damage causes extensive ubiquitination of ribosomal proteins associated with a decrease in protein translation

(2018) Vincentius A. Halim et al.   MOLECULAR & CELLULAR PROTEOMICS

Cellular Handling of Protein Aggregates by Disaggregation Machines

(2018) Axel Mogk et al.   MOLECULAR CELL

A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation

(2018) Thomas R. Peskett et al.   MOLECULAR CELL

Intra-molecular pathways of allosteric control in Hsp70s

(2018) Matthias P. Mayer   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

ATM directs DNA damage responses and proteostasis via genetically separable pathways

(2018) Ji-Hoon Lee et al.   Science Signaling

Pi-Pi contacts are an overlooked protein feature relevant to phase separation

(2018) Robert McCoy Vernon et al.   eLife

ATM directs DNA damage responses and proteostasis via genetically separable pathways

(2018) Ji-Hoon Lee et al.   Science Signaling

CRYAB protects cardiomyocytes against heat stress by preventing caspase-mediated apoptosis and reducing F-actin aggregation

(2018) Bin Yin et al.   CELL STRESS & CHAPERONES

Essential Function of Mec1, the Budding Yeast ATM/ATR Checkpoint-Response Kinase, in Protein Homeostasis

(2018) Isaac Corcoles-Saez et al.   DEVELOPMENTAL CELL

Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

(2018) Leeanne McGurk et al.   MOLECULAR CELL

Relation Between Stress Granules and Cytoplasmic Protein Aggregates Linked to Neurodegenerative Diseases

(2018) Ioana Dobra et al.   Current Neurology and Neuroscience Reports

HSPB5 engages multiple states of a destabilized client to enhance chaperone activity in a stress-dependent manner.

(2018) Scott P. Delbecq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PRIDE database and related tools and resources in 2019: improving support for quantification data

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Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease

(2017) Rishika Kundra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatiotemporal Proteomic Profiling of Huntington’s Disease Inclusions Reveals Widespread Loss of Protein Function

(2017) Fabian Hosp et al.   Cell Reports

The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

(2017) Francesco A. Aprile et al.   Scientific Reports

HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse models

(2017) Andreas Neueder et al.   Scientific Reports

The Impact of Small Heat Shock Proteins (HspBs) in Alzheimer’s and Other Neurological Diseases

(2016) Nikola Golenhofen et al.   CURRENT PHARMACEUTICAL DESIGN

The Chaperone Activity and Substrate Spectrum of Human Small Heat Shock Proteins

(2016) Evgeny V. Mymrikov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vulnerability of newly synthesized proteins to proteostasis stress

(2016) Guilian Xu et al.   JOURNAL OF CELL SCIENCE

Heat shock proteins as potential targets for protective strategies in neurodegeneration

(2016) Harm H Kampinga et al.   LANCET NEUROLOGY

A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism

(2016) Massimo Ganassi et al.   MOLECULAR CELL

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model

(2016) Vaishali Kakkar et al.   MOLECULAR CELL

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression

(2016) Chadwick M. Hales et al.   PROTEOMICS

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimers disease

(2016) R. Freer et al.   Science Advances

Distinct stress conditions result in aggregation of proteins with similar properties

(2016) Alan J. Weids et al.   Scientific Reports

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases

(2015) Prajwal Ciryam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Proteome Metastability in Health, Aging, and Disease

(2015) Prajwal Ciryam et al.   BIOPHYSICAL JOURNAL

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

(2014) Raymond J Deshaies   BMC BIOLOGY

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease

(2013) Tali Gidalevitz et al.   BMC BIOLOGY

Structural and Functional Aspects of Hetero-oligomers Formed by the Small Heat Shock Proteins αB-Crystallin and HSP27

(2013) J. Andrew Aquilina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Widespread Aggregation and Neurodegenerative Diseases Are Associated with Supersaturated Proteins

(2013) Prajwal Ciryam et al.   Cell Reports

Comparative Proteomic Analysis of Eleven Common Cell Lines Reveals Ubiquitous but Varying Expression of Most Proteins

(2012) Tamar Geiger et al.   MOLECULAR & CELLULAR PROTEOMICS

Global analysis of yeast mRNPs

(2012) Sarah F Mitchell et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Coaggregation of RNA-Binding Proteins in a Model of TDP-43 Proteinopathy with Selective RGG Motif Methylation and a Role for RRM1 Ubiquitination

(2012) Eric B. Dammer et al.   PLoS One

ATM and the Molecular Pathogenesis of Ataxia Telangiectasia

(2011) Peter J. McKinnon   Annual Review of Pathology-Mechanisms of Disease

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

(2011) Jurre Hageman et al.   BIOCHEMICAL JOURNAL

Proteotoxic stress of cancer: Implication of the heat-shock response in oncogenesis

(2011) Chengkai Dai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

The Stress of Protein Misfolding: From Single Cells to Multicellular Organisms

(2011) T. Gidalevitz et al.   Cold Spring Harbor Perspectives in Biology

Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies

(2010) Dee Shen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

A cellular perspective on conformational disease: the role of genetic background and proteostasis networks

(2010) Tali Gidalevitz et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A DNAJB Chaperone Subfamily with HDAC-Dependent Activities Suppresses Toxic Protein Aggregation

(2010) Jurre Hageman et al.   MOLECULAR CELL

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Mammalian Heat Shock Factor 1 Is Essential for Oocyte Meiosis and Directly Regulates Hsp90α Expression

(2009) Aïcha Metchat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY