STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy
出版年份 2022 全文链接
标题
STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy
作者
关键词
-
出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 119, Issue 15, Pages -
出版商
Proceedings of the National Academy of Sciences
发表日期
2022-04-09
DOI
10.1073/pnas.2118819119
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The cell biology of Parkinson’s disease
- (2021) Nikhil Panicker et al. JOURNAL OF CELL BIOLOGY
- The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
- (2021) Roberta Cascella et al. Nature Communications
- Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C
- (2021) Ting-Ting Chu et al. NATURE
- NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING
- (2021) Yujun Hou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Microglia contribute to the propagation of Aβ into unaffected brain tissue
- (2021) Paolo d’Errico et al. NATURE NEUROSCIENCE
- Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease
- (2020) Min Guo et al. BRAIN
- The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice
- (2020) Valeria Gerbino et al. NEURON
- Chronic Infiltration of T Lymphocytes into the Brain in a Non-human Primate Model of Parkinson’s Disease
- (2020) Jincheol Seo et al. NEUROSCIENCE
- α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease
- (2020) Cecilia S. Lindestam Arlehamn et al. Nature Communications
- TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
- (2020) Katherine R. Balka et al. Cell Reports
- Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase
- (2020) Salim Abdisalaam et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease
- (2020) Manish Sharma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
- (2020) Chien-Hsiung Yu et al. CELL
- Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
- (2019) Xiang Gui et al. NATURE
- Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression
- (2019) Arshed Nazmi et al. GLIA
- Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia
- (2019) Nikhil Panicker et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Accumulation of cytoplasmic DNA due to ATM deficiency activates the microglial viral response system with neurotoxic consequences
- (2019) Xuan Song et al. JOURNAL OF NEUROSCIENCE
- Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson’s Disease
- (2018) Annika Sommer et al. Cell Stem Cell
- Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
- (2018) Megan F. Duffy et al. Journal of Neuroinflammation
- Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease
- (2018) Seung Pil Yun et al. NATURE MEDICINE
- Parkin and PINK1 mitigate STING-induced inflammation
- (2018) Danielle A. Sliter et al. NATURE
- Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease
- (2018) Tae-In Kam et al. SCIENCE
- Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice
- (2018) Richard Gordon et al. Science Translational Medicine
- cGAS surveillance of micronuclei links genome instability to innate immunity
- (2017) Karen J. Mackenzie et al. NATURE
- Cytoplasmic chromatin triggers inflammation in senescence and cancer
- (2017) Zhixun Dou et al. NATURE
- Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
- (2017) Selene Glück et al. NATURE CELL BIOLOGY
- α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies
- (2017) Yvette C Wong et al. NATURE MEDICINE
- Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation
- (2017) Vidhu Mathur et al. NEURON
- cGAS is essential for cellular senescence
- (2017) Hui Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TBK1: a new player in ALS linking autophagy and neuroinflammation
- (2017) James A. Oakes et al. Molecular Brain
- Human TBK1: A Gatekeeper of Neuroinflammation
- (2016) Liyana Ahmad et al. TRENDS IN MOLECULAR MEDICINE
- Activation of STING requires palmitoylation at the Golgi
- (2016) Kojiro Mukai et al. Nature Communications
- Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS
- (2016) Line S. Reinert et al. Nature Communications
- Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders
- (2015) Stefano G. Daniele et al. Science Signaling
- Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders
- (2015) Stefano G. Daniele et al. Science Signaling
- Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates
- (2014) Laura A Volpicelli-Daley et al. Nature Protocols
- Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities
- (2013) Amos A Fatokun et al. BRITISH JOURNAL OF PHARMACOLOGY
- Targeting CCL5 in inflammation
- (2013) Rafael Elias Marques et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
- (2013) Andrea Ablasser et al. NATURE
- Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
- (2013) Changyoun Kim et al. Nature Communications
- Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
- (2012) Lisa Fellner et al. GLIA
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides
- (2010) John-Demian Sauer et al. INFECTION AND IMMUNITY
- Lipid Rafts As a Membrane-Organizing Principle
- (2010) D. Lingwood et al. SCIENCE
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
- (2008) Hiroki Ishikawa et al. NATURE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now