DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes
出版年份 2022 全文链接
标题
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes
作者
关键词
-
出版物
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 219, Issue 4, Pages -
出版商
Rockefeller University Press
发表日期
2022-03-09
DOI
10.1084/jem.20211121
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- ER-directed TREX1 limits cGAS activation at micronuclei
- (2021) Lisa Mohr et al. MOLECULAR CELL
- Systemic inflammation and chronic kidney disease in a patient due to the RNASEH2B defect
- (2021) Tingyan He et al. Pediatric Rheumatology
- Activation of endogenous retroviruses during brain development causes an inflammatory response
- (2021) Marie E Jönsson et al. EMBO JOURNAL
- Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation
- (2021) Julie Jerber et al. NATURE GENETICS
- Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease
- (2021) Sudha R. Guttikonda et al. NATURE NEUROSCIENCE
- PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage
- (2021) Byeong Jin Ye et al. DNA REPAIR
- Neurotoxic reactive astrocytes induce cell death via saturated lipids
- (2021) Kevin A. Guttenplan et al. NATURE
- Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair
- (2021) Aditi et al. NEURON
- TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis
- (2021) Joschka Willemsen et al. Cell Reports
- R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage
- (2021) Ourania Chatzidoukaki et al. Science Advances
- Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain
- (2020) Yoshiaki Tanaka et al. Cell Reports
- Micronuclei, inflammation and auto-immune disease
- (2020) Micheline Kirsch-Volders et al. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
- Janus Kinase Inhibition in the Aicardi–Goutières Syndrome
- (2020) Adeline Vanderver et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pan-cancer analysis of NLRP3 inflammasome with potential implications in prognosis and immunotherapy in human cancer
- (2020) Mingyi Ju et al. BRIEFINGS IN BIOINFORMATICS
- cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing
- (2020) Carolina Uggenti et al. NATURE GENETICS
- WikiPathways: connecting communities
- (2020) Marvin Martens et al. NUCLEIC ACIDS RESEARCH
- R-Loops as Cellular Regulators and Genomic Threats
- (2019) Madzia P. Crossley et al. MOLECULAR CELL
- Genome instability consequences of RNase H2 Aicardi-Goutières syndrome alleles
- (2019) Catherine J. Potenski et al. DNA REPAIR
- Endogenous Nucleic Acid Recognition by RIG-I-Like Receptors and cGAS
- (2019) Jung-Hyun Lee et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Comprehensive Integration of Single-Cell Data
- (2019) Tim Stuart et al. CELL
- Sources of Pathogenic Nucleic Acids in Systemic Lupus Erythematosus
- (2019) Tomas Mustelin et al. Frontiers in Immunology
- Generation of three iPSC lines from fibroblasts of a patient with Aicardi Goutières Syndrome mutated in TREX1
- (2019) R.M. Ferraro et al. Stem Cell Research
- R Loops: From Physiological to Pathological Roles
- (2019) Tatiana García-Muse et al. CELL
- NLRP3 inflammasome activation drives tau pathology
- (2019) Christina Ising et al. NATURE
- Fast, sensitive and accurate integration of single-cell data with Harmony
- (2019) Ilya Korsunsky et al. NATURE METHODS
- Establishment of three iPSC lines from fibroblasts of a patient with Aicardi Goutières syndrome mutated in RNaseH2B
- (2019) Rosalba Monica Ferraro et al. Stem Cell Research
- Astrocytes, an active player in Aicardi-Goutières syndrome
- (2018) Sunetra Sase et al. BRAIN PATHOLOGY
- Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
- (2018) Hachung Chung et al. CELL
- RNase H2, mutated in Aicardi‐Goutières syndrome, promotes LINE‐1 retrotransposition
- (2018) Maria Benitez‐Guijarro et al. EMBO JOURNAL
- JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies
- (2018) Gina A. Montealegre Sanchez et al. JOURNAL OF CLINICAL INVESTIGATION
- Development of a Validated Interferon Score Using NanoString Technology
- (2018) Hanna Kim et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Brain transcriptome databases: a user's guide
- (2018) Jason M. Keil et al. JOURNAL OF NEUROSCIENCE
- p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells
- (2018) Robert J. Ihry et al. NATURE MEDICINE
- Proteome-wide identification of ubiquitin interactions using UbIA-MS
- (2018) Xiaofei Zhang et al. Nature Protocols
- Human iPSC-based models highlight defective glial and neuronal differentiation from neural progenitor cells in metachromatic leukodystrophy
- (2018) Giacomo Frati et al. Cell Death & Disease
- RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage
- (2018) Agnese Cristini et al. Cell Reports
- Microglial Dynamics During Human Brain Development
- (2018) David A. Menassa et al. Frontiers in Immunology
- CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions
- (2018) Michal Zimmermann et al. NATURE
- Targeting STING with covalent small-molecule inhibitors
- (2018) Simone M. Haag et al. NATURE
- Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency
- (2018) Coralie Briand et al. ANNALS OF THE RHEUMATIC DISEASES
- JAK 1/2 Blockade in MDA5 Gain-of-Function
- (2018) Kirsty E. McLellan et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome
- (2018) Gillian I. Rice et al. NEW ENGLAND JOURNAL OF MEDICINE
- Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development
- (2018) Ryo Uehara et al. Cell Reports
- Inflammatory myopathy in a patient with Aicardi-Goutières syndrome
- (2017) Birutė Tumienė et al. European Journal of Medical Genetics
- Genome integrity and disease prevention in the nervous system
- (2017) Peter J. McKinnon GENES & DEVELOPMENT
- Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy
- (2017) Kareen Bartsch et al. HUMAN MOLECULAR GENETICS
- Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs
- (2017) Martin Achleitner et al. JOURNAL OF IMMUNOLOGY
- R Loops and Links to Human Disease
- (2017) Patricia Richard et al. JOURNAL OF MOLECULAR BIOLOGY
- cGAS surveillance of micronuclei links genome instability to innate immunity
- (2017) Karen J. Mackenzie et al. NATURE
- Mitotic progression following DNA damage enables pattern recognition within micronuclei
- (2017) Shane M. Harding et al. NATURE
- Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
- (2017) Florian T. Merkle et al. NATURE
- Mitochondrial dysfunction as a trigger of innate immune responses and inflammation
- (2017) A. Phillip West TOXICOLOGY
- Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells
- (2017) Renata Santos et al. Stem Cell Reports
- Response to: ‘JAK inhibition in STING-associated interferonopathy’ by Crowet al
- (2016) Victoria Tüngler et al. ANNALS OF THE RHEUMATIC DISEASES
- Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity
- (2016) Franck J. Barrat et al. Annual Review of Medicine
- Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response
- (2016) Karen J Mackenzie et al. EMBO JOURNAL
- Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173 -activating mutations in 3 children
- (2016) Marie-Louise Frémond et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse
- (2016) Ye Zhang et al. NEURON
- Increased global transcription activity as a mechanism of replication stress in cancer
- (2016) Panagiotis Kotsantis et al. Nature Communications
- High-throughput proteomics reveal alarmins as amplifiers of tissue pathology and inflammation after spinal cord injury
- (2016) Athanasios Didangelos et al. Scientific Reports
- Generation of Human Induced Pluripotent Stem Cell-Derived Bona Fide Neural Stem Cells for Ex Vivo Gene Therapy of Metachromatic Leukodystrophy
- (2016) Vasco Meneghini et al. Stem Cells Translational Medicine
- Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders
- (2016) Keren Zhou et al. Journal of Immunology Research
- DNA Damage Response and Immune Defense: Links and Mechanisms
- (2016) Rania Nakad et al. Frontiers in Genetics
- Characterization of human disease phenotypes associated with mutations inTREX1,RNASEH2A,RNASEH2B,RNASEH2C,SAMHD1,ADAR, andIFIH1
- (2015) Yanick J. Crow et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Type I interferonopathies: Mendelian type I interferon up-regulation
- (2015) Yanick J Crow CURRENT OPINION IN IMMUNOLOGY
- Phenotypic Variation in Aicardi–Goutières Syndrome Explained by Cell-Specific IFN-Stimulated Gene Response and Cytokine Release
- (2015) Eloy Cuadrado et al. JOURNAL OF IMMUNOLOGY
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- (2015) Rebecca C Coll et al. NATURE MEDICINE
- Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease
- (2015) Jessica L. Grieves et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A survey of human brain transcriptome diversity at the single cell level
- (2015) Spyros Darmanis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting of type I interferon in systemic autoimmune diseases
- (2015) Mary K. Crow et al. Translational Research
- Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome
- (2015) Yoong Wearn Lim et al. eLife
- Ribonuclease H2 in health and disease
- (2014) Martin A.M. Reijns et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Trimmomatic: a flexible trimmer for Illumina sequence data
- (2014) Anthony M. Bolger et al. BIOINFORMATICS
- Cytosolic RNA:DNA hybrids activate the cGAS–STING axis
- (2014) Arun K Mankan et al. EMBO JOURNAL
- RNA:DNA hybrids are a novel molecular pattern sensed by TLR9
- (2014) R. E. Rigby et al. EMBO JOURNAL
- The 3′–5′ DNA Exonuclease TREX1 Directly Interacts with Poly(ADP-ribose) Polymerase-1 (PARP1) during the DNA Damage Response
- (2014) Takuya Miyazaki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Defective removal of ribonucleotides from DNA promotes systemic autoimmunity
- (2014) Claudia Günther et al. JOURNAL OF CLINICAL INVESTIGATION
- The enemy within: endogenous retroelements and autoimmune disease
- (2014) Hannah E Volkman et al. NATURE IMMUNOLOGY
- Identification of RNA polymerase III-transcribed Alu loci by computational screening of RNA-Seq data
- (2014) Anastasia Conti et al. NUCLEIC ACIDS RESEARCH
- Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome
- (2014) S. Kailasan Vanaja et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
- (2013) Y. Liao et al. BIOINFORMATICS
- Therapies in Aicardi-Goutières syndrome
- (2013) Y. J. Crow et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Cutting Edge: The NLRP3 Inflammasome Links Complement-Mediated Inflammation and IL-1 Release
- (2013) F. Laudisi et al. JOURNAL OF IMMUNOLOGY
- The sub-nanomolar binding of DNA-RNA hybrids by the single-chain Fv fragment of antibody S9.6
- (2013) Damilola D. Phillips et al. JOURNAL OF MOLECULAR RECOGNITION
- Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study
- (2013) Gillian I Rice et al. LANCET NEUROLOGY
- Dysregulation of the immune system in Aicardi-Goutières syndrome: another example in a TREX1-mutated patient
- (2013) I Olivieri et al. LUPUS
- Elevation of proinflammatory cytokines in patients with Aicardi-Goutieres syndrome
- (2013) A. Takanohashi et al. NEUROLOGY
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development
- (2012) Martin A.M. Reijns et al. CELL
- Modeling Brain Disease in a Dish: Really?
- (2012) Maria C. Marchetto et al. Cell Stem Cell
- Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity
- (2012) Bjoern Hiller et al. JOURNAL OF EXPERIMENTAL MEDICINE
- RNase H2-Initiated Ribonucleotide Excision Repair
- (2012) Justin L. Sparks et al. MOLECULAR CELL
- Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature
- (2012) Gillian I Rice et al. NATURE GENETICS
- clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
- (2012) Guangchuang Yu et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- ATM and the Molecular Pathogenesis of Ataxia Telangiectasia
- (2011) Peter J. McKinnon Annual Review of Pathology-Mechanisms of Disease
- Induction of protective antibody response by MF59-adjuvanted 2009 pandemic A/H1N1v influenza vaccine in HIV-1-infected individuals
- (2010) Anna Kajaste-Rudnitski et al. AIDS
- Fast and accurate long-read alignment with Burrows–Wheeler transform
- (2010) Heng Li et al. BIOINFORMATICS
- The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
- (2010) A. McKenna et al. GENOME RESEARCH
- The Structural and Biochemical Characterization of Human RNase H2 Complex Reveals the Molecular Basis for Substrate Recognition and Aicardi-Goutières Syndrome Defects
- (2010) Małgorzata Figiel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease
- (2010) Martin A. M. Reijns et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
- (2010) Nan Yan et al. NATURE IMMUNOLOGY
- Aicardi-Goutières syndrome: an important Mendelian mimic of congenital infection
- (2009) Yanick J Crow et al. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
- Ribonuclease H: the enzymes in eukaryotes
- (2009) Susana M. Cerritelli et al. FEBS Journal
- Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
- (2009) Stuart M Chambers et al. NATURE BIOTECHNOLOGY
- Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity
- (2008) Daniel B. Stetson et al. CELL
- Astrocytes produce interferon-alpha and CXCL10, but not IL-6 or CXCL8, in aicardi-Goutières syndrome
- (2008) Jane T. Van Heteren et al. GLIA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search