New Visions on Natural Products and Cancer Therapy: Autophagy and Related Regulatory Pathways

Effect of casein kinase 1α inhibition on autophagy flux and the AKT/phospho-β-catenin (S552) axis in HCT116, a RAS-mutated colorectal cancer cell line

(2021) Hamid Behrouj et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Emerging Role of Autophagy in Anti-Tumor Immunity: Implications for the Modulation of Immunotherapy Resistance

(2021) Ting Jiang et al.   DRUG RESISTANCE UPDATES

JAK2/STAT3 inhibitor reduced 5-FU resistance and autophagy through ATF6-mediated ER stress

(2021) Lijuan Ma et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia

(2021) Mehdi Eshraghi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Unfolded Protein Response: An Overview

(2021) Adam Read et al.   Biology-Basel

Inhibition of Autophagy Flux Promotes Secretion of Chondroitin Sulfate Proteoglycans in Primary Rat Astrocytes

(2021) Javad Alizadeh et al.   MOLECULAR NEUROBIOLOGY

The curcumin analog (PAC) suppressed cell survival and induced apoptosis and autophagy in oral cancer cells

(2021) Abdelhabib Semlali et al.   Scientific Reports

Delayed effects of sulfur mustard on autophagy suppression in chemically-injured lung tissue

(2020) Marzieh Eghtedardoost et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Autophagy Increases Zinc Bioavailability to Avoid Light-Mediated Reactive Oxygen Species Production under Zinc Deficiency

(2020) Daiki Shinozaki et al.   PLANT PHYSIOLOGY

Augmenting Tumor‐Starvation Therapy by Cancer Cell Autophagy Inhibition

(2020) Bowen Yang et al.   Advanced Science

Differential effects of alliin and allicin on apoptosis and senescence in luminal A and triple‐negative breast cancer: Caspase, ΔΨm, and pro‐apoptotic gene involvement

(2020) Vida Celeste Rosas‐González et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Autophagy promotes mammalian survival by suppressing oxidative stress and p53

(2020) Yang Yang et al.   GENES & DEVELOPMENT

Alteration of the Dopamine Receptors’ Expression in the Cerebellum of the Lysosomal Acid Phosphatase 2 Mutant (Naked–Ataxia (NAX)) Mouse

(2020) Mehdi Mehdizadeh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The regulatory activity of autophagy in conjunctival fibroblasts and its possible role in vernal keratoconjunctivitis

(2020) Paola Brun et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD24 blunts the sensitivity of retinoblastoma to vincristine by modulating autophagy

(2020) Jie Sun et al.   Molecular Oncology

Lysosomal Biology and Function: Modern View of Cellular Debris Bin

(2020) Purvi C. Trivedi et al.   Cells

Closing the Gap: Membrane Contact Sites in the Regulation of Autophagy

(2020) Verena Kohler et al.   Cells

Mechanisms Targeting the Unfolded Protein Response in Asthma

(2020) Sanaz Dastghaib et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation

(2020) Simone C. da Silva Rosa et al.   Autophagy

Small Heat Shock Proteins in Cancers: Functions and Therapeutic Potential for Cancer Therapy

(2020) Jixian Xiong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells

(2020) Sanaz Dastghaib et al.   Cells

The Role of Autophagy in Tumor Immunology—Complex Mechanisms That May Be Explored Therapeutically

(2020) Alana Serrano Campelo de Souza et al.   Frontiers in Oncology

The Role of Autophagy in Gastric Cancer Chemoresistance: Friend or Foe?

(2020) Jing-Li Xu et al.   Frontiers in Cell and Developmental Biology

The ER Stress/UPR Axis in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

(2020) Mahmoud Aghaei et al.   Life-Basel

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

The relationship between autophagy and the immune system and its applications for tumor immunotherapy

(2019) Guan-Min Jiang et al.   Molecular Cancer

Role of Endoplasmic Reticulum Stress in the Anticancer Activity of Natural Compounds

(2019) Patrizia Limonta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Review of Curcumin and Its Derivatives as Anticancer Agents

(2019) Mhd Tomeh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AutophagySMDB: a curated database of small molecules that modulate protein targets regulating autophagy

(2019) Ravikanth Nanduri et al.   Autophagy

Autophagy and cancer research in Iran

(2019) Pooneh Mokarram et al.   Autophagy

Autoimmune Hepatitis and Stellate Cells; an Insight into the Role of Autophagy

(2019) Shahram Golbabapour et al.   CURRENT MEDICINAL CHEMISTRY

Dual Role of Autophagy in Diseases of the Central Nervous System

(2019) Tamara Bar-Yosef et al.   Frontiers in Cellular Neuroscience

Progress in research on paclitaxel and tumor immunotherapy

(2019) Linyan Zhu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences

(2019) Mara Cirone et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Autophagy and mitophagy in cancer metabolic remodelling

(2019) Fabio Ferro et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Astaxanthin Modulation of Signaling Pathways That Regulate Autophagy

(2019) Suhn Hyung Kim et al.   Marine Drugs

Mechanisms of simvastatin myotoxicity: The role of autophagy flux inhibition

(2019) Arya Emami et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Autophagy and the unfolded protein response promote profibrotic effects of TGF-β1 in human lung fibroblasts

(2018) Saeid Ghavami et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Autophagy in Human Health and Disease: Novel Therapeutic Opportunities

(2018) Francesca Giampieri et al.   ANTIOXIDANTS & REDOX SIGNALING

Metabolism and pharmacokinetics of resveratrol and pterostilbene

(2018) Pei Wang et al.   BIOFACTORS

Autophagy in health and disease: A comprehensive review

(2018) Sarbari Saha et al.   BIOMEDICINE & PHARMACOTHERAPY

Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead

(2018) Emanuela Martino et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

CD24 is a Potential Biomarker for Prognosis in Human Breast Carcinoma

(2018) Xuan Jing et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Involvement of CD24 in Multiple Cancer Related Pathways Makes It an Interesting New Target for Cancer Therapy

(2018) Shirin Eyvazi et al.   CURRENT CANCER DRUG TARGETS

Pimpinelol, a novel atypical Sesquiterpene lactone from Pimpinella haussknechtii fruits with evaluation of endoplasmic reticulum stress in breast cancer cells

(2018) Mahmoud Aghaei et al.   FITOTERAPIA

Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling

(2018) Hongbing Fu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

(−)- Epigallocatechin-3-gallate induces GRP78 accumulation in the ER and shifts mesothelioma constitutive UPR into proapoptotic ER stress

(2018) Simona Martinotti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells

(2018) Zhenxing Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Quercetin suppresses breast cancer stem cells (CD44 + /CD24 − ) by inhibiting the PI3K/Akt/mTOR-signaling pathway

(2018) Xiuli Li et al.   LIFE SCIENCES

Resveratrol: An overview of its anti-cancer mechanisms

(2018) Mohamed Elshaer et al.   LIFE SCIENCES

7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway

(2018) Tsung-Chang Tsai et al.   Marine Drugs

Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy

(2018) Mija Marinković et al.   Oxidative Medicine and Cellular Longevity

CD24 regulates sorafenib resistance via activating autophagy in hepatocellular carcinoma

(2018) Shuai Lu et al.   Cell Death & Disease

Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress

(2018) Voin Petrovic et al.   Nutrients

Paclitaxel promotes lung cancer cell apoptosis via MEG3-P53 pathway activation

(2018) Jianhao Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Camptothecin enhances c-Myc-mediated endoplasmic reticulum stress and leads to autophagy by activating Ca2+-mediated AMPK

(2018) Rajapaksha Gedara Prasad Tharanga Jayasooriya et al.   FOOD AND CHEMICAL TOXICOLOGY

HAMdb: a database of human autophagy modulators with specific pathway and disease information

(2018) Ning-Ning Wang et al.   Journal of Cheminformatics

Genes involved in the regulation of different types of autophagy and their participation in cancer pathogenesis

(2018) Martyna Bednarczyk et al.   Oncotarget

A mono-carbonyl analog of curcumin induces apoptosis in drug-resistant EGFR-mutant lung cancer through the generation of oxidative stress and mitochondrial dysfunction

(2018) Xuanxuan Dai et al.   Cancer Management and Research

Chrysophanol selectively represses breast cancer cell growth by inducing reactive oxygen species production and endoplasmic reticulum stress via AKT and mitogen-activated protein kinase signal pathways

(2018) Sunwoo Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Autophagy: An Essential Degradation Program for Cellular Homeostasis and Life

(2018) Yoomi Chun et al.   Cells

ER stress promotes antitumor effects in BRAFi/MEKi resistant human melanoma induced by natural compound 4-nerolidylcathecol (4-NC)

(2018) Débora Kristina Alves-Fernandes et al.   PHARMACOLOGICAL RESEARCH

Curcumin Induces Autophagy, Apoptosis, and Cell Cycle Arrest in Human Pancreatic Cancer Cells

(2017) Yaping Zhu et al.   Evidence-based Complementary and Alternative Medicine

Autophagy and disease

(2017) Andrew Thorburn   JOURNAL OF BIOLOGICAL CHEMISTRY

Carbonaceous sorbents alongside an optimized magnetic solid phase extraction (MSPE) towards enrichment of crude Paclitaxel extracts from callus cultures of Taxus baccata

(2017) Jaber Nasiri et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

The Essential Medicinal Chemistry of Curcumin

(2017) Kathryn M. Nelson et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis

(2017) En-Hua Xia et al.   Molecular Plant

The Cytotoxicity of the Ajoene Analogue BisPMB in WHCO1 Oesophageal Cancer Cells Is Mediated by CHOP/GADD153

(2017) Vuyolwethu Siyo et al.   MOLECULES

Microenvironmental autophagy promotes tumour growth

(2017) Nadja S. Katheder et al.   NATURE

Dual role of autophagy in hallmarks of cancer

(2017) Shikha Satendra Singh et al.   ONCOGENE

Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cells

(2017) Zhuo Yao et al.   Cell Death & Disease

JNK pathway mediates curcumin-induced apoptosis and autophagy in osteosarcoma MG63 cells

(2017) Yaowu Zhang et al.   Experimental and Therapeutic Medicine

Anticancer effect of curcumin inhibits cell growth through miR-21/PTEN/Akt pathway in breast cancer cell

(2017) Xinzheng Wang et al.   Oncology Letters

CD24 Expression and differential resistance to chemotherapy in triple-negative breast cancer

(2017) Xinyu Deng et al.   Oncotarget

Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species

(2017) Jane L. Roberts et al.   Oncotarget

Curcumin enhances the effects of irinotecan on colorectal cancer cells through the generation of reactive oxygen species and activation of the endoplasmic reticulum stress pathway

(2017) Yan-Feng Huang et al.   Oncotarget

Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers

(2017) T Avril et al.   Oncogenesis

From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home

(2017) Margaret M. Harnett et al.   Biomedical Journal

Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells

(2017) Mariela Rivera et al.   PLoS One

Modulation of p-eIF2α cellular levels and stress granule assembly/disassembly by trehalose

(2017) Pasquale Dimasi et al.   Scientific Reports

Garcinone E induces apoptosis and inhibits migration and invasion in ovarian cancer cells

(2017) Xiao-Huang Xu et al.   Scientific Reports

Natural products as modulator of autophagy with potential clinical prospects

(2016) Peiqi Wang et al.   APOPTOSIS

Anti-tumor activity evaluation of novel chrysin–organotin compound in MCF-7 cells

(2016) Hong-zhuan Xuan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Autophagy is associated with chemoresistance in neuroblastoma

(2016) Assila Belounis et al.   BMC CANCER

Abstract 1295: Evaluation of the efficacy of TRAIL plus quercetin as a potential breast carcinoma therapeutic

(2016) Jasmine M. Manouchehri et al.   CANCER RESEARCH

ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction underlie apoptosis induced by resveratrol and arsenic trioxide in A549 cells

(2016) Shiyan Gu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Paclitaxel induces apoptosis in leukemia cells through a JNK activation-dependent pathway

(2016) Z.G. Peng et al.   GENETICS AND MOLECULAR RESEARCH

Reactivation of mutant p53 by capsaicin, the major constituent of peppers

(2016) Alessia Garufi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Carbazole alkaloids from Murraya koenigii trigger apoptosis and autophagic flux inhibition in human oral squamous cell carcinoma cells

(2016) Tanyarath Utaipan et al.   Journal of Natural Medicines

A phase I study of TPI 287 in combination with temozolomide for patients with metastatic melanoma

(2016) Jennifer L. McQuade et al.   MELANOMA RESEARCH

Cabazitaxel-induced autophagy via the PI3K/Akt/mTOR pathway contributes to A549 cell death

(2016) Ruichao Huo et al.   Molecular Medicine Reports

Curcumin activates autophagy and attenuates oxidative damage in EA.hy926 cells via the Akt/mTOR pathway

(2016) SHOUYU GUO et al.   Molecular Medicine Reports

Gartanin, an isoprenylated xanthone from the mangosteen fruit (Garcinia mangostana), is an androgen receptor degradation enhancer

(2016) Gongbo Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Autophagy-related protein 7 level in patients with ulcerative colitis

(2016) Kamran B Lankarani et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Autophagy regulates resistance of non-small cell lung cancer cells to paclitaxel

(2016) Kan Chen et al.   TUMOR BIOLOGY

Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation

(2016) Lei Chen et al.   Cell Death & Disease

FoxO1-mediated autophagy is required for NK cell development and innate immunity

(2016) Shuo Wang et al.   Nature Communications

Curcumin targets the TFEB-lysosome pathway for induction of autophagy

(2016) Jianbin Zhang et al.   Oncotarget

Salvianolic acid B, a novel autophagy inducer, exerts antitumor activity as a single agent in colorectal cancer cells

(2016) Zhao Jing et al.   Oncotarget

Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers

(2016) Betty Yuen Kwan Law et al.   Oncotarget

Effect of new berberine derivatives on colon cancer cells

(2015) Luis Miguel Guamán Ortiz et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Modified AHP-based decision-making model toward accurate selection of eligible maintenance media for production of taxanes in Taxus baccata callus culture

(2015) Jaber Nasiri et al.   ACTA PHYSIOLOGIAE PLANTARUM

Autophagy in airway diseases: a new frontier in human asthma?

(2015) A. A. Zeki et al.   ALLERGY

Autophagy Regulatory Network — A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy

(2015) Dénes Türei et al.   Autophagy

Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells

(2015) Xuejiao Zhao et al.   Autophagy

Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer

(2015) Mehdi Shakibaei et al.   BMC CANCER

Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin

(2015) C. Torricelli et al.   CANCER LETTERS

Rapamycin-induced G1 cell cycle arrest employs both TGF-β and Rb pathways

(2015) Amrita Chatterjee et al.   CANCER LETTERS

Lipoic acid inhibits the DNA repair proteinO6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction

(2015) Anja Göder et al.   CARCINOGENESIS

Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses

(2015) J Arnold et al.   CELL DEATH AND DIFFERENTIATION

SI113, a Specific Inhibitor of the Sgk1 Kinase Activity that Counteracts Cancer Cell Proliferation

(2015) Lucia D''Antona et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ceramide generation during curcumin-induced apoptosis is controlled by crosstalk among Bcl-2, Bcl-xL, caspases and glutathione

(2015) Abo Bakr Abdel Shakor et al.   CELLULAR SIGNALLING

Bisdemethoxycurcumin-induced S phase arrest through the inhibition of cyclin A and E and induction of apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathways in human lung cancer NCI H460 cells

(2015) Su-Tso Yang et al.   ENVIRONMENTAL TOXICOLOGY

Basic mechanisms in endoplasmic reticulum stress and relation to cardiovascular diseases

(2015) Erdi Sozen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells

(2015) Guowen Ren et al.   Journal of Natural Medicines

Bisleuconothine A Induces Autophagosome Formation by Interfering with AKT-mTOR Signaling Pathway

(2015) Chin Piow Wong et al.   JOURNAL OF NATURAL PRODUCTS

Antitumor activity of paclitaxel is significantly enhanced by a novel proapoptotic agent in non–small cell lung cancer

(2015) Syed S. Razi et al.   JOURNAL OF SURGICAL RESEARCH

Met Signaling Cascade Is Amplified by the Recruitment of Phosphorylated Met to Lipid Rafts via CD24 and Leads to Drug Resistance in Endometrial Cancer Cell Lines

(2015) Y. J. Ono et al.   MOLECULAR CANCER THERAPEUTICS

The garlic compound ajoene targets protein folding in the endoplasmic reticulum of cancer cells

(2015) Catherine H. Kaschula et al.   MOLECULAR CARCINOGENESIS

Resveratrol activates autophagic cell death in prostate cancer cells via downregulation of STIM1 and the mTOR pathway

(2015) Senthil Selvaraj et al.   MOLECULAR CARCINOGENESIS

Quercetin regulates β-catenin signaling and reduces the migration of triple negative breast cancer

(2015) Asha Srinivasan et al.   MOLECULAR CARCINOGENESIS

Combinational Treatment of Curcumin and Quercetin against Gastric Cancer MGC-803 Cells in Vitro

(2015) Jian-Ye Zhang et al.   MOLECULES

Curcumin induces autophagy, inhibits proliferation and invasion by downregulating AKT/mTOR signaling pathway in human melanoma cells

(2015) GUANGMING ZHAO et al.   ONCOLOGY REPORTS

Demethoxycurcumin induces the apoptosis of human lung cancer NCI-H460 cells through the mitochondrial-dependent pathway

(2015) YANG-CHING KO et al.   ONCOLOGY REPORTS

Guttiferone K induces autophagy and sensitizes cancer cells to nutrient stress-induced cell death

(2015) Man Wu et al.   PHYTOMEDICINE

CD24 promotes HCC progression via triggering Notch-related EMT and modulation of tumor microenvironment

(2015) Xin Wan et al.   TUMOR BIOLOGY

Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response

(2015) Behzad Yeganeh   WORLD JOURNAL OF GASTROENTEROLOGY

Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin

(2015) H-Y Tan et al.   Cell Death & Disease

Interplay between unfolded protein response and autophagy promotes tumor drug resistance

(2015) MING-MING YAN et al.   Oncology Letters

A preliminary study of the effect of curcumin on the expression of p53 protein in a human multiple myeloma cell line

(2015) WEI LI et al.   Oncology Letters

Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers

(2015) Shanshan He et al.   Nature Communications

New insights into the anti-obesity activity of xanthones from Garcinia mangostana

(2015) Qian-Yu Liu et al.   Food & Function

(Z)3,4,5,4′-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium level

(2015) Xing-Xing Fan et al.   Scientific Reports

Dual Targeted Therapy with p53 siRNA and Epigallocatechingallate in a Triple Negative Breast Cancer Cell Model

(2015) Cornelia Braicu et al.   PLoS One

Functional Role of NRF2 in Cervical Carcinogenesis

(2015) Jun-Qi Ma et al.   PLoS One

MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin

(2015) Zhiyu Wang et al.   Oncotarget

Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer

(2014) Yang Shen et al.   Autophagy

Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: The protective role of autophagy in apoptosis

(2014) Kyoung-Sub Song et al.   Autophagy

The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation

(2014) Yuanzhi Lao et al.   Autophagy

Hepatitis C virus core protein activates autophagy through EIF2AK3 and ATF6 UPR pathway-mediated MAP1LC3B and ATG12 expression

(2014) Ji Wang et al.   Autophagy

Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells

(2014) Jian-wei Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Curcumin induces apoptosis of multidrug-resistant human leukemia HL60 cells by complex pathways leading to ceramide accumulation

(2014) Abo Bakr Abdel Shakor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The TRAIL Sensitization Effect of Substituted Triazolyl Curcumin Mimics Against Brain Cancer Cells

(2014) Daeho Kwon et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Autophagy and Heart Disease: Implications for Cardiac Ischemia- Reperfusion Damage

(2014) S. Ghavami et al.   CURRENT MOLECULAR MEDICINE

Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells

(2014) XIU CHENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Role of Activating Transcription Factor 3 (ATF3) in Endoplasmic Reticulum (ER) Stress-induced Sensitization of p53-deficient Human Colon Cancer Cells to Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-mediated Apoptosis through Up-regulation of Death Receptor 5 (DR5) by Zerumbone and Celecoxib

(2014) Makoto Edagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells

(2014) Xiaofei Zhao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

How Taxol/paclitaxel kills cancer cells

(2014) Beth A. Weaver   MOLECULAR BIOLOGY OF THE CELL

Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via G1 arrest and apoptosis triggered by endoplasmic reticulum stress

(2014) Paul B. Yaffe et al.   MOLECULAR CARCINOGENESIS

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells

(2014) Meng Wang et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer

(2014) TAO BAI et al.   ONCOLOGY REPORTS

Natural autophagy regulators in cancer therapy: a review

(2014) Qian Ding et al.   PHYTOCHEMISTRY REVIEWS

Subditine, a New Monoterpenoid Indole Alkaloid from Bark of Nauclea subdita (Korth.) Steud. Induces Apoptosis in Human Prostate Cancer Cells

(2014) Sook Yee Liew et al.   PLoS One

Ampelopsin Induces Cell Growth Inhibition and Apoptosis in Breast Cancer Cells through ROS Generation and Endoplasmic Reticulum Stress Pathway

(2014) Yong Zhou et al.   PLoS One

Resveratrol Inhibits Breast Cancer Stem-Like Cells and Induces Autophagy via Suppressing Wnt/β-Catenin Signaling Pathway

(2014) Yujie Fu et al.   PLoS One

Resveratrol Enhances Palmitate-Induced ER Stress and Apoptosis in Cancer Cells

(2014) Cristina Rojas et al.   PLoS One

Autophagy promotes paclitaxel resistance of cervical cancer cells: involvement of Warburg effect activated hypoxia-induced factor 1-α-mediated signaling

(2014) X Peng et al.   Cell Death & Disease

Synergistic Effect of COX-2 Inhibitor on Paclitaxel-Induced Apoptosis in the Human Ovarian Cancer Cell Line OVCAR-3

(2014) Hee Jung Kim et al.   Cancer Research and Treatment

Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults

(2014) Richard D. Semba et al.   JAMA Internal Medicine

Resveratrol induced ER expansion and ER caspase-mediated apoptosis in human nasopharyngeal carcinoma cells

(2013) Shu-Er Chow et al.   APOPTOSIS

Saxifragifolin D induces the interplay between apoptosis and autophagy in breast cancer cells through ROS-dependent endoplasmic reticulum stress

(2013) Jun-Min Shi et al.   BIOCHEMICAL PHARMACOLOGY

Synergistic combination therapy with nanoliposomal C6-ceramide and vinblastine is associated with autophagy dysfunction in hepatocarcinoma and colorectal cancer models

(2013) Pavan P. Adiseshaiah et al.   CANCER LETTERS

Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway

(2013) Dhruv Kumar et al.   CANCER LETTERS

Polyphenon E®, a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis

(2013) Federica Rizzi et al.   CARCINOGENESIS

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Resveratrol induces cell death in cervical cancer cells through apoptosis and autophagy

(2013) Sihomara P. García-Zepeda et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Synthesis and cytotoxic activity on human cancer cells of carbamate derivatives of 4β-(1,2,3-triazol-1-yl)podophyllotoxin

(2013) Jian-Fei Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Autophagy in blood cancers: biological role and therapeutic implications

(2013) A. Nencioni et al.   HAEMATOLOGICA

Curcumin Induces Cross-Regulation Between Autophagy and Apoptosis in Uterine Leiomyosarcoma Cells

(2013) Bin Li et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Curcumin Induces Autophagy via Activating the AMPK Signaling Pathway in Lung Adenocarcinoma Cells

(2013) Kui Xiao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Curcumin enhances TRAIL-induced apoptosis of breast cancer cells by regulating apoptosis-related proteins

(2013) Sojung Park et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms

(2013) Dhruv Kumar et al.   Molecular Cancer

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Tanshinone IIA Induces Autophagic Cell Death via Activation of AMPK and ERK and Inhibition of mTOR and p70 S6K in KBM-5 Leukemia Cells

(2013) Sun-Mi Yun et al.   PHYTOTHERAPY RESEARCH

Casticin Potentiates TRAIL-Induced Apoptosis of Gastric Cancer Cells through Endoplasmic Reticulum Stress

(2013) Yuan Zhou et al.   PLoS One

bis-Dehydroxy-Curcumin Triggers Mitochondrial-Associated Cell Death in Human Colon Cancer Cells through ER-Stress Induced Autophagy

(2013) Valentina Basile et al.   PLoS One

Emblica officinalis Extract Induces Autophagy and Inhibits Human Ovarian Cancer Cell Proliferation, Angiogenesis, Growth of Mouse Xenograft Tumors

(2013) Alok De et al.   PLoS One

PTEN Increases Autophagy and Inhibits the Ubiquitin-Proteasome Pathway in Glioma Cells Independently of its Lipid Phosphatase Activity

(2013) Rajaa Errafiy et al.   PLoS One

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway

(2013) Q Deng et al.   Cell Death & Disease

Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells

(2013) Y Yuan et al.   Cell Death & Disease

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Role of the Crosstalk between Autophagy and Apoptosis in Cancer

(2013) Minfei Su et al.   Journal of Oncology

Curcumin potentiates the antitumor effects of 5-FU in treatment of esophageal squamous carcinoma cells through downregulating the activation of NF- B signaling pathway in vitro and in vivo

(2012) F. Tian et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Honokiol induces cytotoxic and cytostatic effects in malignant melanoma cancer cells

(2012) Gaurav Kaushik et al.   AMERICAN JOURNAL OF SURGERY

Bioavailability and Pharmacokinetics of Genistein: Mechanistic Studies on its ADME

(2012) Zhen Yang et al.   Anti-Cancer Agents in Medicinal Chemistry

Curcumin-induced autophagy contributes to the decreased survival of oral cancer cells

(2012) Ji Young Kim et al.   ARCHIVES OF ORAL BIOLOGY

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy

(2012) Jia-Hong Lu et al.   Autophagy

Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells

(2012) Brahma N. Singh et al.   BIOCHEMICAL PHARMACOLOGY

NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death

(2012) Chuan Bian Lim et al.   BMC Complementary and Alternative Medicine

Crosstalk between endoplasmic reticulum stress and oxidative stress in apoptosis induced by α-tocopheryl succinate in human gastric carcinoma cells

(2012) Xiaoli Huang et al.   BRITISH JOURNAL OF NUTRITION

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Matrine, a novel autophagy inhibitor, blocks trafficking and the proteolytic activation of lysosomal proteases

(2012) Z. Wang et al.   CARCINOGENESIS

Autophagy in tumor suppression and cancer therapy

(2012) Che-Pei Kung et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Alternative Pathways of Cancer Cell Death by Rottlerin: Apoptosis versus Autophagy

(2012) Claudia Torricelli et al.   Evidence-based Complementary and Alternative Medicine

Furanodiene Induces Endoplasmic Reticulum Stress and Presents Antiproliferative Activities in Lung Cancer Cells

(2012) Wen-Shan Xu et al.   Evidence-based Complementary and Alternative Medicine

Autophagy inhibition enhances isobavachalcone-induced cell death in multiple myeloma cells

(2012) SHAN ZHAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Vincristine induces cell cycle arrest and apoptosis in SH-SY5Y human neuroblastoma cells

(2012) YUE TU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells

(2012) HISANORI MIKI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy

(2012) Rita A. Hanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD24 Expression as a Marker for Predicting Clinical Outcome in Human Gliomas

(2012) Jianping Deng et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells

(2012) Cristina P.R. Xavier et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cellular Entry of Human Papillomavirus Type 16 Involves Activation of the Phosphatidylinositol 3-Kinase/Akt/mTOR Pathway and Inhibition of Autophagy

(2012) Z. Surviladze et al.   JOURNAL OF VIROLOGY

Increase of autophagy and attenuation of apoptosis by Salvigenin promote survival of SH-SY5Y cells following treatment with H2O2

(2012) Ghazaleh Rafatian et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

TPI-287, a New Taxane Family Member, Reduces the Brain Metastatic Colonization of Breast Cancer Cells

(2012) D. P. Fitzgerald et al.   MOLECULAR CANCER THERAPEUTICS

Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression

(2012) XIAO-DONG SUN et al.   Molecular Medicine Reports

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells

(2012) C Gong et al.   ONCOGENE

Resveratrol-Mediated Downregulation of Rictor Attenuates Autophagic Process and Suppresses UV-Induced Skin Carcinogenesis†

(2012) Jung H. Back et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle

(2011) Saeid Ghavami et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Bioavailability of resveratrol

(2011) Thomas Walle   Annals of the New York Academy of Sciences

Cryptotanshinone induces ER stress-mediated apoptosis in HepG2 and MCF7 cells

(2011) In-Ja Park et al.   APOPTOSIS

Beclin 1 or not Beclin 1...

(2011) Tassula Proikas-Cezanne et al.   Autophagy

Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation

(2011) Mario Mauthe et al.   Autophagy

Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling

(2011) Kui Wang et al.   Autophagy

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

(2011) Shinji Saiki et al.   Autophagy

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Vinblastine sensitizes leukemia cells to cyclin-dependent kinase inhibitors, inducing acute cell cycle phase-independent apoptosis

(2011) Darcy J.P. Bates et al.   CANCER BIOLOGY & THERAPY

Chemo-resistant melanoma sensitized by tamoxifen to low dose curcumin treatment through induction of apoptosis and autophagy

(2011) Sudipa June Chatterjee et al.   CANCER BIOLOGY & THERAPY

Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy

(2011) Wenzhuo Zhuang et al.   CANCER SCIENCE

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Induction of apoptosis by curcumin in murine myelomonocytic leukemia WEHI-3 cells is mediated via endoplasmic reticulum stress and mitochondria-dependent pathways

(2011) An-Cheng Huang et al.   ENVIRONMENTAL TOXICOLOGY

Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival XBP1 signaling in human multiple myeloma cells

(2011) Feng-Ming Wang et al.   EXPERIMENTAL HEMATOLOGY

Selective targeting of breast cancer cells through ROS-mediated mechanisms potentiates the lethality of paclitaxel by a novel diterpene, gelomulide K

(2011) Juan-Cheng Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The dynamic nature of autophagy in cancer

(2011) A. C. Kimmelman   GENES & DEVELOPMENT

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Proteasome inhibition by quercetin triggers macroautophagy and blocks mTOR activity

(2011) Anja K. Klappan et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): Anti-inflammatory and anti-cancer properties

(2011) Anlys Olivera et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways

(2011) AZHAR RASUL et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

(2011) Eugenia Morselli et al.   JOURNAL OF CELL BIOLOGY

Autophagy and disease: always two sides to a problem

(2011) Sunandini Sridhar et al.   JOURNAL OF PATHOLOGY

Virus-triggered autophagy in viral hepatitis - possible novel strategies for drug development

(2011) S. M. Alavian et al.   JOURNAL OF VIRAL HEPATITIS

Involvement of ROS in Curcumin-induced Autophagic Cell Death

(2011) Youn Ju Lee et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells

(2011) Jia-Ching Wu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Diallyl Disulphide, a Beneficial Component of Garlic Oil, Causes a Redistribution of Cell-Cycle Growth Phases, Induces Apoptosis, and Enhances Butyrate-Induced Apoptosis in Colorectal Adenocarcinoma Cells (HT-29)

(2011) Mohammed O. Altonsy et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Mevalonate Cascade Regulation of Airway Mesenchymal Cell Autophagy and Apoptosis: A Dual Role for p53

(2011) Saeid Ghavami et al.   PLoS One

Autophagy Interplay with Apoptosis and Cell Cycle Regulation in the Growth Inhibiting Effect of Resveratrol in Glioma Cells

(2011) Eduardo C. Filippi-Chiela et al.   PLoS One

Effects and Action Mechanisms of Berberine and Rhizoma coptidis on Gut Microbes and Obesity in High-Fat Diet-Fed C57BL/6J Mice

(2011) Weidong Xie et al.   PLoS One

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Baicalein inhibits the migration and invasive properties of human hepatoma cells

(2011) Yung-Wei Chiu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects of quercetin on the apoptosis of the human gastric carcinoma cells

(2011) Ping Wang et al.   TOXICOLOGY IN VITRO

Atg8: an autophagy-related ubiquitin-like protein family

(2011) Tomer Shpilka et al.   GENOME BIOLOGY

The inhibition of autophagy potentiates anti-angiogenic effects of sulforaphane by inducing apoptosis

(2010) Takeshi Nishikawa et al.   ANGIOGENESIS

Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD

(2010) Jae-woong Hwang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Matrine Inhibits Proliferation and Induces Apoptosis of Pancreatic Cancer Cells in Vitro and in Vivo

(2010) Tianyou Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling

(2010) Sook Kyung Park et al.   BREAST CANCER RESEARCH AND TREATMENT

Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells

(2010) Xiaoli Huang et al.   CANCER LETTERS

Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation

(2010) A. Puissant et al.   CANCER RESEARCH

p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways

(2010) Frank Christian et al.   CELLULAR SIGNALLING

Targeting the p53 Pathway of Apoptosis

(2010) Joana D. Amaral et al.   CURRENT PHARMACEUTICAL DESIGN

Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells

(2010) Yu-Feng Kuo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell

(2010) Min-Bin Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Resveratrol Arrests Cell Cycle and Induces Apoptosis in Human Hepatocellular Carcinoma Huh-7 Cells

(2010) Pei-Chi Liao et al.   JOURNAL OF MEDICINAL FOOD

Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial

(2010) Johann Sebastian de Bono et al.   LANCET

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Cancer Therapies Utilizing the Camptothecins: A Review of thein VivoLiterature

(2010) Vincent J. Venditto et al.   MOLECULAR PHARMACEUTICS

Cabazitaxel

(2010) Matthew D. Galsky et al.   NATURE REVIEWS DRUG DISCOVERY

The Autophagy Database: an all-inclusive information resource on autophagy that provides nourishment for research

(2010) K. Homma et al.   NUCLEIC ACIDS RESEARCH

Allicin Purified From Fresh Garlic Cloves Induces Apoptosis in Colon Cancer Cells Via Nrf2

(2010) Wolf Bat-Chen et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Production of the anticancer drug taxol in Taxus baccata suspension cultures: A review

(2010) Sonia Malik et al.   PROCESS BIOCHEMISTRY

Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy

(2010) R R Ruela-de-Sousa et al.   Cell Death & Disease

Resveratrol-induced autophagy in human U373 glioma cells

(2010) MIDORI YAMAMOTO et al.   Oncology Letters

Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis

(2010) An-Chin Cheng et al.   Food & Function

Activation of Jun N-terminal kinase is a mediator of vincristine-induced apoptosis of melanoma cells

(2009) Bi-ke Zhu et al.   ANTI-CANCER DRUGS

The paradox of autophagy and its implication in cancer etiology and therapy

(2009) Avital Eisenberg-Lerner et al.   APOPTOSIS

Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells

(2009) Keng-Fu Hsu et al.   Autophagy

Tetrandrine induces apoptosis and growth suppression of colon cancer cells in mice

(2009) Jiann-Ming Wu et al.   CANCER LETTERS

Resveratrol and quercetin cooperate to induce senescence-like growth arrest in C6 rat glioma cells

(2009) Lauren L. Zamin et al.   CANCER SCIENCE

Life and death partners: apoptosis, autophagy and the cross-talk between them

(2009) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

Phase I and Pharmacokinetic Study of XRP6258 (RPR 116258A), a Novel Taxane, Administered as a 1-Hour Infusion Every 3 Weeks in Patients with Advanced Solid Tumors

(2009) A. C. Mita et al.   CLINICAL CANCER RESEARCH

Autophagy and metastasis: another double-edged sword

(2009) Candia M Kenific et al.   CURRENT OPINION IN CELL BIOLOGY

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

(2009) Einat Zalckvar et al.   EMBO REPORTS

Potentiation of paclitaxel-induced apoptosis by galectin-13 overexpression via activation of Ask-1-p38-MAP kinase and JNK/SAPK pathways and suppression of Akt and ERK1/2 activation in U-937 human macrophage cells

(2009) Arpad Boronkai et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Differential effects of triterpene glycosides, frondoside A and cucumarioside A2-2 isolated from sea cucumbers on caspase activation and apoptosis of human leukemia cells

(2009) Jun-O Jin et al.   FEBS LETTERS

Autophagic and apoptotic mechanisms of curcumin-induced death in K562 cells

(2009) Yan-Li Jia et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Oxidative and endoplasmic reticulum stress signaling are involved in dehydrocostuslactone-mediated apoptosis in human non-small cell lung cancer cells

(2009) Jen-Yu Hung et al.   LUNG CANCER

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling

(2009) Jane L. Watson et al.   MOLECULAR CARCINOGENESIS

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Natural compounds for cancer treatment and prevention

(2009) Stefania Nobili et al.   PHARMACOLOGICAL RESEARCH

Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

(2009) Aruna D. Balgi et al.   PLoS One

A multicenter phase II study of XRP6258 administered as a 1-h i.v. infusion every 3 weeks in taxane-resistant metastatic breast cancer patients

(2008) X. Pivot et al.   ANNALS OF ONCOLOGY

Ran suppresses paclitaxel-induced apoptosis in human glioblastoma cells

(2008) Im Sun Woo et al.   APOPTOSIS

Role of Bax in quercetin-induced apoptosis in human prostate cancer cells

(2008) Dae-Hee Lee et al.   BIOCHEMICAL PHARMACOLOGY

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells

(2008) F Scarlatti et al.   CELL DEATH AND DIFFERENTIATION

Phase I and Pharmacokinetic Study of Gimatecan Given Orally Once a Week for 3 of 4 Weeks in Patients with Advanced Solid Tumors

(2008) A. X. Zhu et al.   CLINICAL CANCER RESEARCH

Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma

(2008) Tingyan Liu et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Systemic Treatment of Colorectal Cancer

(2008) Brian M. Wolpin et al.   GASTROENTEROLOGY

Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice

(2008) Mihye Kim et al.   INTERNATIONAL JOURNAL OF CANCER

Tetrandrine suppresses tumor growth and angiogenesis of gliomas in rats

(2008) Yun Chen et al.   INTERNATIONAL JOURNAL OF CANCER

Phase I and pharmacokinetic study of karenitecin in patients with recurrent malignant gliomas

(2008) Stuart A. Grossman et al.   NEURO-ONCOLOGY

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): Induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways

(2008) Fung-Ming Siu et al.   PROTEOMICS