Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cells

The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression

(2016) Jiandong Chen   Cold Spring Harbor Perspectives in Medicine

Oridonin triggers apoptosis in colorectal carcinoma cells and suppression of microRNA-32 expression augments oridonin-mediated apoptotic effects

(2015) Jie Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

(2015) Colin A. Flaveny et al.   CANCER CELL

Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells

(2015) Ricardo Amorim et al.   CANCER LETTERS

MicroRNAs affect dendritic cell function and phenotype

(2015) Lesley A. Smyth et al.   IMMUNOLOGY

AMPK binds to Sestrins and mediates the effect of exercise to increase insulin-sensitivity through autophagy

(2015) Xiaolei Liu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy

(2015) S Fulda et al.   ONCOGENE

RRAD inhibits aerobic glycolysis, invasion, and migration and is associated with poor prognosis in hepatocellular carcinoma

(2015) Runze Shang et al.   TUMOR BIOLOGY

Cell Death Signaling

(2015) Douglas R. Green et al.   Cold Spring Harbor Perspectives in Biology

Follow the ATP: Tumor Energy Production: A Perspective

(2014) Bryan Oronsky et al.   Anti-Cancer Agents in Medicinal Chemistry

Overcoming 5-Fu Resistance of Colon Cells through Inhibition of Glut1 by the Specific Inhibitor WZB117

(2014) Wei Liu et al.   Asian Pacific Journal of Cancer Prevention

Role of MicroRNAs in the Warburg Effect and Mitochondrial Metabolism in Cancer

(2014) Li-Hui Jin et al.   Asian Pacific Journal of Cancer Prevention

The AMPK Inhibitor Compound C Is a Potent AMPK-Independent Antiglioma Agent

(2014) X. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Autophagy—a key player in cellular and body metabolism

(2014) Kook Hwan Kim et al.   Nature Reviews Endocrinology

Autophagy-dependent ATP release from dying cells via lysosomal exocytosis

(2013) Yidan Wang et al.   Autophagy

Targeting glucose metabolism in patients with cancer

(2013) Shannon E. Elf et al.   CANCER

The Monocarboxylate Transporter Inhibitor α-Cyano-4-Hydroxycinnamic Acid Disrupts Rat Lung Branching

(2013) Sara Granja et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Reactive oxygen species H2O2 and OH, but not O2− promote oridonin-induced phagocytosis of apoptotic cells by human histocytic lymphoma U937 cells

(2013) Linghe Zang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Possible involvement of AMPK in acute exercise-induced expression of monocarboxylate transporters MCT1 and MCT4 mRNA in fast-twitch skeletal muscle

(2013) Masaki Takimoto et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

(2013) Ning Wu et al.   MOLECULAR CELL

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Oxidants, antioxidants and the current incurability of metastatic cancers

(2013) J. Watson   Open Biology

MicroRNAs in autophagy and their emerging roles in crosstalk with apoptosis

(2012) Jianzhen Xu et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Glucose transporters in cancer metabolism

(2012) Kehinde Adekola et al.   CURRENT OPINION IN ONCOLOGY

Overexpression of Monocarboxylate Transporter-1 (Slc16a1) in Mouse Pancreatic  -Cells Leads to Relative Hyperinsulinism During Exercise

(2012) T. J. Pullen et al.   DIABETES

Oridonin Up-regulates Expression of P21 and Induces Autophagy and Apoptosis in Human Prostate Cancer Cells

(2012) Xiang Li et al.   International Journal of Biological Sciences

Investigation of possible endogenous hypoxia markers in colorectal cancer

(2012) Maud Verstraete et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells

(2012) Hiu-Yee Kwan et al.   JOURNAL OF GASTROENTEROLOGY

Roles of microRNA on cancer cell metabolism

(2012) Bing Chen et al.   Journal of Translational Medicine

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Triggering Fbw7-Mediated Proteasomal Degradation of c-Myc by Oridonin Induces Cell Growth Inhibition and Apoptosis

(2012) H.-L. Huang et al.   MOLECULAR CANCER THERAPEUTICS

Therapeutic targets in cancer cell metabolism and autophagy

(2012) Heesun Cheong et al.   NATURE BIOTECHNOLOGY

Targeting of AML1-ETO in t(8;21) Leukemia by Oridonin Generates a Tumor Suppressor-Like Protein

(2012) T. Zhen et al.   Science Translational Medicine

Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells

(2011) Ya-hong Zhang et al.   ACTA PHARMACOLOGICA SINICA

Involvement of mitophagy in oncogenic K-Ras-induced transformation

(2011) June-Hyung Kim et al.   Autophagy

Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics

(2011) Chun-yang Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Small molecules from natural sources, targeting signaling pathways in diabetes

(2010) Qiong Liu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc

(2010) Feng-Hou Gao et al.   BMC CANCER

Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism

(2010) C. V. Dang   CANCER RESEARCH

miR-378 ∗ Mediates Metabolic Shift in Breast Cancer Cells via the PGC-1β/ERRγ Transcriptional Pathway

(2010) Lillian J. Eichner et al.   Cell Metabolism

Downregulation of AP-1 gene expression is an initial event in the oridonin-mediated inhibition of colorectal cancer: Studies in vitro and in vivo

(2010) Heiying Jin et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells

(2009) Yan Cheng et al.   Autophagy

GLUT1 gene is a potential hypoxic marker in colorectal cancer patients

(2009) Fu-Yen Chung et al.   BMC CANCER

Intracellular Mechanisms of Metabolism Regulation: The Role of Signaling via the Mammalian Target of Rapamycin Pathway and Other Routes

(2008) Vincenzo Flati et al.   AMERICAN JOURNAL OF CARDIOLOGY