Application of Novel Degraders Employing Autophagy for Expediting Medicinal Research

Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30

(2022) Xuan Qin et al.   Autophagy

The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system

(2022) Chang Hoon Ji et al.   Nature Communications

The state of the art of PROTAC technologies for drug discovery

(2022) Chao Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ispinesib as an Effective Warhead for the Design of Autophagosome-Tethering Chimeras: Discovery of Potent Degraders of Nicotinamide Phosphoribosyltransferase (NAMPT)

(2022) Guoqiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proteolysis-targeting chimeras (PROTACs) in cancer therapy

(2022) Xinyi Li et al.   Molecular Cancer

An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion

(2022) Caroline Gubser Keller et al.   Nature Communications

USP30: Structure, Emerging Physiological Role, and Target Inhibition

(2022) Feng Wang et al.   Frontiers in Pharmacology

Targeted protein degradation via the autophagy-lysosome system: AUTOTAC (AUTOphagy-TArgeting Chimera)

(2022) Chang Hoon Ji et al.   Autophagy

Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy

(2022) Jing Gao et al.   Nature Communications

Recent advancements in the discovery of cereblon-based protease-targeted chimeras with potential for therapeutic intervention

(2022) Harbinder Singh et al.   Future Medicinal Chemistry

Recent Advances in PROTACs for Drug Targeted Protein Research

(2022) Tingting Yao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Immune System as a Therapeutic Target for Alzheimer’s Disease

(2022) Tarek Zieneldien et al.   Life-Basel

Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

(2021) Adam D. Cotton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gene-based therapies for neurodegenerative diseases

(2021) Jichao Sun et al.   NATURE NEUROSCIENCE

Targeted drug delivery strategies for precision medicines

(2021) Mandana T. Manzari et al.   Nature Reviews Materials

Targeting Lysosomal Degradation Pathways: New Strategies and Techniques for Drug Discovery

(2021) Junping Pei et al.   JOURNAL OF MEDICINAL CHEMISTRY

Parkinson's disease

(2021) Bastiaan R Bloem et al.   LANCET

Advances in targeting ‘undruggable’ transcription factors with small molecules

(2021) Matthew J. Henley et al.   NATURE REVIEWS DRUG DISCOVERY

Kinase drug discovery 20 years after imatinib: progress and future directions

(2021) Philip Cohen et al.   NATURE REVIEWS DRUG DISCOVERY

Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy

(2021) Chi Zhang et al.   Nature Communications

Downregulation of glial genes involved in synaptic function mitigates Huntington's Disease pathogenesis

(2021) Tarik Seref Onur et al.   eLife

PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy

(2021) Si-Min Qi et al.   Frontiers in Pharmacology

Alzheimer disease

(2021) David S. Knopman et al.   Nature Reviews Disease Primers

Degradation of lipid droplets by chimeric autophagy-tethering compounds

(2021) Yuhua Fu et al.   CELL RESEARCH

Bifunctional small molecules that mediate the degradation of extracellular proteins

(2021) David F. Caianiello et al.   Nature Chemical Biology

The PROTACtable genome

(2021) Melanie Schneider et al.   NATURE REVIEWS DRUG DISCOVERY

Mitophagy Regulates Neurodegenerative Diseases

(2021) Xufeng Cen et al.   Cells

The role of distinct BRD4 isoforms and their contribution to high-grade serous ovarian carcinoma pathogenesis

(2021) Ana Luiza Drumond-Bock et al.   Molecular Cancer

Properties of FDA-approved small molecule protein kinase inhibitors: A 2022 update

(2021) Robert Roskoski Jr.   PHARMACOLOGICAL RESEARCH

Targeting selective autophagy by AUTAC degraders

(2020) Daiki Takahashi et al.   Autophagy

Autophagy and disease: unanswered questions

(2020) Ying Yang et al.   CELL DEATH AND DIFFERENTIATION

Diagnosis and Treatment of Parkinson Disease

(2020) Melissa J. Armstrong et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Autophagy and autophagy-related proteins in cancer

(2020) Xiaohua Li et al.   Molecular Cancer

Regulation of intestinal lipid metabolism: current concepts and relevance to disease

(2020) Chih-Wei Ko et al.   Nature Reviews Gastroenterology & Hepatology

The future of stem cell therapies for Parkinson disease

(2020) Malin Parmar et al.   NATURE REVIEWS NEUROSCIENCE

Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection

(2020) Yao Wei et al.   Nature Communications

Light-induced control of protein destruction by opto-PROTAC

(2020) Jing Liu et al.   Science Advances

PHOTACs enable optical control of protein degradation

(2020) Martin Reynders et al.   Science Advances

Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy

(2020) Xin Li et al.   Journal of Hematology & Oncology

Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown

(2020) Yu-Hui Jin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives

(2020) Srimanta Patra et al.   SEMINARS IN CANCER BIOLOGY

Emerging New Concepts of Degrader Technologies

(2020) Yu Ding et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Safety and immunogenicity of the α-synuclein active immunotherapeutic PD01A in patients with Parkinson's disease: a randomised, single-blinded, phase 1 trial

(2020) Dieter Volc et al.   LANCET NEUROLOGY

Lysosome-targeting chimaeras for degradation of extracellular proteins

(2020) Steven M. Banik et al.   NATURE

Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities

(2020) Sarah J. Tabrizi et al.   Nature Reviews Neurology

Autophagy in Human Diseases

(2020) Noboru Mizushima et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy and Autophagy-Related Diseases: A Review

(2020) Tadashi Ichimiya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The dual face of NAMPT: Intracellular/extracellular protein and diagnostic/therapeutic target in cancer

(2020) Valentina Audrito   EBioMedicine

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Huntingtin Lowering Strategies for Disease Modification in Huntington’s Disease

(2019) Sarah J. Tabrizi et al.   NEURON

Breaking the chains: deubiquitylating enzyme specificity begets function

(2019) Michael J. Clague et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deciphering the Rules of in Silico Autophagy Methods for Expediting Medicinal Research

(2019) Yi Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Applications of machine learning in drug discovery and development

(2019) Jessica Vamathevan et al.   NATURE REVIEWS DRUG DISCOVERY

Targeted protein degradation: elements of PROTAC design

(2019) Stacey-Lynn Paiva et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Development of targeted protein degradation therapeutics

(2019) Philip P. Chamberlain et al.   Nature Chemical Biology

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

ATTEC: a potential new approach to target proteinopathies

(2019) Zhaoyang Li et al.   Autophagy

Exploring the new horizons of drug repurposing: A vital tool for turning hard work into smart work

(2019) Rajesh Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

(2019) Zhaoyang Li et al.   NATURE

Lysosomes as dynamic regulators of cell and organismal homeostasis

(2019) Andrea Ballabio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases

(2019) Alvin Djajadikerta et al.   JOURNAL OF MOLECULAR BIOLOGY

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

(2019) Daiki Takahashi et al.   MOLECULAR CELL

HIPK3 modulates autophagy and HTT protein levels in neuronal and mouse models of Huntington disease

(2018) Yuhua Fu et al.   Autophagy

Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole derivative

(2018) Shusuke Tomoshige et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting Gpr52 lowers mutant HTT levels and rescues Huntington’s disease-associated phenotypes

(2018) Haikun Song et al.   BRAIN

Conformation Polymorphism of Polyglutamine Proteins

(2018) Xinran Feng et al.   TRENDS IN BIOCHEMICAL SCIENCES

Selective autophagy as a potential therapeutic target for neurodegenerative disorders

(2018) Aurora Scrivo et al.   LANCET NEUROLOGY

BRD4 and Cancer: going beyond transcriptional regulation

(2018) Benedetta Donati et al.   Molecular Cancer

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

(2018) Quanyin Hu et al.   Nature Biomedical Engineering

Dopamine restores cognitive motivation in Parkinson’s disease

(2018) Sara McGuigan et al.   BRAIN

Shaping proteostasis at the cellular, tissue, and organismal level

(2017) Ambre J. Sala et al.   JOURNAL OF CELL BIOLOGY

Suppression of glioblastoma growth and angiogenesis through molecular targeting of methionine aminopeptidase-2

(2017) Ming Lin et al.   JOURNAL OF NEURO-ONCOLOGY

Therapies targeting DNA and RNA in Huntington's disease

(2017) Edward J Wild et al.   LANCET NEUROLOGY

Lipid droplets and liver disease: from basic biology to clinical implications

(2017) Nina L. Gluchowski et al.   Nature Reviews Gastroenterology & Hepatology

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

Mitochondrial dynamics and quality control in Huntington's disease

(2016) Pedro Guedes-Dias et al.   NEUROBIOLOGY OF DISEASE

Methionine Aminopeptidase 2 as a Potential Therapeutic Target for Human Non-Small-Cell Lung Cancers

(2016) Hajime Shimizu et al.   Advances in Clinical and Experimental Medicine

Targeting the lysosome in cancer

(2015) Shengfu Piao et al.   Annals of the New York Academy of Sciences

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

(2015) Christian N. Cunningham et al.   NATURE CELL BIOLOGY

siRNA screen identifies QPCT as a druggable target for Huntington's disease

(2015) Maria Jimenez-Sanchez et al.   Nature Chemical Biology

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment

(2015) Sylvia Lombardo et al.   NEUROPHARMACOLOGY

Strategic Approaches to Optimizing Peptide ADME Properties

(2014) Li Di   AAPS Journal

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

(2014) Baris Bingol et al.   NATURE

Huntington disease: natural history, biomarkers and prospects for therapeutics

(2014) Christopher A. Ross et al.   Nature Reviews Neurology

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Identification of NUB1 as a suppressor of mutant Huntingtin toxicity via enhanced protein clearance

(2013) Boxun Lu et al.   NATURE NEUROSCIENCE

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

(2013) J. Kronke et al.   SCIENCE

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis

(2012) Holly B. Kordasiewicz et al.   NEURON

PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition

(2012) Yasir H. Ibrahim et al.   Cancer Discovery

Autophagy receptors in developmental clearance of mitochondria

(2011) Ivana Novak et al.   Autophagy

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Protacs for Treatment of Cancer

(2010) Kathleen M Sakamoto   PEDIATRIC RESEARCH

The Atg1 Kinase Complex Is Involved in the Regulation of Protein Recruitment to Initiate Sequestering Vesicle Formation for Nonspecific Autophagy in Saccharomyces cerevisiae

(2007) Heesun Cheong et al.   MOLECULAR BIOLOGY OF THE CELL