Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

Leveraging Engineering of Cells for Drug Delivery

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CAR T therapies drive into new terrain

(2017) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy

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Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus

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The role of platelets in the tumor microenvironment: From solid tumors to leukemia

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Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

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Driving CAR T-cells forward

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Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

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Spatiotemporal control of cell–cell reversible interactions using molecular engineering

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Non-genetic engineering of cells for drug delivery and cell-based therapy

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PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome

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PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

(2015) F. McClanahan et al.   BLOOD

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

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Nanoparticle biointerfacing by platelet membrane cloaking

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Acute Myeloid Leukemia

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Remote control of therapeutic T cells through a small molecule-gated chimeric receptor

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Copper-free click chemistry for attachment of biomolecules in magnetic tweezers

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Clickable Protein Nanocapsules for Targeted Delivery of Recombinant p53 Protein

(2014) Muxun Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PD-1 blockade induces responses by inhibiting adaptive immune resistance

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Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

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Engineered nanomedicine for myeloma and bone microenvironment targeting

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CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

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Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell–selectin interaction kinetics

(2012) Hao Cheng et al.   BIOMATERIALS

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Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

(2012) Li Ding et al.   NATURE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia

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Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia

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PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model

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Anthracycline Dose Intensification in Acute Myeloid Leukemia

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