RING-finger E3 ligases regulatory network in PI3K/AKT-mediated glucose metabolism

Metabolism in Pulmonary Hypertension

(2021) Weiling Xu et al.   Annual Review of Physiology

Regulation of Glucose Metabolism by MuRF1 and Treatment of Myopathy in Diabetic Mice with Small Molecules Targeting MuRF1

(2021) Siegfried Labeit et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cullin-RING Ubiquitin Ligase Regulatory Circuits: a Quarter Century Beyond the F-box Hypothesis

(2021) J. Wade Harper et al.   Annual Review of Biochemistry

The Structure and Ubiquitin Binding Properties of TRAF RING Heterodimers

(2021) Anubrita Das et al.   JOURNAL OF MOLECULAR BIOLOGY

Suppression of GOLM1 by EGCG through HGF/HGFR/AKT/GSK-3β/β-catenin/c-Myc signaling pathway inhibits cell migration of MDA-MB-231

(2021) Ling Xie et al.   FOOD AND CHEMICAL TOXICOLOGY

A Novel PTP1B Inhibitor-Phosphate of Polymannuronic Acid Ameliorates Insulin Resistance by Regulating IRS-1/Akt Signaling

(2021) Dan Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

KDM4B facilitates colorectal cancer growth and glucose metabolism by stimulating TRAF6-mediated AKT activation

(2020) Haijie Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Role of the COP1 protein in cancer development and therapy

(2020) Yizuo Song et al.   SEMINARS IN CANCER BIOLOGY

Disorders of the glucose metabolism correlate with the phenotype and the severity in women with polycystic ovary syndrome

(2020) Josef Helden et al.   CLINICAL ENDOCRINOLOGY

Skp2 in the ubiquitin‐proteasome system: A comprehensive review

(2020) Moges Dessale Asmamaw et al.   MEDICINAL RESEARCH REVIEWS

Diabetic ketoacidosis

(2020) Ketan K. Dhatariya et al.   Nature Reviews Disease Primers

Trends in the Prevalence of Metabolic Syndrome in the United States, 2011-2016

(2020) Grishma Hirode et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

MuRF1/TRIM63, Master Regulator of Muscle Mass

(2020) Dulce Peris-Moreno et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of long noncoding RNA in lipid, cholesterol, and glucose metabolism and treatment of obesity syndrome

(2020) Qirong Lu et al.   MEDICINAL RESEARCH REVIEWS

Balanophorin B inhibited glycolysis with the involvement of HIF-1α

(2020) Tingting Dai et al.   LIFE SCIENCES

Overexpression of TRIM26 suppresses the proliferation, metastasis, and glycolysis in papillary thyroid carcinoma cells

(2019) Kefeng Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation

(2019) Heng Lin et al.   Frontiers in Immunology

Research Progress on Plant RING-Finger Proteins

(2019) Jinhao Sun et al.   Genes

COP1 and BBXs‐HY5‐mediated light signal transduction in plants

(2019) Dongqing Xu   NEW PHYTOLOGIST

TRIM32 promotes proliferation and confers chemoresistance to breast cancer cells through activation of the NF-κB pathway

(2018) Ting-Ting Zhao et al.   Journal of Cancer

TRIM31 Deficiency Is Associated with Impaired Glucose Metabolism and Disrupted Gut Microbiota in Mice

(2018) Jing Cheng et al.   Frontiers in Physiology

The PI3K/AKT pathway in obesity and type 2 diabetes

(2018) Xingjun Huang et al.   International Journal of Biological Sciences

Structure of TRAF Family: Current Understanding of Receptor Recognition

(2018) Hyun H. Park   Frontiers in Immunology

The E3 ligase March5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes

(2018) Simon T. Bond et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

VBP1 represses cancer metastasis by enhancing HIF-1α degradation induced by pVHL

(2017) Ji Ae Kim et al.   FEBS Journal

Ubiquitinated CD36 sustains insulin-stimulated Akt activation by stabilizing insulin receptor substrate 1 in myotubes

(2017) Shishuo Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIM31 is upregulated in hepatocellular carcinoma and promotes disease progression by inducing ubiquitination of TSC1–TSC2 complex

(2017) P Guo et al.   ONCOGENE

GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis

(2017) Lingdi Wang et al.   Nature Communications

Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin

(2017) Althea N. Waldhart et al.   Cell Reports

Types of Ubiquitin Ligases

(2016) Francesca Ester Morreale et al.   CELL

Oncogenic activation of the PI3K/Akt pathway promotes cellular glucose uptake by downregulating the expression of thioredoxin-interacting protein

(2016) Shin Yee Hong et al.   CELLULAR SIGNALLING

Constitutive photomorphogenesis protein 1 (COP1) and COP9 signalosome, evolutionarily conserved photomorphogenic proteins as possible targets of melatonin

(2016) Emilio J. Sanchez-Barcelo et al.   JOURNAL OF PINEAL RESEARCH

Upregulated TRIM32 correlates with enhanced cell proliferation and poor prognosis in hepatocellular carcinoma

(2016) Xiaopeng Cui et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

(2016) Hiroaki Semba et al.   Nature Communications

TRIM26 functions as a novel tumor suppressor of hepatocellular carcinoma and its downregulation contributes to worse prognosis

(2015) Yi Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor necrosis factor receptor- associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system

(2015) Matthew C. Walsh et al.   IMMUNOLOGICAL REVIEWS

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

Type 2 diabetes mellitus

(2015) Ralph A. DeFronzo et al.   Nature Reviews Disease Primers

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation

(2014) Alfredo Csibi et al.   CURRENT BIOLOGY

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Posttranslational regulation of Akt in human cancer

(2014) Chia-Hsin Chan et al.   Cell and Bioscience

MYC Degradation

(2014) A. S. Farrell et al.   Cold Spring Harbor Perspectives in Medicine

TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt

(2013) Kenneth K. Y. Cheng et al.   BIOCHEMICAL JOURNAL

TRAF4 Is a Critical Molecule for Akt Activation in Lung Cancer

(2013) W. Li et al.   CANCER RESEARCH

Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling

(2013) Florian Scheufele et al.   CELLULAR SIGNALLING

The ubiquitin code and its decoding machinery in the endocytic pathway

(2013) H. Tanno et al.   JOURNAL OF BIOCHEMISTRY

Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes

(2013) David J. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of Constitutive Photomorphogenesis 1 Protein with Protein-Tyrosine Phosphatase 1B Suppresses Protein-Tyrosine Phosphatase 1B Activity and Enhances Insulin Signaling

(2013) Wenying Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

(2013) Ning Wu et al.   MOLECULAR CELL

The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis

(2012) Chia-Hsin Chan et al.   CELL

Hepatitis C Virus Activates the mTOR/S6K1 Signaling Pathway in Inhibiting IRS-1 Function for Insulin Resistance

(2012) S. K. Bose et al.   JOURNAL OF VIROLOGY

mTOR Complex 2 Regulates Proper Turnover of Insulin Receptor Substrate-1 via the Ubiquitin Ligase Subunit Fbw8

(2012) Sung Jin Kim et al.   MOLECULAR CELL

APPL1 potentiates insulin secretion in pancreatic   cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice

(2012) K. K. Y. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid non-genomic signalling by 17β-oestradiol through c-Src involves mTOR-dependent expression of HIF-1α in breast cancer cells

(2011) S Sudhagar et al.   BRITISH JOURNAL OF CANCER

APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice

(2011) Yi Wang et al.   DIABETES

Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma

(2011) B. Herquel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors

(2011) Lee E. Moore et al.   PLoS Genetics

The MARCH Family E3 Ubiquitin Ligase K5 Alters Monocyte Metabolism and Proliferation through Receptor Tyrosine Kinase Modulation

(2011) Roshan Karki et al.   PLoS Pathogens

The cullin protein family

(2011) Antonio Sarikas et al.   GENOME BIOLOGY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

The RING-CH Ligase K5 Antagonizes Restriction of KSHV and HIV-1 Particle Release by Mediating Ubiquitin-Dependent Endosomal Degradation of Tetherin

(2010) Claire Pardieu et al.   PLoS Pathogens

APPL1 Potentiates Insulin-Mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice

(2009) Kenneth K.Y. Cheng et al.   Cell Metabolism

TRIM32 is an E3 ubiquitin ligase for dysbindin

(2009) Matthew Locke et al.   HUMAN MOLECULAR GENETICS

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

(2009) Min Zhuang et al.   MOLECULAR CELL

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex

(2008) Lingyan Jin et al.   CELL

Rapid Activation of Akt2 Is Sufficient to Stimulate GLUT4 Translocation in 3T3-L1 Adipocytes

(2008) Yvonne Ng et al.   Cell Metabolism

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

COP1 Functions as a FoxO1 Ubiquitin E3 Ligase to Regulate FoxO1-mediated Gene Expression

(2008) Satomi Kato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The CUL7 E3 Ubiquitin Ligase Targets Insulin Receptor Substrate 1 for Ubiquitin-Dependent Degradation

(2008) Xinsong Xu et al.   MOLECULAR CELL