The Structure and Ubiquitin Binding Properties of TRAF RING Heterodimers

Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells

(2020) Christos Karathanasis et al.   Science Signaling

Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain

(2020) Helge M. Magnussen et al.   Nature Communications

Adaptor proteins: Flexible and dynamic modulators of immune cell signaling

(2020) Paweł Borowicz et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

(2019) David W. Vredevoogd et al.   CELL

UCHL3 promotes ovarian cancer progression by stabilizing TRAF2 to activate the NF-κB pathway

(2019) Ming-Hui Zhang et al.   ONCOGENE

TRAF6-Mediated Inflammatory Cytokines Secretion in LPS-induced Colorectal Cancer Cells Is Regulated by miR-140

(2019) GUANGWEI ZHU et al.   Cancer Genomics & Proteomics

Structural principles of tumor necrosis factor superfamily signaling

(2018) Éva S. Vanamee et al.   Science Signaling

Structural principles of tumor necrosis factor superfamily signaling

(2018) Éva S. Vanamee et al.   Science Signaling

Structure of TRAF Family: Current Understanding of Receptor Recognition

(2018) Hyun H. Park   Frontiers in Immunology

Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity

(2017) Koji Nomura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1

(2017) Adam J. Middleton et al.   Nature Communications

Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity

(2017) Koji Nomura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner

(2017) Run Fang et al.   PLoS Pathogens

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chemically induced dimerization: reversible and spatiotemporal control of protein function in cells

(2015) Stephanie Voß et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes

(2015) Swarupa Panda et al.   IMMUNITY

Increased serum tumor necrosis factor receptor-associated factor-6 expression in patients with non-metastatic triple-negative breast cancer

(2015) CEMIL BILIR et al.   Oncology Letters

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

(2015) Nima Etemadi et al.   eLife

TRAF6 is upregulated in colon cancer and promotes proliferation of colon cancer cells

(2014) Heng Sun et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

TRAF5 Negatively Regulates TLR Signaling in B Lymphocytes

(2013) C. M. Buchta et al.   JOURNAL OF IMMUNOLOGY

Clinical targeting of the TNF and TNFR superfamilies

(2013) Michael Croft et al.   NATURE REVIEWS DRUG DISCOVERY

TRAF2 is an NF-κB-activating oncogene in epithelial cancers

(2013) R R Shen et al.   ONCOGENE

MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

(2013) Siqi Liu et al.   eLife

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB

(2012) Monika Schneider et al.   NATURE IMMUNOLOGY

Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl

(2012) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b

(2011) Y. Kobashigawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RINGs hold the key to ubiquitin transfer

(2011) Rhesa Budhidarmo et al.   TRENDS IN BIOCHEMICAL SCIENCES

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

(2009) Qian Yin et al.   BIOCHEMISTRY

E2 interaction and dimerization in the crystal structure of TRAF6

(2009) Qian Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY