A Novel PTP1B Inhibitor-Phosphate of Polymannuronic Acid Ameliorates Insulin Resistance by Regulating IRS-1/Akt Signaling

ER stress in Cardiometabolic Diseases: from Molecular Mechanisms to Therapeutics

(2021) Amir Ajoolabady et al.   ENDOCRINE REVIEWS

Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Systematic Review

(2021) Chukwuebuka Egbuna et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Alginate-Derived Mannuronate Oligosaccharide Attenuates Tauopathy through Enhancing Autophagy

(2021) Decheng Bi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Essential Role of PRAK in Preserving Cardiac Function and Insulin Resistance in High-Fat Diet-Induced Diabetes

(2021) Jianfeng Du et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alginate oligosaccharide improves lipid metabolism and inflammation by modulating gut microbiota in high-fat diet fed mice

(2020) Yuting Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Advances in Research on the Bioactivity of Alginate Oligosaccharides

(2020) Maochen Xing et al.   Marine Drugs

Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus

(2020) Habib Yaribeygi et al.   Oxidative Medicine and Cellular Longevity

Evaluation of oxidative stress levels in obesity and diabetes by the free oxygen radical test and free oxygen radical defence assays and correlations with anthropometric and laboratory parameters

(2020) Mihnea-Alexandru Găman et al.   World Journal of Diabetes

Molecular Dynamics Simulations of A27S and K120A Mutated PTP1B Reveals Selective Binding of the Bidentate Inhibitor

(2019) Xi Chen et al.   Biomed Research International

Insulin-Driven PI3K-AKT Signaling in the Hepatocyte Is Mediated by Redundant PI3Kα and PI3Kβ Activities and Is Promoted by RAS

(2019) Angela Molinaro et al.   Cell Metabolism

Alginate enhances memory properties of antitumor CD8+ T Cells by promoting cellular antioxidation

(2019) Yongli Fan et al.   ACS Biomaterials-Science & Engineering

Solubility, structural properties, and immunomodulatory activities of rice dreg protein modified with sodium alginate under microwave heating

(2019) Xiangyong Meng et al.   Food Science & Nutrition

Xanthohumol, a Prenylated Flavonoid from Hops, Induces Caspase-Dependent Degradation of Oncoprotein BCR-ABL in K562 Cells

(2019) Lu et al.   Antioxidants

Anti-diabetic activities of agaropectin-derived oligosaccharides from Gloiopeltis furcata via regulation of mitochondrial function

(2019) Xueliang Wang et al.   CARBOHYDRATE POLYMERS

A β-glucan from Durvillaea Antarctica has immunomodulatory effects on RAW264.7 macrophages via toll-like receptor 4

(2018) Yi Yang et al.   CARBOHYDRATE POLYMERS

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

(2018) N.H. Cho et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes

(2018) Qi Xu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers

(2018) Midori Honma et al.   INTERNATIONAL JOURNAL OF OBESITY

Prebiotic Mannan-Oligosaccharides Augment the Hypoglycemic Effects of Metformin in Correlation with Modulating Gut Microbiota

(2018) Jialin Zheng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

(2018) Ying Wang et al.   JOURNAL OF CELL BIOLOGY

Mannan-oligosaccharide modulates the obesity and gut microbiota in high-fat diet-fed mice

(2018) Hongshan Wang et al.   Food & Function

Curcumin ameliorates palmitate-induced inflammation in skeletal muscle cells by regulating JNK/NF-kB pathway and ROS production

(2018) Asie Sadeghi et al.   INFLAMMOPHARMACOLOGY

Genetic, structural and pharmacological characterization of polymannuronate synthesized by algG mutant indigenous soil bacterium Pseudomonas aeruginosa CMG1421

(2018) Muhammadi et al.   JOURNAL OF APPLIED MICROBIOLOGY

d -limonene ameliorates diabetes and its complications in streptozotocin-induced diabetic rats

(2017) Merve Bacanlı et al.   FOOD AND CHEMICAL TOXICOLOGY

Unraveling the role of ER stress inhibitors in the context of metabolic diseases

(2017) Chodisetty Sarvani et al.   PHARMACOLOGICAL RESEARCH

PINK1 alleviates palmitate induced insulin resistance in HepG2 cells by suppressing ROS mediated MAPK pathways

(2016) Xiaomin Cang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The design strategy of selective PTP1B inhibitors over TCPTP

(2016) XiangQian Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules

(2015) Megumi Ishii et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Alginate oligosaccharide enhances LDL uptake via regulation of LDLR and PCSK9 expression

(2015) Ji Hye Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Fatty Acids, Obesity and Insulin Resistance

(2015) Peter Arner et al.   Obesity Facts

Preparation, characterization and antioxidant activities of polymannuronic acid phosphate, H-phosphonate and sulfate

(2013) Quancai Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Increased oxidative stress in obesity: Implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer

(2013) Morihiro Matsuda et al.   Obesity Research & Clinical Practice

Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway

(2012) Jie Cao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Role of inhibitory κB kinase and c-Jun NH2-terminal kinase in the development of hepatic insulin resistance in critical illness diabetes

(2011) Shaoning Jiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Phosphorylation of Alginate: Synthesis, Characterization, and Evaluation of in Vitro Mineralization Capacity

(2011) Robert J. Coleman et al.   BIOMACROMOLECULES

Protein Tyrosine Phosphatase-1B (PTP-1B) Knockdown Improves Palmitate-Induced Insulin Resistance in C2C12 Skeletal Muscle Cells

(2010) Salar Bakhtiyari et al.   LIPIDS

In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis

(2010) Matthew Stuible et al.   TRENDS IN CELL BIOLOGY

Structure-based virtual screening approach to identify novel classes of PTP1B inhibitors

(2009) Hwangseo Park et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells

(2009) Do-Sung Kim et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Recent Advances in the Discovery of Competitive Protein Tyrosine Phosphatase 1B Inhibitors for the Treatment of Diabetes, Obesity, and Cancer

(2009) Andrew P. Combs   JOURNAL OF MEDICINAL CHEMISTRY

Palmitate induces insulin resistance without significant intracellular triglyceride accumulation in HepG2 cells

(2009) Jin-young Lee et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Lipid induced overexpression of NF-κB in skeletal muscle cells is linked to insulin resistance

(2008) Pomy Barma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PTP1B and TC-PTP: regulators of transformation and tumorigenesis

(2008) Matthew Stuible et al.   CANCER AND METASTASIS REVIEWS