标题
Skp2 in the ubiquitin‐proteasome system: A comprehensive review
作者
关键词
-
出版物
MEDICINAL RESEARCH REVIEWS
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2020-05-11
DOI
10.1002/med.21675
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Skp2 Pathway: A Critical Target for Cancer Therapy
- (2020) Zhen Cai et al. SEMINARS IN CANCER BIOLOGY
- SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination
- (2019) Ce Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Mechanism of Low Expression of miR-30a-5p on Epithelial–Mesenchymal Transition and Metastasis in Ovarian Cancer
- (2019) Lei Wang et al. DNA AND CELL BIOLOGY
- Combined menin and EGFR inhibitors synergize to suppress colorectal cancer via EGFR-independent and calcium-mediated repression of SKP2 transcription
- (2019) Bryson William Katona et al. CANCER RESEARCH
- Skp2 inhibitor SKPin C1 decreased viability and proliferation of multiple myeloma cells and induced apoptosis
- (2019) Ying Yang et al. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
- SKP2 targeted inhibition suppresses human uveal melanoma progression by blocking ubiquitylation of p27
- (2019) Hongbo Zhao et al. OncoTargets and Therapy
- Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers
- (2019) Yizuo Song et al. Stem Cell Research & Therapy
- USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia
- (2019) Yuning Liao et al. Cell Discovery
- High Skp2 expression is associated with a mesenchymal phenotype and increased tumorigenic potential of prostate cancer cells
- (2019) Šárka Šimečková et al. Scientific Reports
- Skp2-mediated ubiquitination and mitochondrial localization of Akt drive tumor growth and chemoresistance to cisplatin
- (2019) Xinfang Yu et al. ONCOGENE
- Gartanin is a novel NEDDylation inhibitor for induction of Skp2 degradation, FBXW2 expression, and autophagy
- (2019) Victor Pham et al. MOLECULAR CARCINOGENESIS
- Cdh1-mediated Skp2 degradation by dioscin reprogrammes aerobic glycolysis and inhibits colorectal cancer cells growth
- (2019) Li Zhou et al. EBioMedicine
- FBXO2, a novel marker for metastasis in human gastric cancer
- (2018) Xu Sun et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Regulation of Akt/FoxO3a/Skp2 Axis Is Critically Involved in Berberine-Induced Cell Cycle Arrest in Hepatocellular Carcinoma Cells
- (2018) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Identification of aberrantly expressed F-box proteins in squamous-cell lung carcinoma
- (2018) Kai Wang et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors
- (2018) Emilie Clement et al. Science Signaling
- MiR-339 depresses cell proliferation via directly targeting S-phase kinase-associated protein 2 mRNA in lung cancer
- (2018) Hong Ren et al. Thoracic Cancer
- Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors
- (2018) Emilie Clement et al. Science Signaling
- Optimizing Tumor Microenvironment for Cancer Immunotherapy: β-Glucan-Based Nanoparticles
- (2018) Mei Zhang et al. Frontiers in Immunology
- Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment
- (2018) Xu Wu et al. Acta Pharmaceutica Sinica B
- Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer
- (2017) Qirong Geng et al. Molecular Cancer
- MicroRNA-508-5p suppresses metastasis in human gastric cancer by targeting S-phase kinase-associated protein 2
- (2017) Xiangguo Duan et al. Molecular Medicine Reports
- MicroRNA-340 inhibits tumor cell proliferation, migration and invasion, and induces apoptosis in hepatocellular carcinoma
- (2017) Ziyao Wang et al. Molecular Medicine Reports
- Skp2 deficiency restricts the progression and stem cell features of castration-resistant prostate cancer by destabilizing Twist
- (2017) D Ruan et al. ONCOGENE
- Inhibition of Skp2 suppresses the proliferation and invasion of osteosarcoma cells
- (2017) Lu Ding et al. ONCOLOGY REPORTS
- Inhibition of Skp2 sensitizes lung cancer cells to paclitaxel
- (2017) Tonghai Huang et al. OncoTargets and Therapy
- Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells
- (2017) Sin-Ting Wang et al. Cell Death & Disease
- Inhibition of SKP2 Sensitizes Bromocriptine-Induced Apoptosis in Human Prolactinoma Cells
- (2017) Jinxiang Huang et al. Cancer Research and Treatment
- Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy
- (2016) J. M. Pitt et al. ANNALS OF ONCOLOGY
- Skp2 is over-expressed in breast cancer and promotes breast cancer cell proliferation
- (2016) Wenwen Zhang et al. CELL CYCLE
- Recent progress in ubiquitin and ubiquitin-like protein (Ubl) signaling
- (2016) Ronggui Hu et al. CELL RESEARCH
- Ubiquitin modifications
- (2016) Kirby N Swatek et al. CELL RESEARCH
- Skp2 Inhibitors: Novel Anticancer Strategies
- (2016) Yeongju Lee et al. CURRENT MEDICINAL CHEMISTRY
- Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins
- (2016) Nana Zheng et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Oncogenic Actions of SKP2 Involves Deregulation of CDK1 Turnover Mediated by FOXM1
- (2016) Anand Krishnan et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Pharmacogenomics and chemical library screens reveal a novel SCFSKP2 inhibitor that overcomes Bortezomib resistance in multiple myeloma
- (2016) E Malek et al. LEUKEMIA
- Skp2 is associated with paclitaxel resistance in prostate cancer cells
- (2016) YEGUO YANG et al. ONCOLOGY REPORTS
- Small molecule therapeutics targeting F-box proteins in cancer
- (2016) Yuan Liu et al. SEMINARS IN CANCER BIOLOGY
- Involvement of F-BOX proteins in progression and development of human malignancies
- (2016) Shahab Uddin et al. SEMINARS IN CANCER BIOLOGY
- A Chemical Inhibitor of the Skp2/p300 Interaction that Promotes p53-Mediated Apoptosis
- (2015) Misook Oh et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Developing structure–activity relationships from an HTS hit for inhibition of the Cks1–Skp2 protein–protein interaction
- (2015) Rajinder Singh et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- SKP2 is a direct transcriptional target of MYCN and a potential therapeutic target in neuroblastoma
- (2015) Laura Evans et al. CANCER LETTERS
- The G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2
- (2015) Azfar Jamal et al. CELL CYCLE
- Skp2 is required for Aurora B activation in cell mitosis and spindle checkpoint
- (2015) Juan Wu et al. CELL CYCLE
- The inhibition of activated hepatic stellate cells proliferation by arctigenin through G0/G1 phase cell cycle arrest: Persistent p27Kip1 induction by interfering with PI3K/Akt/FOXO3a signaling pathway
- (2015) Ao Li et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Targeting ubiquitination for cancer therapies
- (2015) John Kenneth Morrow et al. Future Medicinal Chemistry
- p27 Kip1 signaling: Transcriptional and post-translational regulation
- (2015) Su Su Thae Hnit et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment
- (2015) Kazuhiro Tanaka et al. JOURNAL OF CLINICAL INVESTIGATION
- E2F-1 overexpression inhibits human gastric cancer MGC-803 cell growthin vivo
- (2015) Wei-Yuan Wei WORLD JOURNAL OF GASTROENTEROLOGY
- Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model
- (2015) Xuesen Li et al. Oncotarget
- Curcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cells
- (2015) Lixia Wang et al. Oncotarget
- Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2
- (2015) Zhiwei Wang et al. Oncotarget
- Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling
- (2015) Elizabeth Rico-Bautista et al. Oncotarget
- E3-ligase Skp2 predicts poor prognosis and maintains cancer stem cell pool in nasopharyngeal carcinoma
- (2015) Jing Wang et al. Oncotarget
- Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2
- (2015) Zuzana Pernicová et al. NEOPLASIA
- RBR E3 ubiquitin ligases: new structures, new insights, new questions
- (2014) Donald E. Spratt et al. BIOCHEMICAL JOURNAL
- Skp2: A dream target in the coming age of cancer therapy
- (2014) Chia-Hsin Chan et al. CELL CYCLE
- RBR E3-ligases at work
- (2014) J. J. Smit et al. EMBO REPORTS
- Interference of Skp2 effectively inhibits the development and metastasis of colon carcinoma
- (2014) HAIJIN CHEN et al. Molecular Medicine Reports
- SCF ubiquitin ligase-targeted therapies
- (2014) Jeffrey R. Skaar et al. NATURE REVIEWS DRUG DISCOVERY
- CCN5/WISP-2 promotes growth arrest of triple-negative breast cancer cells through accumulation and trafficking of p27Kip1 via Skp2 and FOXO3a regulation
- (2014) I Haque et al. ONCOGENE
- RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination
- (2013) Meredith B. Metzger et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The oncoprotein HBXIP up-regulates Skp2 via activating transcription factor E2F1 to promote proliferation of breast cancer cells
- (2013) Fuqiang Xu et al. CANCER LETTERS
- Identification of small molecule inhibitors of p27Kip1ubiquitination by high-throughput screening
- (2013) Li-Ching Ooi et al. CANCER SCIENCE
- Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression
- (2013) Chia-Hsin Chan et al. CELL
- STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells
- (2013) Zheng Wei et al. CELLULAR SIGNALLING
- Regulation of the CRL4Cdt2 Ubiquitin Ligase and Cell-Cycle Exit by the SCFFbxo11 Ubiquitin Ligase
- (2013) Mario Rossi et al. MOLECULAR CELL
- CRL1-FBXO11 Promotes Cdt2 Ubiquitylation and Degradation and Regulates Pr-Set7/Set8-Mediated Cellular Migration
- (2013) Tarek Abbas et al. MOLECULAR CELL
- FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade
- (2013) Shafi Kuchay et al. NATURE CELL BIOLOGY
- Mechanisms and function of substrate recruitment by F-box proteins
- (2013) Jeffrey R. Skaar et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3
- (2013) Hao Dou et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- SKP2 overexpression is associated with a poor prognosis of rectal cancer treated with chemoradiotherapy and represents a therapeutic target with high potential
- (2013) Yu-Feng Tian et al. TUMOR BIOLOGY
- Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3
- (2013) Hari B Kamadurai et al. eLife
- Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions
- (2012) Koraljka Husnjak et al. Annual Review of Biochemistry
- Stat3 induces oncogenic Skp2 expression in human cervical carcinoma cells
- (2012) Hanhui Huang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A Crosstalk Imbalance Between p27Kip1 and Its Interacting Molecules Enhances Breast Carcinogenesis
- (2012) Weiwei He et al. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
- Rapamycin Resistance Is Linked to Defective Regulation of Skp2
- (2012) H. Totary-Jain et al. CANCER RESEARCH
- Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair
- (2012) Vincenzo D'Angiolella et al. CELL
- Acetylation-Dependent Regulation of Skp2 Function
- (2012) Hiroyuki Inuzuka et al. CELL
- The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis
- (2012) Chia-Hsin Chan et al. CELL
- Skipping Cancer: Small Molecule Inhibitors of SKP2-Mediated p27 Degradation
- (2012) Elizabeth Rico-Bautista et al. CHEMISTRY & BIOLOGY
- Specific Small Molecule Inhibitors of Skp2-Mediated p27 Degradation
- (2012) Lily Wu et al. CHEMISTRY & BIOLOGY
- Governance of Endocytic Trafficking and Signaling by Reversible Ubiquitylation
- (2012) Michael J. Clague et al. DEVELOPMENTAL CELL
- Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism
- (2012) Ethan D. Emberley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- No one can whistle a symphony alone - how different ubiquitin linkages cooperate to orchestrate NF- B activity
- (2012) A. C. Schmukle et al. JOURNAL OF CELL SCIENCE
- The Size of the Proteasomal Substrate Determines Whether Its Degradation Will Be Mediated by Mono- or Polyubiquitylation
- (2012) Nitzan Shabek et al. MOLECULAR CELL
- Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases
- (2012) Jonathan N. Pruneda et al. MOLECULAR CELL
- Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis
- (2012) Anna Plechanovová et al. NATURE
- BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer
- (2012) Hao Dou et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex
- (2012) J Wu et al. ONCOGENE
- Coordination of cell growth and division by the ubiquitin–proteasome system
- (2012) Jennifer A. Benanti SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Downregulation of Skp2 inhibits the growth and metastasis of gastric cancer cells in vitro and in vivo
- (2012) Zheng Wei et al. TUMOR BIOLOGY
- Skp2 is a Promising Therapeutic Target in Breast Cancer
- (2012) Zhiwei Wang et al. Frontiers in Oncology
- Skp2: A novel potential therapeutic target for prostate cancer
- (2011) Zhiwei Wang et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells
- (2011) Elizabeth Rico-Bautista et al. BMC BIOLOGY
- Cellular strategies for making monoubiquitin signals
- (2011) Harish N. Ramanathan et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Regulatory Functions of Ubiquitin in Diverse DNA Damage Responses
- (2011) C. H.M.A. Ramaekers et al. CURRENT MOLECULAR MEDICINE
- Structural regulation of cullin-RING ubiquitin ligase complexes
- (2011) David M Duda et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation
- (2011) Elena Maspero et al. EMBO REPORTS
- The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor
- (2011) L. Zhang et al. GENES & DEVELOPMENT
- Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
- (2011) Woong Kim et al. MOLECULAR CELL
- Structural basis for the subunit assembly of the anaphase-promoting complex
- (2011) Anne Schreiber et al. NATURE
- UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids
- (2011) Dawn M. Wenzel et al. NATURE
- Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression
- (2011) Chia-Hsin Chan et al. TheScientificWorldJOURNAL
- K11-linked ubiquitin chains as novel regulators of cell division
- (2011) Katherine E. Wickliffe et al. TRENDS IN CELL BIOLOGY
- The cullin protein family
- (2011) Antonio Sarikas et al. GENOME BIOLOGY
- RING domain dimerization is essential for RNF4 function
- (2010) Chu Wai Liew et al. BIOCHEMICAL JOURNAL
- Regulation of Akt signaling activation by ubiquitination
- (2010) Wei-Lei Yang et al. CELL CYCLE
- Skp2B attenuates p53 function by inhibiting prohibitin
- (2010) Harish Chander et al. EMBO REPORTS
- The Steady-State Repertoire of Human SCF Ubiquitin Ligase Complexes Does Not Require Ongoing Nedd8 Conjugation
- (2010) J. Eugene Lee et al. MOLECULAR & CELLULAR PROTEOMICS
- Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
- (2010) Hui-Kuan Lin et al. NATURE
- SCFCyclin F controls centrosome homeostasis and mitotic fidelity through CP110 degradation
- (2010) Vincenzo D’Angiolella et al. NATURE
- Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis
- (2010) Chia-Hsin Chan et al. NATURE CELL BIOLOGY
- Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development
- (2010) W-L Yang et al. ONCOGENE
- RING Domain E3 Ubiquitin Ligases
- (2009) Raymond J. Deshaies et al. Annual Review of Biochemistry
- How the Fanconi Anemia Pathway Guards the Genome
- (2009) George-Lucian Moldovan et al. Annual Review of Genetics
- Rapid E2-E3 Assembly and Disassembly Enable Processive Ubiquitylation of Cullin-RING Ubiquitin Ligase Substrates
- (2009) Gary Kleiger et al. CELL
- Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation
- (2009) Ping Xu et al. CELL
- Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis
- (2009) Y. Kee et al. GENES & DEVELOPMENT
- Loss of cks1 homeostasis deregulates cell division cycle
- (2009) Anand Krishnan et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Transcriptional activation of Skp2 by BCR-ABL in K562 chronic myeloid leukemia cells
- (2009) Jing-Yi Chen et al. LEUKEMIA RESEARCH
- Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex
- (2009) Hari B. Kamadurai et al. MOLECULAR CELL
- Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction
- (2009) Daming Gao et al. NATURE CELL BIOLOGY
- Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB
- (2009) Hui-Kuan Lin et al. NATURE CELL BIOLOGY
- Targeting the phosphoinositide 3-kinase pathway in cancer
- (2009) Pixu Liu et al. NATURE REVIEWS DRUG DISCOVERY
- Building ubiquitin chains: E2 enzymes at work
- (2009) Yihong Ye et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways
- (2009) Brenda A. Schulman et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Physiological functions of the HECT family of ubiquitin ligases
- (2009) Daniela Rotin et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Breaking the chains: structure and function of the deubiquitinases
- (2009) David Komander et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation
- (2009) W.-L. Yang et al. SCIENCE
- Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy
- (2008) Q. Chen et al. BLOOD
- Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer
- (2008) Dan D. Hershko CANCER
- Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APCCdh1 in G1 phase
- (2008) Geneviève Rodier et al. EMBO JOURNAL
- Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment
- (2008) Peter D. Mace et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Skp2 Suppresses p53-Dependent Apoptosis by Inhibiting p300
- (2008) Mayumi Kitagawa et al. MOLECULAR CELL
- The tumor microenvironment and its role in promoting tumor growth
- (2008) T L Whiteside ONCOGENE
- Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling
- (2008) Wei Li et al. PLoS One
- Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes
- (2008) Zhen Xu et al. BMC STRUCTURAL BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now