TRIM31 is upregulated in hepatocellular carcinoma and promotes disease progression by inducing ubiquitination of TSC1–TSC2 complex

TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells

(2016) Eun A. Ra et al.   Nature Communications

The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3

(2016) Hui Song et al.   Nature Communications

Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway

(2016) Xiaomin Ma et al.   Oncotarget

Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism

(2015) Wen-Chuan Shen et al.   Autophagy

TRIM26 functions as a novel tumor suppressor of hepatocellular carcinoma and its downregulation contributes to worse prognosis

(2015) Yi Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis

(2015) Amal M. El-Naggar et al.   CANCER CELL

The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex

(2015) Lucie Kozakova et al.   CELL CYCLE

Estrogen suppresses hepatocellular carcinoma cells through ERβ-mediated upregulation of the NLRP3 inflammasome

(2015) Qing Wei et al.   LABORATORY INVESTIGATION

Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus

(2015) H. Huynh et al.   MOLECULAR CANCER THERAPEUTICS

Downregulation of TRIM21 contributes to hepatocellular carcinoma carcinogenesis and indicates poor prognosis of cancers

(2015) Qianshan Ding et al.   TUMOR BIOLOGY

Hypoxia-Inducible Factor-1 Promotes Pancreatic Ductal Adenocarcinoma Invasion and Metastasis by Activating Transcription of the Actin-Bundling Protein Fascin

(2014) X. Zhao et al.   CANCER RESEARCH

Emerging trends in hepatocellular carcinoma incidence and mortality

(2014) Basile Njei et al.   HEPATOLOGY

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3

(2014) K M Dodd et al.   ONCOGENE

TRIM31 is downregulated in non-small cell lung cancer and serves as a potential tumor suppressor

(2014) Hui Li et al.   TUMOR BIOLOGY

MiR-424-5p reversed epithelial-mesenchymal transition of anchorage-independent HCC cells by directly targeting ICAT and suppressed HCC progression

(2014) Ying Zhang et al.   Scientific Reports

The mTOR pathway in hepatic malignancies

(2013) Mamatha Bhat et al.   HEPATOLOGY

Loss of Tsc1 accelerates malignant gliomagenesis when combined with oncogenic signals

(2013) Daisuke Yamada et al.   JOURNAL OF BIOCHEMISTRY

Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression

(2013) Qing Wei et al.   LABORATORY INVESTIGATION

High dose of extracellular ATP switched autophagy to apoptosis in anchorage-dependent and anchorage-independent hepatoma cells

(2013) Qing Wei et al.   Purinergic Signalling

Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer inCd39/Entpd1null Mice

(2012) Xiaofeng Sun et al.   HEPATOLOGY

Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice

(2012) S. Menon et al.   Science Signaling

Structural and biochemical studies of RIG-I antiviral signaling

(2012) Miao Feng et al.   Protein & Cell

The cellular level of TRIM31, an RBCC protein overexpressed in gastric cancer, is regulated by multiple mechanisms including the ubiquitin–proteasome system

(2011) Takeyuki Sugiura   CELL BIOLOGY INTERNATIONAL

mTOR links oncogenic signaling to tumor cell metabolism

(2011) Jessica L. Yecies et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma

(2011) B. Herquel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factors in mantle cell lymphoma: implication for an activated mTORC1→HIF-1α pathway

(2010) Pinelopi Argyriou et al.   ANNALS OF HEMATOLOGY

The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis

(2010) Y J Kang et al.   CELL DEATH AND DIFFERENTIATION

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Ubiquitin Chain Editing Revealed by Polyubiquitin Linkage-Specific Antibodies

(2008) Kim Newton et al.   CELL

Pam (Protein associated with Myc) functions as an E3 Ubiquitin ligase and regulates TSC/mTOR signaling

(2008) Sangyeul Han et al.   CELLULAR SIGNALLING

Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma

(2008) Augusto Villanueva et al.   GASTROENTEROLOGY

WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase

(2008) J. Hu et al.   GENES & DEVELOPMENT

Characterization of TRIM31, upregulated in gastric adenocarcinoma, as a novel RBCC protein

(2008) Takeyuki Sugiura et al.   JOURNAL OF CELLULAR BIOCHEMISTRY