TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

(2013) Ruisheng Song et al.   NATURE

Ubiquitin and Membrane Protein Turnover: From Cradle to Grave

(2012) Jason A. MacGurn et al.   Annual Review of Biochemistry

The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis

(2012) Chia-Hsin Chan et al.   CELL

Hepatic TRAF2 Regulates Glucose Metabolism Through Enhancing Glucagon Responses

(2012) Z. Chen et al.   DIABETES

Phosphorylation of Adaptor Protein Containing Pleckstrin Homology Domain, Phosphotyrosine Binding Domain, and Leucine Zipper Motif 1 (APPL1) at Ser430Mediates Endoplasmic Reticulum (ER) Stress-induced Insulin Resistance in Hepatocytes

(2012) Meilian Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APPL1 potentiates insulin secretion in pancreatic   cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice

(2012) K. K. Y. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice

(2011) Yi Wang et al.   DIABETES

Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment

(2011) Iwona Pilecka et al.   EXPERIMENTAL CELL RESEARCH

The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway

(2011) M E Cleasby et al.   JOURNAL OF ENDOCRINOLOGY

An Activating Mutation of AKT2 and Human Hypoglycemia

(2011) K. Hussain et al.   SCIENCE

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

(2011) N. R. Sundaresan et al.   Science Signaling

An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart

(2010) Xiangping Fang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes

(2009) Roberto Zoncu et al.   CELL

APPL1 Potentiates Insulin-Mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice

(2009) Kenneth K.Y. Cheng et al.   Cell Metabolism

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development

(2008) Annette Schenck et al.   CELL