Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes

PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes

(2013) Chen Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impaired translocation and activation of mitochondrial Akt1 mitigated mitochondrial oxidative phosphorylation Complex V activity in diabetic myocardium

(2013) Jia-Ying Yang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Extent of Mitochondrial Hexokinase II Dissociation During Ischemia Correlates With Mitochondrial Cytochrome c Release, Reactive Oxygen Species Production, and Infarct Size on Reperfusion

(2013) Philippe Pasdois et al.   Journal of the American Heart Association

Mechanisms of Cell Death in Heart Disease

(2012) Klitos Konstantinidis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MicroRNA-143 (miR-143) Regulates Cancer Glycolysis via Targeting Hexokinase 2 Gene

(2012) Rong Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic targets in cancer cell metabolism and autophagy

(2012) Heesun Cheong et al.   NATURE BIOTECHNOLOGY

Choline Kinase Alpha and Hexokinase-2 Protein Expression in Hepatocellular Carcinoma: Association with Survival

(2012) Sandi A. Kwee et al.   PLoS One

Bax regulates primary necrosis through mitochondrial dynamics

(2012) R. S. Whelan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

(2012) E. C. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzymatic properties of the N- and C-terminal halves of human hexokinase II

(2011) Keun-Jae Ahn et al.   BMB Reports

Disruption of Hexokinase II–Mitochondrial Binding Blocks Ischemic Preconditioning and Causes Rapid Cardiac Necrosis

(2011) Kirsten M.A. Smeele et al.   CIRCULATION RESEARCH

Myocardial AKT: The Omnipresent Nexus

(2011) Mark A. Sussman et al.   PHYSIOLOGICAL REVIEWS

Subcellular Localization of Hexokinases I and II Directs the Metabolic Fate of Glucose

(2011) Scott John et al.   PLoS One

The Cardiac Mitochondrion: Nexus of Stress

(2010) Christopher P. Baines   Annual Review of Physiology

PHLPP-1 Negatively Regulates Akt Activity and Survival in the Heart

(2010) Shigeki Miyamoto et al.   CIRCULATION RESEARCH

Reduction in Hexokinase II Levels Results in Decreased Cardiac Function and Altered Remodeling After Ischemia/Reperfusion Injury

(2010) Rongxue Wu et al.   CIRCULATION RESEARCH

Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria

(2010) Nataly Shulga et al.   JOURNAL OF CELL SCIENCE

The role of the mitochondrial permeability transition pore in heart disease

(2009) Andrew P. Halestrap et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Glycogen Synthase Kinase 3 Inhibition Slows Mitochondrial Adenine Nucleotide Transport and Regulates Voltage-Dependent Anion Channel Phosphorylation

(2008) Samarjit Das et al.   CIRCULATION RESEARCH

Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury

(2008) Elizabeth Murphy et al.   PHYSIOLOGICAL REVIEWS

Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels

(2008) Federica Chiara et al.   PLoS One

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

(2008) Saroj P. Mathupala et al.   SEMINARS IN CANCER BIOLOGY