Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and application

Nobiletin Exhibits Neuroprotective Effects against Mitochondrial Complex I Inhibition via Regulating Apoptotic Signaling

(2021) Khulan Amarsanaa et al.   Experimental Neurobiology

Role of mitophagy in mitochondrial quality control: Mechanisms and potential implications for neurodegenerative diseases

(2021) Xiao-Le Wang et al.   PHARMACOLOGICAL RESEARCH

NAD + supplementation prevents STING‐induced senescence in ataxia telangiectasia by improving mitophagy

(2021) Beimeng Yang et al.   AGING CELL

Mitochondrial quality control: from molecule to organelle

(2021) Alba Roca-Portoles et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Reactive Oxygen Species Responsive Polymers for Drug Delivery Systems

(2021) Fengxiang Gao et al.   Frontiers in Chemistry

Lighting up ATP in cells and tissues using a simple aptamer-based fluorescent probe

(2021) Wenjun Liu et al.   MICROCHIMICA ACTA

Nanoparticles of cisplatin augment drug accumulations and inhibit multidrug resistance transporters in human glioblastoma cells

(2021) Naseer Maliyakkal et al.   SAUDI PHARMACEUTICAL JOURNAL

Inhibition of RhoA/Rho kinase signaling pathway by fasudil protects against kainic acid‐induced neurite injury

(2021) Yingchun Xiang et al.   Brain and Behavior

Commentary: PROTACs make undruggable targets druggable: Challenge and opportunity

(2021) Bin Lu et al.   Acta Pharmaceutica Sinica B

Insights into the Antioxidant Mechanism of Newly Synthesized Benzoxazinic Nitrones: In Vitro and In Silico Studies with DPPH Model Radical

(2021) Stefania Marano et al.   Antioxidants

Adenosine triphosphate (ATP) and zinc(II) ions responsive pyrene based turn-on fluorescent probe and its application in live cell imaging

(2021) Xiaoping Zhang et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection

(2020) Yao Wei et al.   Nature Communications

Adiponectin Paradox in Alzheimer's Disease; Relevance to Amyloidogenic Evolvability?

(2020) Masaaki Waragai et al.   Frontiers in Endocrinology

Novel α-Lipoic Acid/3-n-Butylphthalide Conjugate Enhances Protective Effects against Oxidative Stress and 6-OHDA Induced Neuronal Damage

(2020) Kwanchanok Uppakara et al.   ACS Chemical Neuroscience

Qi-activating quercetin alleviates mitochondrial dysfunction and neuroinflammation in vivo and in vitro

(2020) Sora Kang et al.   ARCHIVES OF PHARMACAL RESEARCH

Mitochondrial Delivery of an Anticancer Drug Via Systemic Administration Using a Mitochondrial Delivery System that Inhibits the Growth of Drug-Resistant Cancer Engrafted on Mice

(2020) Yuma Yamada et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Overexpression of pigment epithelium-derived factor in placenta-derived mesenchymal stem cells promotes mitochondrial biogenesis in retinal cells

(2020) Jae Yeon Kim et al.   LABORATORY INVESTIGATION

A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing

(2020) Beverly Y. Mok et al.   NATURE

Validation of Gene Therapy for Mutant Mitochondria by Delivering Mitochondrial RNA Using a MITO-Porter

(2020) Eriko Kawamura et al.   Molecular Therapy-Nucleic Acids

Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria

(2020) Danielle E. Mor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An improved and simplified protocol to combine Golgi-Cox staining with immunofluorescence and transmission electron microscopy techniques

(2020) Matteo Pedrazzoli et al.   NEUROCHEMISTRY INTERNATIONAL

Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation

(2020) Pedro Norat et al.   npj Regenerative Medicine

A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP

(2019) Mark A. Lobas et al.   Nature Communications

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Small-molecule allosteric inhibitors of BAX

(2019) Thomas P. Garner et al.   Nature Chemical Biology

Plant-derived mitochondria-targeting cysteine-rich peptide modulates cellular bioenergetics

(2019) Antony Kam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria-Targeting, Intracellular Delivery of Native Proteins Using Biodegradable Silica Nanoparticles

(2019) Peiyan Yuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small molecules as therapeutic drugs for Alzheimer's disease

(2019) Darryll M.A. Oliver et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Knock-In Strategy for Editing Human and Zebrafish Mitochondrial DNA Using Mito-CRISPR/Cas9 System

(2019) Wan-Ping Bian et al.   ACS Synthetic Biology

Andrographolide alleviates parkinsonism in MPTP‐PD mice via targeting DRP1‐mediated mitochondrial fission

(2019) Ji Geng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding

(2019) Jung Dae Kim et al.   Cell Metabolism

The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice

(2019) Melissa L. Young et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion

(2019) Yu-Chen Chen et al.   MOLECULAR THERAPY

Mitochondria-targeted delocalized lipophilic cation complexed with human serum albumin for tumor cell imaging and treatment

(2019) Kun Qian et al.   Nanomedicine-Nanotechnology Biology and Medicine

A VDAC1-Derived N-Terminal Peptide Inhibits Mutant SOD1-VDAC1 Interactions and Toxicity in the SOD1 Model of ALS

(2019) Anna Shteinfer-Kuzmine et al.   Frontiers in Cellular Neuroscience

Silver staining (Campbell-Switzer) of neuronal α-synuclein assemblies induced by multiple system atrophy and Parkinson’s disease brain extracts in transgenic mice

(2019) Isabelle Lavenir et al.   Acta Neuropathologica Communications

Targeted mitochondrial delivery of antisense RNA-containing nanoparticles by a MITO-Porter for safe and efficient mitochondrial gene silencing

(2019) Eriko Kawamura et al.   MITOCHONDRION

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis

(2019) Anushka Chakravorty et al.   Frontiers in Aging Neuroscience

Isolation and Characterization of Neural Stem Cells from the Rat Inferior Colliculus

(2019) Johannes Völker et al.   Stem Cells International

Hydrogen sulfide attenuates hyperhomocysteinemia-induced mitochondrial dysfunctions in brain

(2019) Mohit Kumar et al.   MITOCHONDRION

Ceria Nanoparticle Systems for Selective Scavenging of Mitochondrial, Intracellular, and Extracellular Reactive Oxygen Species in Parkinson's Disease

(2018) Hyek Jin Kwon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A mitochondria-targeting hetero-binuclear Ir(iii)–Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells

(2018) Cheng Ouyang et al.   CHEMICAL COMMUNICATIONS

Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function

(2018) Martijn F. Hoes et al.   EUROPEAN JOURNAL OF HEART FAILURE

Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs

(2018) Yi Yang et al.   Protein & Cell

Non-Peptidic Cell-Penetrating Motifs for Mitochondrion-Specific Cargo Delivery

(2018) George Appiah Kubi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann’s area 32 and area 21

(2018) Caroline Magnain et al.   Brain Structure & Function

AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression

(2018) Liting Hang et al.   NEUROMOLECULAR MEDICINE

Rapamycin Enhances Mitophagy and Attenuates Apoptosis After Spinal Ischemia-Reperfusion Injury

(2018) Qiang Li et al.   Frontiers in Neuroscience

Local Field Potentials Reflect Dopaminergic and Non-Dopaminergic Activities within the Primate Midbrain

(2018) Benjamin Pasquereau et al.   NEUROSCIENCE

Neuroprotective effects of Kukoamine A on neurotoxin-induced Parkinson's model through apoptosis inhibition and autophagy enhancement

(2017) XiaoLong Hu et al.   NEUROPHARMACOLOGY

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits

(2017) Guillaume M. Hautbergue et al.   Nature Communications

The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes

(2017) Nicolas Merienne et al.   Cell Reports

Mitochondria-targeted antioxidant mitotempo protects mitochondrial function against amyloid beta toxicity in primary cultured mouse neurons

(2016) Hongtao Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional role of mitochondrial reactive oxygen species in physiology

(2016) Plamena R. Angelova et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway

(2016) Xian Jiang et al.   MOLECULAR CELL

Triphenylphosphonium Decorated Liposomes and Dendritic Polymers: Prospective Second Generation Drug Delivery Systems for Targeting Mitochondria

(2016) Constantinos M. Paleos et al.   MOLECULAR PHARMACEUTICS

Stimulating mitochondria to protect the brain following traumatic brain injury

(2016) LoraTalley Watts   Neural Regeneration Research

Mito-priming as a method to engineer Bcl-2 addiction

(2016) Jonathan Lopez et al.   Nature Communications

Cellular model of neuronal atrophy induced by DYNC1I1 deficiency reveals protective roles of RAS-RAF-MEK signaling

(2016) Zhi-Dong Liu et al.   Protein & Cell

Mitochondria-targeted antioxidant SkQT1 decreases trauma-induced neurological deficit in rat and prevents amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices

(2015) Elisaveta E. Genrikhs et al.   JOURNAL OF DRUG TARGETING

Methylene Blue Improves Brain Mitochondrial ABAD Functions and Decreases Aβ in a Neuroinflammatory Alzheimer’s Disease Mouse Model

(2015) Aya Zakaria et al.   MOLECULAR NEUROBIOLOGY

Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq

(2015) Cathryn R Cadwell et al.   NATURE BIOTECHNOLOGY

Gene introduction into the mitochondria of Arabidopsis thaliana via peptide-based carriers

(2015) Jo-Ann Chuah et al.   Scientific Reports

Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations

(2014) P. A. Gammage et al.   EMBO Molecular Medicine

Imaging of Superoxide Generation in the Dopaminergic Area of the Brain in Parkinson’s Disease, Using Mito-TEMPO

(2013) Zhivko Zhelev et al.   ACS Chemical Neuroscience

The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease

(2012) María E. Solesio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Genetic Correction of Huntington's Disease Phenotypes in Induced Pluripotent Stem Cells

(2012) Mahru C. An et al.   Cell Stem Cell

AMP Kinase Activation Mitigates Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson's Disease

(2012) C.-H. Ng et al.   JOURNAL OF NEUROSCIENCE

Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington’s Disease

(2012) Zhiyin Xun et al.   Cell Reports

Delivery of bioactive molecules to the mitochondrial genome using a membrane-fusing, liposome-based carrier, DF-MITO-Porter

(2011) Yuma Yamada et al.   BIOMATERIALS

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

(2011) Frank Soldner et al.   CELL

Melatonin treatment restores mitochondrial function in Alzheimer’s mice: a mitochondrial protective role of melatonin membrane receptor signaling

(2011) Natasa Dragicevic et al.   JOURNAL OF PINEAL RESEARCH

From Serendipity to Mitochondria-Targeted Nanocarriers

(2011) Volkmar Weissig   PHARMACEUTICAL RESEARCH

Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons

(2010) Maarit Hellman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mitochondria-Targeted Vitamin E Derivative Decreases Hepatic Oxidative Stress and Inhibits Fat Deposition in Mice

(2010) Gaowei Mao et al.   JOURNAL OF NUTRITION

Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators

(2009) H. Imamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Mitochondria

(2008) Adam T. Hoye et al.   ACCOUNTS OF CHEMICAL RESEARCH

Targeting lipophilic cations to mitochondria

(2008) Michael P. Murphy   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria-Penetrating Peptides

(2008) Kristin L. Horton et al.   CHEMISTRY & BIOLOGY

MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion

(2007) Yuma Yamada et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES