Article
Biochemistry & Molecular Biology
Tatsuhiro Ayabe, Chika Takahashi, Rena Ohya, Yasuhisa Ano
Summary: Beta-lactolin improves mitochondrial functions and prevents neuronal cell death in Alzheimer's disease-related neuronal cell models, demonstrating its advantage in maintaining neuronal health.
Review
Biochemistry & Molecular Biology
Zdenek Fisar
Summary: Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as Alzheimer's disease (AD). Injury to synapses and neurons and accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles are considered the main morphological and neuropathological features of AD. Age, genetic and epigenetic factors, environmental stressors, and lifestyle contribute to the risk of AD onset and progression. These risk factors are associated with structural and functional changes in the brain, leading to cognitive decline. Biomarkers of AD reflect or cause specific changes in brain function, especially changes in pathways associated with neurotransmission, neuroinflammation, bioenergetics, apoptosis, and oxidative and nitrosative stress. Even in the initial stages, AD is associated with A beta neurotoxicity, mitochondrial dysfunction, and tau neurotoxicity. The integrative amyloid-tau-mitochondrial hypothesis assumes that the primary cause of AD is the neurotoxicity of A beta oligomers and tau oligomers, mitochondrial dysfunction, and their mutual synergy. For the development of new efficient AD drugs, targeting the elimination of neurotoxicity, mutual potentiation of effects, and unwanted protein interactions of risk factors and biomarkers (mainly A beta oligomers, tau oligomers, and mitochondrial dysfunction) in the early stage of the disease seems promising.
Article
Neurosciences
Jing Tian, Chase Samuel Stucky, Tienju Wang, Nancy A. Muma, Michael Johnson, Heng Du
Summary: This study investigated the impact of mitochondrial dysfunction on decreased hippocampal serotonin release in an AD amyloidosis mouse model. The results showed that 5xFAD mice had decreased serotonin release in the hippocampus, and oligomeric amyloid-beta had an inhibitory effect on serotonin release. Pharmaceutical uncoupling of mitochondrial oxidative phosphorylation also disrupted serotonin release. These findings suggest a link between mitochondrial dysfunction and serotonin transmission defects in AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Jasvinder Singh Bhatti, Satinder Kaur, Jayapriya Mishra, Harikrishnareddy Dibbanti, Arti Singh, Arubala P. Reddy, Gurjit Kaur Bhatti, P. Hemachandra Reddy
Summary: Alzheimer's disease (AD) is a neurodegenerative disease that involves synaptic damage, mitochondrial abnormalities, microRNA deregulation, hormonal imbalance, increased astrocytes & microglia, and accumulation of amyloid & beta; and phosphorylated Tau. Targeting mitochondrial proteins, including dynamin-related protein 1 (Drp1), may be a potential therapeutic approach for preventing AD pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Lili Donner, Tobias Feige, Carolin Freiburg, Laura Mara Toska, Andreas S. Reichert, Madhumita Chatterjee, Margitta Elvers
Summary: Alzheimer's disease is characterized by an accumulation of amyloid beta (Aβ) peptides in the brain and mitochondrial dysfunction. Platelet activation is enhanced in AD, leading to pathological manifestations, and anti-platelet therapy has shown promising results in reducing these effects. Mitochondrial dysfunction plays a significant role in platelet-mediated Aβ aggregate formation, suggesting it as a potential target for limiting pathological manifestations in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lukas Babylon, Rekha Grewal, Pascal-L. Stahr, Ralph W. Eckert, Cornelia M. Keck, Gunter P. Eckert
Summary: The study investigated the effects of HstN on AD-related mitochondrial dysfunction, revealing that HstN significantly improved mitochondrial dysfunction by increasing ATP levels and respiratory chain complex activity.
Article
Clinical Neurology
Yutong Shang, Xiaoyan Sun, Xiaoqin Chen, Quanqiu Wang, Evan J. Wang, Emiko Miller, Rong Xu, Andrew A. Pieper, Xin Qi
Summary: This study reveals that CHCHD6 mechanistically connects APP processing and mitochondrial dysfunction in Alzheimer's disease through a circular feedback loop. Reduced CHCHD6 enhances APP accumulation on mitochondria-associated ER membranes, accelerates APP processing, and induces mitochondrial dysfunction and neuronal cholesterol accumulation, promoting amyloid pathology in Alzheimer's disease.
ACTA NEUROPATHOLOGICA
(2022)
Review
Neurosciences
Vanlalrinchhani Varte, Jeremy W. Munkelwitz, Diego E. Rincon-Limas
Summary: Alzheimer's disease (AD) is a common neurodegenerative dementia, but there are currently no effective therapies available. AD is characterized by the accumulation of amyloid beta (A beta) and hyperphosphorylated tau, leading to mitochondrial dysfunction. The mechanisms linking mitochondrial dysfunction to AD are still largely unknown. This review discusses how studying mitochondrial biology in the fruit fly Drosophila melanogaster can provide insights into these mechanisms and potential therapeutic strategies.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Xuexia Li, Qingqing Shi, Hao Xu, Yufang Xiong, Chao Wang, Linfeng Le, Junliang Lian, Guoli Wu, Feiyuan Peng, Qiong Liu, Xiubo Du
Summary: This study found that Ebselen can improve cognitive abilities, restore synaptic damage, and repair damaged mitochondrial morphology and function in AD mice by protecting the mitochondria.
Article
Neurosciences
Alexandra A. Sandberg, Evan Manning, Heather M. Wilkins, Randall Mazzarino, Taylor Minckley, Russell H. Swerdlow, David Patterson, Yan Qin, Daniel A. Linseman
Summary: In this study, the potential of mitochondrial-targeted AICD to induce neuronal apoptosis and its mechanism of neurotoxicity were examined. The results showed that only when AICD was targeted to the mitochondria, significant neuronal apoptosis was induced. Furthermore, AICD induced apoptosis via a mechanism that is distinct from that of A beta.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Moritz A. Niederschweiberer, Patrick M. Schaefer, Larry N. Singh, Ludwig Lausser, Devyani Bhosale, Raphael Hesse, Enrico Calzia, Hans A. Kestler, Angelika Rueck, Douglas C. Wallace, Bjoern von Einem, Christine A. F. von Arnim
Summary: Alzheimer's disease affects over 30 million people globally and mitochondrial dysfunction plays a significant role in its development. However, the selective vulnerability and associated mitochondrial dysfunction remain unresolved.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Clinical Neurology
Loan Vaillant-Beuchot, Arnaud Mary, Raphaelle Pardossi-Piquard, Alexandre Bourgeois, Inger Lauritzen, Fanny Eysert, Paula Fernanda Kinoshita, Julie Cazareth, Celine Badot, Konstantina Fragaki, Renaud Bussiere, Cecile Martin, Rosanna Mary, Charlotte Bauer, Sophie Pagnotta, Veronique Paquis-Flucklinger, Valerie Buee-Scherrer, Luc Buee, Sandra Lacas-Gervais, Frederic Checler, Mounia Chami
Summary: Recent evidence suggests that APP-CTFs may trigger AD pathology, while mitochondrial dysfunction is considered an early event in AD development. Accumulation of APP-CTFs can lead to mitochondrial morphological changes and impaired basal mitophagy, possibly playing a crucial role in AD pathogenesis.
ACTA NEUROPATHOLOGICA
(2021)
Article
Chemistry, Medicinal
Li-Cheng Zhou, Ying-Fan Liang, Yi Huang, Gui-Xiang Yang, Lu-Lu Zheng, Jia-Min Sun, Yang Li, Fu-Li Zhu, He-Wen Qian, Rui Wang, Lei Ma
Summary: The study developed diosgenin-indole compounds with potential neuroprotective effects against H2O2, 6-OHDA, and Aβ damages. Compound 5b showed promising results with strong binding affinity to Aβ(1-42), favorable BBB permeation, and absorption abilities. In vivo experiments demonstrated that 5b attenuated memory and learning impairments of Aβ-injected mice, suggesting its potential as a dual-functional neuroprotective agent against AD.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Neurosciences
Yu-Ling Wang, Chung-Ching Chio, Shu-Chun Kuo, Chao-Hung Yeh, Jui-Ti Ma, Wen-Pin Liu, Mao-Tsun Lin, Kao-Chang Lin, Ching-Ping Chang
Summary: This study aims to investigate the beneficial effects of exercise rehabilitation and/or astragaloside in counteracting amyloid-beta pathology. The results showed that exercise rehabilitation and/or astragaloside reversed the neurobehavioral disorders and neuropathology caused by amyloid-beta. The application of BDNF and/or astragaloside also reversed the cytotoxicity and mitochondrial distress induced by amyloid-beta in cortical neurons. The combined therapy of exercise rehabilitation (or BDNF) and astragaloside showed superior therapeutic effects compared to individual treatments. The results indicate that exercise rehabilitation (or BDNF) and astragaloside attenuate amyloid-beta pathology by reversing BDNF/TrkB signaling deficits and mitochondrial dysfunction, and their combination potentiates each other's therapeutic effects. Astragaloside can be an alternative therapy to replace exercise rehabilitation.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tiago Sousa, Paula I. Moreira, Susana Cardoso
Summary: Alzheimer's disease is a prevalent neurodegenerative disorder without an effective treatment. Dysfunction of mitochondria has been found in AD, and restoring their function may be a crucial strategy for tackling the disease.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)