期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 286, 期 4, 页码 2675-2680出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M110.146738
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资金
- Academy of Finland [122170, 131144]
- Sigrid Juselius Foundation
- [11186236]
- [1126735]
- Academy of Finland (AKA) [131144, 122170, 122170, 131144] Funding Source: Academy of Finland (AKA)
Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects neurons and repairs the Parkinson disease-like symptoms in a rat 6-hydroxydopamine model. We show a three-dimensional solution structure of human MANF that differs drastically from other neurotrophic factors. Remarkably, the C-terminal domain of MANF (C-MANF) is homologous to the SAP domain of Ku70, a well known inhibitor of proapoptotic Bax (Bcl-2-associated X protein). Cellular studies confirm that MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.
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