标题
Histone H2A variants: Diversifying chromatin to ensure genome integrity
作者
关键词
H2A variants, Histones, H2AX, MacroH2A, Genome integrity, DNA repair
出版物
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume -, Issue -, Pages -
出版商
Elsevier BV
发表日期
2022-03-22
DOI
10.1016/j.semcdb.2022.03.011
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Histone Variants in the Specialization of Plant Chromatin
- (2022) Maryam Foroozani et al. Annual Review of Plant Biology
- Loop extrusion as a mechanism for formation of DNA damage repair foci
- (2021) Coline Arnould et al. NATURE
- Poly(ADP-ribose) binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions
- (2021) Ramhari Kumbhar et al. JOURNAL OF CELL BIOLOGY
- The chromatin remodeler DDM1 prevents transposon mobility through deposition of histone variant H2A.W
- (2021) Akihisa Osakabe et al. NATURE CELL BIOLOGY
- Towards a Human Cell Atlas: Taking Notes from the Past
- (2021) Rik G.H. Lindeboom et al. TRENDS IN GENETICS
- The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation
- (2021) Pierre Bourguet et al. Nature Communications
- The evolving complexity of DNA damage foci: RNA, condensates and chromatin in DNA double-strand break repair
- (2021) Carel Fijen et al. DNA REPAIR
- Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin
- (2021) Linchang Dai et al. MOLECULAR CELL
- Mechanisms of BRCA1–BARD1 nucleosome recognition and ubiquitylation
- (2021) Qi Hu et al. NATURE
- BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination
- (2021) Jordan R. Becker et al. NATURE
- Cellular functions of the protein kinase ATM and their relevance to human disease
- (2021) Ji-Hoon Lee et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- LSH catalyzes ATP-driven exchange of histone variants macroH2A1 and macroH2A2
- (2021) Kai Ni et al. NUCLEIC ACIDS RESEARCH
- TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells
- (2021) Bruno Silva et al. Nature Communications
- The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation
- (2021) Xiaoping Xu et al. Nature Communications
- BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage
- (2021) Jekaterina Vohhodina et al. Nature Communications
- GRB2 enforces homology-directed repair initiation by MRE11
- (2021) Zu Ye et al. Science Advances
- Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair
- (2021) Nazanin Rahmanian et al. DNA REPAIR
- Biomolecular condensates at sites of DNA damage: More than just a phase
- (2021) Vincent Spegg et al. DNA REPAIR
- Structural basis of chromatin regulation by histone variant H2A.Z
- (2021) Tyler S Lewis et al. NUCLEIC ACIDS RESEARCH
- Spatial and Functional Organization of Human Papillomavirus Replication Foci in the Productive Stage of Infection
- (2021) Simran Khurana et al. mBio
- Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells
- (2021) Christophe E. Redon et al. Genes
- Encounters in Three Dimensions: How Nuclear Topology Shapes Genome Integrity
- (2021) Robin Sebastian et al. Frontiers in Genetics
- Making Connections: Integrative Signaling Mechanisms Coordinate DNA Break Repair in Chromatin
- (2021) Anthony Sanchez et al. Frontiers in Genetics
- 53BP1: a DSB escort
- (2020) Zachary Mirman et al. GENES & DEVELOPMENT
- Nuclear envelope dysfunction and its contribution to the aging process
- (2020) Filipa Martins et al. AGING CELL
- The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution
- (2020) Orit Rozenblatt-Rosen et al. CELL
- DNA polymerase theta (Polθ) – an error-prone polymerase necessary for genome stability
- (2020) Alessandra Brambati et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Perfecting DNA double-strand break repair on transcribed chromatin
- (2020) Xin Yi Tan et al. Essays in Biochemistry
- Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination
- (2020) Jessica L. Kelliher et al. Nature Communications
- How to maintain the genome in nuclear space
- (2020) Ioanna Mitrentsi et al. CURRENT OPINION IN CELL BIOLOGY
- Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability
- (2020) Robin Sebastian et al. MOLECULAR CELL
- RNA: a double-edged sword in genome maintenance
- (2020) Dali Zong et al. NATURE REVIEWS GENETICS
- The plasticity of DNA replication forks in response to clinically relevant genotoxic stress
- (2020) Matteo Berti et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner
- (2020) Patrick L. Collins et al. Nature Communications
- Community Assessment of the Predictability of Cancer Protein and Phosphoprotein Levels from Genomics and Transcriptomics
- (2020) Mi Yang et al. Cell Systems
- The molecular basis and disease relevance of non-homologous DNA end joining
- (2020) Bailin Zhao et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- ADP‐ribosylation of histone variant H2AX promotes base excision repair
- (2020) Qian Chen et al. EMBO JOURNAL
- Histone Variant H2A.J Marks Persistent DNA Damage and Triggers the Secretory Phenotype in Radiation-Induced Senescence
- (2020) Anna Isermann et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis
- (2019) Urbain Weyemi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening
- (2019) Jeongkyu Kim et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Shieldin – the protector of DNA ends
- (2019) Dheva Setiaputra et al. EMBO REPORTS
- Histone variant macroH2A: from chromatin deposition to molecular function
- (2019) Zhen Sun et al. Essays in Biochemistry
- XLF and H2AX function in series to promote replication fork stability
- (2019) Bo-Ruei Chen et al. JOURNAL OF CELL BIOLOGY
- Preserving genome integrity and function: the DNA damage response and histone modifications
- (2019) Jae Jin Kim et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Non-canonical DNA/RNA structures during Transcription-Coupled Double-Strand Break Repair: Roadblocks or Bona fide repair intermediates?
- (2019) Nadine Puget et al. DNA REPAIR
- Nuclear failure, DNA damage, and cell cycle disruption after migration through small pores: a brief review
- (2019) Charlotte R. Pfeifer et al. Essays in Biochemistry
- DNA double-strand break repair-pathway choice in somatic mammalian cells
- (2019) Ralph Scully et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Bon voyage: A transcriptional journey around DNA breaks
- (2019) Pierre Caron et al. DNA REPAIR
- MacroH2A1 Regulation of Poly(ADP-Ribose) Synthesis and Stability Prevents Necrosis and Promotes DNA Repair
- (2019) Penelope D. Ruiz et al. MOLECULAR AND CELLULAR BIOLOGY
- Stabilization of chromatin topology safeguards genome integrity
- (2019) Fena Ochs et al. NATURE
- MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance
- (2019) Israel Salguero et al. Nature Communications
- H2A.Z facilitates licensing and activation of early replication origins
- (2019) Haizhen Long et al. NATURE
- Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions
- (2018) Jeongkyu Kim et al. MOLECULAR CELL
- Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis
- (2018) Urbain Weyemi et al. Nature Communications
- PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading
- (2018) Gergely Rona et al. eLife
- Oxidative stress, aging, and diseases
- (2018) Ilaria Liguori et al. Clinical Interventions in Aging
- Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse
- (2018) Anthony Tubbs et al. CELL
- MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms
- (2018) Marek Kozlowski et al. EMBO REPORTS
- The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects
- (2018) Anjana Srivatsan et al. Nature Communications
- The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage
- (2018) Sandra Piquet et al. MOLECULAR CELL
- MacroH2A1 chromatin specification requires its docking domain and acetylation of H2B lysine 20
- (2018) Penelope D. Ruiz et al. Nature Communications
- Histone demethylase KDM5A regulates the ZMYND8–NuRD chromatin remodeler to promote DNA repair
- (2017) Fade Gong et al. JOURNAL OF CELL BIOLOGY
- The control of DNA repair by the cell cycle
- (2017) Nicole Hustedt et al. NATURE CELL BIOLOGY
- Synthetic lethality and cancer
- (2017) Nigel J. O'Neil et al. NATURE REVIEWS GENETICS
- Non-homologous DNA end joining and alternative pathways to double-strand break repair
- (2017) Howard H. Y. Chang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Variants of core histones and their roles in cell fate decisions, development and cancer
- (2017) Marcus Buschbeck et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption
- (2017) Melanija Posavec Marjanović et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay
- (2017) Jiuping Ji et al. PLoS One
- PARP inhibitors: Synthetic lethality in the clinic
- (2017) Christopher J. Lord et al. SCIENCE
- gamma-H2AX: Can it be established as a classical cancer prognostic factor?
- (2017) Viktoria-Varvara Palla et al. TUMOR BIOLOGY
- Identification of the elementary structural units of the DNA damage response
- (2017) Francesco Natale et al. Nature Communications
- Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
- (2017) Kévin Contrepois et al. Nature Communications
- MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption
- (2017) Melanija Posavec Marjanović et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Microhomology-mediated end joining: new players join the team
- (2017) Hailong Wang et al. Cell and Bioscience
- The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate
- (2017) Beom-Jun Kim et al. Cell Reports
- Heterochromatin and DNA damage repair: Use different histone variants and relax
- (2017) Zdravko J. Lorković et al. Nucleus
- Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes
- (2017) Amanda C. Hall et al. Nucleus
- Heterochromatin and DNA damage repair: Use different histone variants and relax
- (2017) Zdravko J. Lorković et al. Nucleus
- Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes
- (2017) Amanda C. Hall et al. Nucleus
- Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients
- (2016) Tina Gruosso et al. EMBO Molecular Medicine
- The structural basis of modified nucleosome recognition by 53BP1
- (2016) Marcus D. Wilson et al. NATURE
- The histone variant H2A.X is a regulator of the epithelial–mesenchymal transition
- (2016) Urbain Weyemi et al. Nature Communications
- Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin
- (2016) Pavel Savitsky et al. Cell Reports
- ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage
- (2016) Cornelia G. Spruijt et al. Cell Reports
- Spatiotemporal regulation of posttranslational modifications in the DNA damage response
- (2015) N. P. Dantuma et al. EMBO JOURNAL
- Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners
- (2015) H. F. O'Connor et al. EMBO REPORTS
- Removal of H2A.Z by INO80 promotes homologous recombination
- (2015) H. E. Alatwi et al. EMBO REPORTS
- Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination
- (2015) Fade Gong et al. GENES & DEVELOPMENT
- The chromatin environment shapes DNA replication origin organization and defines origin classes
- (2015) Christelle Cayrou et al. GENOME RESEARCH
- MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype
- (2015) Hongshan Chen et al. MOLECULAR CELL
- Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage
- (2015) Tina Thorslund et al. NATURE
- Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
- (2015) Raphael Ceccaldi et al. NATURE
- Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination
- (2015) Pedro A. Mateos-Gomez et al. NATURE
- Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response
- (2015) Ralph E Kleiner et al. Nature Chemical Biology
- Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions
- (2015) Valentina Turinetto et al. NUCLEIC ACIDS RESEARCH
- Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization and DNA repair
- (2015) Ozge Gursoy-Yuzugullu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutations in CDCA7 and HELLS cause immunodeficiency–centromeric instability–facial anomalies syndrome
- (2015) Peter E. Thijssen et al. Nature Communications
- Mice without MacroH2A Histone Variants
- (2014) J. R. Pehrson et al. MOLECULAR AND CELLULAR BIOLOGY
- MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation
- (2014) Hongshan Chen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks
- (2014) François Aymard et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The histone variant H2A.Bbd is enriched at sites of DNA synthesis
- (2014) Viola Sansoni et al. NUCLEIC ACIDS RESEARCH
- Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair
- (2014) Kenbun Sone et al. Nature Communications
- A Macrohistone Variant Links Dynamic Chromatin Compaction to BRCA1-Dependent Genome Maintenance
- (2014) Simran Khurana et al. Cell Reports
- Activation of DNA Damage Response Signaling by Condensed Chromatin
- (2014) Rebecca C. Burgess et al. Cell Reports
- Out of Balance: R-loops in Human Disease
- (2014) Matthias Groh et al. PLoS Genetics
- The Chromatin Response to DNA Breaks: Leaving a Mark on Genome Integrity
- (2013) Godelieve Smeenk et al. Annual Review of Biochemistry
- Chromatin Remodeling at DNA Double-Strand Breaks
- (2013) Brendan D. Price et al. CELL
- 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark
- (2013) Amélie Fradet-Turcotte et al. NATURE
- Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination
- (2013) Jiangbo Tang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- macroH2A1 histone variant represses rDNA transcription
- (2013) Rong Cong et al. NUCLEIC ACIDS RESEARCH
- Repair of Strand Breaks by Homologous Recombination
- (2013) M. Jasin et al. Cold Spring Harbor Perspectives in Biology
- RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling
- (2012) Francesca Mattiroli et al. CELL
- The histone variant macroH2A1.1 is recruited to DSBs through a mechanism involving PARP1
- (2012) Chang Xu et al. FEBS LETTERS
- Systematic Identification of Functional Residues in Mammalian Histone H2AX
- (2012) W.-T. Chen et al. MOLECULAR AND CELLULAR BIOLOGY
- Histone Variant H2A.Bbd Is Associated with Active Transcription and mRNA Processing in Human Cells
- (2012) Michael Y. Tolstorukov et al. MOLECULAR CELL
- Histone H2A.Z Controls a Critical Chromatin Remodeling Step Required for DNA Double-Strand Break Repair
- (2012) Ye Xu et al. MOLECULAR CELL
- H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization
- (2012) Clemens Bönisch et al. NUCLEIC ACIDS RESEARCH
- Monoubiquitination of H2AX Protein Regulates DNA Damage Response Signaling
- (2011) Mei-Ren Pan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Critical Role of Monoubiquitination of Histone H2AX Protein in Histone H2AX Phosphorylation and DNA Damage Response
- (2011) Ching-Yuan Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- H2AX post-translational modifications in the ionizing radiation response and homologous recombination
- (2010) Anyong Xie et al. CELL CYCLE
- High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome
- (2010) Jason S Iacovoni et al. EMBO JOURNAL
- Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway
- (2010) Xiaofeng Jiang et al. FEBS LETTERS
- γH2AX: a sensitive molecular marker of DNA damage and repair
- (2010) L-J Mah et al. LEUKEMIA
- The DNA Damage Response: Making It Safe to Play with Knives
- (2010) Alberto Ciccia et al. MOLECULAR CELL
- H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes
- (2010) Beth A. Helmink et al. NATURE
- Formation of Dynamic γ-H2AX Domains along Broken DNA Strands Is Distinctly Regulated by ATM and MDC1 and Dependent upon H2AX Densities in Chromatin
- (2009) Velibor Savic et al. MOLECULAR CELL
- Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
- (2009) Peter J. Cook et al. NATURE
- The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress
- (2009) Joanna R. Morris et al. NATURE
- Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
- (2009) Yaron Galanty et al. NATURE
- The DNA-damage response in human biology and disease
- (2009) Stephen P. Jackson et al. NATURE
- A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation
- (2009) Gyula Timinszky et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Replication fork arrest, recombination and the maintenance of ribosomal DNA stability
- (2008) E TSANG et al. DNA REPAIR
- Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
- (2008) J Ross Chapman et al. EMBO REPORTS
- ATR and H2AX Cooperate in Maintaining Genome Stability under Replication Stress
- (2008) Rebecca A. Chanoux et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage–modified chromatin
- (2008) Fredrik Melander et al. JOURNAL OF CELL BIOLOGY
- Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin
- (2008) Christoph Spycher et al. JOURNAL OF CELL BIOLOGY
- WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity
- (2008) Andrew Xiao et al. NATURE
- MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
- (2008) L. Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A phosphorylated subpopulation of the histone variant macroH2A1 is excluded from the inactive X chromosome and enriched during mitosis
- (2008) E. Bernstein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Complementary functions of ATM and H2AX in development and suppression of genomic instability
- (2008) S. Zha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started