Biomolecular condensates at sites of DNA damage: More than just a phase

Biomolecular condensates and cancer

(2021) Ann Boija et al.   CANCER CELL

Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System

(2021) Yasunori Hayashi et al.   JOURNAL OF NEUROSCIENCE

TopBP1 assembles nuclear condensates to switch on ATR signaling

(2021) Camilla Frattini et al.   MOLECULAR CELL

Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies

(2021) Jia-Min Zhang et al.   MOLECULAR CELL

Wetting regulates autophagy of phase-separated compartments and the cytosol

(2021) Jaime Agudo-Canalejo et al.   NATURE

How Hierarchical Interactions Make Membraneless Organelles Tick Like Clockwork

(2021) Jeremy D. Schmit et al.   TRENDS IN BIOCHEMICAL SCIENCES

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

(2021) Shan Lu et al.   Nature Communications

Liquid-liquid phase separation of light-inducible transcription factors increases transcription activation in mammalian cells and mice

(2021) Nils Schneider et al.   Science Advances

FUS-dependent liquid–liquid phase separation is important for DNA repair initiation

(2021) Brunno R. Levone et al.   JOURNAL OF CELL BIOLOGY

Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency

(2021) Ji-Hoon Lee et al.   MOLECULAR CELL

Loop extrusion as a mechanism for formation of DNA damage repair foci

(2021) Coline Arnould et al.   NATURE

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

(2021) Simon Alberti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation

(2021) Erik W Martin et al.   NUCLEIC ACIDS RESEARCH

Biomolecular Condensates and Their Links to Cancer Progression

(2021) Danfeng Cai et al.   TRENDS IN BIOCHEMICAL SCIENCES

Sequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies

(2021) Taranpreet Kaur et al.   Nature Communications

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

(2021) Georg Krainer et al.   Nature Communications

Single molecule microscopy reveals key physical features of repair foci in living cells

(2021) Judith Miné-Hattab et al.   eLife

Bridging-induced phase separation induced by cohesin SMC protein complexes

(2021) Je-Kyung Ryu et al.   Science Advances

The role of liquid–liquid phase separation in regulating enzyme activity

(2021) Brian G. O'Flynn et al.   CURRENT OPINION IN CELL BIOLOGY

The HSV-1 Transcription Factor ICP4 Confers Liquid-Like Properties to Viral Replication Compartments

(2021) Michael Seyffert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Data-Driven Hydrophobicity Scale for Predicting Liquid–Liquid Phase Separation of Proteins

(2021) Thomas Dannenhoffer-Lafage et al.   JOURNAL OF PHYSICAL CHEMISTRY B

TIRR inhibits the 53BP1-p53 complex to alter cell-fate programs

(2021) Nishita Parnandi et al.   MOLECULAR CELL

AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation

(2021) Indrajeet Ghodke et al.   MOLECULAR CELL

Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication

(2021) Manzar Hossain et al.   MOLECULAR CELL

p53 mediates target gene association with nuclear speckles for amplified RNA expression

(2021) Katherine A. Alexander et al.   MOLECULAR CELL

DNA-driven condensation assembles the meiotic DNA break machinery

(2021) Corentin Claeys Bouuaert et al.   NATURE

Liquid-like protein interactions catalyse assembly of endocytic vesicles

(2021) Kasey J. Day et al.   NATURE CELL BIOLOGY

Phase Separation in Genome Organization across Evolution

(2021) Marina Feric et al.   TRENDS IN CELL BIOLOGY

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

(2021) Jasmine Cubuk et al.   Nature Communications

New Faces of old Friends: Emerging new Roles of RNA-Binding Proteins in the DNA Double-Strand Break Response

(2021) Julie A. Klaric et al.   Frontiers in Molecular Biosciences

Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells

(2021) Jone Michelena et al.   Life Science Alliance

Roles of liquid–liquid phase separation in bacterial RNA metabolism

(2021) Vidhyadhar Nandana et al.   CURRENT OPINION IN MICROBIOLOGY

Repair of DNA double-strand breaks in RNAPI- and RNAPII-transcribed loci

(2021) E. Lesage et al.   DNA REPAIR

Mechanistic dissection of increased enzymatic rate in a phase-separated compartment

(2021) William Peeples et al.   Nature Chemical Biology

Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions

(2020) Jeong-Mo Choi et al.   Annual Review of Biophysics

Liquid-Liquid Phase Separation of Histone Proteins in Cells: Role in Chromatin Organization

(2020) Anisha Shakya et al.   BIOPHYSICAL JOURNAL

Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation

(2020) Fabian Erdel et al.   MOLECULAR CELL

Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation

(2020) Jamie A. Greig et al.   MOLECULAR CELL

Stress- and ubiquitylation-dependent phase separation of the proteasome

(2020) Sayaka Yasuda et al.   NATURE

Valence and patterning of aromatic residues determine the phase behavior of prion-like domains

(2020) Erik W. Martin et al.   SCIENCE

Phase separation provides a mechanism to reduce noise in cells

(2020) A. Klosin et al.   SCIENCE

Poly(ADP-ribose): A Dynamic Trigger for Biomolecular Condensate Formation

(2020) Anthony K.L. Leung   TRENDS IN CELL BIOLOGY

DNA repair by Rad52 liquid droplets

(2020) Roxanne Oshidari et al.   Nature Communications

Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains

(2020) Kiyoto Kamagata et al.   Scientific Reports

Biomolecular Phase Separation: From Molecular Driving Forces to Macroscopic Properties

(2020) Gregory L. Dignon et al.   Annual Review of Physical Chemistry

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization

(2020) David W. Sanders et al.   CELL

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

(2020) Peiguo Yang et al.   CELL

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

(2020) Jordina Guillén-Boixet et al.   CELL

Repetitive RNAs as Regulators of Chromatin-Associated Subcompartment Formation by Phase Separation

(2020) Lukas Frank et al.   JOURNAL OF MOLECULAR BIOLOGY

Composition-dependent thermodynamics of intracellular phase separation

(2020) Joshua A. Riback et al.   NATURE

Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression

(2020) Yi Lu et al.   NATURE CELL BIOLOGY

Making the Case for Disordered Proteins and Biomolecular Condensates in Bacteria

(2020) Megan C. Cohan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Managing Hyperosmotic Stress through Phase Separation

(2020) Ivan Peran et al.   TRENDS IN BIOCHEMICAL SCIENCES

Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks

(2020) Jia-Min Zhang et al.   Cell and Bioscience

Measles virus nucleo- and phosphoproteins form liquid-like phase-separated compartments that promote nucleocapsid assembly

(2020) Serafima Guseva et al.   Science Advances

The Role of Liquid–Liquid Phase Separation in the Compartmentalization of Cell Nucleus and Spatial Genome Organization

(2020) S. V. Razin et al.   BIOCHEMISTRY-MOSCOW

ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs

(2020) S. Pankivskyi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates

(2020) Yan G. Zhao et al.   DEVELOPMENTAL CELL

CDK-Regulated Phase Separation Seeded by Histone Genes Ensures Precise Growth and Function of Histone Locus Bodies

(2020) Woonyung Hur et al.   DEVELOPMENTAL CELL

Phase separation drives decision making in cell division

(2020) Xing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear body phase separation drives telomere clustering in ALT cancer cells

(2020) Huaiying Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

MeCP2 links heterochromatin condensates and neurodevelopmental disease

(2020) Charles H. Li et al.   NATURE

Nucleolar RNA polymerase II drives ribosome biogenesis

(2020) Karan J. Abraham et al.   NATURE

RNA: a double-edged sword in genome maintenance

(2020) Dali Zong et al.   NATURE REVIEWS GENETICS

RNA contributions to the form and function of biomolecular condensates

(2020) Christine Roden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Partitioning of cancer therapeutics in nuclear condensates

(2020) Isaac A. Klein et al.   SCIENCE

Biomolecular Condensates in the Nucleus

(2020) Benjamin R. Sabari et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Condensed View of the Chromosome Passenger Complex

(2020) Prasad Trivedi et al.   TRENDS IN CELL BIOLOGY

Ubiquitin‐Modulated Phase Separation of Shuttle Proteins: Does Condensate Formation Promote Protein Degradation?

(2020) Thuy P. Dao et al.   BIOESSAYS

Emerging Roles for Phase Separation in Plants

(2020) Ryan J. Emenecker et al.   DEVELOPMENTAL CELL

Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force

(2020) Aurélie Zbinden et al.   DEVELOPMENTAL CELL

Phase Separation—A Physical Mechanism for Organizing Information and Biochemical Reactions

(2020) Rohit V. Pappu   DEVELOPMENTAL CELL

Ewing sarcoma protein promotes dissociation of poly( ADP ‐ribose) polymerase 1 from chromatin

(2020) Seon‐gyeong Lee et al.   EMBO REPORTS

Organization and function of paraspeckles

(2020) Yang Wang et al.   Essays in Biochemistry

Enzymatic Reactions inside Biological Condensates

(2020) Yi Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Partitioning of Chemotherapeutics into Nuclear Condensates—Opening the Door to New Approaches for Drug Development

(2020) Thomas P. Howard et al.   MOLECULAR CELL

Multivalent Proteins Rapidly and Reversibly Phase-Separate upon Osmotic Cell Volume Change

(2020) Ameya P. Jalihal et al.   MOLECULAR CELL

Phase Separation in Cell Division

(2020) Joseph Y. Ong et al.   MOLECULAR CELL

A protein assembly mediates Xist localization and gene silencing

(2020) Amy Pandya-Jones et al.   NATURE

Nucleated transcriptional condensates amplify gene expression

(2020) Ming-Tzo Wei et al.   NATURE CELL BIOLOGY

The nucleolus as a multiphase liquid condensate

(2020) Denis L. J. Lafontaine et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation

(2020) Song My Hoang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PML nuclear bodies and chromatin dynamics: catch me if you can!

(2020) Armelle Corpet et al.   NUCLEIC ACIDS RESEARCH

Beyond aggregation: Pathological phase transitions in neurodegenerative disease

(2020) Cécile Mathieu et al.   SCIENCE

DNA Damage Triggers a New Phase in Neurodegeneration

(2020) Fabio Pessina et al.   TRENDS IN GENETICS

Tunable multiphase dynamics of arginine and lysine liquid condensates

(2020) Rachel S. Fisher et al.   Nature Communications

Phase-Separated Transcriptional Condensates Accelerate Target-Search Process Revealed by Live-Cell Single-Molecule Imaging

(2020) Samantha Kent et al.   Cell Reports

Transcriptional suppression of ribosomal DNA with phase separation

(2020) Satoru Ide et al.   Science Advances

Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells

(2020) Hilmar Strickfaden et al.   CELL

Cellular Control of Viscosity Counters Changes in Temperature and Energy Availability

(2020) Laura B. Persson et al.   CELL

RNA-Mediated Feedback Control of Transcriptional Condensates

(2020) Jonathan E. Henninger et al.   CELL

SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs

(2020) Theodora Myrto Perdikari et al.   EMBO JOURNAL

Liquid–Liquid Phase Separation by Intrinsically Disordered Protein Regions of Viruses: Roles in Viral Life Cycle and Control of Virus–Host Interactions

(2020) Stefania Brocca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Liquid-Liquid Phase Separation of Tau Driven by Hydrophobic Interaction Facilitates Fibrillization of Tau

(2020) Yanxian Lin et al.   JOURNAL OF MOLECULAR BIOLOGY

Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions

(2020) Christopher R. Carlson et al.   MOLECULAR CELL

Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid

(2020) Christiane Iserman et al.   MOLECULAR CELL

A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits

(2020) Florian Wilfling et al.   MOLECULAR CELL

Widespread occurrence of the droplet state of proteins in the human proteome

(2020) Maarten Hardenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein condensates as aging Maxwell fluids

(2020) Louise Jawerth et al.   SCIENCE

The Hammer and the Dance of Cell Cycle Control

(2020) Andreas Panagopoulos et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates

(2020) Adriana Savastano et al.   Nature Communications

Biomolecular condensates as arbiters of biochemical reactions inside the nucleus

(2020) Guillaume Laflamme et al.   Communications Biology

How do intrinsically disordered protein regions encode a driving force for liquid–liquid phase separation?

(2020) Wade Borcherds et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Dealing with DNA lesions: When one cell cycle is not enough

(2020) Aleksandra Lezaja et al.   CURRENT OPINION IN CELL BIOLOGY

A Snapshot on the Cis Chromatin Response to DNA Double-Strand Breaks

(2019) Thomas Clouaire et al.   TRENDS IN GENETICS

Designer membraneless organelles enable codon reassignment of selected mRNAs in eukaryotes

(2019) Christopher D. Reinkemeier et al.   SCIENCE

A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS

(2019) William Y. C. Huang et al.   SCIENCE

Stoichiometry controls activity of phase-separated clusters of actin signaling proteins

(2019) Lindsay B. Case et al.   SCIENCE

Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly

(2019) Sreejith J. Nair et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids

(2019) Kyosuke Nakamura et al.   NATURE CELL BIOLOGY

Cellular sensing by phase separation: Using the process, not just the products

(2019) Haneul Yoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins

(2019) Yongjia Duan et al.   CELL RESEARCH

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Regulation of Transmembrane Signaling by Phase Separation

(2019) Lindsay B. Case et al.   Annual Review of Biophysics

New insights of poly(ADP-ribosylation) in neurodegenerative diseases: A focus on protein phase separation and pathologic aggregation

(2019) Cong Liu et al.   BIOCHEMICAL PHARMACOLOGY

PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA

(2019) Anastasia S. Singatulina et al.   Cell Reports

Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

(2019) David Trombley McSwiggen et al.   eLife

Phase separation of 53 BP 1 determines liquid‐like behavior of DNA repair compartments

(2019) Sinan Kilic et al.   EMBO JOURNAL

Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52

(2019) Jaewon Min et al.   GENES & DEVELOPMENT

Molecular interactions underlying liquid−liquid phase separation of the FUS low-complexity domain

(2019) Anastasia C. Murthy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The nucleolus functions as a phase-separated protein quality control compartment

(2019) F. Frottin et al.   SCIENCE

Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly

(2019) Xinrui Gui et al.   Nature Communications

Liquid–Liquid Phase Separation in Disease

(2019) Simon Alberti et al.   Annual Review of Genetics

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

(2019) Ya-Cheng Liao et al.   CELL

Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism

(2019) Liang Wang et al.   MOLECULAR CELL

Organization and regulation of gene transcription

(2019) Patrick Cramer   NATURE

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors

(2019) Fabio Pessina et al.   NATURE CELL BIOLOGY

The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex

(2019) Prasad Trivedi et al.   NATURE CELL BIOLOGY

Poly(ADP-Ribosylation) in Age-Related Neurological Disease

(2019) Leeanne McGurk et al.   TRENDS IN GENETICS

A new class of disordered elements controls DNA replication through initiator self-assembly

(2019) Matthew W Parker et al.   eLife

Phase Separation in Asymmetric Cell Division

(2019) Wenyu Wen   BIOCHEMISTRY

Organization of Chromatin by Intrinsic and Regulated Phase Separation

(2019) Bryan A. Gibson et al.   CELL

Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences

(2019) David T. McSwiggen et al.   GENES & DEVELOPMENT

The Control Centers of Biomolecular Phase Separation: How Membrane Surfaces, PTMs, and Active Processes Regulate Condensation

(2019) Wilton T. Snead et al.   MOLECULAR CELL

The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation

(2019) Xiangru Huo et al.   MOLECULAR CELL

HP1 reshapes nucleosome core to promote phase separation of heterochromatin

(2019) S. Sanulli et al.   NATURE

Stabilization of chromatin topology safeguards genome integrity

(2019) Fena Ochs et al.   NATURE

Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides

(2019) Bartosz Gabryelczyk et al.   Nature Communications

LASSI: A lattice model for simulating phase transitions of multivalent proteins

(2019) Jeong-Mo Choi et al.   PLoS Computational Biology

Molecular structure in biomolecular condensates

(2019) Ivan Peran et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression

(2019) Danfeng Cai et al.   NATURE CELL BIOLOGY

53BP1–RIF1: sculpting the DNA repair focus in 3D

(2019) Indrajeet Ghodke et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reshaping Chromatin Architecture around DNA Breaks

(2019) Pierre Caron et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mobility and Repair of Damaged DNA: Random or Directed?

(2019) Roxanne Oshidari et al.   TRENDS IN CELL BIOLOGY

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

(2018) Jie Wang et al.   CELL

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

(2018) Seema Qamar et al.   CELL

TAR DNA-binding protein 43 (TDP-43) liquid–liquid phase separation is mediated by just a few aromatic residues

(2018) Hao-Ru Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RGG/RG Motif Regions in RNA Binding and Phase Separation

(2018) P. Andrew Chong et al.   JOURNAL OF MOLECULAR BIOLOGY

Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

(2018) Tomohiro Yamazaki et al.   MOLECULAR CELL

Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2

(2018) Elizabeth L. Guenther et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA buffers the phase separation behavior of prion-like RNA binding proteins

(2018) Shovamayee Maharana et al.   SCIENCE

mRNA structure determines specificity of a polyQ-driven phase separation

(2018) Erin M. Langdon et al.   SCIENCE

Imaging dynamic and selective low-complexity domain interactions that control gene transcription

(2018) Shasha Chong et al.   SCIENCE

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks

(2018) Michael P. Hughes et al.   SCIENCE

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

(2018) Won-Ki Cho et al.   SCIENCE

Phase separation of a yeast prion protein promotes cellular fitness

(2018) Titus M. Franzmann et al.   SCIENCE

Paraspeckles: Where Long Noncoding RNA Meets Phase Separation

(2018) Archa H. Fox et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2

(2018) Elizabeth L. Guenther et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pi-Pi contacts are an overlooked protein feature relevant to phase separation

(2018) Robert McCoy Vernon et al.   eLife

Who's In and Who's Out—Compositional Control of Biomolecular Condensates

(2018) Jonathon A. Ditlev et al.   JOURNAL OF MOLECULAR BIOLOGY

Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

(2018) Leeanne McGurk et al.   MOLECULAR CELL

Extreme disorder in an ultrahigh-affinity protein complex

(2018) Alessandro Borgia et al.   NATURE

Nuclear F-actin and myosins drive relocalization of heterochromatic breaks

(2018) Christopher P. Caridi et al.   NATURE

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

(2018) Benjamin R. Schrank et al.   NATURE

RNA polymerase II clustering through carboxy-terminal domain phase separation

(2018) Marc Boehning et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

(2018) Ann Boija et al.   CELL

Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds

(2018) Dan Bracha et al.   CELL

Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation

(2018) Roubina Tatavosian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease

(2018) Tae-In Kam et al.   SCIENCE

Chromatin and nucleosome dynamics in DNA damage and repair

(2017) Michael H. Hauer et al.   GENES & DEVELOPMENT

Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs

(2017) Yuan Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription and DNA Damage: Holding Hands or Crossing Swords?

(2017) Giuseppina D'Alessandro et al.   JOURNAL OF MOLECULAR BIOLOGY

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reading chromatin signatures after DNA double-strand breaks

(2017) Marcus D. Wilson et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Direct observation of structure and dynamics during phase separation of an elastomeric protein

(2017) Sean E. Reichheld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation

(2017) Jacob P. Brady et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Special focus on the Cajal Body

(2017) Karla M. Neugebauer   RNA Biology

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin

(2017) Stefania Pellegrino et al.   Cell Reports

The liquid structure of elastin

(2017) Sarah Rauscher et al.   eLife

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

Adaptation to Stressors by Systemic Protein Amyloidogenesis

(2016) Timothy E. Audas et al.   DEVELOPMENTAL CELL

Droplet organelles?

(2016) Edward M Courchaine et al.   EMBO JOURNAL

PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining

(2016) Martijn S. Luijsterburg et al.   MOLECULAR CELL

53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms

(2016) Raquel Cuella-Martin et al.   MOLECULAR CELL

Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein

(2016) Chi W. Pak et al.   MOLECULAR CELL

H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex

(2016) Giulia Saredi et al.   NATURE

The structural basis of modified nucleosome recognition by 53BP1

(2016) Marcus D. Wilson et al.   NATURE

Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers

(2016) Petra Schwertman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage

(2016) Sarah J. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

Phase Separation: Linking Cellular Compartmentalization to Disease

(2016) Adriano Aguzzi et al.   TRENDS IN CELL BIOLOGY

Cross-β Polymerization of Low Complexity Sequence Domains

(2016) Masato Kato et al.   Cold Spring Harbor Perspectives in Biology

Interplay between Ubiquitin, SUMO, and Poly(ADP-Ribose) in the Cellular Response to Genotoxic Stress

(2016) Stefania Pellegrino et al.   Frontiers in Genetics

Biochemical Properties and Biological Functions of FET Proteins

(2015) Jacob C. Schwartz et al.   Annual Review of Biochemistry

DNA Replication Stress as a Hallmark of Cancer

(2015) Morgane Macheret et al.   Annual Review of Pathology-Mechanisms of Disease

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles

(2015) Sven Hennig et al.   JOURNAL OF CELL BIOLOGY

Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II

(2015) Kathleen A. Burke et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Polymer physics of intracellular phase transitions

(2015) Clifford P. Brangwynne et al.   Nature Physics

Readers of poly(ADP-ribose): designed to be fit for purpose

(2015) Federico Teloni et al.   NUCLEIC ACIDS RESEARCH

PARP-1 Inhibition Is Neuroprotective in the R6/2 Mouse Model of Huntington’s Disease

(2015) Antonella Cardinale et al.   PLoS One

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

(2015) Matthias Altmeyer et al.   Nature Communications

A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors

(2015) Lior Izhar et al.   Cell Reports

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Spatial genome organization: contrasting views from chromosome conformation capture and fluorescence in situ hybridization

(2014) Iain Williamson et al.   GENES & DEVELOPMENT

Poly(ADP-ribose): An organizer of cellular architecture

(2014) Anthony K.L. Leung   JOURNAL OF CELL BIOLOGY

FUS is Phosphorylated by DNA-PK and Accumulates in the Cytoplasm after DNA Damage

(2014) Q. Deng et al.   JOURNAL OF NEUROSCIENCE

DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal

(2014) Sébastien Britton et al.   NUCLEIC ACIDS RESEARCH

The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage

(2013) Adam S. Mastrocola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling

(2013) Matthias Altmeyer et al.   MOLECULAR CELL

Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons

(2013) Wen-Yuan Wang et al.   NATURE NEUROSCIENCE

The SH2 Domain Interaction Landscape

(2013) Michele Tinti et al.   Cell Reports

Regulation of DNA-End Resection by hnRNPU-like Proteins Promotes DNA Double-Strand Break Signaling and Repair

(2012) Sophie E. Polo et al.   MOLECULAR CELL

Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response

(2012) Petra Beli et al.   MOLECULAR CELL

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response

(2012) Britt Adamson et al.   NATURE CELL BIOLOGY

Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm

(2011) Anthony K.L. Leung et al.   MOLECULAR CELL

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insight into p53 Recognition by the 53BP1 Tandem Tudor Domain

(2010) Siddhartha Roy et al.   JOURNAL OF MOLECULAR BIOLOGY

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

(2010) D. M. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

An Oligomerized 53BP1 Tudor Domain Suffices for Recognition of DNA Double-Strand Breaks

(2008) O. Zgheib et al.   MOLECULAR AND CELLULAR BIOLOGY