Article
Genetics & Heredity
Milad Shirvaliloo
Summary: The article summarizes the importance of histones and their role in gene expression regulation. It highlights the significance of recent research on histone modifications published in Epigenomics since 2020.
Article
Oncology
Nabamita Boruah, Chongtham Sovachandra Singh, Pooja Swargiary, Hughbert Dkhar, Anupam Chatterjee
Summary: The study found that consumption of raw areca nut (RAN) induced gastric cancer with securin overexpression in stomach tissues of mice, along with increased H3 lysine 4 trimethylation and lysine 9 and 18 acetylation in the promoter region of the securin gene. These results suggest that RAN-induced epigenetic changes, securin overexpression and subsequent elevation of chromosomal instability are likely byproducts of pRb pathway inactivation.
CANCER CELL INTERNATIONAL
(2022)
Review
Pharmacology & Pharmacy
Qiuyu Cai, Can Gan, Chengwei Tang, Hao Wu, Jinhang Gao
Summary: Histone modifications play a crucial role in the pathogenesis of chronic liver disease and provide a potential target for therapeutic interventions. Pharmacological modulation of histone modifications may offer a promising approach to reverse CLD and prevent progression to liver cirrhosis and malignancy.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Urology & Nephrology
Jun Wang, Fengchen Shen, Feng Liu, Shougang Zhuang
Summary: Histone modifications play a crucial role in the pathogenesis of AKI, and understanding epigenetic regulation in AKI will help establish the utility of pharmacologic targeting of histone modification as a potential novel therapy for AKI.
Review
Oncology
Chiara Mazziotta, Carmen Lanzillotti, Roberta Gafa, Antoine Touze, Marie-Alice Durand, Fernanda Martini, John Charles Rotondo
Summary: This article reviews the recent progress in understanding the etiology and treatment of Merkel Cell Carcinoma (MCC), focusing on the role of histone post-translational modifications (PTMs) and their potential as diagnostic and therapeutic markers.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ashby J. Morrison
Summary: Cellular adaptation to nutrient environment is crucial for survival, failure to adapt can result in cell death and diseases. Metabolism alterations, particularly in cancer cells, play a significant role in the pathogenesis of diseases. Recent studies have shown the interplay between metabolic pathways, epigenetic modifications, and transcriptional regulation in cancer cells.
Review
Plant Sciences
Rocio Nunez-Vazquez, Benedicte Desvoyes, Crisanto Gutierrez
Summary: Plants have developed various mechanisms to adapt to abiotic stresses, which involve transcriptional regulation and chromatin modifications. Understanding and manipulating these regulatory networks are crucial for enhancing crop resilience and performance against stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Soorya P. Illam, Sruthi P. Kandiyil, Achuthan C. Raghavamenon
Summary: Epigenetic mechanisms, such as DNA methylation and histone modifications, regulate gene expression and play important roles in normal growth and metabolism. Aberrant histone modifications are linked to pathological conditions and have been a focus of research. Nutri-epigenetics explores the influence of dietary compounds on epigenetics.
CURRENT DRUG TARGETS
(2021)
Article
Oncology
Margarita E. Neganova, Sergey G. Klochkov, Yulia R. Aleksandrova, Gjumrakch Aliev
Summary: Epigenetic changes associated with histone modifications are important in the emergence and maintenance of various cancer types. Inhibitors of enzymes involved in these modifications are promising for anticancer drug development. This review explores the main features of common histone modifications and their role in malignant neoplasms, discussing strategies for inhibitor development and analyzing the use of multitarget drugs as the most promising strategy.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Joana Esteves de Lima, Frederic Relaix
Summary: This passage discusses the importance of epigenetic regulation of gene expression in maintaining cell differentiation status and cellular identity, focusing on chromatin structure remodeling and changes in nucleosome composition. It emphasizes the role of histone post-translational modifications and histone variants in cell fate and differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Naoki Kamo, Tomoya Kujirai, Hitoshi Kurumizaka, Hiroshi Murakami, Gosuke Hayashi, Akimitsu Okamoto
Summary: The utilization of an air-tolerant organoruthenium catalyst has enabled a more efficient and rapid synthesis of medium-sized proteins with site-specific PTMs, as well as facilitating rapid deprotection of proteins even in the presence of excess thiol moieties. This new ruthenium chemistry approach paves the way for the preparation of a variety of biologically and medically significant proteins containing PTMs and non-natural amino acids.
Review
Microbiology
Yiman Li, Zhihui Song, Ente Wang, Liming Dong, Jie Bai, Dong Wang, Jinyan Zhu, Chao Zhang
Summary: Invasive aspergillosis is a significant cause of death in patients with hematological malignancies and transplant recipients. Antifungal drug resistance has become a concern in managing infections, and understanding histone posttranslational modifications may provide insights for developing new antifungal drugs.
FRONTIERS IN MICROBIOLOGY
(2022)
Editorial Material
Cell Biology
Christian Agatemor, Sasa Ama Dyese Middleton, Daniela Toledo
Summary: Cells utilize post-translational and post-transcription modifications as crucial mechanisms to maintain homeostasis and regulate gene transcription. Recent discoveries have shown that these modifications are more pervasive and important than previously thought.
TRENDS IN CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Melody D. Fulton, Tran Dang, Tyler Brown, Y. George Zheng
Summary: This study explores how local changes on adjacent residues in histone substrate regulate the activities of PRMT1 and PRMT5 enzymes. Phosphorylation at H4S1 inhibits the activity of both enzymes, while the presence of a positively charged H4K5 is important for PRMT1 catalysis. Acetylation of H4K5 or loss of the H4K5 epsilon-amine affects the methylation of H4R3.
Review
Biochemistry & Molecular Biology
Kwon Young Chou, Jun-Yeong Lee, Kee-Beom Kim, Eunjeong Kim, Hyun-Shik Lee, Hong-Yeoul Ryu
Summary: The budding yeast Saccharomyces cerevisiae is a widely used model system for studying histone modifications and chromatin states. Recent advances in biotechnology have allowed for the detection and quantification of protein post-translational modifications, leading to the identification of new modification sites in histones. Understanding the cellular functions of these new histone markers is crucial for unraveling epigenetic mechanisms and their impact on biological processes.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Catherine Corbel, Edith Heard
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2016)
Article
Genetics & Heredity
Tim Pollex, Edith Heard
Article
Biochemistry & Molecular Biology
Verena Mutzel, Ikuhiro Okamoto, Ilona Dunkel, Mitinori Saitou, Luca Giorgetti, Edith Heard, Edda G. Schulz
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Aurelie Bousard, Ana Claudia Raposo, Jan Jakub Zylicz, Christel Picard, Vanessa Borges Pires, Yanyan Qi, Claudia Gil, Laurene Syx, Howard Y. Chang, Edith Heard, Simao Teixeira da Rocha
Article
Biochemical Research Methods
Scott A. Ugrin, A. Michelle English, John E. P. Syka, Dina L. Bai, Lissa C. Anderson, Jeffrey Shabanowitz, Donald F. Hunt
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2019)
Review
Genetics & Heredity
Agnese Loda, Edith Heard
Article
Multidisciplinary Sciences
Antoine Graindorge, Ines Pinheiro, Anna Nawrocka, Allison C. Mallory, Peter Tsvetkov, Noa Gil, Carlo Carolis, Frank Buchholz, Igor Ulitsky, Edith Heard, Mikko Taipale, Alena Shkumatava
NATURE COMMUNICATIONS
(2019)
Correction
Multidisciplinary Sciences
Antoine Graindorge, Ines Pinheiro, Anna Nawrocka, Allison C. Mallory, Peter Tsvetkov, Noa Gil, Carlo Carolis, Frank Buchholz, Igor Ulitsky, Edith Heard, Mikko Taipale, Alena Shkumatava
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Lucile Marion-Poll, Benjamin Foret, Dina Zielinski, Florian Massip, Mikael Attia, Ava C. Carter, Laurene Syx, Howard Y. Chang, Anne-Valerie Gendrel, Edith Heard
Summary: Researchers have identified robust monoallelic expression in cell lines and mice, with some genes displaying various modalities of allelic expression and different degrees of allelic imbalance. Non-canonical allelic regulation has been found to have important implications for development and disease, including autosomal dominant disorders.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Agnese Loda, Samuel Collombet, Edith Heard
Summary: This article reviews the recent advances in understanding the mechanisms of X chromosome inactivation (XCI) and the accompanying chromosome reshaping. It discusses the genetic and epigenetic regulation underlying the initiation and maintenance of XCI, focusing on the role of XIST, the silencing of X-linked genes, and the structural changes of the inactive X chromosome.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Plant Sciences
Rodolfo Zentella, Yan Wang, Emily Zahn, Jianhong Hu, Liang Jiang, Jeffrey Shabanowitz, Donald F. Hunt, Tai-ping Sun
Summary: SPINDLY (SPY) is a nucleocytoplasmic protein O-fucosyltransferase that modulates the activity or stability of target proteins via O-fucosylation of specific Ser/Thr residues. Previous studies have shown that AtSPY plays a role in regulating plant development, circadian clock, and responses to biotic and abiotic stresses. However, the targets of AtSPY have not been well characterized.
Article
Biochemistry & Molecular Biology
Samuel Collombet, Isabell Rall, Claire Dugast-Darzacq, Alec Heckert, Aliaksandr Halavatyi, Agnes Le Saux, Gina Dailey, Xavier Darzacq, Edith Heard
Summary: The authors demonstrate that the disappearance of RNA polymerase II (RNAPII) from the inactive X chromosome territory is not caused by biophysical compartmentalization, but rather due to the loss of RNAPII bound fraction on chromatin. They show that RNAPII freely accesses the Xist territory during the initiation of X chromosome inactivation (XCI), indicating that the exclusion of RNAPII is not a consequence of physical compartmentalization. These findings highlight the importance of actively transcribing RNAPII in the regulation of gene silencing during XCI.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Edilene Siqueira, Bo-Hyun Kim, Larry Reser, Robert Chow, Kerry Delaney, Manel Esteller, Mark M. Ross, Jeffrey Shabanowitz, Donald F. Hunt, Sonia Guil, Juan Ausio
Summary: This study used a neural cell line derived from the human ventral mesencephalon, called ReNCell, and its MeCP2 knock out to investigate the changes in linker histones during neural cell differentiation. The results showed that MeCP2 played a crucial role in dendrite and axon development and exhibited extensive co-localization with linker histones. Additionally, the size of the nucleus decreased during differentiation, but the MeCP2 knock out cells showed a significant increase in nucleus size after differentiation.
Meeting Abstract
Peripheral Vascular Disease
Brandon A. Kemp, Nancy L. Howell, Susanna R. Keller, John J. Gildea, Josh D. Hinkle, Jeffrey Shabanowitz, Donald F. Hunt
Review
Biotechnology & Applied Microbiology
Luca Giorgetti, Edith Heard