Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

Overexpression of POLQ Confers a Poor Prognosis in Early Breast Cancer Patients

(2015)   Oncotarget

Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans

(2014) S. F. Roerink et al.   GENOME RESEARCH

RPA antagonizes microhomology-mediated repair of DNA double-strand breaks

(2014) Sarah K Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A role for DNA polymerase θ in the timing of DNA replication

(2014) Anne Fernandez-Vidal et al.   Nature Communications

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites

(2014) Wouter Koole et al.   Nature Communications

Nucleosome Acidic Patch Promotes RNF168- and RING1B/BMI1-Dependent H2AX and H2A Ubiquitination and DNA Damage Signaling

(2014) Justin W. Leung et al.   PLoS Genetics

RPA Coordinates DNA End Resection and Prevents Formation of DNA Hairpins

(2013) Huan Chen et al.   MOLECULAR CELL

A two-step mechanism for TRF2-mediated chromosome-end protection

(2013) Keiji Okamoto et al.   NATURE

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells

(2013) Ranjit S. Bindra et al.   NUCLEIC ACIDS RESEARCH

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells

(2013) L. N. Truong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered proteins detect spontaneous DNA breakage in human and bacterial cells

(2013) Chandan Shee et al.   eLife

Telomeres at a glance

(2012) A. Sfeir   JOURNAL OF CELL SCIENCE

Removal of Shelterin Reveals the Telomere End-Protection Problem

(2012) A. Sfeir et al.   SCIENCE

Tracking genome engineering outcome at individual DNA breakpoints

(2011) Michael T Certo et al.   NATURE METHODS

Promiscuous DNA synthesis by human DNA polymerase θ

(2011) Matthew Hogg et al.   NUCLEIC ACIDS RESEARCH

DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

(2011) Deniz Simsek et al.   PLoS Genetics

The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres

(2010) Rekha Rai et al.   EMBO JOURNAL

Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4–ligase IV during chromosomal translocation formation

(2010) Deniz Simsek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA polymerase   up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

(2010) F. Lemee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal

(2010) A. Sfeir et al.   SCIENCE

Dual Roles for DNA Polymerase Theta in Alternative End-Joining Repair of Double-Strand Breaks in Drosophila

(2010) Sze Ham Chan et al.   PLoS Genetics

Human DNA polymerase   possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro

(2009) R. Prasad et al.   NUCLEIC ACIDS RESEARCH

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

(2008) Wataru Sakai et al.   NATURE

Low-fidelity DNA synthesis by human DNA polymerase theta

(2008) M. E. Arana et al.   NUCLEIC ACIDS RESEARCH