Histone variant macroH2A: from chromatin deposition to molecular function

The Role of Phase Separation in Heterochromatin Formation, Function, and Regulation

(2018) Adam G. Larson et al.   BIOCHEMISTRY

Induction of cancer cell stemness by depletion of macrohistone H2A1 in hepatocellular carcinoma

(2018) Oriana Lo Re et al.   HEPATOLOGY

Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions

(2018) Jeongkyu Kim et al.   MOLECULAR CELL

MacroH2A1.2 inhibits prostate cancer-induced osteoclastogenesis through cooperation with HP1α and H1.2

(2018) Jin-Man Kim et al.   ONCOGENE

Three-dimensional Epigenome Statistical Model: Genome-wide Chromatin Looping Prediction

(2018) Ziad Al Bkhetan et al.   Scientific Reports

Regulation of Breast Cancer-Induced Osteoclastogenesis by MacroH2A1.2 Involving EZH2-Mediated H3K27me3

(2018) Jinman Kim et al.   Cell Reports

MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms

(2018) Marek Kozlowski et al.   EMBO REPORTS

Transcription-associated histone pruning demarcates macroH2A chromatin domains

(2018) Zhen Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MacroH2A1 chromatin specification requires its docking domain and acetylation of H2B lysine 20

(2018) Penelope D. Ruiz et al.   Nature Communications

The MacroH2A1.1 – PARP1 Axis at the Intersection Between Stress Response and Metabolism

(2018) Sarah Hurtado-Bagès et al.   Frontiers in Genetics

MacroH2A histone variants maintain nuclear organization and heterochromatin architecture

(2017) Julien Douet et al.   JOURNAL OF CELL SCIENCE

Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene

(2017) Barbara Fontanals-Cirera et al.   MOLECULAR CELL

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

Variants of core histones and their roles in cell fate decisions, development and cancer

(2017) Marcus Buschbeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone chaperone networks shaping chromatin function

(2017) Colin M. Hammond et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption

(2017) Melanija Posavec Marjanović et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The histone variant macroH2A confers functional robustness to the intestinal stem cell compartment

(2017) Ryan James Cedeno et al.   PLoS One

MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption

(2017) Melanija Posavec Marjanović et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate

(2017) Beom-Jun Kim et al.   Cell Reports

Histone MacroH2A1: A Chromatin Point of Intersection between Fasting, Senescence and Cellular Regeneration

(2017) Oriana Lo Re et al.   Genes

Cellular Metabolism and Induced Pluripotency

(2016) Jun Wu et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

The characterization of macroH2A beyond vertebrates supports an ancestral origin and conserved role for histone variants in chromatin

(2016) Ciro Rivera-Casas et al.   Epigenetics

Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome

(2016) Alexey A. Soshnev et al.   MOLECULAR CELL

Histone variants on the move: substrates for chromatin dynamics

(2016) Paul B. Talbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation

(2016) B. A. Gibson et al.   SCIENCE

The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1

(2016) Stefania Dell’Orso et al.   Cell Reports

SIRT1-metabolite binding histone macroH2A1.1 protects hepatocytes against lipid accumulation

(2016) Valerio Pazienza et al.   Aging-US

The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3' processing

(2015) K.-i. Abe et al.   EMBO JOURNAL

Histone H3.3 maintains genome integrity during mammalian development

(2015) Chuan-Wei Jang et al.   GENES & DEVELOPMENT

Loss of histone variant macroH2A2 expression associates with progression of anal neoplasm

(2015) Wan-Hsiang Hu et al.   JOURNAL OF CLINICAL PATHOLOGY

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype

(2015) Hongshan Chen et al.   MOLECULAR CELL

The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations

(2015) Célia Jeronimo et al.   MOLECULAR CELL

Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma

(2015) Chiara Vardabasso et al.   MOLECULAR CELL

MacroH2A1 downregulation enhances the stem-like properties of bladder cancer cells by transactivation of Lin28B

(2015) S-J Park et al.   ONCOGENE

Skp2–MacroH2A1–CDK8 axis orchestrates G2/M transition and tumorigenesis

(2015) Dazhi Xu et al.   Nature Communications

Composite macroH2A/NRF-1 Nucleosomes Suppress Noise and Generate Robustness in Gene Expression

(2015) Matthieu D. Lavigne et al.   Cell Reports

MacroH2A1 associates with nuclear lamina and maintains chromatin architecture in mouse liver cells

(2015) Yuhua Fu et al.   Scientific Reports

The Histone Variant H2A.W Defines Heterochromatin and Promotes Chromatin Condensation in Arabidopsis

(2014) Ramesh Yelagandula et al.   CELL

Histone variants: dynamic punctuation in transcription

(2014) C. M. Weber et al.   GENES & DEVELOPMENT

Genetic ablation of macrohistone H2A1 leads to increased leanness, glucose tolerance and energy expenditure in mice fed a high-fat diet

(2014) F Sheedfar et al.   INTERNATIONAL JOURNAL OF OBESITY

Mice without MacroH2A Histone Variants

(2014) J. R. Pehrson et al.   MOLECULAR AND CELLULAR BIOLOGY

MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation

(2014) Hongshan Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The histone variant H2A.Bbd is enriched at sites of DNA synthesis

(2014) Viola Sansoni et al.   NUCLEIC ACIDS RESEARCH

Histone variant H3.3 is an essential maternal factor for oocyte reprogramming

(2014) D. Wen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Macrohistone Variant Links Dynamic Chromatin Compaction to BRCA1-Dependent Genome Maintenance

(2014) Simran Khurana et al.   Cell Reports

A System for Genome-Wide Histone Variant Dynamics In ES Cells Reveals Dynamic MacroH2A2 Replacement at Promoters

(2014) Ozlem Yildirim et al.   PLoS Genetics

Histone variants: emerging players in cancer biology

(2013) Chiara Vardabasso et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Macro Histone Variants Are Critical for the Differentiation of Human Pluripotent Cells

(2013) María J. Barrero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

macroH2A1 histone variant represses rDNA transcription

(2013) Rong Cong et al.   NUCLEIC ACIDS RESEARCH

MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency

(2013) Alexandre Gaspar-Maia et al.   Nature Communications

Macrohistone Variants Preserve Cell Identity by Preventing the Gain of H3K4me2 during Reprogramming to Pluripotency

(2013) María J. Barrero et al.   Cell Reports

The histone variant MacroH2A regulates Ca2+ influx through TRPC3 and TRPC6 channels

(2013) J-M Kim et al.   Oncogenesis

Differential Regulation and Predictive Potential of MacroH2A1 Isoforms in Colon Cancer

(2012) Judith C. Sporn et al.   AMERICAN JOURNAL OF PATHOLOGY

The histone variant macroH2A1.1 is recruited to DSBs through a mechanism involving PARP1

(2012) Chang Xu et al.   FEBS LETTERS

ATRX-mediated chromatin association of histone variant macroH2A1 regulates  -globin expression

(2012) K. Ratnakumar et al.   GENES & DEVELOPMENT

Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency

(2012) V. Pasque et al.   JOURNAL OF CELL SCIENCE

MacroH2A1 Regulates the Balance between Self-Renewal and Differentiation Commitment in Embryonic and Adult Stem Cells

(2012) C. Creppe et al.   MOLECULAR AND CELLULAR BIOLOGY

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness

(2012) Etienne Dardenne et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The basic linker of macroH2A stabilizes DNA at the entry/exit site of the nucleosome

(2012) Srinivas Chakravarthy et al.   NUCLEIC ACIDS RESEARCH

Epigenetic stability of repressed states involving the histone variant macroH2A revealed by nuclear transfer to Xenopus oocytes

(2012) Vincent Pasque et al.   Nucleus

Histone variant macroH2A confers resistance to nuclear reprogramming

(2011) Vincent Pasque et al.   EMBO JOURNAL

The Linker Region of MacroH2A Promotes Self-association of Nucleosomal Arrays

(2011) Uma M. Muthurajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

QKI-Mediated Alternative Splicing of the Histone Variant MacroH2A1 Regulates Cancer Cell Proliferation

(2011) L. Novikov et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA Repair Factor APLF Is a Histone Chaperone

(2011) Pawan Vinod Mehrotra et al.   MOLECULAR CELL

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation

(2011) Anton Wutz   NATURE REVIEWS GENETICS

X Chromosome Inactivation and Differentiation Occur Readily in ES Cells Doubly-Deficient for MacroH2A1 and MacroH2A2

(2011) Borko Tanasijevic et al.   PLoS One

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

Multiple facets of the unique histone variant macroH2A: From genomics to cell biology

(2010) Matthew J. Gamble et al.   CELL CYCLE

Rapid Elimination of the Histone Variant MacroH2A from Somatic Cell Heterochromatin after Nuclear Transfer

(2010) Ching-Chien Chang et al.   Cellular Reprogramming

Changes in the nuclear deposition of histone H2A variants during pre-implantation development in mice

(2010) B. Nashun et al.   DEVELOPMENT

Approaching the molecular and physiological function of macroH2A variants

(2010) Marcus Buschbeck et al.   Epigenetics

Genome-Wide Distribution of MacroH2A1 Histone Variants in Mouse Liver Chromatin

(2010) L. N. Changolkar et al.   MOLECULAR AND CELLULAR BIOLOGY

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

(2010) Avnish Kapoor et al.   NATURE

Histone variant macroH2A1 deletion in mice causes female-specific steatosis

(2010) Mathieu Boulard et al.   Epigenetics & Chromatin

The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing

(2009) M. J. Gamble et al.   GENES & DEVELOPMENT

Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones

(2009) Mitsuru Okuwaki et al.   GENES TO CELLS

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

(2009) Gyula Timinszky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The histone variant macroH2A is an epigenetic regulator of key developmental genes

(2009) Marcus Buschbeck et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone macroH2A isoforms predict the risk of lung cancer recurrence

(2009) J C Sporn et al.   ONCOGENE

MacroH2A Allows ATP-Dependent Chromatin Remodeling by SWI/SNF and ACF Complexes but Specifically Reduces Recruitment of SWI/SNF†

(2008) Evelyn Y. Chang et al.   BIOCHEMISTRY

Weak but Uniform Enrichment of the Histone Variant macroH2A1 along the Inactive X Chromosome

(2008) F. Mietton et al.   MOLECULAR AND CELLULAR BIOLOGY

macroH2A1-Dependent Silencing of Endogenous Murine Leukemia Viruses

(2008) L. N. Changolkar et al.   MOLECULAR AND CELLULAR BIOLOGY

FACT-Mediated Exchange of Histone Variant H2AX Regulated by Phosphorylation of H2AX and ADP-Ribosylation of Spt16

(2008) Kyu Heo et al.   MOLECULAR CELL

A phosphorylated subpopulation of the histone variant macroH2A1 is excluded from the inactive X chromosome and enriched during mitosis

(2008) E. Bernstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA