Desaturases and elongases involved in long-chain polyunsaturated fatty acid biosynthesis in aquatic animals: From genes to functions

Biosynthesis of LC-PUFAs and VLC-PUFAs in Pampus argenteus: Characterization of Elovl4 Elongases and Regulation under Acute Salinity

(2021) Jiaxiang Luo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Lipid nutritional quality of marine and freshwater bivalves and their aquaculture potential

(2021) Karsoon Tan et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Trophic upgrading of long-chain polyunsaturated fatty acids by polychaetes: a stable isotope approach using Alitta virens

(2021) Supanut Pairohakul et al.   MARINE BIOLOGY

Biosynthesis of Long-Chain Polyunsaturated Fatty Acids in Marine Gammarids: Molecular Cloning and Functional Characterisation of Three Fatty Acyl Elongases

(2021) Alberto Ribes-Navarro et al.   Marine Drugs

Regulation of long-chain polyunsaturated fatty acid biosynthesis in teleost fish

(2021) Dizhi Xie et al.   PROGRESS IN LIPID RESEARCH

A complete enzymatic capacity for biosynthesis of docosahexaenoic acid (DHA, 22 : 6n–3) exists in the marine Harpacticoida copepod Tigriopus californicus

(2021) Naoki Kabeya et al.   Open Biology

Lack of support for Deuterostomia prompts reinterpretation of the first Bilateria

(2021) Paschalia Kapli et al.   Science Advances

The evolutionary ecology of fatty‐acid variation: Implications for consumer adaptation and diversification

(2021) Cornelia W. Twining et al.   ECOLOGY LETTERS

Lack of ∆5 Desaturase Activity Impairs EPA and DHA Synthesis in Fish Cells from Red Sea Bream and Japanese Flounder

(2021) Hayato Nyunoya et al.   MARINE BIOTECHNOLOGY

The structural basis of fatty acid elongation by the ELOVL elongases

(2021) Laiyin Nie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Potential modulatory mechanisms of action by long-chain polyunsaturated fatty acids on bone cell and chondrocyte metabolism

(2021) Maryam Abshirini et al.   PROGRESS IN LIPID RESEARCH

Reconstruction of proto-vertebrate, proto-cyclostome and proto-gnathostome genomes provides new insights into early vertebrate evolution

(2021) Yoichiro Nakatani et al.   Nature Communications

Evolution and Functional Characteristics of the Novel elovl8 That Play Pivotal Roles in Fatty Acid Biosynthesis

(2021) Shouxiang Sun et al.   Genes

The Malaysian Mahseer, Tor tambroides possess all required biosynthesis enzymes for the conversion of C18 polyunsaturated fatty acids to long-chain polyunsaturated fatty acids

(2021) Ka-Kei Sam et al.   AQUACULTURE

Widespread patterns of gene loss in the evolution of the animal kingdom

(2020) Cristina Guijarro-Clarke et al.   Nature Ecology & Evolution

A comparative study of food selectivity of the benthic copepod Tigriopus japonicus and the pelagic copepod Paracyclopina nana: A genome-wide identification of fatty acid conversion genes and nitrogen isotope investigation

(2020) Min-Chul Lee et al.   AQUACULTURE

Genome wide identification and functional characterization of two LC-PUFA biosynthesis elongase (elovl8) genes in rabbitfish (Siganus canaliculatus)

(2020) Yang Li et al.   AQUACULTURE

Cloning and functional characterization of an elovl4-like gene involved in the biosynthesis of long-chain polyunsaturated fatty acids in the swimming crab Portunus trituberculatus

(2020) Peng Sun et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular and Functional Characterization of Elovl4 Genes in Sparus aurata and Solea senegalensis Pointing to a Critical Role in Very Long-Chain (>C24) Fatty Acid Synthesis during Early Neural Development of Fish

(2020) Sofia Morais et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Two Elongases, Elovl4 and Elovl6, Fulfill the Elongation Routes of the LC-PUFA Biosynthesis Pathway in the Orange Mud Crab (Scylla olivacea)

(2020) Seng Yeat Ting et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Functional characterisation of fatty acyl desaturase, Fads2, and elongase, Elovl5, in the Boddart's goggle‐eyed goby Boleophthalmus boddarti (Gobiidae) suggests an incapacity for long‐chain polyunsaturated fatty acid biosynthesis

(2020) Han‐Jie Soo et al.   JOURNAL OF FISH BIOLOGY

Omega-3 microbial oils from marine thraustochytrids as a sustainable and technological solution: A review and patent landscape

(2020) Brigitte Sthepani Orozco Colonia et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

fat-1 transgenic zebrafish are protected from abnormal lipid deposition induced by high-vegetable oil feeding

(2020) Shouxiang Sun et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Lipid metabolism in Tinca tinca and its n-3 LC-PUFA biosynthesis capacity

(2020) D. Garrido et al.   AQUACULTURE

The fatty acid elongation genes elovl4a and elovl4b are present and functional in the genome of tambaqui (Colossoma macropomum)

(2020) Renato B. Ferraz et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Unique fatty acid desaturase capacities uncovered in Hediste diversicolor illustrate the roles of aquatic invertebrates in trophic upgrading

(2020) Naoki Kabeya et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Fatty acid bioconversion in harpacticoid copepods in a changing environment: a transcriptomic approach

(2020) Jens Boyen et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Molecular mechanisms for biosynthesis and assembly of nutritionally important very long chain polyunsaturated fatty acids in microorganisms

(2020) Xiao Qiu et al.   PROGRESS IN LIPID RESEARCH

Functional kleptoplasts intermediate incorporation of carbon and nitrogen in cells of the Sacoglossa sea slug Elysia viridis

(2020) Sónia Cruz et al.   Scientific Reports

Complete repertoire of long‐chain polyunsaturated fatty acids biosynthesis enzymes in a cyprinid, silver barb ( Barbonymus gonionotus ): Cloning, functional characterization and dietary regulation of Elovl2 and Elovl4

(2020) Manogoran Janaranjani et al.   AQUACULTURE NUTRITION

Integrated transcriptome and phosphoproteome analyses reveal that fads2 is critical for maintaining body LC-PUFA homeostasis

(2020) Yan Zhao et al.   Journal of Proteomics

Elovl2 But Not Elovl5 Is Essential for the Biosynthesis of Docosahexaenoic Acid (DHA) in Zebrafish: Insight from a Comparative Gene Knockout Study

(2020) Chengjie Liu et al.   MARINE BIOTECHNOLOGY

Flatfishes colonised freshwater environments by acquisition of various DHA biosynthetic pathways

(2020) Yoshiyuki Matsushita et al.   Communications Biology

Identification of new, very long-chain polyunsaturated fatty acids in fish by gas chromatography coupled to quadrupole/time-of-flight mass spectrometry with atmospheric pressure chemical ionization

(2020) Roque Serrano et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Polyunsaturated fatty acid metabolism in three fish species with different trophic level

(2020) A. Galindo et al.   AQUACULTURE

Targeted mutagenesis of ∆5 and ∆6 fatty acyl desaturases induce dysregulation of lipid metabolism in Atlantic salmon (Salmo salar)

(2020) Yang Jin et al.   BMC GENOMICS

Towards understanding the origin of animal development

(2020) Iñaki Ruiz-Trillo et al.   DEVELOPMENT

Elovl2 Is Required for Robust Visual Function in Zebrafish

(2020) Manish Dasyani et al.   Cells

A New Spiralian Phylogeny Places the Enigmatic Arrow Worms among Gnathiferans

(2019) Ferdinand Marlétaz et al.   CURRENT BIOLOGY

Omega-3 Long-Chain Polyunsaturated Fatty Acids, EPA and DHA: Bridging the Gap between Supply and Demand

(2019) Douglas Tocher et al.   Nutrients

Editorial

(2019) Philip C. Calder et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Presence or absence? Primary structure, regioselectivity and evolution of Δ12/ω3 fatty acid desaturases in nematodes

(2019) Ralph Menzel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Molecular cloning and functional characterization of elongase (elovl5) and fatty acyl desaturase (fads2) in sciaenid, Nibea diacanthus (Lacepède, 1802)

(2019) Weiguang Zou et al.   GENE

Molecular cloning, phylogenetic analysis and functional characterisation of an Elovl7-like elongase from a marine crustacean, the orange mud crab (Scylla olivacea)

(2019) Min-Qian Mah et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

You are not always what you eat—Fatty acid bioconversion and lipid homeostasis in the larvae of the sand mason worm Lanice conchilega

(2019) Rita M. Franco-Santos et al.   PLoS One

A key metabolic gene for recurrent freshwater colonization and radiation in fishes

(2019) Asano Ishikawa et al.   SCIENCE

Functional diversification of teleost Fads2 fatty acyl desaturases occurs independently of the trophic level

(2019) Diego Garrido et al.   Scientific Reports

CRISPR/Cas9-mediated ablation of elovl2 in Atlantic salmon (Salmo salar L.) inhibits elongation of polyunsaturated fatty acids and induces Srebp-1 and target genes

(2019) Alex K. Datsomor et al.   Scientific Reports

Molecular cloning, functional characterization and nutritional regulation of two elovl4b elongases from rainbow trout (Oncorhynchus mykiss)

(2019) Nannan Zhao et al.   AQUACULTURE

Biosynthesis of long-chain polyunsaturated fatty acids in the razor clam Sinonovacula constricta: Characterization of four fatty acyl elongases and a novel desaturase capacity

(2019) Zhaoshou Ran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Methyl-end desaturases with ∆12 and ω3 regioselectivities enable the de novo PUFA biosynthesis in the cephalopod Octopus vulgaris

(2019) Diego Garrido et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Novel Cellular Functions of Very Long Chain-Fatty Acids: Insight From ELOVL4 Mutations

(2019) Ferenc Deák et al.   Frontiers in Cellular Neuroscience

CRISPR/Cas9-mediated editing of Δ5 and Δ6 desaturases impairs Δ8-desaturation and docosahexaenoic acid synthesis in Atlantic salmon (Salmo salar L.)

(2019) Alex K. Datsomor et al.   Scientific Reports

Molecular and functional characterisation of a putative elovl4 gene and its expression in response to dietary fatty acid profile in Atlantic bluefin tuna (Thunnus thynnus)

(2019) Mónica B. Betancor et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

The catadromous teleost Anguilla japonica has a complete enzymatic repertoire for the biosynthesis of docosahexaenoic acid from α-linolenic acid: Cloning and functional characterization of an Elovl2 elongase

(2019) Wenju Xu et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Essential fatty acid metabolism and requirements of the cleaner fish, ballan wrasse Labrus bergylta : Defining pathways of long-chain polyunsaturated fatty acid biosynthesis

(2018) Naoki Kabeya et al.   AQUACULTURE

Molecular cloning, tissue expression and regulation of nutrition and temperature on Δ6 fatty acyl desaturase-like gene in the red claw crayfish ( Cherax quadricarinatus )

(2018) Dong-Lei Wu et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Biosynthesis of Polyunsaturated Fatty Acids in the Razor Clam Sinonovacula constricta: Characterization of Δ5 and Δ6 Fatty Acid Desaturases

(2018) Zhaoshou Ran et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Reconstruction of the ancestral metazoan genome reveals an increase in genomic novelty

(2018) Jordi Paps et al.   Nature Communications

Insights into the phylogenetic and molecular evolutionary histories of Fad and Elovl gene families in Actiniaria

(2018) Joachim M. Surm et al.   Ecology and Evolution

Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals

(2018) Naoki Kabeya et al.   Science Advances

Capacity for eicosapentaenoic acid and arachidonic acid biosynthesis in silver barb (Barbonymus gonionotus): Functional characterisation of a Δ6/Δ8/Δ5 Fads2 desaturase and Elovl5 elongase

(2018) M. Janaranjani et al.   AQUACULTURE

Desaturases and elongases involved in polyunsaturated fatty acid biosynthesis in aquatic invertebrates: a comprehensive review

(2018) Óscar Monroig et al.   FISHERIES SCIENCE

Long-chain polyunsaturated fatty acid biosynthesis and its response to cadmium exposure in silver pomfret

(2018) Kai Liao et al.   AQUATIC TOXICOLOGY

Retention of fatty acyl desaturase 1 (fads1) in Elopomorpha and Cyclostomata provides novel insights into the evolution of long-chain polyunsaturated fatty acid biosynthesis in vertebrates

(2018) Mónica Lopes-Marques et al.   BMC EVOLUTIONARY BIOLOGY

A complete enzymatic capacity for long-chain polyunsaturated fatty acid biosynthesis is present in the Amazonian teleost tambaqui, Colossoma macropomum

(2018) Renato B. Ferraz et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

“Out of the Can”: A Draft Genome Assembly, Liver Transcriptome, and Nutrigenomics of the European Sardine, Sardina pilchardus

(2018) André Machado et al.   Genes

Lipidomics of the sea sponge Amphimedon queenslandica and implication for biomarker geochemistry

(2017) D. A. Gold et al.   Geobiology

The Expression of the Δ6 Fatty Acyl Desaturase-Like Gene from Pacific White Shrimp (Litopenaeus vannamei) Under Different Salinities and Dietary Lipid Compositions

(2017) Ke Chen et al.   JOURNAL OF SHELLFISH RESEARCH

Determination of Substrate Preferences for Desaturases and Elongases for Production of Docosahexaenoic Acid from Oleic Acid in Engineered Canola

(2017) Jenny Lindberg Yilmaz et al.   LIPIDS

Elongation of very Long-Chain (>C24) Fatty Acids in Clarias gariepinus: Cloning, Functional Characterization and Tissue Expression of elovl4 Elongases

(2017) Angela Oboh et al.   LIPIDS

Fatty acid recovery after starvation: insights into the fatty acid conversion capabilities of a benthic copepod (Copepoda, Harpacticoida)

(2017) Eva Werbrouck et al.   MARINE BIOLOGY

A Novel ω3-Desaturase in the Deep Sea Giant Tubeworm Riftia pachyptila

(2017) Helu Liu et al.   MARINE BIOTECHNOLOGY

Biosynthesis of Polyunsaturated Fatty Acids in Sea Urchins: Molecular and Functional Characterisation of Three Fatty Acyl Desaturases from Paracentrotus lividus (Lamark 1816)

(2017) Naoki Kabeya et al.   PLoS One

The FAD2 Gene in Plants: Occurrence, Regulation, and Role

(2017) Aejaz A. Dar et al.   Frontiers in Plant Science

Two alternative pathways for docosahexaenoic acid (DHA, 22:6n-3) biosynthesis are widespread among teleost fish

(2017) Angela Oboh et al.   Scientific Reports

Biosynthesis of long-chain polyunsaturated fatty acids in the African catfish Clarias gariepinus: Molecular cloning and functional characterisation of fatty acyl desaturase (fads2) and elongase (elovl2) cDNAs7

(2016) Angela Oboh et al.   AQUACULTURE

In vivo metabolism of unsaturated fatty acids in Sepia officinalis hatchlings

(2016) D.B. Reis et al.   AQUACULTURE

A fatty acyl desaturase ( fads2 ) with dual Δ6 and Δ5 activities from the freshwater carnivorous striped snakehead Channa striata

(2016) Meng-Kiat Kuah et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Long-chain polyunsaturated fatty acid biosynthesis in the euryhaline herbivorous teleost Scatophagus argus: Functional characterization, tissue expression and nutritional regulation of two fatty acyl elongases

(2016) Dizhi Xie et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Cloning and functional characterization of Δ6 fatty acid desaturase (FADS2) in Eurasian perch (Perca fluviatilis)

(2016) F. Geay et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Production and use of two marine zooplanktons, Tigriopus japonicus and Diaphanosoma celebensis, as live food for red sea bream Pagrus major larvae

(2016) Atsushi Hagiwara et al.   FISHERIES SCIENCE

Cloning, expression and functional characterization of the polyunsaturated fatty acid elongase ( ELOVL5 ) gene from sea cucumber ( Apostichopus japonicus )

(2016) Wenxia Li et al.   GENE

Isolation and Functional Characterisation of a fads2 in Rainbow Trout (Oncorhynchus mykiss) with Δ5 Desaturase Activity

(2016) Noor Khalidah Abdul Hamid et al.   PLoS One

Long-chain polyunsaturated fatty acid biosynthesis in chordates: Insights into the evolution of Fads and Elovl gene repertoire

(2016) L. Filipe C. Castro et al.   PROGRESS IN LIPID RESEARCH

Evolutionary functional elaboration of the Elovl2/5 gene family in chordates

(2016) Óscar Monroig et al.   Scientific Reports

Impact of sustainable feeds on omega-3 long-chain fatty acid levels in farmed Atlantic salmon, 2006–2015

(2016) M. Sprague et al.   Scientific Reports

Omega-3 long-chain polyunsaturated fatty acids and aquaculture in perspective

(2015) Douglas R. Tocher   AQUACULTURE

Transgenic modification of the n-3 HUFA biosynthetic pathway in nibe croaker larvae: improved DPA (docosapentaenoic acid; 22:5n-3) production

(2015) N. Kabeya et al.   AQUACULTURE NUTRITION

Molecular cloning and functional characterization of a putative Elovl4 gene and its expression in response to dietary fatty acid profiles in orange-spotted grouper Epinephelus coioides

(2015) Songlin Li et al.   AQUACULTURE RESEARCH

The capacity for long-chain polyunsaturated fatty acid synthesis in a carnivorous vertebrate: Functional characterisation and nutritional regulation of a Fads2 fatty acyl desaturase with Δ4 activity and an Elovl5 elongase in striped snakehead (Channa striata)

(2015) Meng-Kiat Kuah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Polyunsaturated fatty acid metabolism in a marine teleost, Nibe croaker Nibea mitsukurii: Functional characterization of Fads2 desaturase and Elovl5 and Elovl4 elongases

(2015) Naoki Kabeya et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Production, distribution, and abundance of long-chain omega-3 polyunsaturated fatty acids: a fundamental dichotomy between freshwater and terrestrial ecosystems

(2015) Stefanie M. Hixson et al.   ENVIRONMENTAL REVIEWS

Evo-devo of non-bilaterian animals

(2015) Emilio Lanna   GENETICS AND MOLECULAR BIOLOGY

X-ray structure of a mammalian stearoyl-CoA desaturase

(2015) Yonghong Bai et al.   NATURE

The octopus genome and the evolution of cephalopod neural and morphological novelties

(2015) Caroline B. Albertin et al.   NATURE

Crystal structure of human stearoyl–coenzyme A desaturase in complex with substrate

(2015) Hui Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain?

(2015) Anthony F. Domenichiello et al.   PROGRESS IN LIPID RESEARCH

Production, distribution, and abundance of long-chain omega-3 polyunsaturated fatty acids: a fundamental dichotomy between freshwater and terrestrial ecosystems

(2015) Stefanie M. Hixson et al.   ENVIRONMENTAL REVIEWS

Crystal structure of human stearoyl–coenzyme A desaturase in complex with substrate

(2015) Hui Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comparative Analysis and Distribution of Omega-3 lcPUFA Biosynthesis Genes in Marine Molluscs

(2015) Joachim M. Surm et al.   PLoS One

Investigating long-chain polyunsaturated fatty acid biosynthesis in teleost fish: Functional characterization of fatty acyl desaturase (Fads2) and Elovl5 elongase in the catadromous species, Japanese eel Anguilla japonica

(2014) Shuqi Wang et al.   AQUACULTURE

Characterization, mRNA expression and regulation of Δ6 fatty acyl desaturase (FADS2) by dietary n−3 long chain polyunsaturated fatty acid (LC-PUFA) levels in grouper larvae (Epinephelus coioides)

(2014) Songlin Li et al.   AQUACULTURE

In vivo metabolism of unsaturated fatty acids in Octopus vulgaris hatchlings determined by incubation with 14C-labelled fatty acids added directly to seawater as protein complexes

(2014) D.B. Reis et al.   AQUACULTURE

Rainbow trout (Oncorhynchus mykiss) Elovl5 and Elovl2 differ in selectivity for elongation of omega-3 docosapentaenoic acid

(2014) Melissa K. Gregory et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Nutritional quality of salmon products available from major retailers in the UK: content and composition of n-3 long-chain PUFA

(2014) João Henriques et al.   BRITISH JOURNAL OF NUTRITION

Unexpected functional diversity in the fatty acid desaturases of the flour beetle Tribolium castaneum and identification of key residues determining activity

(2014) Victoria S. Haritos et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

PUFA Biosynthesis Pathway in Marine Scallop Chlamys nobilis Reeve

(2014) Helu Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Modification of the n-3 HUFA biosynthetic pathway by transgenesis in a marine teleost, nibe croaker

(2014) Naoki Kabeya et al.   JOURNAL OF BIOTECHNOLOGY

Diversification of substrate specificities in teleostei Fads2: characterization of Δ4 and Δ6Δ5 desaturases ofChirostoma estor

(2014) Jorge Fonseca-Madrigal et al.   JOURNAL OF LIPID RESEARCH

Four Amino Acid Residues Influence the Substrate Chain-Length and Regioselectivity of Siganus canaliculatus Δ4 and Δ5/6 Desaturases

(2014) Ze Long Lim et al.   LIPIDS

Double Transgenesis of Humanized fat1 and fat2 Genes Promotes Omega-3 Polyunsaturated Fatty Acids Synthesis in a Zebrafish Model

(2014) Shao-Chen Pang et al.   MARINE BIOTECHNOLOGY

Functional characterization of a Δ5-like fatty acyl desaturase and its expression during early embryogenesis in the noble scallop Chlamys nobilis Reeve

(2014) Helu Liu et al.   MOLECULAR BIOLOGY REPORTS

Diversity of fatty acid composition of symbiotic dinoflagellates in corals: Evidence for the transfer of host PUFAs to the symbionts

(2014) Andrey B. Imbs et al.   PHYTOCHEMISTRY

Hydrostatic Pressure and Temperature Effects on the Membranes of a Seasonally Migrating Marine Copepod

(2014) David W. Pond et al.   PLoS One

Interaction of diet and the masou salmon Δ5-desaturase transgene on Δ6-desaturase and stearoyl-CoA desaturase gene expression and N-3 fatty acid level in common carp (Cyprinus carpio)

(2014) Qi Cheng et al.   TRANSGENIC RESEARCH

The rainbow trout genome provides novel insights into evolution after whole-genome duplication in vertebrates

(2014) Camille Berthelot et al.   Nature Communications

ω3 fatty acid desaturases from microorganisms: structure, function, evolution, and biotechnological use

(2013) Mingxuan Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Cloning and functional characterization of a polyunsaturated fatty acid elongase in a marine bivalve noble scallop Chlamys nobilis Reeve

(2013) Helu Liu et al.   AQUACULTURE

Characterization of two Δ5 fatty acyl desaturases in abalone (Haliotis discus hannai Ino)

(2013) Mingzhu Li et al.   AQUACULTURE

Functional characterisation of a Fads2 fatty acyl desaturase with Δ6/Δ8 activity and an Elovl5 with C16, C18 and C20 elongase activity in the anadromous teleost meagre (Argyrosomus regius)

(2013) Óscar Monroig et al.   AQUACULTURE

An evolutionary perspective on Elovl5 fatty acid elongase: comparison of Northern pike and duplicated paralogs from Atlantic salmon

(2013) Greta Carmona-Antoñanzas et al.   BMC EVOLUTIONARY BIOLOGY

Functional Characterization of Polyunsaturated Fatty Acid Delta 6-Desaturase and Elongase Genes from the Black Seabream (Acanthopagrus schlegelii)

(2013) Sun Hee Kim et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Cloning and tissue distribution of a fatty acyl Δ6-desaturase-like gene and effects of dietary lipid levels on its expression in the hepatopancreas of Chinese mitten crab (Eriocheir sinensis)

(2013) Zhigang Yang et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Characterization of fatty acid delta-6 desaturase gene in Nile tilapia and heterogenous expression in Saccharomyces cerevisiae

(2013) Supamas Tanomman et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Two Δ6-desaturase-like genes in common carp (Cyprinus carpio var. Jian): Structure characterization, mRNA expression, temperature and nutritional regulation

(2013) Hong-tao Ren et al.   GENE

Biosynthesis of Polyunsaturated Fatty Acids in Marine Invertebrates: Recent Advances in Molecular Mechanisms

(2013) Óscar Monroig et al.   Marine Drugs

Biosynthesis of essential fatty acids in Octopus vulgaris (Cuvier, 1797): Molecular cloning, functional characterisation and tissue distribution of a fatty acyl elongase

(2012) Óscar Monroig et al.   AQUACULTURE

Elongation of long-chain fatty acids in rabbitfish Siganus canaliculatus: Cloning, functional characterisation and tissue distribution of Elovl5- and Elovl4-like elongases

(2012) Óscar Monroig et al.   AQUACULTURE

An alternative n-3 fatty acid elongation pathway utilising 18:3n-3 in barramundi (Lates calcarifer)

(2012) Wei-Chun Tu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Long chain polyunsaturated fatty acid synthesis in a marine vertebrate: Ontogenetic and nutritional regulation of a fatty acyl desaturase with Δ4 activity

(2012) Sofia Morais et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Barramundi (Lates calcarifer) desaturase with Δ6/Δ8 dual activities

(2012) Wei-Chun Tu et al.   BIOTECHNOLOGY LETTERS

Lipid class and fatty acid composition of copepods (Calanus finmarchicus, C. glacialis, Pseudocalanus sp., Tisbe furcata and Nitokra lacustris) fed various combinations of autotrophic and heterotrophic protists

(2012) C. C. Parrish et al.   JOURNAL OF PLANKTON RESEARCH

Bioconversion of fatty acids at the basis of marine food webs: insights from a compound-specific stable isotope analysis

(2012) M De Troch et al.   MARINE ECOLOGY PROGRESS SERIES

Insights into bilaterian evolution from three spiralian genomes

(2012) Oleg Simakov et al.   NATURE

Functional Desaturase Fads1 (Δ5) and Fads2 (Δ6) Orthologues Evolved before the Origin of Jawed Vertebrates

(2012) Luís Filipe Costa Castro et al.   PLoS One

The convergent evolution of defensive polyacetylenic fatty acid biosynthesis genes in soldier beetles

(2012) Victoria S. Haritos et al.   Nature Communications

Expression of fatty acyl desaturase and elongase genes, and evolution of DHA:EPA ratio during development of unfed larvae of Atlantic bluefin tuna (Thunnus thynnus L.)

(2011) Sofia Morais et al.   AQUACULTURE

Functional characterization of a delta 6-desaturase gene from the black seabream (Acanthopagrus schlegeli)

(2011) Sun Hee Kim et al.   BIOTECHNOLOGY LETTERS

The evolutionary history of the stearoyl-CoA desaturase gene family in vertebrates

(2011) L Filipe C Castro et al.   BMC EVOLUTIONARY BIOLOGY

Biosynthesis of very long-chain fatty acids (C>24) in Atlantic salmon: Cloning, functional characterisation, and tissue distribution of an Elovl4 elongase

(2011) Greta Carmona-Antoñanzas et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Delta-8 desaturation activity varies among fatty acyl desaturases of teleost fish: High activity in delta-6 desaturases of marine species

(2011) Óscar Monroig et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Caenorhabditis elegansΔ12-Desaturase FAT-2 Is a Bifunctional Desaturase Able to Desaturate a Diverse Range of Fatty Acid Substrates at the Δ12 and Δ15 Positions

(2011) Xue-Rong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Front-end Desaturase: Structure, Function, Evolution and Biotechnological Use

(2011) Dauenpen Meesapyodsuk et al.   LIPIDS

Identification of a Δ5-like Fatty Acyl Desaturase from the Cephalopod Octopus vulgaris (Cuvier 1797) Involved in the Biosynthesis of Essential Fatty Acids

(2011) Óscar Monroig et al.   MARINE BIOTECHNOLOGY

Biosynthesis of polyunsaturated fatty acids in zooxanthellae and polyps of corals

(2011) A. B. Imbs et al.   Russian Journal of Marine Biology

Biosynthesis of long-chain polyunsaturated fatty acids in marine fish: Characterization of an Elovl4-like elongase from cobia Rachycentron canadum and activation of the pathway during early life stages

(2010) Óscar Monroig et al.   AQUACULTURE

Expression and role of Elovl4 elongases in biosynthesis of very long-chain fatty acids during zebrafish Danio rerio early embryonic development

(2010) Óscar Monroig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Multiple genes for functional ∆6 fatty acyl desaturases (Fad) in Atlantic salmon (Salmo salar L.): Gene and cDNA characterization, functional expression, tissue distribution and nutritional regulation

(2010) Óscar Monroig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Investigation of highly unsaturated fatty acid metabolism in the Asian sea bass, Lates calcarifer

(2010) N. Y. Mohd-Yusof et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

Retinal very long-chain PUFAs: new insights from studies on ELOVL4 protein

(2010) Martin-Paul Agbaga et al.   JOURNAL OF LIPID RESEARCH

ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice

(2010) Damir Zadravec et al.   JOURNAL OF LIPID RESEARCH

Cloning, Tissue Expression Analysis, and Functional Characterization of Two Δ6-Desaturase Variants of Sea Bass (Dicentrarchus labrax L.)

(2010) Ester Santigosa et al.   MARINE BIOTECHNOLOGY

Demospongic Acids Revisited

(2010) Jean-Michel Kornprobst et al.   Marine Drugs

The Amphimedon queenslandica genome and the evolution of animal complexity

(2010) Mansi Srivastava et al.   NATURE

Vertebrate fatty acyl desaturase with  4 activity

(2010) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The fatty acid synthasefasn-1acts upstream of WNK and Ste20/GCK-VI kinases to modulate antimicrobial peptide expression inC. elegansepidermis

(2010) Kwang-Zin Lee et al.   Virulence

Physiological roles of fatty acyl desaturases and elongases in marine fish: Characterisation of cDNAs of fatty acyl Δ6 desaturase and elovl5 elongase of cobia (Rachycentron canadum)

(2009) Xiaozhong Zheng et al.   AQUACULTURE

Molecular and functional characterization and expression analysis of a Δ6 fatty acyl desaturase cDNA of European Sea Bass (Dicentrarchus labrax L.)

(2009) Almudena González-Rovira et al.   AQUACULTURE

Expression of long-chain polyunsaturated fatty acid (LC-PUFA) biosynthesis genes during zebrafish Danio rerio early embryogenesis

(2009) Óscar Monroig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Non-methylene-interrupted fatty acids from marine invertebrates: Occurrence, characterization and biological properties

(2009) Gilles Barnathan   BIOCHIMIE

Novel Lipogenic Enzyme ELOVL7 Is Involved in Prostate Cancer Growth through Saturated Long-Chain Fatty Acid Metabolism

(2009) K. Tamura et al.   CANCER RESEARCH

Cloning and functional characterisation of a fatty acyl elongase from southern bluefin tuna (Thunnus maccoyii)

(2009) Melissa K. Gregory et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Highly Unsaturated Fatty Acid Synthesis in Atlantic Salmon: Characterization of ELOVL5- and ELOVL2-like Elongases

(2009) Sofia Morais et al.   MARINE BIOTECHNOLOGY

Net gain of long-chain polyunsaturated fatty acids (PUFA) in a lugworm Arenicola marina bioturbated mesocosm

(2009) PJW Olive et al.   MARINE ECOLOGY PROGRESS SERIES

Fish, docosahexaenoic acid and Alzheimer’s disease

(2009) S.C. Cunnane et al.   PROGRESS IN LIPID RESEARCH

The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice

(2009) Hervé Guillou et al.   PROGRESS IN LIPID RESEARCH

Cloning and over-expression of a masu salmon (Oncorhynchus masou) fatty acid elongase-like gene in zebrafish

(2008) Alimuddin et al.   AQUACULTURE

Isolation and functional characterization of two independently-evolved fatty acid Δ12-desaturase genes from insects

(2008) X.-R. Zhou et al.   INSECT MOLECULAR BIOLOGY

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

(2008) Nicole King et al.   NATURE