标题
Metformin: Is it a drug for all reasons and diseases?
作者
关键词
Metformin, Diabetes, Cancer, Aging, Neurodegenerative diseases, COVID-19
出版物
METABOLISM-CLINICAL AND EXPERIMENTAL
Volume -, Issue -, Pages 155223
出版商
Elsevier BV
发表日期
2022-05-29
DOI
10.1016/j.metabol.2022.155223
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Low-dose metformin targets the lysosomal AMPK pathway through PEN2
- (2022) Teng Ma et al. NATURE
- Pharmaceutical pollution of the world’s rivers
- (2022) John L. Wilkinson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metformin and the heart: Update on mechanisms of cardiovascular protection with special reference to comorbid type 2 diabetes and heart failure
- (2022) Guntram Schernthaner et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis
- (2022) Traci E. LaMoia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metformin Intervention—A Panacea for Cancer Treatment?
- (2022) Angelika Buczyńska et al. Cancers
- Diabetes, obesity, metabolism and SARS-CoV-2 infection: The end of the beginning
- (2021) Daniel J. Drucker Cell Metabolism
- Metformin Use Is Associated With Reduced Mortality in a Diverse Population With COVID-19 and Diabetes
- (2021) Andrew B. Crouse et al. Frontiers in Endocrinology
- Does metformin modulate mitochondrial dynamics and function in type 2 diabetic patients?
- (2021) Aranzazu Martinez de Marañón et al. ANTIOXIDANTS & REDOX SIGNALING
- Metformin restores hippocampal neurogenesis and learning and memory via regulating gut microbiota in the obese mouse model
- (2021) Xiaoyi Ma et al. BRAIN BEHAVIOR AND IMMUNITY
- Prescribing in Type 2 Diabetes Patients With and Without Cardiovascular Disease History: a Descriptive Analysis in the UK CPRD
- (2021) Ruth E. Farmer et al. CLINICAL THERAPEUTICS
- Rapid Changes in Serum Testosterone in Men with Newly Diagnosed Type 2 Diabetes With Intensive Insulin and Metformin
- (2021) Yun Hu et al. DIABETES CARE
- Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO study
- (2021) Matthieu Wargny et al. DIABETOLOGIA
- Association of metformin with susceptibility to COVID-19 in people with Type 2 diabetes
- (2021) Jingya Wang et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Detection of endocrine disrupting chemicals in Danio rerio and Daphnia pulex: Step-one, behavioral screen
- (2021) Lakshmi Neha Reddy Alla et al. CHEMOSPHERE
- SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2
- (2021) Yuyang Lei et al. CIRCULATION RESEARCH
- Metformin’s Therapeutic Action in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase
- (2021) Michael J. MacDonald et al. DIABETES
- Metformin perturbs pancreatic differentiation from human embryonic stem cells
- (2021) Linh Nguyen et al. DIABETES
- Metformin environmental exposure: A systematic review
- (2021) Eliane Papa Ambrosio-Albuquerque et al. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- Glucose-lowering treatments and COVID-19 mortality in T2DM
- (2021) Samy Hadjadj et al. Nature Reviews Endocrinology
- Therapeutic Potential of Metformin in COVID-19: Reasoning for Its Protective Role
- (2021) Samson Mathews Samuel et al. TRENDS IN MICROBIOLOGY
- Can glucose-lowering drugs affect the prognosis of COVID-19 in patients with type 2 diabetes?
- (2021) Guntram Schernthaner Lancet Diabetes & Endocrinology
- Prescription of glucose-lowering therapies and risk of COVID-19 mortality in people with type 2 diabetes: a nationwide observational study in England
- (2021) Kamlesh Khunti et al. Lancet Diabetes & Endocrinology
- The Efficacy and Potential Mechanisms of Metformin in the Treatment of COVID-19 in the Diabetics: A Systematic Review
- (2021) Moein Zangiabadian et al. Frontiers in Endocrinology
- Hyperglycemia in Acute COVID-19 is Characterized by Insulin Resistance and Adipose Tissue Infectivity by SARS-CoV-2
- (2021) Moritz Reiterer et al. Cell Metabolism
- First‐line pharmacotherapy for incident type 2 diabetes: Prescription patterns, adherence and associated costs
- (2021) David J. T. Campbell et al. DIABETIC MEDICINE
- Orphan nuclear receptor 4A1 (NR4A1) and novel ligands
- (2021) Stephen Safe et al. Essays in Biochemistry
- Biguanides: Species with versatile therapeutic applications
- (2021) Deepika Kathuria et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- The Hormetic Effect of Metformin: “Less Is More”?
- (2021) Isabella Panfoli et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Interaction between Metformin, Folate and Vitamin B12 and the Potential Impact on Fetal Growth and Long-Term Metabolic Health in Diabetic Pregnancies
- (2021) Manon D. Owen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Metformin prevents hyperglycaemia-associated, oxidative stress-induced vascular endothelial dysfunction: essential role for the orphan nuclear receptor, Nr4a1 (Nur77).
- (2021) Vivek Krishna Pulakazhi Venu et al. MOLECULAR PHARMACOLOGY
- Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit
- (2021) Timothy V. Pyrkov et al. Nature Communications
- Diabetes and coronavirus (SARS-CoV-2): Molecular mechanism of Metformin intervention and the scientific basis of drug repurposing
- (2021) Elizabeth Varghese et al. PLoS Pathogens
- Update on the effects of GLP-1 receptor agonists for the treatment of polycystic ovary syndrome
- (2021) Maka Siamashvili et al. Expert Review of Clinical Pharmacology
- Metformin Adjunct With Antineoplastic Agents for the Treatment of Lung Cancer: A Meta-Analysis of Randomized Controlled Trials and Observational Cohort Studies
- (2021) Xiaofeng Luo et al. Frontiers in Pharmacology
- The effectiveness and safety of liraglutide in treating overweight/obese patients with polycystic ovary syndrome: a meta-analysis
- (2021) J. J. Ge et al. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
- Metformin and Covid-19: Focused Review of Mechanisms and Current Literature Suggesting Benefit
- (2021) Sherehan Ibrahim et al. Frontiers in Endocrinology
- A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan
- (2021) Ibrahim Mohammed et al. Frontiers in Endocrinology
- Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions
- (2021) J. Silvio Gutkind et al. JCI Insight
- Metformin a Potential Pharmacological Strategy in Late Onset Alzheimer’s Disease Treatment
- (2021) Saghar Rabiei Poor et al. Pharmaceuticals
- Metformin Treatment Among Men With Diabetes and the Risk of Prostate Cancer: A Population-Based Historical Cohort Study
- (2021) Laurence S Freedman et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Metformin improves skeletal muscle microvascular insulin resistance in metabolic syndrome
- (2021) Linda A. Jahn et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Metformin to decrease COVID-19 severity and mortality: Molecular mechanisms and therapeutic potential
- (2021) Olexandr Kamyshnyi et al. BIOMEDICINE & PHARMACOTHERAPY
- Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19
- (2021) Jihoon Shin et al. DIABETES
- Biguanides drugs: Past success stories and promising future for drug discovery
- (2021) Oleksandr Grytsai et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- The antidiabetic drug metformin acts on the bone microenvironment to promote myeloma cell adhesion to preosteoblasts and increase myeloma tumour burden in vivo
- (2021) Beatriz Gámez et al. Translational Oncology
- Are 50 years enough to prove the brilliant Dilman’s idea?
- (2021) Vladimir N. Anisimov Oncotarget
- Effect of Metformin on Testosterone Levels in Male Patients With Type 2 Diabetes Mellitus Treated With Insulin
- (2021) Tingting Cai et al. Frontiers in Endocrinology
- Effects of Metformin in Heart Failure: From Pathophysiological Rationale to Clinical Evidence
- (2021) Teresa Salvatore et al. Biomolecules
- Is insulin-like growth factor-1 involved in Parkinson’s disease development?
- (2020) Inma Castilla-Cortázar et al. Journal of Translational Medicine
- Mitochondrial Complex I Inhibition by Metformin: Drug–Exercise Interactions
- (2020) S. Martín-Rodríguez et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease.’
- (2020) Christopher R. Triggle et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Benefits of Metformin in Attenuating the Hallmarks of Aging
- (2020) Ameya S. Kulkarni et al. Cell Metabolism
- Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes
- (2020) Lihua Zhu et al. Cell Metabolism
- Clinical Characteristics and Outcomes of Patients With Diabetes and COVID-19 in Association With Glucose-Lowering Medication
- (2020) Yuchen Chen et al. DIABETES CARE
- COVID-19 and diabetes: Is metformin a friend or foe?
- (2020) Francesco Ursini et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study
- (2020) Bertrand Cariou et al. DIABETOLOGIA
- Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?
- (2020) Alexis Diaz-Vegas et al. ENDOCRINE REVIEWS
- Obesity, polycystic ovary syndrome and infertility: a new avenue for GLP-1 receptor agonists
- (2020) Hellas Cena et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Metformin therapy and cognitive dysfunction in patients with type 2 diabetes
- (2020) Qing-Qing Zhang et al. MEDICINE
- Impact of antidiabetic agents on dementia risk: A Bayesian network meta-analysis
- (2020) Jian-Bo Zhou et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
- (2020) David E. Gordon et al. NATURE
- Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China
- (2020) Chaomin Wu et al. JAMA Internal Medicine
- Prevalence and impact of diabetes among people infected with SARS-CoV-2
- (2020) G. P. Fadini et al. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
- Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions
- (2020) Nadezda Apostolova et al. Redox Biology
- Metformin and COVID-19: From cellular mechanisms to reduced mortality
- (2020) A.J. Scheen DIABETES & METABOLISM
- A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19
- (2020) Zohreh Esam DIABETES RESEARCH AND CLINICAL PRACTICE
- Metformin in COVID-19: A possible role beyond diabetes
- (2020) Swati Sharma et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Targeting Glucose Metabolism to Overcome Resistance to Anticancer Chemotherapy in Breast Cancer
- (2020) Elizabeth Varghese et al. Cancers
- Association between metformin and neurodegenerative diseases of observational studies: systematic review and meta-analysis
- (2020) Fan Ping et al. BMJ Open Diabetes Research & Care
- ACE2, Metformin, and COVID-19
- (2020) Atul Malhotra et al. iScience
- Hydroxychloroquine: A comprehensive review and its controversial role in coronavirus disease 2019
- (2020) Pankaj Bansal et al. ANNALS OF MEDICINE
- Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes
- (2020) Xu Cheng et al. Cell Metabolism
- Janus sword actions of chloroquine and hydroxychloroquine against COVID-19
- (2020) Xuesong Chen et al. CELLULAR SIGNALLING
- Risk of Metformin in Patients With Type 2 Diabetes With COVID‐19: A Preliminary Retrospective Report
- (2020) Yongchao Gao et al. CTS-Clinical and Translational Science
- Metformin: A Growing Journey from Glycemic Control to the Treatment of Alzheimer’s Disease and Depression
- (2020) Mohamed El Massry et al. CURRENT MEDICINAL CHEMISTRY
- Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study
- (2020) Katherine Samaras et al. DIABETES CARE
- Cellular and Molecular Mechanisms of Metformin Action
- (2020) Traci E LaMoia et al. ENDOCRINE REVIEWS
- Anti-inflammatory properties of antidiabetic drugs: A “promised land” in the COVID-19 era?
- (2020) Niki Katsiki et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer
- (2020) Stephen Safe et al. MOLECULAR CANCER RESEARCH
- A specific gut microbiota and metabolomic profiles shifts related to antidiabetic action: The similar and complementary antidiabetic properties of type 3 resistant starch from Canna edulis and metformin
- (2020) Chi Zhang et al. PHARMACOLOGICAL RESEARCH
- Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits
- (2020) Julia Böhme et al. Nature Communications
- A national observation study of cancer incidence and mortality risks in type 2 diabetes compared to the background population over time
- (2020) Hulda Hrund Bjornsdottir et al. Scientific Reports
- Counteracting Chemoresistance with Metformin in Breast Cancers: Targeting Cancer Stem Cells
- (2020) Samson Mathews Samuel et al. Cancers
- Sodium-glucose co-transporter-2 (SGLT-2) inhibition reduces glucose uptake to induce breast cancer cell growth arrest through AMPK/mTOR pathway
- (2020) Jun Zhou et al. BIOMEDICINE & PHARMACOTHERAPY
- Mortality and other adverse outcomes in patients with type 2 diabetes mellitus admitted for COVID-19 in association with glucose-lowering drugs: a nationwide cohort study
- (2020) Luis M. Pérez-Belmonte et al. BMC Medicine
- Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells
- (2020) Ya-Hui Chen et al. Molecular Medicine Reports
- Association between Growth Differentiation Factor-15 (GDF-15) Serum Levels, Anorexia and Low Muscle Mass among Cancer Patients
- (2020) Alessio Molfino et al. Cancers
- Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects?
- (2020) Teresa Salvatore et al. Biomedicines
- Where Does Metformin Stand in Modern Day Management of Type 2 Diabetes?
- (2020) Ehtasham Ahmad et al. Pharmaceuticals
- Feasibility and Acceptability of Metformin to Augment Low Milk Supply: A Pilot Randomized Controlled Trial
- (2019) Laurie Nommsen-Rivers et al. JOURNAL OF HUMAN LACTATION
- Does metformin therapy influence the effects of intensive lifestyle intervention? Exploring the interaction between first line therapies in the look AHEAD trial
- (2019) Tasuku Terada et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases
- (2019) Seung Joon Baek et al. PHARMACOLOGY & THERAPEUTICS
- Metformin was associated with lower all-cause mortality in type 2 diabetes with acute coronary syndrome: A Nationwide registry with propensity score-matched analysis
- (2019) Chien-Boon Jong et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Metformin Treatment and Cancer Risk: Cox Regression Analysis with Time-Dependent Covariates of 320,000 Individuals with Incident Diabetes Mellitus
- (2019) Rachel Dankner et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Metformin overdose: A serious iatrogenic complication—Western France Poison Control Centre Data Analysis
- (2019) Alexandre Stevens et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Mitochondrial targets of metformin—Are they physiologically relevant?
- (2019) Alena Pecinová et al. BIOFACTORS
- Effect of metformin on all-cause and cardiovascular mortality in patients with coronary artery diseases: a systematic review and an updated meta-analysis
- (2019) Yechen Han et al. Cardiovascular Diabetology
- Metformin in breast cancer: preclinical and clinical evidence
- (2019) Anindita De et al. CURRENT PROBLEMS IN CANCER
- Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation
- (2019) Ji-Chang Wang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Effect of metformin on neurodegenerative disease among elderly adult US veterans with type 2 diabetes mellitus
- (2019) Qian Shi et al. BMJ Open
- Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double‐blind, placebo‐controlled, multicenter trial: The MASTERS trial
- (2019) R. Grace Walton et al. AGING CELL
- Metformin and Aging: A Review
- (2019) Hartmut H. Glossmann et al. GERONTOLOGY
- Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
- (2019) LaTonya J. Hickson et al. EBioMedicine
- Impact of metformin on the risk and treatment outcomes of tuberculosis in diabetics: a systematic review
- (2019) Xinyu Yu et al. BMC INFECTIOUS DISEASES
- Metformin as Anti-Aging Therapy: Is It for Everyone?
- (2019) Alexander A. Soukas et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK
- (2019) Yu Wang et al. Cell Reports
- Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy
- (2019) Samson Mathews Samuel et al. Cancers
- Pharmacology of metformin – An update
- (2019) Hartmut H. Glossmann et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
- (2019) B. Pajak et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Degree of hyperglycemia independently associates with hospital mortality and length of stay in critically ill, nondiabetic patients: Results from the ANZICS CORE binational registry
- (2019) Manju Mamtani et al. JOURNAL OF CRITICAL CARE
- GDF15 mediates the effects of metformin on body weight and energy balance
- (2019) Anthony P. Coll et al. NATURE
- Metformin: The Answer to Cancer in a Flower? Current Knowledge and Future Prospects of Metformin as an Anti-Cancer Agent in Breast Cancer
- (2019) Samson Mathews Samuel et al. Biomolecules
- Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults
- (2018) Ameya S Kulkarni et al. AGING CELL
- Plasma proteomic signature of age in healthy humans
- (2018) Toshiko Tanaka et al. AGING CELL
- AMPK Phosphorylation of ACE2 in Endothelium Mitigates Pulmonary Hypertension
- (2018) Jiao Zhang et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Low-dose metformin exposure causes changes in expression of endocrine disruption-associated genes
- (2018) Nicholas J. Niemuth et al. AQUATIC TOXICOLOGY
- Metformin-induced anticancer activities: recent insights
- (2018) Stephen Safe et al. BIOLOGICAL CHEMISTRY
- Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice
- (2018) Zhenri Ou et al. BRAIN BEHAVIOR AND IMMUNITY
- Metformin Alters Upper Small Intestinal Microbiota that Impact a Glucose-SGLT1-Sensing Glucoregulatory Pathway
- (2018) Paige V. Bauer et al. Cell Metabolism
- The Risk of TB in Patients With Type 2 Diabetes Initiating Metformin vs Sulfonylurea Treatment
- (2018) Sheng-Wei Pan et al. CHEST
- Repurposing Metformin for Cardiovascular Disease
- (2018) Graham Rena et al. CIRCULATION
- Metformin, A New Era for an Old Drug in the Treatment of Immune Mediated Disease?
- (2018) Mark Schuiveling et al. CURRENT DRUG TARGETS
- Metformin
- (2018) Julie Rodriguez et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- Is metformin poised for a second career as an antimicrobial?
- (2018) Faiza Malik et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Control of mitochondrial superoxide production by reverse electron transport at complex I
- (2018) Ellen L. Robb et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- GDF15 promotes the proliferation of cervical cancer cells by phosphorylating AKT1 and Erk1/2 through the receptor ErbB2
- (2018) Shan Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo
- (2018) Anila K. Madiraju et al. NATURE MEDICINE
- Anti-Diabetic Drugs: Cure or Risk Factors for Cancer?
- (2018) Jeny Laskar et al. PATHOLOGY & ONCOLOGY RESEARCH
- Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration – A Mass Spectrometry Imaging Study of the Perfused Rat Liver
- (2018) Giulio Calza et al. Frontiers in Pharmacology
- The Therapeutic Potential of Metformin in Neurodegenerative Diseases
- (2018) Carola Rotermund et al. Frontiers in Endocrinology
- The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality
- (2018) Jyotiska Chaudhuri et al. Cell Metabolism
- Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer
- (2018) Simon R. Lord et al. Cell Metabolism
- Incidence of Dementia is Increased in Type 2 Diabetes and Reduced by the Use of Sulfonylureas and Metformin
- (2018) Chih-Cheng Hsu et al. JOURNAL OF ALZHEIMERS DISEASE
- Long-Term Metformin Usage and Cognitive Function among Older Adults with Diabetes
- (2018) Tze Pin Ng et al. JOURNAL OF ALZHEIMERS DISEASE
- Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1
- (2018) Jong-Ho Cha et al. MOLECULAR CELL
- Endothelial function and dysfunction: Impact of metformin
- (2018) Asma Nafisa et al. PHARMACOLOGY & THERAPEUTICS
- Metformin as an Anticancer Agent
- (2018) Ales Vancura et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Metformin from mother to unborn child – Are there unwarranted effects?
- (2018) Linh Nguyen et al. EBioMedicine
- Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults
- (2018) Adam R. Konopka et al. AGING CELL
- Novel application of metformin combined with targeted drugs on anticancer treatment
- (2018) Jun Deng et al. CANCER SCIENCE
- High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions
- (2018) Birsen Elibol et al. Frontiers in Endocrinology
- Metformin is associated with reduced cell proliferation in human endometrial cancer by inbibiting PI3K/AKT/mTOR signaling
- (2017) Yan Zhao et al. GYNECOLOGICAL ENDOCRINOLOGY
- Sodium glucose cotransporter 2 inhibitor canagliflozin attenuates liver cancer cell growth and angiogenic activity by inhibiting glucose uptake
- (2017) Kosuke Kaji et al. INTERNATIONAL JOURNAL OF CANCER
- Regulation of organelle function by metformin
- (2017) Jeongho Kim et al. IUBMB LIFE
- Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity
- (2017) Takahiro Horiuchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Concentration-dependent metabolic effects of metformin in healthy and Fanconi anemia lymphoblast cells
- (2017) Silvia Ravera et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Effect of Metformin on Vascular Function in Children With Type 1 Diabetes: A 12-Month Randomized Controlled Trial
- (2017) Jemma J A Anderson et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Transporters Involved in Metformin Pharmacokinetics and Treatment Response
- (2017) Xiaomin Liang et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
- (2017) Linda Yang et al. NATURE MEDICINE
- GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
- (2017) Shannon E Mullican et al. NATURE MEDICINE
- Association between diabetes mellitus and active tuberculosis: A systematic review and meta-analysis
- (2017) Rami H. Al-Rifai et al. PLoS One
- Metformin – its potential anti-cancer and anti-aging effects
- (2017) Monika Podhorecka et al. Postepy Higieny I Medycyny Doswiadczalnej
- Effects of metformin exposure on neurodegenerative diseases in elderly patients with type 2 diabetes mellitus
- (2017) Yi-Chun Kuan et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Vorinostat and metformin sensitize EGFR-TKI resistant NSCLC cells via BIM-dependent apoptosis induction
- (2017) Hengyi Chen et al. Oncotarget
- Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial
- (2017) John R Petrie et al. Lancet Diabetes & Endocrinology
- Results from 11C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly
- (2017) Ane B. Iversen et al. Scientific Reports
- Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice
- (2016) Joanne S. Allard et al. BEHAVIOURAL BRAIN RESEARCH
- Metformin Activates AMPK through the Lysosomal Pathway
- (2016) Chen-Song Zhang et al. Cell Metabolism
- Metformin as a Tool to Target Aging
- (2016) Nir Barzilai et al. Cell Metabolism
- Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?
- (2016) Navdeep S. Chandel et al. Cell Metabolism
- Anti-Inflammatory Effects of Metformin Irrespective of Diabetes StatusNovelty and Significance
- (2016) Amy R. Cameron et al. CIRCULATION RESEARCH
- Impact of Insulin Sensitizers on the Incidence of Dementia: A Meta-Analysis
- (2016) Fang Ye et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- [11C]-Labeled Metformin Distribution in the Liver and Small Intestine Using Dynamic Positron Emission Tomography in Mice Demonstrates Tissue-Specific Transporter Dependency
- (2016) Jonas B. Jensen et al. DIABETES
- Growth Differentiation Factor 15 as a Novel Biomarker for Metformin
- (2016) Hertzel C. Gerstein et al. DIABETES CARE
- Anti-inflammatory Agents in the Treatment of Diabetes and Its Vascular Complications
- (2016) Rena M. Pollack et al. DIABETES CARE
- Mechanism of Metformin: A Tale of Two Sites
- (2016) Ruisheng Song DIABETES CARE
- Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? Yes, They Should Be Relaxed! What’s the Fuss?: Table 1
- (2016) George L. Bakris et al. DIABETES CARE
- Cancer incidence in persons with type 1 diabetes: a five-country study of 9,000 cancers in type 1 diabetic individuals
- (2016) Bendix Carstensen et al. DIABETOLOGIA
- Metformin and the gastrointestinal tract
- (2016) Laura J. McCreight et al. DIABETOLOGIA
- Impact of Metformin on Exercise-Induced Metabolic Adaptations to Lower Type 2 Diabetes Risk
- (2016) Steven K. Malin et al. EXERCISE AND SPORT SCIENCES REVIEWS
- Cation-selective transporters are critical to the AMPK-mediated antiproliferative effects of metformin in human breast cancer cells
- (2016) Hao Cai et al. INTERNATIONAL JOURNAL OF CANCER
- Insulin-Like Growth Factor 1/Mammalian Target of Rapamycin and AMP-Activated Protein Kinase Signaling Involved in the Effects of Metformin in the Human Endometrial Cancer
- (2016) Dongge Cai et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation
- (2016) Sung Min Son et al. JOURNAL OF ALZHEIMERS DISEASE
- NHX-5, an Endosomal Na+/H+Exchanger, Is Associated with Metformin Action
- (2016) Jeongho Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- In Vivo Imaging of Human 11C-Metformin in Peripheral Organs: Dosimetry, Biodistribution, and Kinetic Analyses
- (2016) L. C. Gormsen et al. JOURNAL OF NUCLEAR MEDICINE
- Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer
- (2016) Stepana Boukalova et al. MOLECULAR CANCER THERAPEUTICS
- Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy
- (2016) Erica Barini et al. Molecular Neurodegeneration
- G6PD protects from oxidative damage and improves healthspan in mice
- (2016) Sandrina Nóbrega-Pereira et al. Nature Communications
- Trends in incidence, prevalence and prescribing in type 2 diabetes mellitus between 2000 and 2013 in primary care: a retrospective cohort study
- (2016) Manuj Sharma et al. BMJ Open
- Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes
- (2016) Adam R. Konopka et al. Cell Reports
- New insights into the anti-diabetic actions of metformin: from the liver to the gut
- (2016) Tongzhi Wu et al. Expert Review of Gastroenterology & Hepatology
- Diabetes and infection: assessing the association with glycaemic control in population-based studies
- (2016) Jonathan Pearson-Stuttard et al. Lancet Diabetes & Endocrinology
- If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice
- (2016) Vladimir N. Anisimov et al. Aging-US
- Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade
- (2016) Fenqing Shang et al. PLoS One
- MATE2 Expression Is Associated with Cancer Cell Response to Metformin
- (2016) Sanjana Chowdhury et al. PLoS One
- Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells
- (2015) Jaslyn Sian-Siu Soo et al. APOPTOSIS
- Prevention of Tumor Growth Driven by PIK3CA and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3
- (2015) D. Madera et al. Cancer Prevention Research
- Metformin Use and Risk of Prostate Cancer: Results from the REDUCE Study
- (2015) T. Feng et al. Cancer Prevention Research
- Metformin Action: Concentrations Matter
- (2015) Ling He et al. Cell Metabolism
- Emerging wastewater contaminant metformin causes intersex and reduced fecundity in fish
- (2015) Nicholas J. Niemuth et al. CHEMOSPHERE
- Identifying Novel Biomarkers for Cardiovascular Events or Death in People With DysglycemiaClinical Perspective
- (2015) Hertzel C. Gerstein et al. CIRCULATION
- Metformin Does Not Reduce Markers of Cell Proliferation in Esophageal Tissues of Patients With Barrett’s Esophagus
- (2015) Amitabh Chak et al. Clinical Gastroenterology and Hepatology
- Therapeutic Concentrations of Metformin: A Systematic Review
- (2015) Farshad Kajbaf et al. CLINICAL PHARMACOKINETICS
- The Primary Glucose-Lowering Effect of Metformin Resides in the Gut, Not the Circulation. Results From Short-term Pharmacokinetic and 12-Week Dose-Ranging Studies
- (2015) John B. Buse et al. DIABETES CARE
- Unexpectedly long half-life of metformin elimination in cases of metformin accumulation
- (2015) F. Kajbaf et al. DIABETIC MEDICINE
- Steady-state pharmacokinetics of metformin is independent of the OCT1 genotype in healthy volunteers
- (2015) Mette Marie Hougaard Christensen et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Role of organic cation transporters in drug–drug interaction
- (2015) Hermann Koepsell Expert Opinion on Drug Metabolism & Toxicology
- Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis
- (2015) Negar Naderpoor et al. HUMAN REPRODUCTION UPDATE
- Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium
- (2015) Mustafa Kinaan et al. MEDICAL PRINCIPLES AND PRACTICE
- No reduced risk of overall, colorectal, lung, breast, and prostate cancer with metformin therapy in diabetic patients: database analyses from Germany and the UK
- (2015) Bernd Kowall et al. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
- Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions
- (2015) Alessandra Silvestri et al. PLoS One
- Metformin for cancer and aging prevention: is it a time to make the long story short?
- (2015) Vladimir N. Anisimov Oncotarget
- Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation
- (2015) Michael Fatt et al. Stem Cell Reports
- Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect
- (2015) Yoshifumi Saisho Endocrine Metabolic & Immune Disorders-Drug Targets
- Association between metformin use and progression of monoclonal gammopathy of undetermined significance to multiple myeloma in US veterans with diabetes mellitus: a population-based retrospective cohort study
- (2015) Su-Hsin Chang et al. Lancet Haematology
- Oncobiguanides: Paracelsus’ law and nonconventional routes for administering diabetobiguanides for cancer treatment
- (2015) Javier A. Menendez et al. Oncotarget
- Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
- (2014) Hannah R. Bridges et al. BIOCHEMICAL JOURNAL
- Biomolecular Mode of Action of Metformin in Relation to Its Copper Binding Properties
- (2014) Peter Repiščák et al. BIOCHEMISTRY
- The Effect of Metformin on Mortality Following Cancer among Patients with Diabetes
- (2014) I. C. Lega et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders
- (2014) S. Gandini et al. Cancer Prevention Research
- Metformin Sensitizes EGFR-TKI-Resistant Human Lung Cancer Cells In Vitro and In Vivo through Inhibition of IL-6 Signaling and EMT Reversal
- (2014) L. Li et al. CLINICAL CANCER RESEARCH
- Metformin and Cancer: Mounting Evidence Against an Association: Figure 1
- (2014) Samy Suissa et al. DIABETES CARE
- Incidence of Bladder Cancer in Patients With Type 2 Diabetes Treated With Metformin or Sulfonylureas
- (2014) Ronac Mamtani et al. DIABETES CARE
- Metformin Does Not Affect Cancer Risk: A Cohort Study in the U.K. Clinical Practice Research Datalink Analyzed Like an Intention-to-Treat Trial
- (2014) Konstantinos K. Tsilidis et al. DIABETES CARE
- Cancer Risk Among People With Type 1 and Type 2 Diabetes: Disentangling True Associations, Detection Bias, and Reverse Causation
- (2014) Jessica L. Harding et al. DIABETES CARE
- Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls
- (2014) C. A. Bannister et al. DIABETES OBESITY & METABOLISM
- Diabetes and cancer: 5years into the recent controversy
- (2014) Ellena Badrick et al. EUROPEAN JOURNAL OF CANCER
- Metformin Activates AMP-activated Protein Kinase by Promoting Formation of the αβγ Heterotrimeric Complex
- (2014) Shumei Meng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Type 2 Diabetes and Antidiabetic Medications in Relation to Dementia Diagnosis
- (2014) Chin Cheng et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
- (2014) Anila K. Madiraju et al. NATURE
- Metformin—mode of action and clinical implications for diabetes and cancer
- (2014) Ida Pernicova et al. Nature Reviews Endocrinology
- Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice
- (2014) Rachael Lennox et al. NEUROPHARMACOLOGY
- Neuroprotective effect of metformin in MPTP-induced Parkinson’s disease in mice
- (2014) S.P. Patil et al. NEUROSCIENCE
- Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2
- (2014) W. De Haes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin
- (2014) Ligong Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metformin as adjunct antituberculosis therapy
- (2014) A. Singhal et al. Science Translational Medicine
- The γ-secretase complex: from structure to function
- (2014) Xian Zhang et al. Frontiers in Cellular Neuroscience
- Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis
- (2014) William W Wheaton et al. eLife
- Colorectal and Prostate Cancer Risk in Diabetes: Metformin, an Actor behind the Scene
- (2014) M. Akhtar Anwar et al. Journal of Cancer
- Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation
- (2013) Olga Moiseeva et al. AGING CELL
- Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1
- (2013) Gnanapragasam Arunachalam et al. BRITISH JOURNAL OF PHARMACOLOGY
- ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis
- (2013) AC Simões e Silva et al. BRITISH JOURNAL OF PHARMACOLOGY
- Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism
- (2013) Filipe Cabreiro et al. CELL
- Metformin—Acting through Cyclic AMP as well as AMP?
- (2013) D. Grahame Hardie Cell Metabolism
- Pharmaceuticals and personal care products found in the Great Lakes above concentrations of environmental concern
- (2013) Benjamin D. Blair et al. CHEMOSPHERE
- Association Between Metformin Therapy and Mortality After Breast Cancer: A population-based study
- (2013) I. C. Lega et al. DIABETES CARE
- Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp
- (2013) N. K. Stepto et al. HUMAN REPRODUCTION
- Potential applications for biguanides in oncology
- (2013) Michael Pollak JOURNAL OF CLINICAL INVESTIGATION
- Long-term effects of metformin on endothelial function in type 2 diabetes: a randomized controlled trial
- (2013) J. de Jager et al. JOURNAL OF INTERNAL MEDICINE
- Protein glycation during aging and in cardiovascular disease
- (2013) Andreas Simm Journal of Proteomics
- Metformin inhibits hepatitis B virus protein production and replication in human hepatoma cells
- (2013) Y.-H. Xun et al. JOURNAL OF VIRAL HEPATITIS
- Metformin and Sulfonylureas in Relation to Cancer Risk in Type II Diabetes Patients: A Meta-analysis using primary data of published studies
- (2013) Bindiya Thakkar et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Metformin reverses multidrug resistance and epithelial–mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells
- (2013) Chen Qu et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- mTOR is a key modulator of ageing and age-related disease
- (2013) Simon C. Johnson et al. NATURE
- Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
- (2013) Russell A. Miller et al. NATURE
- Glucose Levels and Risk of Dementia
- (2013) Paul K. Crane et al. NEW ENGLAND JOURNAL OF MEDICINE
- Longitudinal weight gain in women identified With polycystic ovary syndrome: Results of an observational study in young women
- (2013) Helena J. Teede et al. Obesity
- Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
- (2013) H. A. Hirsch et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metformin improves healthspan and lifespan in mice
- (2013) Alejandro Martin-Montalvo et al. Nature Communications
- Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial
- (2013) David Preiss et al. Lancet Diabetes & Endocrinology
- The Importance of Tau Phosphorylation for Neurodegenerative Diseases
- (2013) Wendy Noble et al. Frontiers in Neurology
- The caloric restriction paradigm: Implications for healthy human aging
- (2012) Rozalyn M. Anderson et al. AMERICAN JOURNAL OF HUMAN BIOLOGY
- Rejuvenating regeneration: Metformin activates endogenous adult stem cells
- (2012) JAVIER MENENDEZ et al. CELL CYCLE
- Metformin is synthetically lethal with glucose withdrawal in cancer cells
- (2012) Javier A. Menendez et al. CELL CYCLE
- TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO
- (2012) Stacey Robida-Stubbs et al. Cell Metabolism
- Mobilizing Endogenous Stem Cells for Repair and Regeneration: Are We There Yet?
- (2012) Freda D. Miller et al. Cell Stem Cell
- Metformin Activates an Atypical PKC-CBP Pathway to Promote Neurogenesis and Enhance Spatial Memory Formation
- (2012) Jing Wang et al. Cell Stem Cell
- Cellular Responses to the Metal-Binding Properties of Metformin
- (2012) L. Logie et al. DIABETES
- Mortality After Incident Cancer in People With and Without Type 2 Diabetes: Impact of metformin on survival
- (2012) C. J. Currie et al. DIABETES CARE
- Long-Term Safety, Tolerability, and Weight Loss Associated With Metformin in the Diabetes Prevention Program Outcomes Study
- (2012) DIABETES CARE
- Metformin and the Risk of Cancer: Time-related biases in observational studies
- (2012) S. Suissa et al. DIABETES CARE
- Metformin improves endothelial function in type 1 diabetic subjects: a pilot, placebo-controlled randomized study
- (2012) D. Pitocco et al. DIABETES OBESITY & METABOLISM
- A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin
- (2012) A. D. McNeilly et al. DIABETOLOGIA
- Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials
- (2012) R. J. Stevens et al. DIABETOLOGIA
- Metformin exposure affects human and mouse fetal testicular cells
- (2012) P. Tartarin et al. HUMAN REPRODUCTION
- Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study
- (2012) Patrick Imfeld et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
- (2012) Yan-yan Zhan et al. Nature Chemical Biology
- Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort
- (2012) Mark L. Wahlqvist et al. PARKINSONISM & RELATED DISORDERS
- Metformin pathways
- (2012) Li Gong et al. Pharmacogenetics and Genomics
- Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila
- (2012) Cathy Slack et al. PLoS One
- Type 2 diabetes and risk of prostate cancer: a meta-analysis of observational studies
- (2012) D Bansal et al. PROSTATE CANCER AND PROSTATIC DISEASES
- Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy
- (2012) W-Y Shi et al. Cell Death & Disease
- Reappraisal of Metformin Efficacy in the Treatment of Type 2 Diabetes: A Meta-Analysis of Randomised Controlled Trials
- (2012) Rémy Boussageon et al. PLOS MEDICINE
- Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals
- (2011) Meei-Shyuan Lee et al. BMC CANCER
- The peptide-hormone glucagon-like peptide-1 activates cAMP and inhibits growth of breast cancer cells
- (2011) Hagai Ligumsky et al. BREAST CANCER RESEARCH AND TREATMENT
- Metformin slows down aging and extends life span of female SHR mice
- (2011) Vladimir N. Anisimov et al. CELL CYCLE
- Clinical Pharmacokinetics of Metformin
- (2011) Garry G. Graham et al. CLINICAL PHARMACOKINETICS
- Association of Biochemical B12 Deficiency With Metformin Therapy and Vitamin B12 Supplements: The National Health and Nutrition Examination Survey, 1999-2006
- (2011) L. Reinstatler et al. DIABETES CARE
- Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration
- (2011) S. Larsen et al. DIABETOLOGIA
- Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
- (2011) X. Stephenne et al. DIABETOLOGIA
- Effect of Metformin Therapy on Vitamin D and Vitamin B12Levels in Patients with Type 2 Diabetes Mellitus
- (2011) Elizabeth Kos et al. Endocrine Practice
- Mechanisms Underlying Metformin-Induced Secretion of Glucagon-Like Peptide-1 from the Intestinal L Cell
- (2011) Andrew J. Mulherin et al. ENDOCRINOLOGY
- Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes
- (2011) Amit Gupta et al. NEUROPHARMACOLOGY
- The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling
- (2011) W van Veelen et al. ONCOGENE
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells
- (2010) Issam Ben Sahra et al. Autophagy
- Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis
- (2010) A. DeCensi et al. Cancer Prevention Research
- Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells
- (2010) I. Ben Sahra et al. CANCER RESEARCH
- Metformin and cancer: Doses, mechanisms and the dandelion and hormetic phenomena
- (2010) Begoña Martin-Castillo et al. CELL CYCLE
- Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
- (2010) Ivana Bjedov et al. Cell Metabolism
- SIRT1 Promotes Proliferation and Prevents Senescence Through Targeting LKB1 in Primary Porcine Aortic Endothelial Cells
- (2010) Yi Zu et al. CIRCULATION RESEARCH
- Metformin and Energy Metabolism in Breast Cancer: From Insulin Physiology to Tumour-initiating Stem Cells
- (2010) A. Vazquez-Martin et al. CURRENT MOLECULAR MEDICINE
- Diabetes and the Severity of Pandemic Influenza A (H1N1) Infection
- (2010) R. Allard et al. DIABETES CARE
- Diabetes and Cancer: A consensus report
- (2010) E. Giovannucci et al. DIABETES CARE
- Experience of malignancies with oral glucose-lowering drugs in the randomised controlled ADOPT (A Diabetes Outcome Progression Trial) and RECORD (Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycaemia in Diabetes) clinical trials
- (2010) P. D. Home et al. DIABETOLOGIA
- The use of metformin in type 1 diabetes: a systematic review of efficacy
- (2010) S. Vella et al. DIABETOLOGIA
- Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
- (2010) Marc Foretz et al. JOURNAL OF CLINICAL INVESTIGATION
- Metformin Supplementation and Life Span in Fischer-344 Rats
- (2010) D. L. Smith et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
- (2010) Brian Onken et al. PLoS One
- Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
- (2010) E. Kickstein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
- (2009) R. J. Shaw Acta Physiologica
- Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells
- (2009) Beate Fisslthaler et al. CIRCULATION RESEARCH
- The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
- (2009) C. J. Currie et al. DIABETOLOGIA
- Enhancing CD8 T-cell memory by modulating fatty acid metabolism
- (2009) Erika L. Pearce et al. NATURE
- Metformin increases phagocytosis and acidifies lysosomal/endosomal compartments in AMPK-dependent manner in rat primary microglia
- (2009) Krzysztof Łabuzek et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK–RhoA signaling pathway
- (2009) S Senapati et al. ONCOGENE
- Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription
- (2009) Y. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Metabolic reprogramming, caloric restriction and aging
- (2009) Rozalyn M. Anderson et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
- (2008) Randy Strong et al. AGING CELL
- A look inside the diabetic brain: Contributors to diabetes-induced brain aging
- (2008) Shayna A. Wrighten et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Metformin and the intestine
- (2008) C. J. Bailey et al. DIABETOLOGIA
- Mechanisms Underlying Saturable Intestinal Absorption of Metformin
- (2008) W. R. Proctor et al. DRUG METABOLISM AND DISPOSITION
- Metformin versus Insulin for the Treatment of Gestational Diabetes
- (2008) Janet A. Rowan et al. NEW ENGLAND JOURNAL OF MEDICINE
- 10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes
- (2008) Rury R. Holman et al. NEW ENGLAND JOURNAL OF MEDICINE
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