Article
Cell Biology
David G. Le Couteur, Samantha M. Solon-Biet, Benjamin L. Parker, Tamara Pulpitel, Amanda E. Brandon, Nicholas J. Hunt, Jibran A. Wali, Rahul Gokarn, Alistair M. Senior, Gregory J. Cooney, David Raubenheimer, Victoria C. Cogger, David E. James, Stephen J. Simpson
Summary: Diet composition has a significant impact on the hepatic proteome, influencing not only metabolic pathways but also fundamental processes like mitochondrial function and RNA splicing.
Article
Multidisciplinary Sciences
Adriana Raluca Vintila, Luke Slade, Michael Cooke, Craig R. G. Willis, Roberta Torregrossa, Mizanur Rahman, Taslim Anupom, Siva A. Vanapalli, Christopher J. Gaffney, Nima Gharahdaghi, Csaba Szabo, Nathaniel J. Szewczyk, Matthew Whiteman, Timothy Etheridge
Summary: This study found that low-dose mtH(2)S treatment in adult animals can improve health span, protect mitochondrial structure and neuromuscular strength, and is associated with mechanisms at the mitochondrial level.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Nutrition & Dietetics
Francesco Visioli, Carla Mucignat-Caretta, Francesca Anile, Stefan-Alexandru Panaite
Summary: Fasting has been practiced for a long time for various reasons and has shown positive health effects. This expert review examines the historical evolution of fasting and analyzes its current medical applications. The review concludes that fasting can improve various health parameters but emphasizes the need for further research and medical supervision.
Review
Geriatrics & Gerontology
Catrin Herpich, Ursula Mueller-Werdan, Kristina Norman
Summary: Western-style obesity-promoting diets are associated with increased inflammation, higher disease incidence and mortality. On the other hand, plant-based diets are generally associated with better health and lower mortality. Adhering to a plant-based diet can improve metabolic and inflammatory profile, and reduce the incidence of cardiovascular disease. Although there is ample evidence from animal studies, large-scale human studies are lacking to demonstrate the effects of a plant-based diet on longevity.
Review
Biochemistry & Molecular Biology
Katharina Jans, Kai Lueersen, Gerald Rimbach
Summary: The fruit fly Drosophila melanogaster is a valuable model organism in nutritional science, revealing evolutionary conserved aspects of trace element homeostasis between the fruit fly and mammalian species. Studies have shown bioactivity of boron and lithium in plants, animals, and humans, highlighting their potential impact on health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Gary Arendash, Chuanhai Cao
Summary: Most diseases of older age are caused by an imbalanced immune system, resulting in chronic inflammation. A potential gerotherapeutic called Transcranial Electromagnetic Wave Treatment (TEMT) is being evaluated to restore immune balance. TEMT has shown promising results in rebalancing cytokines in both blood and brain, reducing inflammation, and improving cognitive function in Alzheimer's Disease (AD) patients. TEMT has the potential to reduce the risk of age-related diseases and increase healthy longevity by rejuvenating the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Tamara Dakic, Tanja Jevdjovic, Predrag Vujovic, Aleksandra Mladenovic
Summary: This review summarizes the current literature on caloric restriction as a potential life-prolonging intervention in humans, and discusses the metabolic pathways underlying this effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Evan G. Williams, Niklas Pfister, Suheeta Roy, Cyril Statzer, Jack Haverty, Jesse Ingels, Casey Bohl, Moaraj Hasan, Jelena Cuklina, Peter Buhlmann, Nicola Zamboni, Lu Lu, Collin Y. Ewald, Robert W. Williams, Ruedi Aebersold
Summary: We analyzed the liver transcriptome, proteome, and metabolome of BXD mice to study the effects of diet and aging on molecular variations and metabolic traits. We identified genes associated with longevity and found common diet-related candidate genes across datasets. Our study provides insights into causal connections between diet, aging, and metabolic traits.
Review
Biochemistry & Molecular Biology
Chi-Hsiao Yeh, Zhao-Qing Shen, Ching-Cheng Lin, Chung-Kuang Lu, Ting-Fen Tsai
Summary: The aging human population and age-associated diseases are global problems. CISD2 plays a crucial role in maintaining mitochondrial function and has an impact on lifespan and healthspan. It has been identified as one of the few pro-longevity genes in mammals and has the potential to alleviate age-associated disorders. The activation of CISD2 through pharmaceutical intervention, such as hesperetin, can slow down aging and promote longevity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Rendan Yang, Yamei Li, Yanli Wang, Jingjing Zhang, Qijing Fan, Jianlin Tan, Weizhen Li, Xiaoju Zou, Bin Liang
Summary: This study reveals the role of the DVE-1-NHR-80-lipogenesis axis in mediating the transmission of mitochondrial stress signal to lipid metabolism, highlighting its importance in cellular homeostasis.
Review
Biochemistry & Molecular Biology
Adriana De Sousa Lages, Valentim Lopes, Joao Horta, Joao Espregueira-Mendes, Renato Andrade, Alexandre Rebelo-Marques
Summary: Improved healthcare access and social conditions globally have led to a significant increase in life expectancy. However, there is a growing prevalence of age-related diseases, impacting both the individual's quality of life and the sustainability of countries and regions. This narrative review examines potential therapeutic targets that can mimic or enhance the anti-aging effects of physical exercise, although more research is needed to determine their effectiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Michael R. MacArthur, Sarah J. Mitchell, Katia S. Chadaideh, J. Humberto Trevino-Villarreal, Jonathan Jung, Krystle C. Kalafut, Justin S. Reynolds, Charlotte G. Mann, Kaspar M. Trocha, Ming Tao, Tay-Zar Aye, Anantawat Koontanatechanon, Vladimir Yeliseyev, Lynn Bry, Alban Longchamp, C. Keith Ozaki, Caroline A. Lewis, Rachel N. Carmody, James R. Mitchell
Summary: Dietary protein restriction has rapid effects on metabolism, improving glucose and lipid homeostasis. This study found that protein restriction altered fecal microbial composition, but the metabolic effects were not transferable through fecal transplantation. Hepatic transcriptome and metabolome were significantly altered in diets with lower protein content, with specific changes in amino acid metabolism.
Article
Multidisciplinary Sciences
Qin-Li Wan, Xiao Meng, Chongyang Wang, Wenyu Dai, Zhenhuan Luo, Zhinan Yin, Zhenyu Ju, Xiaodie Fu, Jing Yang, Qunshan Ye, Zhan-Hui Zhang, Qinghua Zhou
Summary: Obesity is a major risk factor to human health and can be inherited across generations through epigenetic mechanisms. This study established a nematode model to investigate the network of lipid metabolic genes and chromatin modifications involved in transgenerational obesogenic effects.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Seokjin Ham, Sieun S. Kim, Sangsoon Park, Eun Ji E. Kim, Sujeong Kwon, Hae-Eun H. Park, Yoonji Jung, Seung-Jae V. Lee
Summary: Our study analyzed the relationship between transcriptomic features and physiological and chronological aging using Caenorhabditis elegans as a model. We found that noncoding RNAs and intron-derived transcripts were up-regulated with chronological aging, while mRNAs with many biological functions were down-regulated with physiological aging. Additionally, an increase in the usage of distal 3' splice sites in mRNA transcripts was identified as a biomarker for physiological aging.
Article
Biochemistry & Molecular Biology
Qi Chen, Xuan Yang, Esra Capanoglu, Amel Thanina Amrouche, Lipeng Wu, Jingyang Luo, Yuhang Zhu, Yixuan Wang, Xiongtao Jiang, Dayong Zhang, Baiyi Lu
Summary: This study discovered that extracts from edible flowers can prolong the lifespan of C. elegans and improve their health indicators, while enhancing their resistance to oxidative/heat stress. The longevity-extending effect depends on the transcription factor DAF-16 and mitochondrial function. The study also identified the main active compounds in edible flowers.
