标题
Potential applications for biguanides in oncology
作者
关键词
-
出版物
JOURNAL OF CLINICAL INVESTIGATION
Volume 123, Issue 9, Pages 3693-3700
出版商
American Society for Clinical Investigation
发表日期
2013-09-02
DOI
10.1172/jci67232
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation
- (2013) Olga Moiseeva et al. AGING CELL
- Underexpression of tumour suppressor LKB1 in clear cell renal cell carcinoma is common and confers growth advantage in vitro and in vivo
- (2013) W C Duivenvoorden et al. BRITISH JOURNAL OF CANCER
- Targeting Oxidative Phosphorylation: Why, When, and How
- (2013) Michael Pollak CANCER CELL
- The LKB1-AMPK Pathway—Friend or Foe in Cancer?
- (2013) D. Grahame Hardie CANCER CELL
- LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin
- (2013) David B. Shackelford et al. CANCER CELL
- PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress
- (2013) Francisca Vazquez et al. CANCER CELL
- Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF
- (2013) Rizwan Haq et al. CANCER CELL
- Association of metformin use with cancer incidence and mortality: A meta-analysis
- (2013) Pengpeng Zhang et al. Cancer Epidemiology
- Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism
- (2013) Filipe Cabreiro et al. CELL
- Association Between Metformin Therapy and Mortality After Breast Cancer: A population-based study
- (2013) I. C. Lega et al. DIABETES CARE
- IGF2 increases de novo steroidogenesis in prostate cancer cells
- (2013) Amy A Lubik et al. ENDOCRINE-RELATED CANCER
- Effects of Adjunctive Metformin on Metabolic Traits in Nondiabetic Clozapine-Treated Patients With Schizophrenia and the Effect of Metformin Discontinuation on Body Weight
- (2013) Chun-Hsin Chen et al. JOURNAL OF CLINICAL PSYCHIATRY
- Metformin--an Adjunct Antineoplastic Therapy--Divergently Modulates Tumor Metabolism and Proliferation, Interfering with Early Response Prediction by 18F-FDG PET Imaging
- (2013) P. Habibollahi et al. JOURNAL OF NUCLEAR MEDICINE
- Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
- (2013) Russell A. Miller et al. NATURE
- Increased Oxidative Metabolism in the Li–Fraumeni Syndrome
- (2013) Ping-Yuan Wang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Low Concentrations of Metformin Selectively Inhibit CD133+ Cell Proliferation in Pancreatic Cancer and Have Anticancer Action
- (2013) Shanmiao Gou et al. PLoS One
- Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
- (2013) H. A. Hirsch et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study
- (2012) Saroj Niraula et al. BREAST CANCER RESEARCH AND TREATMENT
- Phenformin as prophylaxis and therapy in breast cancer xenografts
- (2012) M V C L Appleyard et al. BRITISH JOURNAL OF CANCER
- Carbon Source and Myc Expression Influence the Antiproliferative Actions of Metformin
- (2012) S. Javeshghani et al. CANCER RESEARCH
- Cellular Responses to the Metal-Binding Properties of Metformin
- (2012) L. Logie et al. DIABETES
- Metformin and the Risk of Cancer: Time-related biases in observational studies
- (2012) S. Suissa et al. DIABETES CARE
- Stimulation of MC38 tumor growth by insulin analog X10 involves the serine synthesis pathway
- (2012) Henning Hvid et al. ENDOCRINE-RELATED CANCER
- Dual Effect of Metformin on Breast Cancer Proliferation in a Randomized Presurgical Trial
- (2012) Bernardo Bonanni et al. JOURNAL OF CLINICAL ONCOLOGY
- The effects of metformin on inflammatory mediators in obese adolescents with insulin resistance: controlled randomized clinical trial
- (2012) Maria Lola Evia-Viscarra et al. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
- Metformin decreases plasma resistin concentrations in pediatric patients with impaired glucose tolerance: a placebo-controlled randomized clinical trial
- (2012) Rita A. Gómez-Díaz et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- How cancer metabolism is tuned for proliferation and vulnerable to disruption
- (2012) Almut Schulze et al. NATURE
- AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
- (2012) Sang-Min Jeon et al. NATURE
- AMPK: a nutrient and energy sensor that maintains energy homeostasis
- (2012) D. Grahame Hardie et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Metformin pathways
- (2012) Li Gong et al. Pharmacogenetics and Genomics
- Cancer Risk in Diabetic Patients Treated with Metformin: A Systematic Review and Meta-analysis
- (2012) Hiroshi Noto et al. PLoS One
- Distinct perturbation of the translatome by the antidiabetic drug metformin
- (2012) O. Larsson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase
- (2012) S. A. Hawley et al. SCIENCE
- Metformin Accelerates the Growth of BRAF V600E -Driven Melanoma by Upregulating VEGF-A
- (2012) Matthew J. Martin et al. Cancer Discovery
- Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning
- (2012) Michael N. Pollak Cancer Discovery
- Relevance of the OCT1 transporter to the antineoplastic effect of biguanides
- (2011) Eric D. Segal et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals
- (2011) Meei-Shyuan Lee et al. BMC CANCER
- Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial
- (2011) Sirwan Hadad et al. BREAST CANCER RESEARCH AND TREATMENT
- Lapatinib Activity in Premalignant Lesions and HER-2-Positive Cancer of the Breast in a Randomized, Placebo-Controlled Presurgical Trial
- (2011) A. DeCensi et al. Cancer Prevention Research
- Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1
- (2011) I. Ben Sahra et al. CANCER RESEARCH
- Impact of Metformin on the Prognosis of Cirrhosis Induced by Viral Hepatitis C in Diabetic Patients
- (2011) Gisèle Nkontchou et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Randomized Trial of Tamoxifen Versus Combined Tamoxifen and Octreotide LAR Therapy in the Adjuvant Treatment of Early-Stage Breast Cancer in Postmenopausal Women: NCIC CTG MA.14
- (2011) Kathleen I. Pritchard et al. JOURNAL OF CLINICAL ONCOLOGY
- Randomized Phase II Neoadjuvant Comparison Between Letrozole, Anastrozole, and Exemestane for Postmenopausal Women With Estrogen Receptor–Rich Stage 2 to 3 Breast Cancer: Clinical and Biomarker Outcomes and Predictive Value of the Baseline PAM50-Based Intrinsic Subtype—ACOSOG Z1031
- (2011) Matthew J. Ellis et al. JOURNAL OF CLINICAL ONCOLOGY
- Insulin- and Obesity-Related Variables in Early-Stage Breast Cancer: Correlations and Time Course of Prognostic Associations
- (2011) Pamela J. Goodwin et al. JOURNAL OF CLINICAL ONCOLOGY
- CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
- (2011) R. Le Floch et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
- (2011) R. Zoncu et al. SCIENCE
- Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial
- (2010) K. Hosono et al. Cancer Prevention Research
- Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells
- (2010) I. Ben Sahra et al. CANCER RESEARCH
- Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner
- (2010) Adem Kalender et al. Cell Metabolism
- Long-Term Metformin Use Is Associated With Decreased Risk of Breast Cancer
- (2010) M. Bodmer et al. DIABETES CARE
- Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase
- (2010) Carolyn Algire et al. ENDOCRINE-RELATED CANCER
- Metformin Activates AMP Kinase through Inhibition of AMP Deaminase
- (2010) Jiangyong Ouyang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
- (2010) Marc Foretz et al. JOURNAL OF CLINICAL INVESTIGATION
- Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
- (2010) C Algire et al. ONCOGENE
- Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism
- (2009) Shinichi Ota et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Histological evaluation of AMPK signalling in primary breast cancer
- (2009) Sirwan M Hadad et al. BMC CANCER
- Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission
- (2009) H. A. Hirsch et al. CANCER RESEARCH
- Tumor suppressors and cell metabolism: a recipe for cancer growth
- (2009) R. G. Jones et al. GENES & DEVELOPMENT
- Enhancing CD8 T-cell memory by modulating fatty acid metabolism
- (2009) Erika L. Pearce et al. NATURE
- Toxicity and toxicokinetics of metformin in rats
- (2009) Michael P. Quaile et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
- (2008) Xu Huang et al. BIOCHEMICAL JOURNAL
- Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action
- (2008) N. Turner et al. DIABETES
- Insulin, the Insulin-Like Growth Factor Axis, and Mortality in Patients With Nonmetastatic Colorectal Cancer
- (2008) Brian M. Wolpin et al. JOURNAL OF CLINICAL ONCOLOGY
- Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis
- (2008) Jing Ma et al. LANCET ONCOLOGY
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- Metformin for the Treatment of the Polycystic Ovary Syndrome
- (2008) John E. Nestler NEW ENGLAND JOURNAL OF MEDICINE
- Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro
- (2008) James A. Dykens et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Immortal Time Bias in Pharmacoepidemiology
- (2007) S. Suissa AMERICAN JOURNAL OF EPIDEMIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started