Article
Biochemistry & Molecular Biology
Dang Wei, Bian Rui, Fan Qingquan, Cai Chen, Hu Yun Ping, Song Xiaoling, Weng Hao, Gu Jun
Summary: Proliferation is a significant hallmark of gallbladder cancer, a relatively rare but fatal malignancy. This study identified KIF11 as a major upregulated regulator of proliferation in gallbladder cancer, potentially promoting GBC cell proliferation through the ERBB2/PI3K/AKT signaling pathway. The findings provide insights into the mechanisms underlying GBC cancer development and may contribute to the development of novel diagnostic and therapeutic targets.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Feng Guo, Yingke Zhou, Hui Guo, Dianyun Ren, Xin Jin, Heshui Wu
Summary: NR5A2 acts as a negative prognostic biomarker in pancreatic ductal adenocarcinoma (PDAC), being transcriptionally upregulated by BRD4 and promoting pancreatic cancer progression through inducing the transcription of GDF15.
CELL DEATH DISCOVERY
(2021)
Article
Cell Biology
Chen Wang, Jie Zeng, Li-Jie Li, Min Xue, Si-Li He
Summary: The study showed that Cdc25A regulates ferroptosis in cervical cancer cells by modulating the levels of PKM2 and ErbB2, affecting the response of cervical cancer cells to sorafenib treatment.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Multidisciplinary
Chunxu Lv, Shutong Li, Jingjing Zhao, Pishan Yang, Chengzhe Yang
Summary: M1 macrophages promote the proliferation, migration, invasion, and xenograft development of oral squamous cell carcinoma cells. Mechanistically, this protumor effect of M1 macrophages is partly associated with inducing GDF15-mediated ErbB2 phosphorylation.
Article
Biochemistry & Molecular Biology
Chirukandath Sidhanth, Sadhanandhan Bindhya, Aboo Shabna, Shyama Krishnapriya, Pacharla Manasa, Rohit Pravin Nagare, Thanda Joshua, Smarkan Sneha, Kanchan Murhekar, Trivadi Sundaram Ganesan
Summary: The interaction between LASP-1 and ErbB2 may play an important role in the pathogenesis of ovarian cancer, with their binding and phosphorylation being independent of the kinase activity of ErbB2.
BIOCHEMICAL JOURNAL
(2022)
Article
Oncology
Zhi Wei, Jianfeng Gan, Xuan Feng, Mo Zhang, Zhixian Chen, Hongbo Zhao, Yan Du
Summary: This study found that A3B is overexpressed in cervical cancer and progressively activated during its development. The results also suggest that A3B promotes cell proliferation, migration, and cell cycle, and inhibits apoptosis in cervical cancer cells through the p53 pathway. Additionally, A3B may contribute to chemoresistance in cervical cancer cells.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Cell Biology
Mingang Hao, Syn Kok Yeo, Jun-Lin Guan
Summary: Autophagy inhibition can effectively prevent the occurrence of ERBB2-driven breast tumors, with stronger effects than previous studies using other models. Autophagy inhibition disrupts intracellular trafficking of ERBB2 and triggers its release via extracellular vesicles.
Article
Multidisciplinary Sciences
Juan Zhang, Graciela Teran, Mihaela Popa, Harsha Madapura, Marcus James Graeme Watson Ladds, Danai Lianoudaki, Jacob Grunler, Marie Arsenian-Henriksson, Emmet McCormack, Martin Enrique Rottenberg, Sergiu-Bogdan Catrina, Sonia Lain, Suhas Darekar
Summary: Pharmacological inhibition of DHODH reduces mitochondrial respiration, promotes glycolysis, enhances GLUT4 translocation, increases expression of GDF15 through p53 activation, and leads to reduced appetite and prolonged lifespan. DHODH inhibitors also elevate levels of circulating GDF15 and improve metabolic balance in obesity-induced diabetes models.
Article
Oncology
Sheng-Kai Huang, Ruo-Xuan Ni, Wen-Jie Wang, Di Wang, Mei Zhao, Cheng-Zhi Lei, Xiao-Jie Sun, Chang-Zhi Huang, Ping Bai, Yi-Qun Che, Jian-Ping Xu
Summary: The study found that LINC00673 was highly expressed in cervical cancer patients, and overexpression of LINC00673 enhanced proliferation and cell cycle progression in cervical cancer cells in in vitro and in vivo experiments.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Min Lin, Jianan Zhang, Hakim Bouamar, Zhiwei Wang, Lu-Zhe Sun, Xueqiong Zhu
Summary: This study reveals that high expression of FBXO22 is associated with clinicopathological characteristics and poor prognosis in cervical cancer patients. Overexpression of FBXO22 promotes cell viability and tumor growth, while knockdown of FBXO22 has opposite effects. Additionally, overexpression of FBXO22 promotes cell cycle progression and inhibits apoptosis in cervical cancer cells. FBXO22 promotes cervical cancer progression by regulating the ubiquitination and proteasomal degradation of the cyclin-dependent kinase inhibitor p57(Kip2).
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Chenglu Zhu, Cuilan Zhang, Xiaoming Cui, Jing Wu, Zhizhu Cui, Xiaojuan Shen
Summary: The natural compound trichosanthin (TCS) shows potential as an antiviral and anti-tumor agent in cervical cancer by inhibiting cell viability, proliferation, migration, and invasion while inducing apoptosis, possibly through the regulation of oxidative stress.
Article
Cell Biology
Yanzong Lai, Yang Yang
Summary: The aim of this study was to evaluate the expression levels of SMYD2 in colon cancer tissue samples and cells, and to explore its potential mechanisms in colon cancer progression. It was found that SMYD2 was highly expressed in human colon cancer tissues and cells, and its expression was correlated with clinical pathological features such as vascular invasion, TNM stage, and lymph node metastasis. The study further demonstrated that SMYD2 affects cell proliferation, invasion, and apoptosis through the regulation of the ERBB2/FUT4 signaling pathway. It was also found that SMYD2 contributes to tumor growth in vivo. The findings suggest that SMYD2 could be a potential therapeutic target for colon cancer.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Yanli Bi, Xiaoyu Chen, Bajin Wei, Linchen Wang, Longyuan Gong, Haomin Li, Xiufang Xiong, Yongchao Zhao
Summary: DEPTOR interacts with and stabilizes ErbB2, promoting proliferation and survival of ErbB2-positive breast cancer cells. Overexpression of DEPTOR is correlated with poorer patient survival, and the membrane localization of DEPTOR may contribute to the oncogenic characteristics of ErbB2.
Article
Oncology
Juan Wang, Yuhong Wu, Yan Li, Yamei Wang, Fangrong Shen, Jinhua Zhou, Youguo Chen
Summary: The study found that GMPS is highly expressed in cervical cancer, positively correlated with tumor differentiation and invasion depth. Furthermore, GMPS knockdown inhibited proliferation and colony formation, while promoting aging and apoptosis of cervical cancer cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Review
Nutrition & Dietetics
Matteo Nadile, Maria Ilektra Retsidou, Katerina Gioti, Apostolos Beloukas, Evangelia Tsiani
Summary: Cervical cancer is a global health concern, with a high number of cases and deaths each year. Resveratrol, a natural substance found in plants, has shown potential anticancer properties. Studies have found that resveratrol can inhibit proliferation, induce cell cycle arrest, and promote apoptosis in cervical cancer cells. It can also reduce the expression of HPV oncoproteins and increase the levels of tumor suppressor p53. In vivo studies on mice have shown a reduction in tumor volume and weight with resveratrol treatment. Overall, resveratrol has the ability to target certain signaling molecules involved in cervical cancer cell proliferation and survival. Further research is needed to fully understand its potential in cervical cancer treatment.