期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 291, 期 35, 页码 18591-18599出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.C116.744037
关键词
autophagy; Caenorhabditis elegans (C; elegans); drug action; endosome; metformin; sodium-proton exchange; Type 2 diabetes; sodium-proton exchange
资金
- National Institutes of Health Office of Research Infrastructure Programs [P40 OD010440]
- Bloomington Drosophila Stock Center
Diabetes is one of the most impactful diseases worldwide. The most commonly prescribed anti-diabetic drug is metformin. In this study, we identified an endosomal Na+/H+ exchanger (NHE) as a new potential target of metformin from an unbiased screen in Caenorhabditis elegans. The same NHE homolog also exists in flies, where it too mediates the effects of metformin. Our results suggest that endosomal NHEs could be a metformin target and provide an insight into a novel mechanism of action of metformin on regulating the endocytic cycle.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据