Oncogene-Induced Reprogramming in Acute Lymphoblastic Leukemia: Towards Targeted Therapy of Leukemia-Initiating Cells

A 2020 View of Thymus Stromal Cells in T Cell Development

(2021) Jianxun Han et al.   JOURNAL OF IMMUNOLOGY

T-ALL can evolve to oncogene independence

(2021) Hesham Abdulla et al.   LEUKEMIA

Toward Therapeutic Targeting of Bone Marrow Leukemic Niche Protective Signals in B-Cell Acute Lymphoblastic Leukemia

(2021) Marjorie C. Delahaye et al.   Frontiers in Oncology

Single-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy

(2021) Tracy Rabilloud et al.   Nature Communications

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics

(2021) Lars Velten et al.   Nature Communications

Molecular-based and antibody-based targeted pharmacological approaches in childhood acute lymphoblastic leukemia

(2021) Magalie Tardif et al.   EXPERT OPINION ON PHARMACOTHERAPY

The New Therapeutic Strategies in Pediatric T-Cell Acute Lymphoblastic Leukemia

(2021) Marta Weronika Lato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Advances in the Diagnosis and Treatment of Pediatric Acute Lymphoblastic Leukemia

(2021) Hiroto Inaba et al.   Journal of Clinical Medicine

The Second Oncogenic Hit Determines the Cell Fate of ETV6-RUNX1 Positive Leukemia

(2021) Guillermo Rodríguez-Hernández et al.   Frontiers in Cell and Developmental Biology

Targeting cytokine and therapy induced PIM1 activation in T-cell acute lymphoblastic leukemia and lymphoma

(2020) Renate De Smedt et al.   BLOOD

Dynamic responses of the haematopoietic stem cell niche to diverse stresses

(2020) Antoniana Batsivari et al.   NATURE CELL BIOLOGY

Relapse fated latent diagnosis subclones in acute B lineage leukaemia are drug tolerant and possess distinct metabolic programs

(2020) Stephanie M. Dobson et al.   Cancer Discovery

A targetable cue in T-cell malignancy

(2020) Bastien Gerby et al.   BLOOD

Molecular markers in ALL: Clinical implications

(2020) Shunsuke Kimura et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells

(2020) Kenly Wuputra et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A 9-gene score for risk stratification in B-cell acute lymphoblastic leukemia

(2020) Feng Yan et al.   LEUKEMIA

Signalling input from divergent pathways subverts B cell transformation

(2020) Lai N. Chan et al.   NATURE

Integrated Genomic Analysis of Chromosomal Alterations and Mutations in B-Cell Acute Lymphoblastic Leukemia Reveals Distinct Genetic Profiles at Relapse

(2020) Maribel Forero-Castro et al.   Diagnostics

Single-cell DNA amplicon sequencing reveals clonal heterogeneity and evolution in T-cell acute lymphoblastic leukemia

(2020) Llucia Albertí-Servera et al.   BLOOD

An intact gut microbiome protects genetically predisposed mice against leukemia

(2020) Carolina Vicente Dueñas et al.   BLOOD

Germline PAX5 mutation predisposes to familial B acute lymphoblastic leukemia

(2020) Nicolas Duployez et al.   BLOOD

EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism

(2020) Senthilkumar Ramamoorthy et al.   GENES & DEVELOPMENT

Pediatric acute lymphoblastic leukemia

(2020) Hiroto Inaba et al.   HAEMATOLOGICA

Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells

(2020) Cedric S. Tremblay et al.   Nature Communications

B-ALL Complexity: Is Targeted Therapy Still A Valuable Approach for Pediatric Patients?

(2020) Stefano Ratti et al.   Cancers

PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia

(2019) Zhaohui Gu et al.   NATURE GENETICS

PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia

(2019) Lorenz Bastian et al.   LEUKEMIA

The NUP98-HOXD13 fusion oncogene induces thymocyte self-renewal via Lmo2/Lyl1

(2019) Benjamin J. Shields et al.   LEUKEMIA

Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress

(2019) Richard Burt et al.   BLOOD

The Biology of B-Progenitor Acute Lymphoblastic Leukemia

(2019) Kathryn G. Roberts et al.   Cold Spring Harbor Perspectives in Medicine

Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID

(2019) Guillermo Rodríguez-Hernández et al.   Nature Communications

Loss of Pax5 Exploits Sca1-BCR-ABLp190Susceptibility to Confer the Metabolic Shift Essential for pB-ALL

(2018) Alberto Martín-Lorenzo et al.   CANCER RESEARCH

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

(2018) Tathiane M. Malta et al.   CELL

Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies

(2018) Robert L. Bowman et al.   Cell Stem Cell

Lmo2 expression defines tumor cell identity during T‐cell leukemogenesis

(2018) Idoia García‐Ramírez et al.   EMBO JOURNAL

Role of CD81 and CD58 in minimal residual disease detection in pediatric B lymphoblastic leukemia

(2018) E. Tsitsikov et al.   International Journal of Laboratory Hematology

Differential expression of CD73, CD86 and CD304 in normal vs. leukemic B-cell precursors and their utility as stable minimal residual disease markers in childhood B-cell precursor acute lymphoblastic leukemia

(2018) Łukasz Sędek et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse

(2018) Zinaida Good et al.   NATURE MEDICINE

The genetic basis and cell of origin of mixed phenotype acute leukaemia

(2018) Thomas B. Alexander et al.   NATURE

Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia

(2018) Elena J. Orlando et al.   NATURE MEDICINE

PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice

(2018) Laura Jamrog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

(2018) Cedric S. Tremblay et al.   Nature Communications

PAX5A and PAX5B isoforms are both efficient to drive B cell differentiation

(2018) Charlotte Cresson et al.   Oncotarget

PAX5 P80R mutation identifies a novel subtype of B-cell precursor acute lymphoblastic leukemia with favorable outcome

(2018) Marie Passet et al.   BLOOD

PDX models recapitulate the genetic and epigenetic landscape of pediatric T‐cell leukemia

(2018) Paulina Richter‐Pechańska et al.   EMBO Molecular Medicine

Next-generation antigen receptor sequencing of paired diagnosis and relapse samples of B-cell acute lymphoblastic leukemia: Clonal evolution and implications for minimal residual disease target selection

(2018) Prisca M.J. Theunissen et al.   LEUKEMIA RESEARCH

Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases

(2018) Jian-Feng Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia

(2018) Peter van Galen et al.   Cell Reports

Copy number profiling of adult relapsed B-cell precursor acute lymphoblastic leukemia reveals potential leukemia progression mechanisms

(2017) Jordi Ribera et al.   GENES CHROMOSOMES & CANCER

Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia

(2017) A Elder et al.   LEUKEMIA

Metabolic gatekeeper function of B-lymphoid transcription factors

(2017) Lai N. Chan et al.   NATURE

Tracing the origins of relapse in acute myeloid leukaemia to stem cells

(2017) Liran I. Shlush et al.   NATURE

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia

(2016) Sarah Ebinger et al.   CANCER CELL

Mass Cytometry: Single Cells, Many Features

(2016) Matthew H. Spitzer et al.   CELL

The hematopoietic stem-cell niche in health and leukemia

(2016) Abel Sánchez-Aguilera et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia

(2016) Aissa Benyoucef et al.   GENES & DEVELOPMENT

Superenhancer reprogramming drives a B-cell–epithelial transition and high-risk leukemia

(2016) Yeguang Hu et al.   GENES & DEVELOPMENT

Thymocytes self-renewal: a major hope or a major threat?

(2016) Laetitia Peaudecerf et al.   IMMUNOLOGICAL REVIEWS

Microenvironmental cues for T-cell acute lymphoblastic leukemia development

(2016) Diana Passaro et al.   IMMUNOLOGICAL REVIEWS

High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells

(2016) Bastien Gerby et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling

(2016) C S Tremblay et al.   LEUKEMIA

Plastic CD34 and CD38 expression in adult B–cell precursor acute lymphoblastic leukemia explains ambiguity of leukemia-initiating stem cell populations

(2016) F Lang et al.   LEUKEMIA

Patient-derived xenotransplants can recapitulate the genetic driver landscape of acute leukemias

(2016) K Wang et al.   LEUKEMIA

A 17-gene stemness score for rapid determination of risk in acute leukaemia

(2016) Stanley W. K. Ng et al.   NATURE

Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia

(2016) Koichi Oshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Speed of leukemia development and genetic diversity in xenograft models of T cell acute lymphoblastic leukemia

(2016) Sandrine Poglio et al.   Oncotarget

PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia

(2015) J. Dang et al.   BLOOD

Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency

(2015) M. A. J. Prasad et al.   BLOOD

Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia

(2015) R. Somasundaram et al.   BLOOD

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemia

(2015) Louise van der Weyden et al.   BMC CANCER

PAX5-ESRRB is a recurrent fusion gene in B-cell precursor pediatric acute lymphoblastic leukemia

(2015) Y. Marincevic-Zuniga et al.   HAEMATOLOGICA

Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia

(2015) Jesús Duque-Afonso et al.   JOURNAL OF CLINICAL INVESTIGATION

Combined heterozygous loss ofEbf1andPax5allows for T-lineage conversion of B cell progenitors

(2015) Jonas Ungerbäck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

c-Myc plays part in drug resistance mediated by bone marrow stromal cells in acute myeloid leukemia

(2015) Bing Xia et al.   LEUKEMIA RESEARCH

Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists

(2015) Stéphane Prost et al.   NATURE

Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia

(2015) Xiaotu Ma et al.   Nature Communications

Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of Pax5-Inherited Susceptibility

(2015) A. Martin-Lorenzo et al.   Cancer Discovery

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors

(2015) Shrikanta Chattopadhyay et al.   Cell Reports

Role of Microenvironment in Resistance to Therapy in AML

(2015) Yoko Tabe et al.   Current Hematologic Malignancy Reports

PAX5-ESRRB is a recurrent fusion gene in B-cell precursor pediatric acute lymphoblastic leukemia

(2015) Y. Marincevic-Zuniga et al.   HAEMATOLOGICA

Stem Cell Hierarchy and Clonal Evolution in Acute Lymphoblastic Leukemia

(2015) Fabian Lang et al.   Stem Cells International

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

(2014) J. E. Roderick et al.   BLOOD

Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia

(2014) Y. Aoki et al.   BLOOD

Single-Cell Trajectory Detection Uncovers Progression and Regulatory Coordination in Human B Cell Development

(2014) Sean C. Bendall et al.   CELL

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

NUP98-PHF23 and NUP98-HOXD13 oncogenes confer aberrant self-renewal potential to thymocyte progenitors

(2014) Magalie Tardif et al.   EXPERIMENTAL HEMATOLOGY

Clonal variegation and dynamic competition of leukemia-initiating cells in infant acute lymphoblastic leukemia with MLL rearrangement

(2014) M Bardini et al.   LEUKEMIA

Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice

(2014) B J Shields et al.   LEUKEMIA

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

(2014) Peter van Galen et al.   NATURE

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-range enhancer activity determinesMycsensitivity to Notch inhibitors in T cell leukemia

(2014) Yumi Yashiro-Ohtani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

(2014) M. R. Corces-Zimmerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Reprogramming of Murine Fibroblasts to Hematopoietic Progenitor Cells

(2014) Kiran Batta et al.   Cell Reports

Controlling Pre-leukemic Thymocyte Self-Renewal

(2014) Steven Goossens et al.   PLoS Genetics

SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells

(2014) Bastien Gerby et al.   PLoS Genetics

Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL

(2013) M. P. McCormack et al.   BLOOD

Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines

(2013) Guangxu Jin et al.   DRUG DISCOVERY TODAY

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

(2013) Kimberly A Hartwell et al.   Nature Chemical Biology

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

(2013) Sohela Shah et al.   NATURE GENETICS

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells

(2012) M. Y. Chiang et al.   BLOOD

The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis

(2012) Roger Revilla-i-Domingo et al.   EMBO JOURNAL

Acute B lymphoblastic leukaemia-propagating cells are present at high frequency in diverse lymphoblast populations

(2012) Klaus Rehe et al.   EMBO Molecular Medicine

Molecular genetics of B-precursor acute lymphoblastic leukemia

(2012) Charles G. Mullighan   JOURNAL OF CLINICAL INVESTIGATION

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL

(2011) J. Tatarek et al.   BLOOD

ETV6/RUNX1-positive relapses evolve from an ancestral clone and frequently acquire deletions of genes implicated in glucocorticoid signaling

(2011) L. Kuster et al.   BLOOD

Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis

(2011) J. Shi et al.   BLOOD

Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia

(2011) F. W. van Delft et al.   BLOOD

Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia

(2011) Nicolas Goardon et al.   CANCER CELL

GATA-2 mediated regulation of normal hematopoietic stem/progenitor cell function, myelodysplasia and myeloid leukemia

(2011) Neil P. Rodrigues et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse

(2011) Emmanuelle Clappier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ebf1orPax5haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia

(2011) Lynn M. Heltemes-Harris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of CD34 and CD7 on human T-cell acute lymphoblastic leukemia discriminates functionally heterogeneous cell populations

(2011) B Gerby et al.   LEUKEMIA

Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells

(2011) Faiyaz Notta et al.   NATURE

CREBBP mutations in relapsed acute lymphoblastic leukaemia

(2011) Charles G. Mullighan et al.   NATURE

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance

(2010) P. P. L. Chiu et al.   BLOOD

Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study

(2010) E. Coyaud et al.   BLOOD

Combinatorial Transcriptional Control In Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators

(2010) Nicola K. Wilson et al.   Cell Stem Cell

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes

(2010) M. Tremblay et al.   GENES & DEVELOPMENT

Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice

(2010) Jean-Emmanuel Sarry et al.   JOURNAL OF CLINICAL INVESTIGATION

Insights into the stem cells of chronic myeloid leukemia

(2010) I Sloma et al.   LEUKEMIA

Genetic variegation of clonal architecture and propagating cells in leukaemia

(2010) Kristina Anderson et al.   NATURE

Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity

(2010) Douglas W McMillin et al.   NATURE MEDICINE

A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice

(2010) K M Draheim et al.   ONCOGENE

The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal

(2010) M. P. McCormack et al.   SCIENCE

Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia

(2009) F. C. Guibal et al.   BLOOD

WT1 mutations in T-ALL

(2009) V. Tosello et al.   BLOOD

Scl regulates the quiescence and the long-term competence of hematopoietic stem cells

(2009) J. Lacombe et al.   BLOOD

The leukemic stem cell niche: current concepts and therapeutic opportunities

(2009) S. W. Lane et al.   BLOOD

Hematopoietic Stem Cell Expansion Precedes the Generation of Committed Myeloid Leukemia-Initiating Cells in C/EBPα Mutant AML

(2009) Oxana Bereshchenko et al.   CANCER CELL

Adult Hematopoietic Stem and Progenitor Cells Require Either Lyl1 or Scl for Survival

(2009) George P. Souroullas et al.   Cell Stem Cell

A NUP98-HOXD13 Fusion Gene Impairs Differentiation of B and T Lymphocytes and Leads to Expansion of Thymocytes with Partial TCRB Gene Rearrangement

(2009) C. W. Choi et al.   JOURNAL OF IMMUNOLOGY

PML–RARα initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors

(2009) S Wojiski et al.   LEUKEMIA

PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study

(2009) J Familiades et al.   LEUKEMIA

Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells

(2008) D. C. Taussig et al.   BLOOD

Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia

(2008) J. J. Yang et al.   BLOOD

NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity

(2008) F. Armstrong et al.   BLOOD

In Childhood Acute Lymphoblastic Leukemia, Blasts at Different Stages of Immunophenotypic Maturation Have Stem Cell Properties

(2008) Christoph le Viseur et al.   CANCER CELL

Malignant Transformation Initiated by Mll-AF9: Gene Dosage and Critical Target Cells

(2008) Weili Chen et al.   CANCER CELL

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells

(2008) Ivan Maillard et al.   Cell Stem Cell

CD34+CD38+CD19+ as well as CD34+CD38−CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL

(2008) Y Kong et al.   LEUKEMIA

Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia

(2008) K Nebral et al.   LEUKEMIA

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

(2008) Adlen Foudi et al.   NATURE BIOTECHNOLOGY

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

(2008) Rihab Nasr et al.   NATURE MEDICINE

Variable breakpoints target PAX5 in patients with dicentric chromosomes: A model for the basis of unbalanced translocations in cancer

(2008) Q. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Initiating and Cancer-Propagating Cells in TEL-AML1-Associated Childhood Leukemia

(2008) D. Hong et al.   SCIENCE

Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

(2008) C. G. Mullighan et al.   SCIENCE