Microenvironmental cues for T-cell acute lymphoblastic leukemia development

Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy

(2015) B.-S. Cho et al.   BLOOD

Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia

(2015) S. L. Maude et al.   BLOOD

CXCR4 Is Required for Leukemia-Initiating Cell Activity in T Cell Acute Lymphoblastic Leukemia

(2015) Diana Passaro et al.   CANCER CELL

CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance

(2015) Lauren A. Pitt et al.   CANCER CELL

Molecular Pathways: Clinical Applications and Future Direction of Insulin-like Growth Factor-1 Receptor Pathway Blockade

(2015) W. T. Iams et al.   CLINICAL CANCER RESEARCH

Ablation ofWntlessin endosteal niches impairs lymphopoiesis rather than HSCs maintenance

(2015) Jingjing Cao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Altered mesenchymal niche cells impede generation of normal hematopoietic progenitor cells in leukemic bone marrow

(2015) M Lim et al.   LEUKEMIA

FAK Mediates a Compensatory Survival Signal Parallel to PI3K-AKT in PTEN-Null T-ALL Cells

(2015) Dewen You et al.   Cell Reports

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

(2014) J. E. Roderick et al.   BLOOD

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model

(2014) S. Degryse et al.   BLOOD

Clonal Evolution Enhances Leukemia-Propagating Cell Frequency in T Cell Acute Lymphoblastic Leukemia through Akt/mTORC1 Pathway Activation

(2014) Jessica S. Blackburn et al.   CANCER CELL

Murine Pten−/− T-ALL requires non-redundant PI3K/mTOR and DLL4/Notch1 signals for maintenance and γc/TCR signals for thymic exit

(2014) Thijs J. Hagenbeek et al.   CANCER LETTERS

Targeting the MYC and PI3K Pathways Eliminates Leukemia-Initiating Cells in T-cell Acute Lymphoblastic Leukemia

(2014) S. Schubbert et al.   CANCER RESEARCH

DLL4 regulates NOTCH signaling and growth of T acute lymphoblastic leukemia cells in NOD/SCID mice

(2014) Sonia Minuzzo et al.   CARCINOGENESIS

Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche

(2014) Maher Hanoun et al.   Cell Stem Cell

Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit

(2014) Hind Medyouf et al.   Cell Stem Cell

Osterix Marks Distinct Waves of Primitive and Definitive Stromal Progenitors during Bone Marrow Development

(2014) Toshihide Mizoguchi et al.   DEVELOPMENTAL CELL

Epigenetics in T-cell acute lymphoblastic leukemia

(2014) Sofie Peirs et al.   IMMUNOLOGICAL REVIEWS

Kit Regulates Maintenance of Quiescent Hematopoietic Stem Cells

(2014) L. A. Thoren et al.   JOURNAL OF IMMUNOLOGY

Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells

(2014) Meng Zhao et al.   NATURE MEDICINE

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

(2014) Ingmar Bruns et al.   NATURE MEDICINE

Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells

(2014) T. Hoshii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multimodal imaging reveals structural and functional heterogeneity in different bone marrow compartments: functional implications on hematopoietic stem cells

(2013) F. Lassailly et al.   BLOOD

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

(2013) María Casanova-Acebes et al.   CELL

The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability

(2013) Bryan King et al.   CELL

SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors

(2013) Hideyuki Oguro et al.   Cell Stem Cell

Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche

(2013) Koen Schepers et al.   Cell Stem Cell

Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12

(2013) C. Zhong et al.   CLINICAL CANCER RESEARCH

Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

(2013) Daniel J. Nolan et al.   DEVELOPMENTAL CELL

Toward a NOTCH1/FBXW7/RAS/PTEN–Based Oncogenetic Risk Classification of Adult T-Cell Acute Lymphoblastic Leukemia: A Group for Research in Adult Acute Lymphoblastic Leukemia Study

(2013) Amélie Trinquand et al.   JOURNAL OF CLINICAL ONCOLOGY

PDGFRα and CD51 mark human Nestin+sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion

(2013) Sandra Pinho et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Relapsed childhood acute lymphoblastic leukaemia

(2013) Deepa Bhojwani et al.   LANCET ONCOLOGY

Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts

(2013) V Agnusdei et al.   LEUKEMIA

Leukemia-initiating cell activity requires calcineurin in T-cell acute lymphoblastic leukemia

(2013) S Gachet et al.   LEUKEMIA

Orai1-NFAT signalling pathway triggered by T cell receptor stimulation

(2013) Sonal Srikanth et al.   MOLECULES AND CELLS

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL

(2013) Gannie Tzoneva et al.   NATURE MEDICINE

Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors

(2013) Michaela Waibel et al.   Cell Reports

Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis

(2013) Michael G. Poulos et al.   Cell Reports

Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia

(2012) E. McCormack et al.   BLOOD

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells

(2012) M. Y. Chiang et al.   BLOOD

In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells

(2012) G. Amabile et al.   BLOOD

Targeting Nonclassical Oncogenes for Therapy in T-ALL

(2012) Prem S. Subramaniam et al.   CANCER CELL

Synergistic, Context-Dependent, and Hierarchical Functions of Epithelial Components in Thymic Microenvironments

(2012) Lesly Calderón et al.   CELL

BMS-936564/MDX-1338: A Fully Human Anti-CXCR4 Antibody Induces Apoptosis In Vitro and Shows Antitumor Activity In Vivo in Hematologic Malignancies

(2012) M. R. Kuhne et al.   CLINICAL CANCER RESEARCH

The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia

(2012) L. Zuurbier et al.   HAEMATOLOGICA

The molecular basis of T cell acute lymphoblastic leukemia

(2012) Pieter Van Vlierberghe et al.   JOURNAL OF CLINICAL INVESTIGATION

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia

(2012) Keunwook Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus

(2012) Tom M. McCaughtry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

(2012) Kim De Keersmaecker et al.   NATURE GENETICS

NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species

(2012) Vincenzo Giambra et al.   NATURE MEDICINE

Anti-IL-7 receptor-  reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function

(2012) L.-F. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL

(2011) J. Tatarek et al.   BLOOD

Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis

(2011) J. Shi et al.   BLOOD

Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia

(2011) Irene Homminga et al.   CANCER CELL

IL-7 Contributes to the Progression of Human T-cell Acute Lymphoblastic Leukemias

(2011) A. Silva et al.   CANCER RESEARCH

Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion

(2011) Tiago C. Luis et al.   Cell Stem Cell

Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor

(2011) R. Mallon et al.   CLINICAL CANCER RESEARCH

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling

(2011) Hind Medyouf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse

(2011) Emmanuelle Clappier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gain-of-function mutations ininterleukin-7 receptor-α(IL7R) in childhood acute lymphoblastic leukemias

(2011) Chen Shochat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

(2011) Andrew Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch1 regulates chemotaxis and proliferation by controlling the CC-chemokine receptors 5 and 9 in T cell acute lymphoblastic leukaemia

(2011) Leonardo Mirandola et al.   JOURNAL OF PATHOLOGY

Expression of CD34 and CD7 on human T-cell acute lymphoblastic leukemia discriminates functionally heterogeneous cell populations

(2011) B Gerby et al.   LEUKEMIA

Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells

(2011) Faiyaz Notta et al.   NATURE

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche

(2011) Joji Fujisaki et al.   NATURE

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

(2011) Konstantinos J Mavrakis et al.   NATURE GENETICS

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia

(2011) Priscila P Zenatti et al.   NATURE GENETICS

Notch3 Is Dispensable for Thymocyte β-Selection and Notch1-Induced T Cell Leukemogenesis

(2011) Sara Suliman et al.   PLoS One

Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia

(2010) Jules P.P. Meijerink   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance

(2010) P. P. L. Chiu et al.   BLOOD

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia

(2010) A. Gutierrez et al.   BLOOD

Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression

(2010) Y.-S. Tzeng et al.   BLOOD

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

(2010) I. G. Winkler et al.   BLOOD

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes

(2010) M. Tremblay et al.   GENES & DEVELOPMENT

HIV-1 Rev–binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in mice

(2010) Shariq S. Khwaja et al.   JOURNAL OF CLINICAL INVESTIGATION

Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment

(2010) Yohei Morita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct Comparison of Dll1- and Dll4-Mediated Notch Activation Levels Shows Differential Lymphomyeloid Lineage Commitment Outcomes

(2010) M. Mohtashami et al.   JOURNAL OF IMMUNOLOGY

Genetic variegation of clonal architecture and propagating cells in leukaemia

(2010) Kristina Anderson et al.   NATURE

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

(2010) Konstantinos J. Mavrakis et al.   NATURE CELL BIOLOGY

Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia

(2010) Maria Kleppe et al.   NATURE GENETICS

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

(2010) I. Beerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Essential Developmental Checkpoint for Production of the T Cell Lineage

(2010) T. Ikawa et al.   SCIENCE

The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal

(2010) M. P. McCormack et al.   SCIENCE

Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4

(2009) Veronique Bodart et al.   BIOCHEMICAL PHARMACOLOGY

CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus

(2009) D. A. Zlotoff et al.   BLOOD

CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus

(2009) A. Krueger et al.   BLOOD

Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss

(2009) H. Medyouf et al.   BLOOD

Kinetics of normal hematopoietic stem and progenitor cells in a Notch1-induced leukemia model

(2009) X. Hu et al.   BLOOD

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

(2009) A. Gutierrez et al.   BLOOD

Genome-wide Lineage-Specific Transcriptional Networks Underscore Ikaros-Dependent Lymphoid Priming in Hematopoietic Stem Cells

(2009) Samuel Yao-Ming Ng et al.   IMMUNITY

Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4

(2009) Michelle L. Janas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia

(2009) Sara González-García et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Gli3 Transcription Factor Expressed in the Thymus Stroma Controls Thymocyte Negative Selection Via Hedgehog-Dependent and -Independent Mechanisms

(2009) A. L. Hager-Theodorides et al.   JOURNAL OF IMMUNOLOGY

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia

(2009) Silvia Buonamici et al.   NATURE

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

CXCR4 acts as a costimulator during thymic β-selection

(2009) Paul C Trampont et al.   NATURE IMMUNOLOGY

Visualization and Identification of IL-7 Producing Cells in Reporter Mice

(2009) Renata I. Mazzucchelli et al.   PLoS One

Evaluation of the Long-Term Reconstituting Subset of Hematopoietic Stem Cells with CD150

(2009) Peter Papathanasiou et al.   STEM CELLS

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML

(2008) Z. Zeng et al.   BLOOD

Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100

(2008) B. Nervi et al.   BLOOD

Stem cell concepts renew cancer research

(2008) J. E. Dick   BLOOD

NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity

(2008) F. Armstrong et al.   BLOOD

Wnt Signaling in the Niche Enforces Hematopoietic Stem Cell Quiescence and Is Necessary to Preserve Self-Renewal In Vivo

(2008) Heather E. Fleming et al.   Cell Stem Cell

Bone marrow stromal cells and the upregulation of interleukin-8 production in human T-cell acute lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF- B and JNK/AP-1 pathways

(2008) M. T. Scupoli et al.   HAEMATOLOGICA

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras–initiated leukemia

(2008) Mark Y. Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

(2008) Ana Silva et al.   JOURNAL OF CLINICAL INVESTIGATION

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

(2008) Ute Koch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Somatically acquiredJAK1mutations in adult acute lymphoblastic leukemia

(2008) Elisabetta Flex et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCR4 is required for the quiescence of primitive hematopoietic cells

(2008) Yuchun Nie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Acute lymphoblastic leukaemia

(2008) Ching-Hon Pui et al.   LANCET

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

(2008) S.-M. Maira et al.   MOLECULAR CANCER THERAPEUTICS

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

(2008) Cristina Lo Celso et al.   NATURE

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

(2008) Wei Guo et al.   NATURE

Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells

(2008) Angela Colmone et al.   SCIENCE