Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

Tracing the origins of relapse in acute myeloid leukaemia to stem cells

(2017) Liran I. Shlush et al.   NATURE

Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure

(2016) M. Mossner et al.   BLOOD

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia

(2016) Sarah Ebinger et al.   CANCER CELL

Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions

(2016) Jeffrey M. Bernitz et al.   CELL

Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling

(2016) C S Tremblay et al.   LEUKEMIA

The LMO2 oncogene regulates DNA replication in hematopoietic cells

(2016) Marie-Claude Sincennes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

Clonal evolution of preleukemic hematopoietic stem cells in acute myeloid leukemia

(2015) Stephen M. Sykes et al.   EXPERIMENTAL HEMATOLOGY

Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia

(2015) Jeffery M. Klco et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Asymmetric cell division during T cell development controls downstream fate

(2015) Kim Pham et al.   JOURNAL OF CELL BIOLOGY

Acute myeloid leukemia ontogeny is defined by distinct somatic mutations

(2014) R. C. Lindsley et al.   BLOOD

Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons

(2014) Eric M. Pietras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice

(2014) B J Shields et al.   LEUKEMIA

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells

(2014) Bastien Gerby et al.   PLoS Genetics

Divisional History and Hematopoietic Stem Cell Function during Homeostasis

(2014) Jiajing Qiu et al.   Stem Cell Reports

Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL

(2013) M. P. McCormack et al.   BLOOD

TGFβ restores hematopoietic homeostasis after myelosuppressive chemotherapy

(2013) Fabienne Brenet et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56

(2013) Y Saito et al.   LEUKEMIA

Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness

(2013) Qing Li et al.   NATURE

DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions

(2013) A. Insinga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concise Review: Preleukemic Stem Cells: Molecular Biology and Clinical Implications of the Precursors to Leukemia Stem Cells

(2013) Ashley Pandolfi et al.   Stem Cells Translational Medicine

Pharmacokinetic Modeling of an Induction Regimen for In Vivo Combined Testing of Novel Drugs against Pediatric Acute Lymphoblastic Leukemia Xenografts

(2012) Barbara Szymanska et al.   PLoS One

The endocytic adaptor Numb regulates thymus size by modulating pre-TCR signaling during asymmetric division

(2010) R. Aguado et al.   BLOOD

IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7R  in T cells

(2010) C. M. Henriques et al.   BLOOD

The miR-17-92 microRNA Polycistron Regulates MLL Leukemia Stem Cell Potential by Modulating p21 Expression

(2010) Piu Wong et al.   CANCER RESEARCH

A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal

(2010) Michael Milyavsky et al.   Cell Stem Cell

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

(2010) Mary Mohrin et al.   Cell Stem Cell

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes

(2010) M. Tremblay et al.   GENES & DEVELOPMENT

Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia

(2010) Letetia Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The TLX1 oncogene drives aneuploidy in T cell transformation

(2010) Kim De Keersmaecker et al.   NATURE MEDICINE

The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal

(2010) M. P. McCormack et al.   SCIENCE

Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer

(2009) R. A. Neumuller et al.   GENES & DEVELOPMENT

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

(2009) Andrea Viale et al.   NATURE

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

(2008) Adlen Foudi et al.   NATURE BIOTECHNOLOGY

Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

(2008) C. G. Mullighan et al.   SCIENCE

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE