Article
Immunology
Robin D. Lee, Todd P. Knutson, Sarah A. Munro, Jeffrey T. Miller, Lynn M. Heltemes-Harris, Charles G. Mullighan, Kristen Jepsen, Michael A. Farrar
Summary: The nuclear corepressors NCOR1/2 play a crucial role in regulating B cell development. Loss of NCOR1/2 leads to defective pre-BCR signaling, aberrant chromatin structure, and gene expression, resulting in accelerated leukemic transformation.
Article
Multidisciplinary Sciences
Katja J. Jarick, Patrycja M. Topczewska, Manuel O. Jakob, Hiroshi Yano, Mohammad Arifuzzaman, Xuemei Gao, Sotiria Boulekou, Vladislava Stokic-Trtica, Pierre S. Leclere, Alexandra Preusser, Zoe A. Rompe, Anton Stamm, Amy M. Tsou, Coco Chu, Frederik R. Heinrich, Gabriela M. Guerra, Pawel Durek, Andranik Ivanov, Dieter Beule, Sofia Helfrich, Claudia U. Duerr, Anja A. Kuehl, Christina Stehle, Chiara Romagnani, Mir-Farzin Mashreghi, Andreas Diefenbach, David Artis, Christoph S. N. Klose
Summary: This article investigates the role of innate lymphoid cells (ILCs) in protective immunity. Using a mouse model specific to ILCs, researchers found that ILC2s have non-redundant functions during steady state and disease, and they interact with adaptive immune cells to organize the immune system.
Article
Immunology
Lucille Stuani, Marie Sabatier, Estelle Saland, Guillaume Cognet, Nathalie Poupin, Claudie Bosc, Florence A. Castelli, Lara Gales, Evgenia Turtoi, Camille Montersino, Thomas Farge, Emeline Boet, Nicolas Broin, Clement Larrue, Natalia Baran, Madi Y. Cisse, Marc Conti, Sylvain Loric, Tony Kaoma, Alexis Hucteau, Aliki Zavoriti, Ambrine Sahal, Pierre-Luc Mouchel, Mathilde Gotanegre, Cedric Cassan, Laurent Fernando, Feng Wang, Mohsen Hosseini, Emeline Chu-Van, Laurent Le Cam, Martin Carroll, Mary A. Selak, Norbert Vey, Remy Castellano, Francois Fenaille, Andrei Turtoi, Guillaume Cazals, Pierre Bories, Yves Gibon, Brandon Nicolay, Sebastien Ronseaux, Joseph R. Marszalek, Koichi Takahashi, Courtney D. DiNardo, Marina Konopleva, Vera Pancaldi, Yves Collette, Floriant Bellvert, Fabien Jourdan, Laetitia K. Linares, Christian Recher, Jean-Charles Portais, Jean-Emmanuel Sarry
Summary: Mutations in IDH lead to enhanced mitochondrial oxidative metabolism in AML, involving increased electron transport chain activity and fatty acid oxidation. IDH1 mutant inhibitors reduce 2-HG levels and CEBPα methylation, but do not reverse fatty acid oxidation and OxPHOS. Targeting mitochondrial activities may improve anti-AML efficacy of IDH mutant inhibitors.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Limei Wu, Srinivas Chatla, Qiqi Lin, Fabliha Ahmed Chowdhury, Werner Geldenhuys, Wei Du
Summary: Chemoresistance and relapse are major challenges in the treatment of acute lymphoblastic leukemia (ALL). The study identifies QC as a sensitizer for AraC and establishes a QC-CASIN regimen to improve leukemia eradication in ALL, showing limited efficacy in secondary transplanted recipients.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Chen Liu, Yandong Gong, Han Zhang, Hua Yang, Yang Zeng, Zhilei Bian, Qian Xin, Zhijie Bai, Man Zhang, Jian He, Jing Yan, Jie Zhou, Zongcheng Li, Yanli Ni, Aiqing Wen, Yu Lan, Hongbo Hu, Bing Liu
Summary: This study focuses on the developmental hierarchy and characteristics of ILCs in early human fetus, starting from hematopoietic stem/progenitor cells in fetal liver and intestine, and analyzing the heterogeneity and tissue distribution of each ILC subpopulation, shedding light on the stepwise formation of human fetal ILC hierarchy with remarkable spatiotemporal heterogeneity.
Review
Biochemistry & Molecular Biology
Thiago Cezar Fujita, Nathalia Sousa-Pereira, Marla Karine Amarante, Maria Angelica Ehara Watanabe
Summary: Acute lymphoid leukemia is a hematological neoplasm that predominantly affects children, with pathophysiology involving chromosomal abnormalities and genetic alterations. While environmental factors are believed to play a role in the development of the disease, there is still conflicting evidence in the literature.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Allergy
Maryam Ghaedi, Fumio Takei
Summary: Innate lymphoid cells (ILCs) mainly reside at barrier surfaces and play a regulatory role in tissue homeostasis and immunity. They are divided into 3 groups based on similar effector programs to T cells, and their development from lymphoid progenitors in adult mouse bone marrow has been extensively studied.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Hematology
Danika Di Giacomo, Roberta La Starza, Paolo Gorello, Fabrizia Pellanera, Zeynep Kalender Atak, Kim De Keersmaecker, Valentina Pierini, Christine J. Harrison, Silvia Arniani, Martina Moretti, Nicoletta Testoni, Giovanna De Santis, Giovanni Roti, Caterina Matteucci, Renato Bassan, Peter Vandenberghe, Stein Aerts, Jan Cools, Beat Bornhauser, Jean-Pierre Bourquin, Rocco Piazza, Cristina Mecucci
Summary: The study identified a distinct subgroup of immature acute leukemias characterized by 14g32/BCL11B translocations, including AML, TIM MPAL, and ETP-ALL. These translocations activate BCL11B, whose expression behaves as a disease biomarker present at diagnosis and co-occurs with variants at FLT3 and epigenetic modulators. Transcriptome analysis revealed a specific expression signature separating BCL11B AL from AML, T-ALL, and ETP-ALL, with an ex vivo drug-sensitivity profile identifying effective antileukemic compounds.
Article
Cell Biology
Robin Canac, Bastien Cimarosti, Aurore Girardeau, Virginie Forest, Pierre Olchesqui, Jeremie Poschmann, Richard Redon, Patricia Lemarchand, Nathalie Gaborit, Guillaume Lamirault
Summary: Transcription factor networks play a crucial role in regulating human heart development by controlling dynamic and temporal gene expression alterations. Through transcriptomic profiling and correlation analysis, this study revealed thousands of interactions between transcription factors, identifying potential regulatory mechanisms governing cardiac development.
Article
Biology
Zhiqiang Wang, Chunxiao Zhang, Charles David Warden, Zheng Liu, Yate-Ching Yuan, Chao Guo, Charles Wang, Jinhui Wang, Xiwei Wu, Richard Ermel, Steven L. Vonderfecht, Xiuli Wang, Christine Brown, Stephen Forman, Yaling Yang, M. James You, WenYong Chen
Summary: SIRT1 plays an unexpected role in promoting aging of HSCs and age-dependent MPAL. Knockout of Sirt1 improves the function of aging HSCs and suppresses the development of MPAL.
COMMUNICATIONS BIOLOGY
(2022)
Article
Immunology
Lucy S. K. Walker
Summary: This article discusses the increased frequency of T cells bearing features of follicular helper T cells in individuals with autoimmunity, and explores potential explanations for this phenomenon. The regulation of T-FH cell differentiation by pathways such as CTLA4 and IL-2, as well as regulatory T cells, is considered, highlighting their crucial role in autoimmune diseases. The potential role of infection in triggering T-FH cell differentiation and autoimmune disease development is also discussed. Overall, the author postulates that alterations in pathways that regulate autoimmunity are coupled to alterations in T-FH cell homeostasis, suggesting that this population may serve as a core sentinel of dysregulated immunity.
NATURE REVIEWS IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Natalie Brown, Rosemary Finnon, Paul Finnon, Roisin Mccarron, Lourdes Cruz-Garcia, Grainne O'Brien, Eleanor Herbert, Cheryl L. Scudamore, Edouard Morel, Christophe Badie
Summary: Ionizing radiation is a risk factor for acute myeloid leukemia, and both gene mutations and chromosomal deletions are involved. The study showed that a single gene mutation can initiate AML development with complete penetrance, and this is accelerated by radiation exposure. Similar gene mutations in humans could lead to increased susceptibility to radiation following medical or environmental exposure.
Article
Oncology
Courtney Chambers, Katerina Cermakova, Yuen San Chan, Kristen Kurtz, Katharina Wohlan, Andrew Henry Lewis, Christiana Wang, Anh Pham, Milan Dejmek, Michal Sala, Mario Loeza Cabrera, Rogelio Aguilar, Radim Nencka, H. Daniel Lacorazza, Rachel E. Rau, H. Courtney Hodges
Summary: In acute myeloid leukemia (AML), SWI/SNF chromatin remodeling complexes sustain leukemic identity by driving high levels of MYC. PU.1 binds to most of its targets in a SWI/SNF-independent manner and recruits SWI/SNF to promote accessibility for other AML core regulatory factors. SWI/SNF inhibition induces therapeutic response in AML but also impairs PU.1-dependent B-cell and monocyte populations, revealing the on-and off-tumor effects of SWI/SNF blockade.
Review
Biochemistry & Molecular Biology
Fiona Reed, Shannon T. Larsuel, Madeline Y. Mayday, Vanessa Scanlon, Diane S. Krause
Summary: Myocardin-related transcription factor A (MRTFA) acts as a coactivator of serum response factor, playing a role in cell growth and apoptosis. It promotes differentiation in various cell types, yet its specific function in malignant hematopoiesis remains unclear.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Kannan Harithpriya, Ravichandran Jayasuriya, Trishla Adhikari, Awantika Rai, Kunka Mohanram Ramkumar
Summary: Transcription factors play crucial roles in regulating gene expression and development of pancreatic B-cells. Hyperglycemia can reduce the expression and/or activities of these transcription factors, leading to loss of B-cell function. Activating transcription factors using small molecules has shown promising results in regenerating and maintaining B-cell function and survival. This review discusses the various transcription factors involved in pancreatic B-cell development and the regulation of their activities in normal and pathological states, as well as the potential pharmacological effects of natural and synthetic compounds on these transcription factors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
