Copy number profiling of adult relapsed B-cell precursor acute lymphoblastic leukemia reveals potential leukemia progression mechanisms

The BAF45a/PHF10 subunit of SWI/SNF-like chromatin remodeling complexes is essential for hematopoietic stem cell maintenance

(2017) Veneta Krasteva et al.   EXPERIMENTAL HEMATOLOGY

Genomic analysis of adult B-ALL identifies potential markers of shorter survival

(2017) Shiven Patel et al.   LEUKEMIA RESEARCH

Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia

(2016) Julie A. E. Irving et al.   BLOOD

Single nucleotide polymorphism array analysis of clonal evolution in younger adult acute lymphoblastic leukemia

(2016) Vaidas Dirse et al.   LEUKEMIA & LYMPHOMA

Biallelic loss of CDKN2A is associated with poor response to treatment in pediatric acute lymphoblastic leukemia

(2016) Marcin Braun et al.   LEUKEMIA & LYMPHOMA

Treating cancer with selective CDK4/6 inhibitors

(2016) Ben O'Leary et al.   Nature Reviews Clinical Oncology

Deletions of multidrug resistance gene loci in breast cancer leads to the down-regulation of its expression and predict tumor response to neoadjuvant chemotherapy

(2016) Nikolai V. Litviakov et al.   Oncotarget

Genome-Wide DNA Copy Number Analysis of Acute Lymphoblastic Leukemia Identifies New Genetic Markers Associated with Clinical Outcome

(2016) Maribel Forero-Castro et al.   PLoS One

Prognostic significance of copy number alterations in adolescent and adult patients with precursor B acute lymphoblastic leukemia enrolled in PETHEMA protocols

(2015) Jordi Ribera et al.   CANCER

Molecular basis and clinical significance of genetic aberrations in B-cell precursor acute lymphoblastic leukemia

(2015) Farzaneh Ghazavi et al.   EXPERIMENTAL HEMATOLOGY

B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia

(2015) Naoto Imoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms

(2015) Jasper Mullenders et al.   JOURNAL OF EXPERIMENTAL MEDICINE

YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway

(2015) Bill H Chang et al.   Journal of Hematology & Oncology

Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells

(2015) D H Spencer et al.   LEUKEMIA

Genetic alterations in glucocorticoid signaling pathway components are associated with adverse prognosis in children with relapsedETV6/RUNX1-positive acute lymphoblastic leukemia

(2015) Reinhard Grausenburger et al.   LEUKEMIA & LYMPHOMA

A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia

(2014) A. V. Moorman et al.   BLOOD

Genetic alterations of the cohesin complex genes in myeloid malignancies

(2014) S. Thota et al.   BLOOD

Novel gene targets detected by genomic profiling in a consecutive series of 126 adults with acute lymphoblastic leukemia

(2014) S. Safavi et al.   HAEMATOLOGICA

Treatment of High-Risk Philadelphia Chromosome–Negative Acute Lymphoblastic Leukemia in Adolescents and Adults According to Early Cytologic Response and Minimal Residual Disease After Consolidation Assessed by Flow Cytometry: Final Results of the PETHEMA ALL-AR-03 Trial

(2014) Josep-Maria Ribera et al.   JOURNAL OF CLINICAL ONCOLOGY

Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia

(2014) Brenton G. Mar et al.   Nature Communications

PDCD2 functions in cancer cell proliferation and predicts relapsed leukemia

(2013) Nora Barboza et al.   CANCER BIOLOGY & THERAPY

VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia

(2013) D S Mangum et al.   LEUKEMIA

Deletions of IKZF1 and SPRED1 are associated with poor prognosis in a population-based series of pediatric B-cell precursor acute lymphoblastic leukemia diagnosed between 1992 and 2011

(2013) L Olsson et al.   LEUKEMIA

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms

(2013) Ayana Kon et al.   NATURE GENETICS

HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1-3 and PKM2

(2013) Alessandro Prigione et al.   STEM CELLS

Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia

(2012) S. K. Tasian et al.   BLOOD

The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia

(2012) Anthony V. Moorman   BLOOD REVIEWS

Treatment of young patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia using increased dose of imatinib and deintensified chemotherapy before allogeneic stem cell transplantation

(2012) Josep-María Ribera et al.   BRITISH JOURNAL OF HAEMATOLOGY

Therapeutic Targeting of the Cyclin D3:CDK4/6 Complex in T Cell Leukemia

(2012) Catherine M. Sawai et al.   CANCER CELL

Regulation of B Cell Linker Protein Transcription by PU.1 and Spi-B in Murine B Cell Acute Lymphoblastic Leukemia

(2012) L. S. Xu et al.   JOURNAL OF IMMUNOLOGY

Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia

(2012) S Krentz et al.   LEUKEMIA

Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemia

(2012) M C Chillón et al.   LEUKEMIA

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

PDCD2 Controls Hematopoietic Stem Cell Differentiation During Development

(2012) Joseph Kramer et al.   STEM CELLS AND DEVELOPMENT

Overexpression of Pyruvate Dehydrogenase Kinase 3 Increases Drug Resistance and Early Recurrence in Colon Cancer

(2011) Chun-Wun Lu et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia

(2011) E. Park et al.   BLOOD

Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies

(2011) L. E. Hogan et al.   BLOOD

Inhibitors of Apoptosis Proteins (IAPs) as Potential Molecular Targets for Therapy of Hematological Malignancies

(2011) P. Smolewski et al.   CURRENT MOLECULAR MEDICINE

Mutations and Deletions of the TP53 Gene Predict Nonresponse to Treatment and Poor Outcome in First Relapse of Childhood Acute Lymphoblastic Leukemia

(2011) Jana Hof et al.   JOURNAL OF CLINICAL ONCOLOGY

CREBBP mutations in relapsed acute lymphoblastic leukaemia

(2011) Charles G. Mullighan et al.   NATURE

Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer

(2011) D. A. Solomon et al.   SCIENCE

Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome

(2010) R. C. Harvey et al.   BLOOD

ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data

(2010) Lihua J Zhu et al.   BMC BIOINFORMATICS

Genome-wide expression analysis of paired diagnosis–relapse samples in ALL indicates involvement of pathways related to DNA replication, cell cycle and DNA repair, independent of immune phenotype

(2010) F J T Staal et al.   LEUKEMIA

HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells

(2010) L Liu et al.   LEUKEMIA

A Novel Plant Homeodomain Finger 10-Mediated Antiapoptotic Mechanism Involving Repression of Caspase-3 in Gastric Cancer Cells

(2010) M. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS

BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3

(2008) J. Nakayama et al.   BLOOD

Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia

(2008) J. J. Yang et al.   BLOOD

Caspase Activity Mediates the Differentiation of Embryonic Stem Cells

(2008) Jun Fujita et al.   Cell Stem Cell

Comparison of the Results of the Treatment of Adolescents and Young Adults With Standard-Risk Acute Lymphoblastic Leukemia With the Programa Español de Tratamiento en Hematología Pediatric-Based Protocol ALL-96

(2008) Josep-María Ribera et al.   JOURNAL OF CLINICAL ONCOLOGY

Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

(2008) C. G. Mullighan et al.   SCIENCE