Emerging role of tumor-derived extracellular vesicles in T cell suppression and dysfunction in the tumor microenvironment

Tumor-Secreted Extracellular Vesicles Regulate T-Cell Costimulation and Can Be Manipulated To Induce Tumor-Specific T-Cell Responses

(2021) Xianda Zhao et al.   GASTROENTEROLOGY

Extracellular vesicles in immunomodulation and tumor progression

(2021) Carolyn Marar et al.   NATURE IMMUNOLOGY

uPAR+ extracellular vesicles: a robust biomarker of resistance to checkpoint inhibitor immunotherapy in metastatic melanoma patients

(2021) Letizia Porcelli et al.   Journal for ImmunoTherapy of Cancer

Tracking the evolution of circulating exosomal-PD-L1 to monitor melanoma patients

(2020) Marine Cordonnier et al.   Journal of Extracellular Vesicles

Pancreatic cancer-derived exosomes induce apoptosis of T lymphocytes through the p38 MAPK-mediated endoplasmic reticulum stress

(2020) Tao Shen et al.   FASEB JOURNAL

Tumor-derived exosomes in the regulation of macrophage polarization

(2020) Mirza S. Baig et al.   INFLAMMATION RESEARCH

Exosomes carrying ALDOA and ALDH3A1 from irradiated lung cancer cells enhance migration and invasion of recipients by accelerating glycolysis

(2020) Chen Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression

(2020) Xueyan Zang et al.   Cell Death & Disease

Radiotherapy-induced overexpression of exosomal miRNA-378a-3p in cancer cells limits natural killer cells cytotoxicity

(2020) Joséphine Briand et al.   Epigenomics

Purine Metabolites in Tumor-Derived Exosomes May Facilitate Immune Escape of Head and Neck Squamous Cell Carcinoma

(2020) Nils Ludwig et al.   Cancers

Immune Suppressive Effects of Plasma-Derived Exosome Populations in Head and Neck Cancer

(2020) Inga J. Beccard et al.   Cancers

MicroRNA-21-Enriched Exosomes as Epigenetic Regulators in Melanomagenesis and Melanoma Progression: The Impact of Western Lifestyle Factors

(2020) Bodo C. Melnik et al.   Cancers

The crosstalk: exosomes and lipid metabolism

(2020) Wei Wang et al.   Cell Communication and Signaling

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

(2020) Yingjie Bian et al.   NATURE

Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

(2020) Yi-Ru Yu et al.   NATURE IMMUNOLOGY

Expression and DNA methylation profiles of EZH2-target genes in plasma exosomes and matched primary tumor tissues of the patients with diffuse large B-cell lymphoma

(2020) I. C. Barıs et al.   Clinical & Translational Oncology

Cyclophosphamide enhances the release of tumor exosomes that elicit a specific immune response in vivo in a murine T-cell lymphoma

(2019) Federico Cocozza et al.   VACCINE

A lipase-independent pathway of lipid release and immune modulation by adipocytes

(2019) Stephen E. Flaherty et al.   SCIENCE

Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift

(2019) Jung Eun Park et al.   ONCOGENE

CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

(2019) Laura M. McLane et al.   Annual Review of Immunology

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

(2019) Xingzhe Ma et al.   Cell Metabolism

Exosome-Mediated Metastasis: Communication from a Distance

(2019) Inbal Wortzel et al.   DEVELOPMENTAL CELL

Exosomes from activated hepatic stellate cells contain GLUT1 and PKM2: a role for exosomes in metabolic switch of liver nonparenchymal cells

(2019) Lu Wan et al.   FASEB JOURNAL

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

(2019) Ladan Mashouri et al.   Molecular Cancer

Consolidation alters motor sequence-specific distributed representations

(2019) Basile Pinsard et al.   eLife

SALL4-mediated upregulation of exosomal miR-146a-5p drives T-cell exhaustion by M2 tumor-associated macrophages in HCC

(2019) Chunlai Yin et al.   OncoImmunology

Circulating exosomes deliver free fatty acids from the bloodstream to cardiac cells: Possible role of CD36

(2019) N. A. Garcia et al.   PLoS One

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion

(2019) Hyungseok Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy

(2019) Mónica Pascual-García et al.   Nature Communications

Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma

(2019) Malgorzata Czystowska-Kuzmicz et al.   Nature Communications

Exosome DNA: Critical regulator of tumor immunity and a diagnostic biomarker

(2019) Aman Sharma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis

(2019) Jinlu Dai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glycan-Modified Melanoma-Derived Apoptotic Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination

(2019) Horrevorts et al.   Cancers

Glycan modification of glioblastoma-derived extracellular vesicles enhances receptor-mediated targeting of dendritic cells

(2019) Sophie A. Dusoswa et al.   Journal of Extracellular Vesicles

Extracellular Vesicles As Nanomedicine: Hopes And Hurdles In Clinical Translation

(2019) Thierry Burnouf et al.   International Journal of Nanomedicine

Regulatory T Cell Development in the Thymus

(2019) David L. Owen et al.   JOURNAL OF IMMUNOLOGY

The Metabolic Profile of Tumor and Virally Infected Cells Shapes Their Microenvironment Counteracting T Cell Immunity

(2019) Isabelle Magalhaes et al.   Frontiers in Immunology

Phenotypic Switching of Naïve T Cells to Immune-Suppressive Treg-Like Cells by Mutant KRAS

(2019) Arjun Kalvala et al.   Journal of Clinical Medicine

MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma

(2019) Virginie Vignard et al.   Cancer Immunology Research

Expression profiles and clinical value of plasma exosomal Tim-3 and Galectin-9 in non-small cell lung cancer

(2018) Jianwei Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer

(2018) Zhonghu Li et al.   CANCER LETTERS

Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγ to promote pancreatic cancer metastasis

(2018) Xiaofeng Wang et al.   CANCER RESEARCH

Exosomes and Ectosomes in Intercellular Communication

(2018) Jacopo Meldolesi   CURRENT BIOLOGY

Exosomes from heat-stressed tumour cells inhibit tumour growth by converting regulatory T cells to Th17 cells via IL-6

(2018) Danfeng Guo et al.   IMMUNOLOGY

Tumor exosomes block dendritic cells maturation to decrease the T cell immune response

(2018) Yongling Ning et al.   IMMUNOLOGY LETTERS

Leukocytes as a reservoir of circulating oncogenic DNA and regulatory targets of tumor-derived extracellular vesicles

(2018) S. Chennakrishnaiah et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

(2018) Daniela S. Thommen et al.   NATURE MEDICINE

The biology of extracellular microvesicles

(2018) Alanna E. Sedgwick et al.   TRAFFIC

Heterologous human/rat HER2-specific exosome-targeted T cell vaccine stimulates potent humoral and CTL responses leading to enhanced circumvention of HER2 tolerance in double transgenic HLA-A2/HER2 mice

(2018) Yufeng Xie et al.   VACCINE

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

(2018) Daniel Torralba et al.   Nature Communications

Exosomes in melanoma: a role in tumor progression, metastasis and impaired immune system activity

(2018) Marco Tucci et al.   Oncotarget

Extracellular vesicle-mediated EBAG9 transfer from cancer cells to tumor microenvironment promotes immune escape and tumor progression

(2018) Toshiaki Miyazaki et al.   Oncogenesis

Combination Therapy With Histone Deacetylase Inhibitors (HDACi) for the Treatment of Cancer: Achieving the Full Therapeutic Potential of HDACi

(2018) Amila Suraweera et al.   Frontiers in Oncology

Exosomes in HNSCC plasma as surrogate markers of tumour progression and immune competence

(2018) M.-N. Theodoraki et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

(2018) Tore Skotland et al.   JOURNAL OF LIPID RESEARCH

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Exosome-related tumor microenvironment

(2018) Cheng Hu et al.   Journal of Cancer

Cytokines in clinical cancer immunotherapy

(2018) Pedro Berraondo et al.   BRITISH JOURNAL OF CANCER

Extracellular vesicles and energy metabolism

(2018) K. Göran Ronquist   CLINICA CHIMICA ACTA

Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts

(2018) Yuan Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity

(2018) Qinqin Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Microenvironmental oxygen pressure orchestrates an anti- and pro-tumoral γδ T cell equilibrium via tumor-derived exosomes

(2018) Ling Li et al.   ONCOGENE

Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg/Th17 Cell Imbalance in Epithelial Ovarian Cancer

(2018) Jieru Zhou et al.   Cancer Immunology Research

Tumor-Derived Microvesicles Enhance Cross-Processing Ability of Clinical Grade Dendritic Cells

(2018) Marco Dionisi et al.   Frontiers in Immunology

Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1+ regulatory B cell expansion

(2018) Linsen Ye et al.   Journal for ImmunoTherapy of Cancer

The effect of tumor-derived exosomes on immune regulation and cancer immunotherapy

(2017) Theresa L Whiteside   Future Oncology

Suppression of T cells by myeloid-derived suppressor cells in cancer

(2017) Jieying Chen et al.   HUMAN IMMUNOLOGY

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity

(2017) Yuichi Kitai et al.   JOURNAL OF IMMUNOLOGY

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Chromatin states define tumour-specific T cell dysfunction and reprogramming

(2017) Mary Philip et al.   NATURE

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

Extracellular Vesicle MicroRNA Transfer in Lung Diseases

(2017) Jie Chen et al.   Frontiers in Physiology

Human tumor-derived exosomes (TEX) regulate Treg functions via cell surface signaling rather than uptake mechanisms

(2017) Laurent Muller et al.   OncoImmunology

Tumor-derived exosomes induce CD8+ T cell suppressors

(2017) Brian T. Maybruck et al.   Journal for ImmunoTherapy of Cancer

Ethanol Induces Enhanced Vascularization Bioactivity of Endothelial Cell-Derived Extracellular Vesicles via Regulation of MicroRNAs and Long Non-Coding RNAs

(2017) Tek N. Lamichhane et al.   Scientific Reports

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA

(2016) Le Qu et al.   CANCER CELL

The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes

(2016) Shu Wen Wen et al.   CANCER RESEARCH

γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation

(2016) Donnele Daley et al.   CELL

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

(2016) Bertram Bengsch et al.   IMMUNITY

Exosomes and nanotubes: Control of immune cell communication

(2016) Kessler McCoy-Simandle et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Exosomes and tumor-mediated immune suppression

(2016) Theresa L. Whiteside   JOURNAL OF CLINICAL INVESTIGATION

ExoCarta: A Web-Based Compendium of Exosomal Cargo

(2016) Shivakumar Keerthikumar et al.   JOURNAL OF MOLECULAR BIOLOGY

Exosomal miR-24-3p impedes T-cell function by targetingFGF11and serves as a potential prognostic biomarker for nasopharyngeal carcinoma

(2016) Shu-Biao Ye et al.   JOURNAL OF PATHOLOGY

Getting to know the extracellular vesicle glycome

(2016) Jared Q. Gerlach et al.   Molecular BioSystems

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

(2016) K. E. Pauken et al.   SCIENCE

Colorectal cancer cell-derived extracellular vesicles induce phenotypic alteration of T cells into tumor-growth supporting cells with transforming growth factor-β1-mediated suppression

(2016) Nami Yamada et al.   Oncotarget

Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages

(2016) Xiang Ying et al.   Oncotarget

The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression

(2016) Jiandong Chen   Cold Spring Harbor Perspectives in Medicine

Treatment of the Immune-Related Adverse Effects of Immune Checkpoint Inhibitors

(2016) Claire F. Friedman et al.   JAMA Oncology

Metabolic communication in tumors: a new layer of immunoregulation for immune evasion

(2016) Ping-Chih Ho et al.   Journal for ImmunoTherapy of Cancer

Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets

(2016) Laurent Muller et al.   Scientific Reports

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival

(2015) Ulf H. Beier et al.   FASEB JOURNAL

RAL-1 controls multivesicular body biogenesis and exosome secretion

(2015) Vincent Hyenne et al.   JOURNAL OF CELL BIOLOGY

Histone Deacetylase 3 Is Required for T Cell Maturation

(2015) Fan-Chi Hsu et al.   JOURNAL OF IMMUNOLOGY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

(2015) Miranda Y. Fong et al.   NATURE CELL BIOLOGY

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

The cytotoxic T cell proteome and its shaping by the kinase mTOR

(2015) Jens L Hukelmann et al.   NATURE IMMUNOLOGY

Glioma-derived extracellular vesicles selectively suppress immune responses

(2015) Justin E. Hellwinkel et al.   NEURO-ONCOLOGY

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Immunosuppression of breast cancer cells mediated by transforming growth factor-β in exosomes from cancer cells

(2015) LEI RONG et al.   Oncology Letters

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade

(2015) R. J. Kelleher et al.   Cancer Immunology Research

Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma

(2015) Shu-biao Ye et al.   Oncotarget

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Human CD4+CD39+regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+exosomes or CD73+cells

(2014) P. J. Schuler et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Improved vaccine efficacy of tumor exosome compared to tumor lysate loaded dendritic cells in mice

(2014) Xiaoyu Gu et al.   INTERNATIONAL JOURNAL OF CANCER

The fusion of two worlds: Non-coding RNAs and extracellular vesicles - diagnostic and therapeutic implications (Review)

(2014) YUKIE SATO-KUWABARA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Effect of Nasopharyngeal Carcinoma-Derived Exosomes on Human Regulatory T Cells

(2014) Dhafer Mrizak et al.   JNCI-Journal of the National Cancer Institute

Bioinformatic analysis revealing association of exosomal mRNAs and proteins in epigenetic inheritance

(2014) Abhay Sharma   JOURNAL OF THEORETICAL BIOLOGY

Extracellular Adenosine-Mediated Modulation of Regulatory T Cells

(2014) Akio Ohta et al.   Frontiers in Immunology

Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice

(2013) O. M. Dovey et al.   BLOOD

Synergistic Induction of Adaptive Antitumor Immunity by Codelivery of Antigen with α-Galactosylceramide on Exosomes

(2013) Ulf Gehrmann et al.   CANCER RESEARCH

T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

(2013) Joel Crespo et al.   CURRENT OPINION IN IMMUNOLOGY

Exosome-like Nanoparticles from Intestinal Mucosal Cells Carry Prostaglandin E2 and Suppress Activation of Liver NKT Cells

(2013) Z.-B. Deng et al.   JOURNAL OF IMMUNOLOGY

Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation

(2013) J Adam Best et al.   NATURE IMMUNOLOGY

Purinergic signalling and cancer

(2013) Geoffrey Burnstock et al.   Purinergic Signalling

Renal Carcinoma Cell-Derived Exosomes Induce Human Immortalized Line of Jurkat T Lymphocyte Apoptosis in vitro

(2013) Lin Yang et al.   UROLOGIA INTERNATIONALIS

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

Tumor-exosomes and leukocyte activation: an ambivalent crosstalk

(2012) Daniela Zech et al.   Cell Communication and Signaling

Metabolic Regulation of Epigenetics

(2012) Chao Lu et al.   Cell Metabolism

CD4+T Cells: Differentiation and Functions

(2012) Rishi Vishal Luckheeram et al.   Clinical & Developmental Immunology

GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker

(2011) Kátia C. Carvalho et al.   Clinics

Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients

(2011) Lukas Baitsch et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

(2011) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

T-cell exhaustion: characteristics, causes and conversion

(2010) John S. Yi et al.   IMMUNOLOGY

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Tumor-Derived Microvesicles Induce, Expand and Up-Regulate Biological Activities of Human Regulatory T Cells (Treg)

(2010) Marta Szajnik et al.   PLoS One

Antigen-loaded exosomes alone induce Th1-type memory through a B cell-dependent mechanism

(2009) K. R. Qazi et al.   BLOOD

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

(2009) E. U. Wieckowski et al.   JOURNAL OF IMMUNOLOGY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

(2008) J. Klibi et al.   BLOOD

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE