Review
Biochemistry & Molecular Biology
Reza Hosseini, Leila Asef-Kabiri, Hassan Yousefi, Hamzeh Sarvnaz, Majid Salehi, Mohammad Esmaeil Akbari, Nahid Eskandari
Summary: This paper delves into the impact of tumor-derived exosomes on dendritic cells and how they induce subversion of DCs differentiation, maturation, and function, as well as their significance at the therapeutic level. Understanding the exosomal content and pathways responsible for immune evasion could lead to the development of novel therapeutic approaches.
Review
Cell Biology
Jun Li, Samuel F. Bakhoum
Summary: In this review, the recent advances in the cGAS-STING field are discussed, with a focus on its crosstalk with other signaling pathways in the tumor microenvironment (TME). A more detailed understanding of the roles of cGAS-STING signaling in the TME will facilitate the design of more precise cancer treatment strategies.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Shiyang Wang, Yue Shi
Summary: Exosomes are small vesicles secreted by living cells, carrying proteins, lipids, RNA, and other important substances for cell-to-cell communication. This review focuses on the effects of immune cell-derived exosomes on tumor cells, immune cells, and other stromal cells in the tumor microenvironment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Cell Biology
Kornel Z. Varga, Katalin Gyurina, Adam Radvanyi, Tibor Pal, Laszlo Sasi-Szabo, Haidong Yu, Eniko Felszeghy, Tamas Szabo, Tamas Roeszer
Summary: Innate immune signaling in adipocytes can affect systemic metabolism. DNA sensing in the cytoplasm of adipocytes can stimulate thermogenic adipocyte differentiation and protect against obesity. However, DNA efflux from adipocyte mitochondria may lead to tissue dysfunction and insulin resistance. This study found that the signal transduction molecule STING can trigger autophagy in adipocytes, thereby protecting them from excessive IFN-I response.
Review
Pharmacology & Pharmacy
Xiaoshuai Li, Qiushi Wang, Rui Wang
Summary: Exosomes are extracellular vesicles that mediate cell-to-cell communication and contain bioactive substances such as DNA, RNA, lipids, and proteins. The DNA in exosomes, mainly consisting of genomic DNA and mitochondrial DNA, plays a crucial role in liquid biopsy of colorectal cancer and immune metabolic regulation. However, research on exosome DNA is still limited.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Joseph R. Podojil, Andrew C. Cogswell, Ming-Yi Chiang, Valerie Eaton, Igal Ifergan, Tobias Neef, Dan Xu, Khyati A. Meghani, Yanni Yu, Sophia M. Orbach, Tushar Murthy, Michael T. Boyne, Adam Elhofy, Lonnie D. Shea, Joshua J. Meeks, Stephen D. Miller
Summary: This study found that the use of ONP-302 can control tumors by reprogramming myeloid cells through the activation of the STING/IL-15/NK cell mechanism, and enhance the efficacy of anti-PD-1.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Jiayu Zhao, Sheng Ma, Yudi Xu, Xinghui Si, Haochen Yao, Zichao Huang, Yu Zhang, Haiyang Yu, Zhaohui Tang, Wantong Song, Xuesi Chen
Summary: The study presented a method for in situ activation of the STING pathway using nanoparticles to deliver DNA-targeting chemo agents, demonstrating the potent ability of SN38 in stimulating interferon secretion and activating the STING pathway. The nanoparticle formulation effectively stimulated STING pathway activation, resulting in significant tumor suppression.
Article
Multidisciplinary Sciences
Xuan Wang, Yingqi Liu, Chencheng Xue, Yan Hu, Yuanyuan Zhao, Kaiyong Cai, Menghuan Li, Zhong Luo
Summary: This study introduces a nanoagonist based on BSA/ferritin that activates the cGAS-STING signaling pathway in DCs in solid tumor microenvironment, offering a promising approach for robust antitumor immunity.
NATURE COMMUNICATIONS
(2022)
Review
Oncology
Natasha Samson, Andrea Ablasser
Summary: The cGAS-STING pathway plays a critical role in cancer and can affect tumor development and treatment outcomes. This article discusses the impact of cGAS-STING signaling on tumors and highlights current research efforts in this field.
Article
Multidisciplinary Sciences
You-Tong Wu, Yan Fang, Qi Wei, Heping Shi, Huiling Tan, Yafang Deng, Zhiqun Zeng, Jian Qiu, Chuo Chen, Lijun Sun, Zhijian J. Chen
Summary: The study demonstrates the development of antibody-drug conjugates (ADCs) by conjugating a STING agonist to tumor-targeting antibodies, which showed well-tolerated systemic administration and potent antitumor efficacy. The STING ADC also promoted multiple aspects of antitumor immune responses, highlighting its potential for clinical development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Wen Song, Shu-Jun Song, Jing Kuang, Hang Yang, Tao Yu, Fan Yang, Tao Wan, Yi Xu, Si-Tian Wei, Mu-Xuan Li, Yuan Xiong, Ying Zhou, Wen-Xiu Qiu
Summary: In this study, M@P@HA nanoparticles were used as a STING signal amplifier to enhance innate immunotherapy in tumors. The nanoparticles released reactive oxygen species under light irradiation, disrupting cellular redox homeostasis and initiating the STING signal through damaged mitochondrial dsDNA. The immunoregulator Mn2+ increased the activity of cGAS and STING, further amplifying the STING signal in tumor cells. Additionally, the STING signal of TAMs was activated by capturing dsDNA and Mn2+ that escaped from tumor cells, enhancing innate immunity.
Article
Immunology
Akemi Kosaka, Kei Ishibashi, Toshihiro Nagato, Hidemitsu Kitamura, Yukio Fujiwara, Syunsuke Yasuda, Marino Nagata, Shohei Harabuchi, Ryusuke Hayashi, Yuki Yajima, Kenzo Ohara, Takumi Kumai, Naoko Aoki, Yoshihiro Komohara, Kensuke Oikawa, Yasuaki Harabuchi, Masahiro Kitada, Hiroya Kobayashi, Takayuki Ohkuri
Summary: Activation of the STING signaling pathway is crucial in anti-tumor immunity, while CD47 overexpression in breast cancer patients is associated with poor survival. Combination therapy with cGAMP and an antagonistic anti-CD47 mAb inhibits tumor growth, enhances phagocytosis of tumor cells, and induces systemic anti-tumor immune responses relying on STING and type I IFN signaling.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Immunology
Zhuoying Tian, Yue Zeng, Yurong Peng, Junqi Liu, Fang Wu
Summary: Activation of the cGAS-STING pathway by cytoplasmic DNA leads to the production of Type-1 interferons, which play a critical role in cancer-immunity cycle. Research has shown that combination therapy of STING agonists has made progress in preclinical and clinical trials, but selecting appropriate combination therapy regimens remains a challenge.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Sofie Hedlund Moller, Limei Wang, Ping-Chih Ho
Summary: Immune cells rely on specific metabolic traits to function, while the extracellular environment can influence cell metabolism and vice versa. Dendritic cell subsets modulate their stimulatory abilities based on unique metabolic programming in diverse environments. The metabolic requirements of dendritic cells are intertwined with their functions.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Immunology
Zhuang Chen, Rui Yuan, Shengyun Hu, Weitang Yuan, Zhenqiang Sun
Summary: This review provides a comprehensive description of the characteristics, functions, and mechanisms of myeloid-derived suppressor cell exosomes (MDSCs-Exos) in tumor immunity. MDSCs-Exos show similar immunosuppressive, angiogenesis, and metastatic effects as parental MDSCs. Immunotherapy targeting MDSCs-Exos has great potential in both cancer and non-cancerous diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Aman Sharma, Anjali Shiras
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Review
Biotechnology & Applied Microbiology
Aman Sharma, Zamila Khatun, Anjali Shiras
Review
Biotechnology & Applied Microbiology
Zamila Khatun, Anjali Bhat, Shivani Sharma, Aman Sharma
Review
Oncology
Aman Sharma
INTERNATIONAL JOURNAL OF CANCER
(2018)
Article
Chemistry, Multidisciplinary
Rajkumar Misra, Aman Sharma, Anjali Shiras, Hosahudya N. Gopi
Review
Biotechnology & Applied Microbiology
Aman Sharma
Article
Oncology
Aman Sharma, Ajinkya Bendre, Abir Mondal, Dattatraya Muzumdar, Naina Goel, Anjali Shiras
FRONTIERS IN ONCOLOGY
(2017)
Article
Biotechnology & Applied Microbiology
Anjali Bhat, Aman Sharma, Alok Chandra Bharti
Article
Chemistry, Organic
Kaushik Pal, Aman Sharma, Apurba L. Koner