Article
Cell Biology
Xiuchao Geng, Yuhao Zhang, Xiaomeng Lin, Zhaomu Zeng, Jun Hu, Liangchao Hao, Jianglong Xu, Xinjuan Wang, Hong Wang, Qiang Li
Summary: The delivery of circWDR62 through exosomes promotes TMZ-resistance and malignant progression in glioma by targeting the miR-370-3p/MGMT axis, providing a new therapeutic strategy. Exosomal circWDR62 in human serum may serve as a promising therapeutic target and prognostic marker for glioma therapy.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Kai Chen, Qi Wang, Xinxin Liu, Feng Wang, Yinmo Yang, Xiaodong Tian
Summary: Most PDAC patients have poor prognosis due to vascular invasion and metastasis. This study identified distinct gene expression profiles of endothelial cells in PDAC and found that hypoxic PDAC cells derived exosomal miR-30b-5p promoted angiogenesis by inhibiting GJA1. Furthermore, miR-30b-5p could be a potential diagnostic marker for PDAC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Pingxin Zhang, Hang Gao, Ruping Yan, Lu Yu, Chengxing Xia, Delin Yang
Summary: This study investigates the effect of hsa_circ_0070512 on the function and mechanism of prostate cancer (PCa). Hsa_circ_0070512 was found to be increased in PCa tissues and cells, predominantly located in the cytoplasm of PCa cells. Overexpression of hsa_circ_0070512 significantly increased PCa cell proliferation and migration, while silencing it decreased these processes. Mechanistically, hsa_circ_0070512 acts as a sponge for miR-338-3p, and its regulation of the hedgehog signaling pathways through miR-338-3p enhances PCa growth and migration.
Article
Biotechnology & Applied Microbiology
Shu Xu, San-Lin Lei, Kui-Jie Liu, Shen-Gen Yi, Zhu-Lin Yang, Hong-Liang Yao
Summary: Pancreatic cancer (PC) is a common and lethal cancer with poor prognosis and limited treatment options. This study found that circSFMBT1 and PAK1 were up-regulated, while miR-330-5p was down-regulated in PC tissues and cells, promoting proliferation and metastasis of PC cells through the regulation of the miR-330-5p/PAK1 pathway.
CANCER GENE THERAPY
(2021)
Article
Cell Biology
Xianglian Zhang, Ya Luo, Yu Cen, Xin Qiu, Jing Li, Mengmeng Jie, Shiming Yang, Shanyu Qin
Summary: MACC1 is found to promote metastasis in pancreatic cancer and is associated with poor prognosis. By binding to SNAI1, MACC1 drives the mesenchymal transition of pancreatic cancer cells, facilitating metastasis. This discovery reveals a new mechanism and suggests that the MACC1-SNAI1 complex-mediated mesenchymal transition may serve as a therapeutic target in pancreatic cancer.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Manya Yu, Lin Ji, Sumei Li, Yanyu Zhang, Xiaoqi Sun, Runjie Sun, Xiubao Chen, Yaqin Luo, Xing Cui
Summary: This study found that exosomes secreted by multiple myeloma (MM) can partially inhibit cardiomyocyte viability and promote apoptosis by regulating the circ-CACNG2/miR-197-3p/caspase3 pathway. circ-CACNG2 was identified as an independent prognostic and diagnostic indicator of MM-related cardiac complications.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell Biology
Xin Wang, Feng-Lin Dong, Ying-Qiao Wang, Hong-Long Wei, Tao Li, Jie Li
Summary: This study reveals that circTGFBR2 in hepatocytic exosomes acts as a tumor promoter and enhances HCC progression by facilitating ATG5-mediated protective autophagy. It serves as a competing endogenous RNA by binding miR-205-5p, leading to resistance to starvation in HCC cells. The findings suggest that circTGFBR2 may serve as a potential therapeutic target for HCC.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Weiqi Dai, Xiaoli Wu, Jingjing Li, Wenxi Tang, Ying Wang, Wenqiang Xu, Dengyu Han, Xiaorong Xu, Xuanfu Xu
Summary: Hedgehog-Gli1-induced exosomal circ-0011536 promotes PNR via the miR-451a/VGF axis, indicating its potential contribution to PDAC-associated nerve changes with activated Hedgehog signaling.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qiyao Yu, Yi Zhang, Yanming Tian, Ale Peng, Xiujing Cui, Boyue Ding, Lei Yang, Yabin Liu, Yingchao Ju, Chao Gao
Summary: This study found that exosomal circular RNA circ_FMN2 was overexpressed in colorectal cancer patients and cells. Overexpression of exosomal circ_FMN2 promoted proliferation and metastasis, while suppressing apoptosis in colorectal cancer cells. Circ_FMN2 acted as a sponge for miR-338-3p, and miR-338-3p targeted MSI1. Moreover, exosomal circ_FMN2 overexpression also facilitated tumor growth in vivo.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Oncology
Dongliang Wang, Shuilong Zhang, Dewei Li, Qiang Wang, Zhifu Xiao, Yuhang Zhang
Summary: The overexpression of circSND1 promotes the occurrence and metastasis of thyroid cancer, involving the inhibition of miR-182-5p expression and the induction of MET upregulation.
JOURNAL OF ONCOLOGY
(2022)
Article
Biology
Ke Zhang, Yu-Jie Li, Lin-Jia Peng, Hui-Feng Gao, Lu-Ming Liu, Hao Chen
Summary: This study explores the role of M2 macrophage-derived exosomes in pancreatic cancer (PC). It is found that exosomal miR-193b-3p derived from M2 macrophages enhances the proliferation, migration, invasion, and glutamine uptake of PC cells by targeting TRIM62, resulting in the decrease of c-Myc ubiquitination.
Article
Oncology
Xingcheng Xiong, Jiarui Feng, Xiao Yang, Hanjun Li, Qiao Shi, Jing Tao, Jian Chang
Summary: The circular RNA CDR1as (circCDR1as) is highly expressed in pancreatic cancer tissues, promoting the migration, invasion, and proliferation of pancreatic cancer cells. It mediates E2F3 expression by sponging miR-432-5p, suggesting it could be a novel diagnostic target for pancreatic cancer.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Shenfeng Zhang, Meiqing Qiu, Shan Gao, Tao Tian
Summary: PCDH10 gene can be transcribed into linear mRNA or circular RNA, with FUS protein inducing the linear mRNA to shift to circPCDH10 in pancreatic cancer (PC) cells. CircPCDH10 acts as a sponge of miR-338-3p to regulate hTERT expression, promoting PC progression.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Environmental Sciences
Chunmei Li, Xiaoqiong Li, Yi Zhang, Liangzhi Wu, Jingjun He, Nan Jiang, Hui Zhao, Wenwen Liu
Summary: This study reveals the upregulation of DSCAM-AS1 in cervical carcinoma cells and its negative correlation with miR-338-3p expression. DSCAM-AS1 promotes cervical carcinoma cell growth and cycle by competitively binding to miR-338-3p.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yun Xia, Min Li, Tao Peng, Weijie Zhang, Jun Xiong, Qinggang Hu, Zifang Song, Qichang Zheng
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2013)
Article
Surgery
Guangyu Chen, Feng Tian, Xin Zhao, Yan Chen, Tao Peng, Jingchi Cui, Dajiang Li, Yu He, Shuguang Wang
JOURNAL OF INVESTIGATIVE SURGERY
(2020)
Article
Biotechnology & Applied Microbiology
Tao Peng, Zhonghu Li, Dajiang Li, Shuguang Wang
ONCOTARGETS AND THERAPY
(2019)
Article
Oncology
Tao Peng, Xiang Deng, Feng Tian, Zhonghu Li, Peng Jiang, Xin Zhao, Guangyu Chen, Yan Chen, Ping Zheng, Dajiang Li, Shuguang Wang
INTERNATIONAL JOURNAL OF ONCOLOGY
(2019)
Article
Surgery
Yan Chen, Peng Jiang, Feng Tian, Guangyu Chen, Tao Peng, Xiaoming Deng, Zhonghu Li, Den Huang, Jin Zhu, Ping Zhen, Chuanming Xie, Shuguang Wang
Summary: High expression of YBOX-1 in cholangiocarcinoma is closely associated with early recurrence and poor prognosis, serving as a potential indicator for predicting adverse outcomes and overall survival in patients with CCA.
JOURNAL OF INVESTIGATIVE SURGERY
(2021)
Article
Biotechnology & Applied Microbiology
Kai Chen, Zhonghu Li, Mengyun Zhang, Bo Wang, Tao Peng, Yanbing Shen, Jianxin Zhang, Jiaxin Ye, Yu Liu, Di Tang, Minjie Peng, Dandan Ma, Zhengkang Xiao, Yujun Zhang, Weidong Jin, Xiaowu Li
BIOMED RESEARCH INTERNATIONAL
(2020)
Editorial Material
Gastroenterology & Hepatology
Tao Peng, Haofeng Lu, Li Deng, Qiaolin Li, Kebing Chen, Bo Xia
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Songsong Liu, Fuming Xie, Lang Gan, Tao Peng, Xuejun Xu, Shixiang Guo, Wen Fu, Yunchao Wang, Yongsheng Ouyang, Jiali Yang, Xianxing Wang, Yao Zheng, Junfeng Zhang, Huaizhi Wang
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.