期刊
JOURNAL OF CANCER
卷 9, 期 17, 页码 3084-3092出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.26422
关键词
exosome; tumor microenvironment; angiogenesis; hypoxia; inflammation
类别
资金
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Research Foundation of Education Bureau of Jiangsu Province [16KJA360001]
- National Natural Science Foundation of China [81503374]
- People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7/2007-2013/ under REA grant [PIRSES-GA-2013-612589]
The tumor microenvironment (tumor cells are located in the internal and external environment) is vital for the occurrence, growth and metastasis of tumors. An increasing number of studies have shown that exosomes are closely related to the tumor microenvironment. The mechanisms involved, however, are unclear. The focus of this review is on the exosome-related tumor microenvironment and other relevant factors, such as hypoxia, inflammation and angiogenesis. Many studies have suggested that exosomes are important mediators of metastasis, angiogenesis, and immune modulation in the tumor microenvironment. Additionally, exosomes can be isolated from bodily fluids of cancer patients, including urine, blood, saliva, milk, tumor effusion, cerebrospinal fluid, amniotic fluid and so on. Consequently, exosomes are potential biomarkers for clinical predictions and are also good drug carriers because they can cross the biofilm without triggering an immune response. Collectively, these findings illustrate that exosomes are crucial for developing potential targets for a new generation of pharmaceutical therapies that would improve the tumor microenvironment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据