Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis

Tumor-Derived Exosomal Long Noncoding RNAs as Promising Diagnostic Biomarkers for Prostate Cancer

(2018) Yu-Hui Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer

(2018) Huimin Lu et al.   MATRIX BIOLOGY

Expression of pyruvate kinase M2 in human bladder cancer and its correlation with clinical parameters and prognosis

(2018) Changkun Huang et al.   OncoTargets and Therapy

Exosomal microRNA profiling to identify hypoxia-related biomarkers in prostate cancer

(2018) Gati K. Panigrahi et al.   Oncotarget

Exosomal lncRNAs as new players in cell-to-cell communication

(2018) Mihnea Dragomir et al.   Translational Cancer Research

Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone Osteoblasts

(2018) Alison B. Shupp et al.   Cancers

Urinary biomarkers of prostate cancer

(2018) Kazutoshi Fujita et al.   INTERNATIONAL JOURNAL OF UROLOGY

Detection of exosome miRNAs using molecular beacons for diagnosing prostate cancer

(2018) Jinhee Lee et al.   Artificial Cells Nanomedicine and Biotechnology

Urinary-exosomal miR-2909: A novel pathognomonic trait of prostate cancer severity

(2017) S. Wani et al.   JOURNAL OF BIOTECHNOLOGY

Pyruvate kinase M2 is a poor prognostic marker of and a therapeutic target in ovarian cancer

(2017) Tai-Kuang Chao et al.   PLoS One

Exosomal miR-141-3p regulates osteoblast activity to promote the osteoblastic metastasis of prostate cancer

(2017) Yun Ye et al.   Oncotarget

The Biology of Bone Metastasis

(2017) Mark Esposito et al.   Cold Spring Harbor Perspectives in Medicine

Discovery and validation of a colorectal cancer classifier in a new blood test with improved performance for high-risk subjects

(2017) Lisa J. Croner et al.   Clinical Proteomics

PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

(2016) Ninel Azoitei et al.   Molecular Cancer

Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome

(2016) Goran Hamid Mohammad et al.   PLoS One

PKM2 and cancer: The function of PKM2 beyond glycolysis

(2016) GAOCHAO DONG et al.   Oncology Letters

Bone metastasis and the metastatic niche

(2015) Guangwen Ren et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Blood-Based Protein Biomarker Panel for the Detection of Colorectal Cancer

(2015) Kim Y. C. Fung et al.   PLoS One

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

(2015) Weibo Luo et al.   Oncotarget

Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers

(2015) Shruti Desai et al.   Oncotarget

An In Vivo Mouse Model for Human Prostate Cancer Metastasis

(2015) Aaron M. Havens et al.   NEOPLASIA

Pyruvate kinase M2 and cancer: an updated assessment

(2014) Mohd Askandar Iqbal et al.   FEBS LETTERS

Activators of PKM2 in cancer metabolism

(2014) Steven L Warner et al.   Future Medicinal Chemistry

Nuclear PKM2 regulates the Warburg effect

(2013) Weiwei Yang et al.   CELL CYCLE

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1 -mediated glucose metabolism

(2013) H.-J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large Oncosomes in Human Prostate Cancer Tissues and in the Circulation of Mice with Metastatic Disease

(2012) Dolores Di Vizio et al.   AMERICAN JOURNAL OF PATHOLOGY

Pyruvate Kinase M2: Multiple Faces for Conferring Benefits on Cancer Cells

(2012) M. Tamada et al.   CLINICAL CANCER RESEARCH

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

(2011) J. L. Hood et al.   CANCER RESEARCH

Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

(2011) Yusuke Shiozawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone metastasis: mechanisms and therapeutic opportunities

(2011) Larry J. Suva et al.   Nature Reviews Endocrinology

Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments

(2011) Douglas D. Taylor et al.   Seminars in Immunopathology

Shedding of RANKL by Tumor-Associated MT1-MMP Activates Src-Dependent Prostate Cancer Cell Migration

(2010) A. L. Sabbota et al.   CANCER RESEARCH

Turning on a Fuel Switch of Cancer: hnRNP Proteins Regulate Alternative Splicing of Pyruvate Kinase mRNA

(2010) M. Chen et al.   CANCER RESEARCH

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Bone Metastases: Molecular Mechanisms and Novel Therapeutic Interventions

(2010) Dionysios J. Papachristou et al.   MEDICINAL RESEARCH REVIEWS

Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells

(2009) S. K. Martin et al.   HAEMATOLOGICA

SDF-1α Expression during Wound Healing in the Aged Is HIF Dependent

(2009) Shang A. Loh et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Osteoclasts Are Active in Bone Forming Metastases of Prostate Cancer Patients

(2008) Ilaria Roato et al.   PLoS One