Article
Oncology
Buhan Liu, Xianzhi Qu, Jian Wang, Long Xu, Lichao Zhang, Bo Xu, Jing Su, Xuehai Bian
Summary: Long non-coding RNAs (lncRNAs) are involved in regulating physiological processes and implicated in various diseases, including cancer. In breast cancer (BC), the role of lncRNAs has been extensively studied. This research focuses on the LINC00365/HIF-1 alpha axis and its impact on tumor growth through glycolysis. The findings suggest that targeting LINC00365 could reverse the glucose metabolism pattern in BC and effectively inhibit BC survival.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiangting Zhang, Luying Zhao, Kanglei Ying, Jun Xu, Yangjin Huang, Ruhuang Zhu, Yinrong Ding, Weimin Cai, Xiao Wu, Dan Miao, Qian Xu, Yuan Zeng, Fujun Yu
Summary: The study revealed that the TUG1 molecule, mediated by glycolysis regulator PDK4, plays an important regulatory role in liver fibrosis. By promoting glycolysis and inhibiting ferroptosis in hepatic stellate cells, it contributes to the progression of liver fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Gastroenterology & Hepatology
Ming-Yu Zhou, Ming-Liang Cheng, Tao Huang, Rui-Han Hu, Gao-Liang Zou, Hong Li, Bao-Fang Zhang, Juan-Juan Zhu, Yong-Mei Liu, Yang Liu, Xue-Ke Zhao
Summary: The study found that TGF-beta 1 induces GLUT1 expression in HSCs and is involved in the development of liver fibrosis. Experimental results showed that GLUT1 inhibition can reduce the degree of liver fibrosis. The mechanisms of action of GLUT1, TGF-beta 1, and aerobic glycolysis in the process of HSC activation during liver fibrosis were explored through various experimental approaches.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Anatomy & Morphology
Jiachi Li, Xiaoyao Fu, Demao Zhang, Daimo Guo, Siqun Xu, Jieya Wei, Jing Xie, Xuedong Zhou
Summary: This study explores the changes in intracellular metabolism of chondrocytes induced by osteoblasts using a co-culture system. It found that osteoblasts enhance the glycolysis in chondrocytes and activate the HIF-1 signaling pathway and ERK and p38/MAPK upstream signaling.
Article
Chemistry, Multidisciplinary
Lei Xu, Tian-yu Yang, Yi-wen Zhou, Mei-fei Wu, Jie Shen, Jie-ling Cheng, Qing-xue Liu, Shi-yang Cao, Jian-qing Wang, Lei Zhang
Summary: The study revealed the regulatory role of Bmal1 in glycolysis in hepatic stellate cells, which can inhibit the development of fibrosis and could be a new avenue for treating liver fibrosis.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Yue Ba, Shuo Yang, Shuiyuan Yu, Xiangbo Hou, Yuhui Du, Minghui Gao, Juan Zuo, Lei Sun, Xiaoli Fu, Zhiyuan Li, Hui Huang, Guoyu Zhou, Fangfang Yu
Summary: This study investigated the effects of fluoride intake on dental fluorosis by identifying differentially expressed proteins and metabolites. The HIF-1 and glycolysis/gluconeogenesis pathways were found to be significantly correlated with dental fluorosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Jing Sun, Meng Wu, Li Wang, Peiwen Wang, Tian Xiao, Suhua Wang, Qizhan Liu
Summary: This study reveals that arsenic exposure may induce Th2 polarization of CD4+ T cells and promote hepatic fibrosis. miR-21 regulates the metabolism of CD4+ T cells and affects cell cycle and proliferation, leading to the release of fibrogenic factor IL-13. Inhibition of Th2 polarization of CD4+ T cells or miR-21 expression may be a therapeutic strategy to combat arsenic-induced hepatic fibrosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Neurosciences
S. J. Kierans, C. T. Taylor
Summary: Under hypoxic conditions, eukaryotic cells can shift metabolism towards glycolysis to maintain ATP levels, a process regulated by HIF-1 alpha. This metabolic switch is crucial for cellular survival during acute hypoxic stress and has implications for cancer cell survival and growth. Understanding the mechanisms central to this reprogramming is important for both physiological and pathophysiological processes.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Medicine, Research & Experimental
Zhiyuan Zheng, Ting Xu, Zhiyan Liu, Wenyue Tian, Zhi-Hong Jiang, Guo-Yuan Zhu, Ting Li, Jin Gao, Li-Ping Bai
Summary: The current study found that Cryptolepine possesses the potential to treat breast cancer by inhibiting HIF-1 activity and decreasing HIF-1α protein expression. It suppresses tumor growth by blocking HIF-1-mediated glycolysis and reducing ATP production. Mechanistically, Cryptolepine inhibits the phosphorylation of eIF4E to suppress HIF-1α mRNA translation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Shuqin Mei, Lin Li, Xiangjun Zhou, Cheng Xue, Man J. Livingston, Qingqing Wei, Bing Dai, Zhiguo Mao, Changlin Mei, Zheng Dong
Summary: Diabetes enhances kidney fibrosis by enhancing HIF-1 activation, leading to impaired kidney repair. In diabetic mice, unilateral ureteral obstruction induces more renal fibrosis, apoptosis, and interstitial macrophage infiltration. High glucose-conditioned renal tubular cells show higher expression of fibrosis marker protein under hypoxia, which is mediated by increased HIF-1α expression. Knockout of proximal tubule-specific HIF-1α attenuates fibrosis induced by UUO in diabetic mice kidneys.
Article
Pharmacology & Pharmacy
Xin Li, Tian-Kui Ma, Min Wang, Xiao-Dan Zhang, Tian-Yan Liu, Yue Liu, Zhao-Hui Huang, Yong-Hong Zhu, Shuang Zhang, Li Yin, Yan-Yan Xu, Hong Ding, Cong Liu, Hang Shi, Qiu-Ling Fan
Summary: This study identified a novel regulatory mechanism of YY1 on ARAP1-AS2 and ARAP1, which promotes aberrant glycolysis and fibrosis in DKD by the EGFR/PKM2/HIF-1 alpha pathway. These findings provide potential therapeutic strategies for treating DKD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Dongli Guo, Jing Jin, Jianghui Liu, Yingying Wang, Daojuan Li, Yutong He
Summary: The aim of this study was to explore the mechanism of baicalein on the radioresistance of esophageal cancer. The results showed that baicalein could significantly inhibit the proliferation and migration of esophageal cancer cells and regulate glucose metabolism and cell cycle changes.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Oncology
Sumaiya Y. Afsar, Shah Alam, Carina Fernandez Gonzalez, Gerhild van Echten-Deckert
Summary: The study revealed that SGPL1-deficient cells tend to convert glucose to lactate under the influence of S1P, leading to increased proliferation rate, but without negatively affecting cellular energy status. Activation of the Akt/mTOR pathway and down-regulation of autophagy were identified as key mechanisms underlying these changes.
MOLECULAR ONCOLOGY
(2022)
Article
Geriatrics & Gerontology
Xue Li, Lin-Lin Luo, Rui-Feng Li, Chun-Lin Chen, Min Sun, Sen Lin
Summary: Lens fibrosis is a common cause of cataract in elderly individuals. This study explored the role of pantothenate kinase 4 (PANK4) and glycolytic metabolism in lens epithelial-mesenchymal transition (EMT). PANK4 levels were associated with aging and loss of function of PANK4 alleviated LEC EMT by promoting glycolysis. The PANK4-PKM2 axis was found to regulate EMT and HIF-1 stabilization, offering potential insights for fibrosis treatment in other organs.
Article
Biochemistry & Molecular Biology
Wen-Jing Zhong, Tian Liu, Hui-Hui Yang, Jia-Xi Duan, Jin-Tong Yang, Xin-Xin Guan, Jian-Bing Xiong, Yan-Feng Zhang, Chen-Yu Zhang, Yong Zhou, Cha-Xiang Guan
Summary: The activation of the triggering receptor expressed on myeloid cells-1 (TREM-1) can potentiate acute lung injury (ALI) and induce inflammation, but the underlying mechanism is unclear. This study found that blocking TREM-1 can attenuate the activation of NOD-, LRR- and pyrin domain-containing 3 (NLRP3) inflammasome and glycolysis in LPS-induced ALI mice. Furthermore, TREM-1 activation enhances glycolysis and inhibits oxidative phosphorylation in macrophages, and this effect is dependent on the hypoxia-inducible factor-1a (HIF-1 alpha)/mTOR/glycolysis pathway. Inhibiting mTOR or HIF-1 alpha can suppress TREM-1-induced metabolic reprogramming and NLRP3/caspase-1 activation. These findings reveal a novel mechanism of TREM-1-mediated NLRP3 inflammasome activation through the mTOR/HIF-1 alpha/glycolysis pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Immunology
Shunmei Huang, Shi Zou, Mingfa Chen, Xiaoyan Gao, Liwen Chen, Xilang Yang, Qing Yu, Xiaoli Zhao, Yanqin Du, Xuecheng Yang, Yong Lin, Baoju Wang, Yinping Lu, Jia Liu, Xin Zheng, Feili Gong, Mengji Lu, Dongliang Yang, Jun Wu
JOURNAL OF IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Shunmei Huang, Jun Wu, Xiaoyan Gao, Shi Zou, Liwen Chen, Xilang Yang, Chan Sun, Yanqin Du, Bin Zhu, Jia Li, Xuecheng Yang, Xuemei Feng, Chunchen Wu, Chunwei Shi, Baoju Wang, Yinping Lu, Jia Liu, Xin Zheng, Feili Gong, Mengji Lu, Dongliang Yang
MOLECULAR IMMUNOLOGY
(2018)
Article
Engineering, Biomedical
Yanqin Du, Xiaoli Yang, Jia Li, Viktoriya Sokolova, Shi Zou, Meihong Han, Hu Yan, Karolin Wey, Mengji Lu, Ulf Dittmer, Dongliang Yang, Matthias Epple, Jun Wu
Summary: Nanoparticles carrying poly(I:C) conjugated with an F4/80 antibody showed enhanced liver targeting and significantly reduced HBV levels in mice, suggesting a promising alternative for future anti-HBV treatment.
ACTA BIOMATERIALIA
(2021)
Article
Immunology
Tanvi Khera, Yanqin Du, Daniel Todt, Katja Deterding, Benedikt Strunz, Svenja Hardtke, Amare Aregay, Kerstin Port, Matthias Hardtke-Wolenski, Eike Steinmann, Niklas K. Bjorkstrom, Michael P. Manns, Julia Hengst, Markus Cornberg, Heiner Wedemeyer
Summary: Patients with acute hepatitis C infection showed significant alterations in soluble inflammatory mediators compared to chronic hepatitis patients and healthy controls. Early treatment with DAAs partially normalized these changes, but long-lasting imprints of HCV remained.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Gastroenterology & Hepatology
Yanqin Du, Olympia E. Anastasiou, Benedikt Strunz, Janina Scheuten, Birgit Bremer, Anke Kraft, Karolina Kleinsimglinhaus, Daniel Todt, Ruth Broering, Matthias Hardtke-Wolenski, Jun Wu, Dongliang Yang, Ulf Dittmer, Mengji Lu, Markus Cornberg, Niklas K. Bjorkstrom, Tanvi Khera, Heiner Wedemeyer
Summary: The study assessed the effects of HBsAg quantities on NK cell functionality in CHB patients, finding a reshaping of the NK cell pool towards more CD56(bright) NK cells during infection. Patients with low HBsAg levels displayed an activated NK cell phenotype with defective functional responses.
LIVER INTERNATIONAL
(2021)
Article
Virology
Shi Zou, Yanqin Du, Shunmei Huang, Mingfa Chen, Xiaoli Yang, Sumeng Li, Yingshan Chen, Meihong Han, Jia Li, Qing Yu, Elisabeth Littwitz-Salomon, Hongming Huang, Mirko Trilling, Shi Liu, Rongjuan Pei, Jia Liu, Baoju Wang, Xin Zheng, Mengji Lu, Ulf Dittmer, Shuilin Sun, Dongliang Yang, Jun Wu
Summary: The study reveals that the application of IFN-I at different time points leads to contrasting outcomes. Activation of the IFN-I pathway before HBV replication induces an immunosuppressive signaling cascade in the liver, causing HBV persistence, whereas IFN-I activation post HBV infection enhances HBV-specific T cell responses, promoting HBV clearance. This provides an important insight into the mechanism of HBV persistence in adult individuals.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Yanqin Du, Tanvi Khera, Benedikt Strunz, Katja Deterding, Daniel Todt, Norman Woller, Sophie Anna Engelskircher, Svenja Hardtke, Kerstin Port, Andrea Ponzetta, Eike Steinmann, Markus Cornberg, Julia Hengst, Niklas K. Bjorkstrom, Heiner Wedemeyer
Summary: This study comprehensively analyzed the phenotype and reinvigoration capacity of unconventional T cells (UTCs) in acute symptomatic HCV infection. It was found that MAIT cells showed reduced frequency, but remaining cells had near-normal phenotype in acute infection, although they exhibited significant dysfunction upon stimulation that persisted even after viral clearance.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yanqin Du, Hu Yan, Shi Zou, Tanvi Khera, Jia Li, Meihong Han, Xiaoli Yang, Baoju Wang, Jia Liu, Shuilin Sun, Xin Zheng, Ulf Dittmer, Mengji Lu, Dongliang Yang, Heiner Wedemeyer, Jun Wu
Summary: NK cells, activated by NOD1, enhance intrahepatic T-cell responses by promoting maturation of LSECs through soluble cytokines and cell-cell contact, thereby controlling HBV replication and expression.
HEPATOLOGY COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Viktoriya Sokolova, Zou Shi, Shunmei Huang, Yanqin Du, Mathis Kopp, Annika Frede, Torben Knuschke, Jan Buer, Dongliang Yang, Jun Wu, Astrid Maria Westendorf, Matthias Epple
ACTA BIOMATERIALIA
(2017)