Gαs–Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling

Synthetic Lethal Screens Reveal Co-Targeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma

(2021) Justine S. Paradis et al.   CLINICAL CANCER RESEARCH

Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

(2021) Cristina Olivieri et al.   Communications Biology

High diagnostic yield in skeletal ciliopathies using massively parallel genome sequencing, structural variant screening and RNA analyses

(2021) Anna Hammarsjö et al.   JOURNAL OF HUMAN GENETICS

Targeted protein degraders crowd into the clinic

(2021) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

(2021) Corvin D. Arveseth et al.   PLOS BIOLOGY

PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies

(2021) Susan S. Taylor et al.   BIOCHEMICAL JOURNAL

Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?

(2021) Caitlin Walker et al.   JOURNAL OF MOLECULAR BIOLOGY

Anti-Inflammatory Drugs Remodel the Tumor Immune Environment to Enhance Immune Checkpoint Blockade Efficacy

(2021) Victoria S. Pelly et al.   Cancer Discovery

Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium

(2020) Philipp Tschaikner et al.   Cells

Membrane mucins of the intestine at a glance

(2020) Thaher Pelaseyed et al.   JOURNAL OF CELL SCIENCE

Sensitive Sequencing Analysis Suggests Thyrotropin Receptor and Guanine Nucleotide-Binding Protein G Subunit Alpha as Sole Driver Mutations in Hot Thyroid Nodules

(2020) Alexandra Stephenson et al.   THYROID

PROTAC Technology: Opportunities and Challenges

(2020) Hongying Gao et al.   ACS Medicinal Chemistry Letters

Prostaglandin E Receptor 4 Antagonist in Cancer Immunotherapy: Mechanisms of Action

(2020) Yukinori Take et al.   Frontiers in Immunology

Mechanistic and Functional Shades of Mucins and Associated Glycans in Colon Cancer

(2020) Ramesh Pothuraju et al.   Cancers

Drugs that Regulate Local Cell Signaling: AKAP Targeting as a Therapeutic Option

(2020) Paula J. Bucko et al.   Annual Review of Pharmacology and Toxicology

Inhibitors and fluorescent probes for protein kinase PKAcβ and its S54L mutant, identified in a patient with cortisol producing adenoma

(2020) Olivier Etebe Nonga et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells

(2020) Garry L. Coles et al.   CANCER CELL

Phosphodiesterase 3A and Arterial Hypertension

(2020) Maria Ercu et al.   CIRCULATION

Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome

(2020) Adrian Palencia-Campos et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling

(2020) Jason Z. Zhang et al.   CELL

Optical Mapping of cAMP Signaling at the Nanometer Scale

(2020) Andreas Bock et al.   CELL

AKAP Signaling Islands: Venues for Precision Pharmacology

(2020) Mitchell H. Omar et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers

(2020) Nadia Arang et al.   FEBS LETTERS

Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma

(2020) Tsan-Wen Lu et al.   PLOS BIOLOGY

Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A

(2020) Chong Liu et al.   Frontiers in Physiology

Structures of the PKA RIα Holoenzyme with the FLHCC Driver J-PKAcα or Wild-Type PKAcα

(2019) Baohua Cao et al.   STRUCTURE

26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation

(2019) Jordan J. S. VerPlank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a PRKAR1A mutation (c.491_492delTG) in familial cardiac myxoma

(2019) Shengjun Ma et al.   MEDICINE

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

(2019) Xiaodong Feng et al.   CANCER CELL

A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A

(2019) Jascha T. Manschwetus et al.   MOLECULES

An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma

(2019) Rigney E Turnham et al.   eLife

Illuminating the Onco-GPCRome: Novel G protein–coupled receptor-driven oncocrine networks and targets for cancer immunotherapy

(2019) Victoria Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm

(2019) Francesco Raimondi et al.   ONCOGENE

Best practice management guidelines for fibrous dysplasia/McCune-Albright syndrome: a consensus statement from the FD/MAS international consortium

(2019) Muhammad Kassim Javaid et al.   Orphanet Journal of Rare Diseases

Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP

(2019) Tsan-Wen Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases

(2019) Faisa Omar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system

(2019) Laura Rinaldi et al.   Nature Communications

Reshaping cAMP nanodomains through targeted disruption of compartmentalised phosphodiesterase signalosomes

(2019) Connor M. Blair et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cushing’s syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity

(2019) Caitlin Walker et al.   Science Advances

Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct

(2019) Aatur D. Singhi et al.   GASTROENTEROLOGY

DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma

(2019) Monika Vyas et al.   MODERN PATHOLOGY

The landscape of somatic mutation in normal colorectal epithelial cells

(2019) Henry Lee-Six et al.   NATURE

ClinVar: improvements to accessing data

(2019) Melissa J Landrum et al.   NUCLEIC ACIDS RESEARCH

G Protein–Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action

(2019) Stacy Gelhaus Wendell et al.   PHARMACOLOGICAL REVIEWS

Subcellular drug targeting illuminates local kinase action

(2019) Paula J Bucko et al.   eLife

Potential use of CXCL12/CXCR4 and sonic hedgehog pathways as therapeutic targets in medulloblastoma

(2018) Marla Karine Amarante et al.   ACTA ONCOLOGICA

Multiple hormone resistance and alterations of G-protein-coupled receptors signaling

(2018) Mantovani Giovanna et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Shaping mitochondrial dynamics: The role of cAMP signalling

(2018) Giulietta Di Benedetto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial cAMP-PKA signaling: What do we really know?

(2018) Yasmine Ould Amer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2

(2018) N. George Bendzunas et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The curious case of Gαs gain-of-function in neoplasia

(2018) Giulio Innamorati et al.   BMC CANCER

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

Disease-Causing Mutations in the G Protein Gαs Subvert the Roles of GDP and GTP

(2018) Qi Hu et al.   CELL

A highlight on Sonic hedgehog pathway

(2018) Gabriela Basile Carballo et al.   Cell Communication and Signaling

BRAF and MEK Inhibitors: Use and Resistance in BRAF-Mutated Cancers

(2018) Jaquelyn N. Sanchez et al.   DRUGS

GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells

(2018) Shu Z. Wiley et al.   FASEB JOURNAL

Fibrolamellar carcinoma in the Carney complex: PRKAR1A loss instead of the classic DNAJB1-PRKACA fusion

(2018) Rondell P. Graham et al.   HEPATOLOGY

Genomic Alterations and Complex Subclonal Architecture in Sporadic GH-Secreting Pituitary Adenomas

(2018) Mirella Hage et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Recurrent left atrial myxoma in Carney complex

(2018) Liaoyuan Wang et al.   MEDICINE

Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism

(2018) Krushna C. Patra et al.   NATURE CELL BIOLOGY

Synthetic lethal therapies for cancer: what’s next after PARP inhibitors?

(2018) Alan Ashworth et al.   Nature Reviews Clinical Oncology

Epidemiology and survival outcomes of mucinous adenocarcinomas: A SEER population-based study

(2018) Guang-Dong Xie et al.   Scientific Reports

Kinetics and inhibition studies of the L205R mutant of cAMP-dependent protein kinase involved in Cushing's syndrome

(2018) Nicole M. Luzi et al.   FEBS Open Bio

The roles of the COX2/PGE2/EP axis in therapeutic resistance

(2018) Dali Tong et al.   CANCER AND METASTASIS REVIEWS

G-Protein–Coupled Receptors in Heart Disease

(2018) Jialu Wang et al.   CIRCULATION RESEARCH

Detection of GNAS mutations in intramuscular / cellular myxomas as diagnostic tool in the classification of myxoid soft tissue tumors

(2018) Sandra Sunitsch et al.   Diagnostic Pathology

Targeting G protein-coupled receptor signalling by blocking G proteins

(2018) Adrian P. Campbell et al.   NATURE REVIEWS DRUG DISCOVERY

The Molecular Basis for Specificity at the Level of the Protein Kinase a Catalytic Subunit

(2018) Kristoffer Søberg et al.   Frontiers in Endocrinology

Carney Complex

(2018) Crystal Kamilaris et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

GNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling

(2018) Noboru Ideno et al.   GASTROENTEROLOGY

FusionGDB: fusion gene annotation DataBase

(2018) Pora Kim et al.   NUCLEIC ACIDS RESEARCH

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of resistance to BRAF and MEK inhibitors and clinical update of US Food and Drug Administration-approved targeted therapy in advanced melanoma

(2018) Sunilkumar Kakadia et al.   OncoTargets and Therapy

Dual role of YAP: oncoprotein and tumor suppressor

(2018) Eekhoon Jho   Journal of Thoracic Disease

Clinical Identification of Oncogenic Drivers and Copy-Number Alterations in Pituitary Tumors

(2017) Wenya Linda Bi et al.   ENDOCRINOLOGY

Cushing's syndrome mutant PKAL 205R exhibits altered substrate specificity

(2017) Joshua M. Lubner et al.   FEBS LETTERS

Regulation of G Protein-Coupled Receptors by Ubiquitination

(2017) Kamila Skieterska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In VivoKnockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

(2017) Nobumichi Ohoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status

(2017) Tsuyoshi Hamada et al.   JOURNAL OF CLINICAL ONCOLOGY

Divalent metal ions control activity and inhibition of protein kinases

(2017) Matthias J. Knape et al.   Metallomics

Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling

(2017) Markus Brockmann et al.   NATURE

An activating mutation of GNB1 is associated with resistance to tyrosine kinase inhibitors in ETV6-ABL1-positive leukemia

(2017) O Zimmermannova et al.   ONCOGENE

Adenylyl cyclase signalling complexes – Pharmacological challenges and opportunities

(2017) Michelle L. Halls et al.   PHARMACOLOGY & THERAPEUTICS

The genetic background of acromegaly

(2017) Mônica R. Gadelha et al.   Pituitary

Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms

(2017) Kristoffer Søberg et al.   PLoS One

Expression of an active Gαsmutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance

(2017) Xuefeng Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNAJB1–PRKACAfusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma

(2017) Edward R. Kastenhuber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

InducedGnasR201Hexpression from the endogenousGnaslocus causes fibrous dysplasia by up-regulating Wnt/β-catenin signaling

(2017) Sanjoy Kumar Khan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local protein kinase A action proceeds through intact holoenzymes

(2017) F. Donelson Smith et al.   SCIENCE

Receptor Tyrosine Kinases: Translocation Partners in Hematopoietic Disorders

(2017) Katelyn N. Nelson et al.   TRENDS IN MOLECULAR MEDICINE

G-Protein-Coupled Receptor Signaling in Cilia

(2017) Kirk Mykytyn et al.   Cold Spring Harbor Perspectives in Biology

Recurrent somatic mutations of PRKAR1A in isolated cardiac myxoma

(2017) Jian He et al.   Oncotarget

Targeting G-protein coupled receptor-related signaling pathway in a murine xenograft model of appendiceal pseudomyxoma peritonei

(2017) Ashok K. Dilly et al.   Oncotarget

Aspirin for the Prevention of Cancer Incidence and Mortality: Systematic Evidence Reviews for the U.S. Preventive Services Task Force

(2016) Jessica Chubak et al.   ANNALS OF INTERNAL MEDICINE

Invited review: Activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis

(2016) Stephen R. Sprang   BIOPOLYMERS

The G protein Gαsacts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis

(2016) Rohit Rao et al.   CELL CYCLE

Current insights into the role of PKA phosphorylation in CFTR channel activity and the pharmacological rescue of cystic fibrosis disease-causing mutants

(2016) Stephanie Chin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Covalent targeting of acquired cysteines in cancer

(2016) Marieke Visscher et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology

(2016) Rigney E. Turnham et al.   GENE

Genetics of gigantism and acromegaly

(2016) Fady Hannah-Shmouni et al.   GROWTH HORMONE & IGF RESEARCH

Gigantism: X-linked acrogigantism and GPR101 mutations

(2016) Donato Iacovazzo et al.   GROWTH HORMONE & IGF RESEARCH

The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β

(2016) Alessandro Dema et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas WithoutPRKACAp.Leu206Arg Mutation

(2016) Cristina L. Ronchi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Structure of a PKA RIα Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation

(2016) Jessica GH Bruystens et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting cAMP/PKA pathway for glycemic control and type 2 diabetes therapy

(2016) Haihua Yang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

GNAS mutations as prognostic biomarker in patients with relapsed peritoneal pseudomyxoma receiving metronomic capecitabine and bevacizumab: a clinical and translational study

(2016) Filippo Pietrantonio et al.   Journal of Translational Medicine

Hyperthyroidism

(2016) Simone De Leo et al.   LANCET

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular Classification of Medulloblastoma

(2016) Noriyuki KIJIMA et al.   NEUROLOGIA MEDICO-CHIRURGICA

Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma

(2016) Kevin M. Riggle et al.   PEDIATRIC RESEARCH

Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling

(2016) Verena A. Bachmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Popeye domain containing protein family – A novel class of cAMP effectors with important functions in multiple tissues

(2016) Roland F.R. Schindler et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability

(2016) D. R. Pattabiraman et al.   SCIENCE

Quantitative Phosphoproteomic Study Reveals that Protein Kinase A Regulates Neural Stem Cell Differentiation Through Phosphorylation of Catenin Beta-1 and Glycogen Synthase Kinase 3β

(2016) Shuxin Wang et al.   STEM CELLS

Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis

(2016) Roberta Palorini et al.   PLoS Genetics

Augmentation of CAR T-cell Trafficking and Antitumor Efficacy by Blocking Protein Kinase A Localization

(2016) K. Newick et al.   Cancer Immunology Research

Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells – Role of Anchored Protein Kinase A Signaling Units

(2016) Vanessa L. Wehbi et al.   Frontiers in Immunology

PKA-Type I Selective Constrained Peptide Disruptors of AKAP Complexes

(2015) Yuxiao Wang et al.   ACS Chemical Biology

Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13

(2015) Cristiane Bentin Toaldo et al.   BMC CANCER

The impact of stage, grade, and mucinous histology on the efficacy of systemic chemotherapy in adenocarcinomas of the appendix: Analysis of the National Cancer Data Base

(2015) Elliot A. Asare et al.   CANCER

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

Ins and outs of GPCR signaling in primary cilia

(2015) K. B. Schou et al.   EMBO REPORTS

Carney complex: an update

(2015) Ricardo Correa et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Germline PRKACA amplification causes variable phenotypes that may depend on the extent of the genomic defect: molecular mechanisms and clinical presentations

(2015) M. B. Lodish et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

TGF-β signalopathies as a paradigm for translational medicine

(2015) Elyssa Cannaerts et al.   European Journal of Medical Genetics

Unique Genomic Profile of Fibrolamellar Hepatocellular Carcinoma

(2015) Helena Cornella et al.   GASTROENTEROLOGY

Cyclic AMP Signaling Reduces Sirtuin 6 Expression in Non-small Cell Lung Cancer Cells by Promoting Ubiquitin-Proteasomal Degradation via Inhibition of the Raf-MEK-ERK (Raf/Mitogen-activated Extracellular Signal-regulated Kinase/Extracellular Signal-regulated Kinase) Pathway

(2015) Eui-Jun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Characterization ofPRKAR1AMutations Reveals a Unique Molecular Mechanism Causing Acrodysostosis but Multiple Mechanisms Causing Carney Complex

(2015) Yara Rhayem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion

(2015) Frank Schwede et al.   MOLECULAR ENDOCRINOLOGY

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Inactivation of a Gα s –PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis

(2015) Ramiro Iglesias-Bartolome et al.   NATURE CELL BIOLOGY

Genomic spectra of biliary tract cancer

(2015) Hiromi Nakamura et al.   NATURE GENETICS

PDE3A mutations cause autosomal dominant hypertension with brachydactyly

(2015) Philipp G Maass et al.   NATURE GENETICS

Signalling scaffolds and local organization of cellular behaviour

(2015) Lorene K. Langeberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural insights into mis-regulation of protein kinase A in human tumors

(2015) Jonah Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of protein kinase A in regulating mitochondrial function and neuronal development: implications to neurodegenerative diseases

(2015) Ruben K. Dagda et al.   REVIEWS IN THE NEUROSCIENCES

Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines

(2015) Ganesh K. Boora et al.   Cancer Genetics

Updated Global Burden of Cholera in Endemic Countries

(2015) Mohammad Ali et al.   PLoS Neglected Tropical Diseases

A dynamic interface between ubiquitylation and cAMP signaling

(2015) Laura Rinaldi et al.   Frontiers in Pharmacology

Targeting protein–protein interactions in complexes organized by A kinase anchoring proteins

(2015) Ana I. Calejo et al.   Frontiers in Pharmacology

GNAS Spectrum of Disorders

(2015) Serap Turan et al.   Current Osteoporosis Reports

Cushing's syndrome: epidemiology and developments in disease management

(2015) Richard Feelders et al.   Clinical Epidemiology

A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy

(2015) Robert D. Leone et al.   Computational and Structural Biotechnology Journal

Constitutive Activity among Orphan Class-A G Protein Coupled Receptors

(2015) Adam L. Martin et al.   PLoS One

Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides

(2014) Yuxiao Wang et al.   ACS Chemical Biology

PRKAR1A in the Development of Cardiac Myxoma

(2014) Joseph J. Maleszewski et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Gain-of-functionADCY5mutations in familial dyskinesia with facial myokymia

(2014) Ying-Zhang Chen et al.   ANNALS OF NEUROLOGY

Soluble adenylyl cyclase in health and disease

(2014) Andreas Schmid et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology

(2014) Tsz Hang Wong et al.   BRAIN

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

(2014) Marcel Kool et al.   CANCER CELL

Sequence analysis of the catalytic subunit of PKA in somatotroph adenomas

(2014) Sarah J Larkin et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases

(2014) Ana Martinez et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The mysterious pathways of cardiac myxomas: a review of histogenesis, pathogenesis and pathology

(2014) Anna Di Vito et al.   HISTOPATHOLOGY

Compartmentalization of cAMP Signaling in Adipogenesis, Lipogenesis, and Lipolysis

(2014) M. Rogne et al.   HORMONE AND METABOLIC RESEARCH

Genomic profile of pseudomyxoma peritonei analyzed using next-generation sequencing and immunohistochemistry

(2014) Pirjo Nummela et al.   INTERNATIONAL JOURNAL OF CANCER

Novel nonsenseGNASmutation in a 14-month-old boy with plate-like osteoma cutis and medulloblastoma

(2014) Ji Young Huh et al.   JOURNAL OF DERMATOLOGY

Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas

(2014) Eliana Amato et al.   JOURNAL OF PATHOLOGY

Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors

(2014) Gerald Goh et al.   NATURE GENETICS

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma

(2014) Xuelian He et al.   NATURE MEDICINE

Regulation of the adrenocortical stem cell niche: implications for disease

(2014) Elisabeth M. Walczak et al.   Nature Reviews Endocrinology

PRKACB and Carney Complex

(2014) Antonella Forlino et al.   NEW ENGLAND JOURNAL OF MEDICINE

Constitutive Activation of PKA Catalytic Subunit in Adrenal Cushing's Syndrome

(2014) Felix Beuschlein et al.   NEW ENGLAND JOURNAL OF MEDICINE

PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling

(2014) S E Moody et al.   ONCOGENE

A GNAS Mutation Found in Pancreatic Intraductal Papillary Mucinous Neoplasms Induces Drastic Alterations of Gene Expression Profiles with Upregulation of Mucin Genes

(2014) Hirotake Komatsu et al.   PLoS One

Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma

(2014) J. N. Honeyman et al.   SCIENCE

G-protein-coupled receptors, Hedgehog signaling and primary cilia

(2014) Saikat Mukhopadhyay et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Primary bilateral macronodular adrenal hyperplasia

(2014) Agostino De Venanzi et al.   Current Opinion in Endocrinology Diabetes and Obesity

PKA catalytic subunit mutations in adrenocortical Cushing’s adenoma impair association with the regulatory subunit

(2014) Davide Calebiro et al.   Nature Communications

Targeting Cancer-Derived Adenosine:New Therapeutic Approaches

(2014) A. Young et al.   Cancer Discovery

Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin

(2014) Hakan Alakus et al.   Genome Medicine

Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs

(2013) Simon H. J. Brown et al.   ACS Chemical Biology

Intraductal Papillary Mucinous Neoplasms of the Pancreas With Distinct Pancreatic Ductal Adenocarcinomas Are Frequently of Gastric Subtype

(2013) Noboru Ideno et al.   ANNALS OF SURGERY

Clinicopathological Correlates of Activating GNAS Mutations in Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas

(2013) Marco Dal Molin et al.   ANNALS OF SURGICAL ONCOLOGY

Prognostic implication of mucinous histology in colorectal cancer patients treated with adjuvant FOLFOX chemotherapy

(2013) D-W Lee et al.   BRITISH JOURNAL OF CANCER

Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms

(2013) G Nishikawa et al.   BRITISH JOURNAL OF CANCER

Interaction of PACAP with Sonic hedgehog reveals complex regulation of the Hedgehog pathway by PKA

(2013) Pawel Niewiadomski et al.   CELLULAR SIGNALLING

Pasireotide: A Review of Its Use in Cushing’s Disease

(2013) Kate McKeage   DRUGS

cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes

(2013) Minchul Kim et al.   EMBO JOURNAL

cAMP signalling decreases p300 protein levels by promoting its ubiquitin/proteasome dependent degradation via Epac and p38 MAPK in lung cancer cells

(2013) Min-Jae Jeong et al.   FEBS LETTERS

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Extremely poor postrecurrence oncological outcome for patients with recurrent mucinous ovarian cancer

(2013) Hiroaki Kajiyama et al.   International Journal of Clinical Oncology

Engineering A-kinase Anchoring Protein (AKAP)-selective Regulatory Subunits of Protein Kinase A (PKA) through Structure-based Phage Selection

(2013) Matthew G. Gold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag

(2013) Oleg G. Chepurny et al.   MOLECULAR ENDOCRINOLOGY

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

(2013) Jonathan M. Ostrem et al.   NATURE

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

(2013) Cory M. Johannessen et al.   NATURE

Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification

(2013) Jean B Regard et al.   NATURE MEDICINE

Mucins in pancreatic cancer and its microenvironment

(2013) Sukhwinder Kaur et al.   Nature Reviews Gastroenterology & Hepatology

Sturge–Weber Syndrome and Port-Wine Stains Caused by Somatic Mutation in GNAQ

(2013) Matthew D. Shirley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Managing hyperglycemia in patients with Cushing’s disease treated with pasireotide: medical expert recommendations

(2013) Annamaria Colao et al.   Pituitary

Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3

(2013) K. Muda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Central Role of RET in Thyroid Cancer

(2013) M. Santoro et al.   Cold Spring Harbor Perspectives in Biology

Future directions in phosphodiesterase drug discovery

(2012) Michael P. DeNinno   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

Activation of Cyclic AMP Signaling Leads to Different Pathway Alterations in Lesions of the Adrenal Cortex Caused by Germline PRKAR1A Defects versus Those due to Somatic GNAS Mutations

(2012) Madson Q. Almeida et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Frequent activating GNAS mutations in villous adenoma of the colorectum

(2012) Masayoshi Yamada et al.   JOURNAL OF PATHOLOGY

Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials

(2012) Peter M Rothwell et al.   LANCET

Assembly of allosteric macromolecular switches: lessons from PKA

(2012) Susan S. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oncogenic K-ras expression is associated with derangement of the cAMP/PKA pathway and forskolin-reversible alterations of mitochondrial dynamics and respiration

(2012) R Palorini et al.   ONCOGENE

The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB

(2012) Eric R Kandel   Molecular Brain

Natural history and outcome of mucinous carcinoma of the ovary

(2011) Maria B. Schiavone et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

CXCR4 Activation Defines a New Subgroup of Sonic Hedgehog-Driven Medulloblastoma

(2011) R. Sengupta et al.   CANCER RESEARCH

Bigger, Better, Faster

(2011) Eric C. Greenwald et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

In VitroStudies of NovelPRKAR1AMutants that Extend the Predicted RIα Protein Sequence into the 3′-Untranslated Open Reading Frame: Proteasomal Degradation Leads to RIα Haploinsufficiency and Carney Complex

(2011) Yianna Patronas et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

PDEs create local domains of cAMP signaling

(2011) Delphine Mika et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Intracellular cAMP signaling by soluble adenylyl cyclase

(2011) Martin Tresguerres et al.   KIDNEY INTERNATIONAL

Control of PKA stability and signalling by the RING ligase praja2

(2011) Luca Lignitto et al.   NATURE CELL BIOLOGY

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RecurrentPRKAR1AMutation in Acrodysostosis with Hormone Resistance

(2011) Agnès Linglart et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cell-Type Specific Expression of a Dominant Negative PKA Mutation in Mice

(2011) Brandon S. Willis et al.   PLoS One

Signaling by Sensory Receptors

(2011) D. Julius et al.   Cold Spring Harbor Perspectives in Biology

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

Genetic hyperthyroidism: hyperthyroidism due to activating TSHR mutations

(2010) A Hébrant et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/− or Rb1+/− backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling

(2010) Madson Q. Almeida et al.   HUMAN MOLECULAR GENETICS

Mutations and polymorphisms in the gene encoding regulatory subunit type 1-alpha of protein kinase A (PRKAR1A): an update

(2010) Anélia Horvath et al.   HUMAN MUTATION

Ric-8B Stabilizes the α Subunit of Stimulatory G Protein by Inhibiting Its Ubiquitination

(2010) Yusuke Nagai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells

(2010) Mara Riminucci et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Networking with AKAPs: Context-dependent Regulation of Anchored Enzymes

(2010) E. J. Welch et al.   MOLECULAR INTERVENTIONS

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

Epidemiology of Cushing’s Syndrome

(2010) Charlotte Steffensen et al.   NEUROENDOCRINOLOGY

Cyclic nucleotides as affinity tools: Phosphorothioate cAMP analogues address specific PKA subproteomes

(2010) Susanne E. Hanke et al.   New Biotechnology

The activating mutation R201C in GNAS promotes intestinal tumourigenesis in ApcMin/+ mice through activation of Wnt and ERK1/2 MAPK pathways

(2010) C H Wilson et al.   ONCOGENE

 2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation

(2010) V. O. Nikolaev et al.   SCIENCE

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

(2009) Wolfram Goessling et al.   CELL

Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein

(2009) Derek M. Erion et al.   Cell Metabolism

Cyclic AMP Produced inside Mitochondria Regulates Oxidative Phosphorylation

(2009) Rebeca Acin-Perez et al.   Cell Metabolism

Bisubstrate Inhibitors of Protein Kinases: from Principle to Practical Applications

(2009) Darja Lavogina et al.   ChemMedChem

Protein Kinase A Activation Confers Resistance to Trastuzumab in Human Breast Cancer Cell Lines

(2009) L. Gu et al.   CLINICAL CANCER RESEARCH

The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation

(2009) William E Tidyman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Prevalence of TSH Receptor and Gsα Mutations in 45 Autonomously Functioning Thyroid Nodules in Japan

(2009) Eijun NISHIHARA et al.   ENDOCRINE JOURNAL

Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base

(2009) M. Barzi et al.   JOURNAL OF CELL SCIENCE

Clinical and Genetic Heterogeneity, Overlap with Other Tumor Syndromes, and Atypical Glucocorticoid Hormone Secretion in Adrenocorticotropin-Independent Macronodular Adrenal Hyperplasia Compared with Other Adrenocortical Tumors

(2009) Hui-Pin Hsiao et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mutations in Regulatory Subunit Type 1A of Cyclic Adenosine 5′-Monophosphate-Dependent Protein Kinase (PRKAR1A): Phenotype Analysis in 353 Patients and 80 Different Genotypes

(2009) Jérôme Bertherat et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Perilipin A and the control of triacylglycerol metabolism

(2009) Dawn L. Brasaemle et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Regulation of the steroidogenic acute regulatory protein gene expression: present and future perspectives

(2009) P. R. Manna et al.   MOLECULAR HUMAN REPRODUCTION

Proximal events in Wnt signal transduction

(2009) Stephane Angers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nonsense-mediated mRNA decay (NMD) mechanisms

(2009) Saverio Brogna et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular Basis of Colorectal Cancer

(2009) Sanford D. Markowitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of COX-2 in intestinal inflammation and colorectal cancer

(2009) D Wang et al.   ONCOGENE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

PKA-Mediated Golgi Remodeling During cAMP Signal Transmission

(2009) Fabiola Mavillard et al.   TRAFFIC

The nature of fibrous dysplasia

(2009) Liviu Feller et al.   Head & Face Medicine

Adenosine receptors in regulation of dendritic cell differentiation and function

(2008) S. V. Novitskiy et al.   BLOOD

Protein Kinase A Effects of an Expressed PRKAR1A Mutation Associated with Aggressive Tumors

(2008) E. Meoli et al.   CANCER RESEARCH

Large Deletions of the PRKAR1A Gene in Carney Complex

(2008) A. Horvath et al.   CLINICAL CANCER RESEARCH

A crucial role of WW45 in developing epithelial tissues in the mouse

(2008) Joo-Hyeon Lee et al.   EMBO JOURNAL

Prevalence of mutations in TSHR, GNAS, PRKAR1A and RAS genes in a large series of toxic thyroid adenomas from Galicia, an iodine-deficient area in NW Spain

(2008) F Palos-Paz et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay

(2008) Elizabeth L. Greene et al.   HUMAN MUTATION

A Molecular Switch for Targeting between Endoplasmic Reticulum (ER) and Mitochondria

(2008) Yuliang Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic Nucleotide-regulated Cation Channels

(2008) Martin Biel   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase A-Dependent Step(s) in Hepatitis C Virus Entry and Infectivity

(2008) M. J. Farquhar et al.   JOURNAL OF VIROLOGY

The differential regulation of steroidogenic acute regulatory protein-mediated steroidogenesis by type I and type II PKA in MA-10 cells

(2008) Matthew T. Dyson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling

(2008) Stacey K. Ogden et al.   NATURE

Pharmacological PKA Inhibition: All May Not Be What It Seems

(2008) A. J. Murray   Science Signaling

Epac-selective cAMP analogs: New tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors

(2007) George G. Holz et al.   CELLULAR SIGNALLING

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphodiesterase inhibitors

(2006) Victoria Boswell-Smith et al.   BRITISH JOURNAL OF PHARMACOLOGY